Alexandra B Moussa-Tooks, Deanna M Barch, William P Hetrick
{"title":"Three principles for the utility of simple tasks that assess elemental processes in parsing heterogeneity.","authors":"Alexandra B Moussa-Tooks, Deanna M Barch, William P Hetrick","doi":"10.1037/abn0000908","DOIUrl":"10.1037/abn0000908","url":null,"abstract":"<p><p>As clinical psychological science and biological psychiatry push to assess, model, and integrate heterogeneity and individual differences, approaches leveraging computational modeling, translational methods, and dimensional approaches to psychopathology are increasingly useful in establishing brain-behavior relationships. The field is ultimately interested in complex human behavior, and disruptions in such behaviors can arise through many different pathways, leading to heterogeneity in etiology for seemingly similar presentations. Parsing this complexity may be enhanced using \"simple\" tasks-which we define as those assaying elemental processes that are the building blocks to complexity. Using eyeblink conditioning as one illustrative example, we propose that simple tasks assessing elemental processes can be leveraged by and enhance computational psychiatry and dimensional approaches in service of understanding heterogeneity in psychiatry, especially when these tasks meet three principles: (a) an extensively mapped circuit, (b) clear brain-behavior relationships, and (c) relevance to understanding etiological processes and/or treatment. (PsycInfo Database Record (c) 2024 APA, all rights reserved).</p>","PeriodicalId":73914,"journal":{"name":"Journal of psychopathology and clinical science","volume":"133 8","pages":"690-696"},"PeriodicalIF":3.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11889992/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142549384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Schizotypy 17 years on: Prediction of schizotypic individual differences in midlife.","authors":"Mark F Lenzenweger","doi":"10.1037/abn0000959","DOIUrl":"https://doi.org/10.1037/abn0000959","url":null,"abstract":"The picture for the long-term prediction of schizotypic individual difference features in relation to schizotypy assessed earlier in life remains opaque. Whereas schizotypy assessed earlier in life, typically during the late teen years, has been shown to predict nonaffective psychotic illness as well as the presence of nonaffective psychotic features (Chapman et al., 1994; Lenzenweger, 2021), the presence in midlife (mid-30s) of nonpsychotic schizotypic features in those assessed for schizotypy earlier in life remains to be demonstrated. The current study, which reports on a 17-year follow-up study, addresses this void in the schizotypy literature. Seventeen years after an initial psychometric assessment for schizotypy, in a sample of emerging adults (age = 18) with no prior history of psychotic illness, Perceptual Aberration Scale scores predicted elevated schizotypal personality features, increased schizophrenia-related personality disorder features (particularly schizotypal and paranoid), and elevated schizophrenia proneness scores at age 35. This pattern of associations was maintained even after the removal of participants with a diagnosis of nonaffective psychosis. The associations also remained largely unchanged net of state anxiety levels at initial and later assessments. These results support the emergence or maintenance of schizotypic psychopathology features consistent with a model that views schizotypy as the underlying liability for schizotypic psychopathology phenotypes. The results also provide additional support for both the construct validity of the initial psychometric schizotypy measure (Perceptual Aberration Scale) as well as the validity of the psychometric high-risk paradigm. Longitudinal research remains an illuminating and informative approach to understanding the nature of schizophrenia-related psychopathology by utilizing time as an essential scientific lever. (PsycInfo Database Record (c) 2024 APA, all rights reserved).","PeriodicalId":73914,"journal":{"name":"Journal of psychopathology and clinical science","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142490942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yoonho Chung,Jeffrey M Girard,Caitlin Ravichandran,Dost Öngür,Bruce M Cohen,Justin T Baker
{"title":"Transdiagnostic modeling of clinician-rated symptoms in affective and nonaffective psychotic disorders.","authors":"Yoonho Chung,Jeffrey M Girard,Caitlin Ravichandran,Dost Öngür,Bruce M Cohen,Justin T Baker","doi":"10.1037/abn0000958","DOIUrl":"https://doi.org/10.1037/abn0000958","url":null,"abstract":"Prevailing factor models of psychosis are centered on schizophrenia-related disorders defined by the Diagnostic and Statistical Manual of Mental Disorders and International Classification of Diseases, restricting generalizability to other clinical presentations featuring psychosis, even though affective psychoses are more common. This study aims to bridge this gap by conducting exploratory and confirmatory factor analyses, utilizing clinical ratings collected from patients with either affective or nonaffective psychoses (n = 1,042). Drawing from established clinical instruments, such as the Positive and Negative Syndrome Scale, Young Mania Rating Scale, and Montgomery-Åsberg Depression Rating Scale, a broad spectrum of core psychotic symptoms was considered for the model development. Among the candidate models considered, including correlated factors and multifactor models, a model with seven correlated factors encompassing positive symptoms, negative symptoms, depression, mania, disorganization, hostility, and anxiety was most interpretable with acceptable fit. The seven factors exhibited expected associations with external validators, were replicable through cross-validation, and were generalizable across affective and nonaffective psychoses. (PsycInfo Database Record (c) 2024 APA, all rights reserved).","PeriodicalId":73914,"journal":{"name":"Journal of psychopathology and clinical science","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142490940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
George D Price,Amanda C Collins,Daniel M Mackin,Michael V Heinz,Nicholas C Jacobson
{"title":"Use of passively collected actigraphy data to detect individual depressive symptoms in a clinical subpopulation and a general population.","authors":"George D Price,Amanda C Collins,Daniel M Mackin,Michael V Heinz,Nicholas C Jacobson","doi":"10.1037/abn0000933","DOIUrl":"https://doi.org/10.1037/abn0000933","url":null,"abstract":"The presentation of major depressive disorder (MDD) can vary widely due to its heterogeneity, including inter- and intraindividual symptom variability, making MDD difficult to diagnose with standard measures in clinical settings. Prior work has demonstrated that passively collected actigraphy can be used to detect MDD at a disorder level; however, given the heterogeneous nature of MDD, comprising multiple distinct symptoms, it is important to measure the degree to which various MDD symptoms may be captured by such passive data. The current study investigated whether individual depressive symptoms could be detected from passively collected actigraphy data in a (a) clinical subpopulation (i.e., moderate depressive symptoms or greater) and (b) general population. Using data from the National Health and Nutrition Examination Survey, a large nationally representative sample (N = 8,378), we employed a convolutional neural network to determine which depressive symptoms in each population could be detected by wrist-worn, minute-level actigraphy data. Findings indicated a small-moderate correspondence between the predictions and observed outcomes for mood, psychomotor, and suicide items (area under the receiver operating characteristic curve [AUCs] = 0.58-0.61); a moderate-large correspondence for anhedonia (AUC = 0.64); and a large correspondence for fatigue (AUC = 0.74) in the clinical subpopulation (n = 766); and a small-moderate correspondence for sleep, appetite, psychomotor, and suicide items (AUCs = 0.56-0.60) in the general population (n = 8,378). Thus, individual depressive symptoms can be detected in individuals who likely meet the criteria for MDD, suggesting that wrist-worn actigraphy may be suitable for passively assessing these symptoms, providing important clinical implications for the diagnosis and treatment of MDD. (PsycInfo Database Record (c) 2024 APA, all rights reserved).","PeriodicalId":73914,"journal":{"name":"Journal of psychopathology and clinical science","volume":"99 34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142486381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Whitney R Ringwald,Elizabeth A Edershile,Janan Mostajabi,Sienna R Nielsen,William C Woods,Leonard J Simms,Aidan G C Wright
{"title":"Daily manifestations of psychopathology in response to stress.","authors":"Whitney R Ringwald,Elizabeth A Edershile,Janan Mostajabi,Sienna R Nielsen,William C Woods,Leonard J Simms,Aidan G C Wright","doi":"10.1037/abn0000954","DOIUrl":"https://doi.org/10.1037/abn0000954","url":null,"abstract":"Psychological functioning is shaped by how people navigate their environment. Accordingly, psychopathology is often caused and maintained by patterns of responding to the environment that do not meet situational demands. In particular, psychopathology is often expressed in an inflexible or intense manner of coping with stressful situations. Prior research on psychopathology and daily life stress is limited by an overreliance on negative affect reactivity, which neglects the myriad responses that can create problems in a person's life. In this study, we assessed a broad range of daily manifestations of psychopathology to examine daily psychopathology-stress associations. We conceptualized individual differences in functioning as psychopathology traits and daily fluctuations in the interrelated thoughts, behaviors, and emotions as psychopathology states, with traits and states corresponding to the same domains of functioning (i.e., antagonism, detachment, disinhibition, negative affectivity, anankastia, psychoticism). Data have been taken from two samples enriched for psychopathology (N = 112, N = 294 participants) who completed daily assessments of stressors and psychopathological states (n = 9,201, n = 4,292 days). We used multilevel structural equation models to examine average, within-person associations between stressors and psychopathological states and correlations between psychopathological traits and stress responses. Results showed that (a) most people experience increases in psychopathological states when stressed and (b) psychopathological traits relate to more consistent and stronger increases in psychopathological states. Our study suggests that psychopathology reflects how people cope with stressful situations, and what distinguishes people with high-trait psychopathology from those who experience typical upticks in psychopathology when stressed is the consistency and extremity of their responses. (PsycInfo Database Record (c) 2024 APA, all rights reserved).","PeriodicalId":73914,"journal":{"name":"Journal of psychopathology and clinical science","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142486382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Daniel P Moriarity,Julia Case,Marin M Kautz,Kubarah Ghias,Kirsta Pennypacker,Douglas J Angus,Eddie Harmon-Jones,Lauren B Alloy
{"title":"Toward diversification of acute stressors and precision stress research: A stage 2 Registered Report validating a reward-salient stress task in emerging adults.","authors":"Daniel P Moriarity,Julia Case,Marin M Kautz,Kubarah Ghias,Kirsta Pennypacker,Douglas J Angus,Eddie Harmon-Jones,Lauren B Alloy","doi":"10.1037/abn0000948","DOIUrl":"https://doi.org/10.1037/abn0000948","url":null,"abstract":"Stress is one of, if not the, most ubiquitously studied risk factor across the health sciences. This is unlikely to change given that the primary drivers of mortality and disability are chronic, stress-mediated illnesses (often highly comorbid with psychopathology). We argue that an important limitation of stress research is the consistency with which the Trier Social Stress Test is used when the research questions are not specific to social stress. We advocate for precision stress research using qualitatively different stressors to facilitate exploration of how different types of stressors might differentially impact health outcomes, including psychopathology. This registered report validates a reward-salient stress task (a modified Anger Incentive Delay Task) in a sample of 101 emerging adults, over half of whom reported clinically relevant anxiety, hypo/mania, depression, and/or suicidal ideation, who participated in a study between 2020 and 2022. This task involves teaching participants a game where they can win money. Part way through, the \"goal frustration\" condition changes the rules such that correct responses to trials with anticipatory stimuli indicating the possibility to win money actually lose money on 56% of trials despite visual feedback indicating that responses were successful. Results consistently indicated that the Anger Incentive Delay Task successfully reduced positive emotions and motivation and increased negative emotions. The magnitude of these responses was predicted by individual differences in reward and punishment sensitivity. Given the breadth of psychopathologies that share both (a) stress and (b) reward and punishment sensitivity as risk factors, a reward-salient acute stress task is an important tool for precision psychopathology research. (PsycInfo Database Record (c) 2024 APA, all rights reserved).","PeriodicalId":73914,"journal":{"name":"Journal of psychopathology and clinical science","volume":"71 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142439655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Elisabeth L de Moor,Sara Campens,Kristina Eggermont,Leni Raemen,Janne Vanderhaegen,Lore Vankerckhoven,Elise van Laere,Annabel Bogaerts,Nagila Koster,Susan Branje,Laurence Claes,Koen Luyckx
{"title":"Mental illness and identity in adolescents with internalizing problems: A qualitative exploration of identity-relevant narratives.","authors":"Elisabeth L de Moor,Sara Campens,Kristina Eggermont,Leni Raemen,Janne Vanderhaegen,Lore Vankerckhoven,Elise van Laere,Annabel Bogaerts,Nagila Koster,Susan Branje,Laurence Claes,Koen Luyckx","doi":"10.1037/abn0000952","DOIUrl":"https://doi.org/10.1037/abn0000952","url":null,"abstract":"Mental illness and identity are related, with issues in identity contributing to the development of psychopathology and vice versa. However, little work has examined how mental illness and identity can become interwoven (i.e., mental illness identity). Mental illness identity may be particularly important during adolescence, as this life phase is marked by the salience of identity and an increase in psychopathology. In the present study, we conducted a qualitative examination of the high point, low point, turning point, and psychopathology-related narratives of 69 Dutch adolescents (Mage = 16.5, 75.4% female, 15.9% male, 8.7% other). The participants were diagnosed with a mood, anxiety, and/or eating disorder, and the majority of them (82.6%) were in treatment at the time of the study. We found that adolescents' mental illness identity could take different forms and that these forms may be more adaptive or maladaptive depending on the context of each adolescent's life. Furthermore, mental illness identity was related to several factors within adolescents (e.g., sense of agency) and their environment (e.g., stigma). These findings contribute to our understanding of adolescent mental illness identity and may be used to improve the treatment of their internalizing problems. (PsycInfo Database Record (c) 2024 APA, all rights reserved).","PeriodicalId":73914,"journal":{"name":"Journal of psychopathology and clinical science","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142439228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Suicidal thoughts are associated with reduced source attribution of emotion.","authors":"Yael Millgram,Amit Goldenberg,Matthew K Nock","doi":"10.1037/abn0000939","DOIUrl":"https://doi.org/10.1037/abn0000939","url":null,"abstract":"Approximately 9% of people think about suicide during their lifetime. Suicidal thoughts are consistently associated with perceived failures in emotion regulation. However, factors contributing to these perceptions remain insufficiently clear. New evidence suggests that when people know little about the cause of their emotions (i.e., low source attribution of emotion), they perceive themselves as less successful in regulating them. Therefore, emotion regulation deficits in people with suicidal thoughts might be related to lower knowledge about sources of emotions. We examined this question in two ecological momentary assessment studies (N₁ = 396, N₂ = 195). We found that participants with current suicidal thoughts knew less about the sources of their emotions compared to participants with no suicidal thoughts history (Studies 1 and 2), and even when compared to controls with similar levels of psychiatric symptoms but no history of suicidal thoughts (Study 2). Using language processing, we found that written descriptions of the source of participants' emotions were less concrete among those with suicidal thoughts compared to participants with no suicidal thoughts history. Among suicidal participants, suicidal thoughts were more likely to be present in moments when participants knew less than usual about the source of their negative emotions (Study 2), and low knowledge of the source was associated with more frequent and prolonged suicidal thoughts (Studies 1 and 2). Finally, lower perceived success in emotion regulation mediated the association between source attribution of emotion and the occurrence of suicidal thoughts. Findings suggest that reduced knowledge about the source of negative emotions might increase the risk for suicidal thinking. (PsycInfo Database Record (c) 2024 APA, all rights reserved).","PeriodicalId":73914,"journal":{"name":"Journal of psychopathology and clinical science","volume":"72 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142386318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Narrative identity disturbances in psychopathology: An ecologically valid transdiagnostic framework.","authors":"Henry R Cowan, Majse Lind","doi":"10.1037/abn0000932","DOIUrl":"10.1037/abn0000932","url":null,"abstract":"<p><p>This article presents an ecologically valid transdiagnostic framework regarding narrative identity disturbances in psychopathology. Problems with self and identity are distressing, disruptive to everyday functioning, and central to theoretical models of recovery. Yet these problems are sorely understudied, in part due to differences in concepts, theories, and measurement models across disorder-specific literatures. Disorder-specific theories are useful for understanding the etiology of disturbances to self and identity. However, while root causes may vary across disorders, their effects on explicit, conscious, reflective experience share important transdiagnostic parallels. These problems affect the extended sense of self as an individual with memories, a present identity, and future expectancies. By extension, these problems are developmental, reflecting an ever-evolving conception of oneself across the life course. Finally, these problems are contextual and intersubjective, constructed over time through interactions with others in the family, community, and society. A unified transdiagnostic model for reflective self-disturbances should therefore be idiographic and grounded in developmental and personality theory, with a strong emphasis on ecological validity. Narrative identity is emerging as a coherent, cross-cutting framework for understanding problems with self and identity across diagnostic boundaries. Important current research directions include transdiagnostic samples and clinical control groups; more diverse samples; expanding on the latent structure of narrative identity in clinical populations, and developing new assessment techniques to supplement trained raters. These directions will further enhance narrative identity's utility for idiographic, developmental, and ecologically valid clinical research. (PsycInfo Database Record (c) 2024 APA, all rights reserved).</p>","PeriodicalId":73914,"journal":{"name":"Journal of psychopathology and clinical science","volume":" ","pages":"503-504"},"PeriodicalIF":3.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141891130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kendra Wyant, Sarah J Sant'Ana, Gaylen E Fronk, John J Curtin
{"title":"Machine learning models for temporally precise lapse prediction in alcohol use disorder.","authors":"Kendra Wyant, Sarah J Sant'Ana, Gaylen E Fronk, John J Curtin","doi":"10.1037/abn0000901","DOIUrl":"10.1037/abn0000901","url":null,"abstract":"<p><p>We developed three machine learning models that predict hour-by-hour probabilities of a future lapse back to alcohol use with increasing temporal precision (i.e., lapses in the next week, next day, and next hour). Model features were based on raw scores and longitudinal change in theoretically implicated risk factors collected through ecological momentary assessment. Participants (<i>N</i> = 151, 51% male, <i>M</i><sub>age</sub> = 41, 87% White, 97% non-Hispanic) in early recovery (1-8 weeks of abstinence) from alcohol use disorder provided 4 × daily ecological momentary assessment for up to 3 months. We used grouped, nested cross-validation to select the best models and evaluate the performance of those best models. Models yielded median areas under the receiver operating curves of 0.89, 0.90, and 0.93 in the 30 held-out test sets for week-, day-, and hour-level models, respectively. Some feature categories consistently emerged as being globally important to lapse prediction across our week-, day-, and hour-level models (i.e., past use, future self-efficacy). However, most of the more punctate, time-varying constructs (e.g., craving, past stressful events, arousal) appear to have a greater impact within the next-hour prediction model. This research represents an important step toward the development of a smart (machine learning guided) sensing system that can both identify periods of peak lapse risk and recommend specific supports to address factors contributing to this risk. (PsycInfo Database Record (c) 2024 APA, all rights reserved).</p>","PeriodicalId":73914,"journal":{"name":"Journal of psychopathology and clinical science","volume":" ","pages":"527-540"},"PeriodicalIF":3.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11556439/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142019782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}