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Serum Lipidomics Characterization of Breast Cancer Progression in a Transgenic Mouse Model of PyMT-Induced Breast Cancer pymt诱导乳腺癌转基因小鼠模型中乳腺癌进展的血清脂质组学表征
Journal of oncology research and therapy Pub Date : 2023-04-13 DOI: 10.29011/2574-710x.10164
{"title":"Serum Lipidomics Characterization of Breast Cancer Progression in a Transgenic Mouse Model of PyMT-Induced Breast Cancer","authors":"","doi":"10.29011/2574-710x.10164","DOIUrl":"https://doi.org/10.29011/2574-710x.10164","url":null,"abstract":"","PeriodicalId":73876,"journal":{"name":"Journal of oncology research and therapy","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89265308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Toxicity of Immune Checkpoint Combination Therapy in Advanced Renal Cell Carcinoma: A Systematic Review and Meta-Analysis of Randomized Clinical Trials 免疫检查点联合治疗晚期肾细胞癌的毒性:随机临床试验的系统回顾和荟萃分析
Journal of oncology research and therapy Pub Date : 2023-03-21 DOI: 10.29011/2574-710x.10159
{"title":"Toxicity of Immune Checkpoint Combination Therapy in Advanced Renal Cell Carcinoma: A Systematic Review and Meta-Analysis of Randomized Clinical Trials","authors":"","doi":"10.29011/2574-710x.10159","DOIUrl":"https://doi.org/10.29011/2574-710x.10159","url":null,"abstract":"","PeriodicalId":73876,"journal":{"name":"Journal of oncology research and therapy","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74378657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Study of Ceramide-Flavone Analogs Showing Self-Fluorescence and Anti-Proliferation Activities. 显示自发荧光和抗增殖活性的神经酰胺-黄酮类似物的研究
Journal of oncology research and therapy Pub Date : 2023-01-01 DOI: 10.29011/2574-710x.10172
Navneet Goyal, Camilla Do, Miriam Hill-Odom, Teresa Beamon, Tulasi Ponnapakkam, Jiawang Liu, Jayalakshmi Sridhar, Thomas Huckaba, Maryam Foroozesh
{"title":"Study of Ceramide-Flavone Analogs Showing Self-Fluorescence and Anti-Proliferation Activities.","authors":"Navneet Goyal, Camilla Do, Miriam Hill-Odom, Teresa Beamon, Tulasi Ponnapakkam, Jiawang Liu, Jayalakshmi Sridhar, Thomas Huckaba, Maryam Foroozesh","doi":"10.29011/2574-710x.10172","DOIUrl":"10.29011/2574-710x.10172","url":null,"abstract":"<p><strong>Background: </strong>Many current anti-cancer drugs used to treat breast cancer mediate tumor cell death through the induction of apoptosis. Cancer cells, however, often acquire multidrug-resistance following prolonged exposure to chemotherapeutics. Consequently, molecular pathways involved in tumor cell proliferation have become potential targets for pharmacological intervention. Ceramides are tumor suppressor lipids naturally found in the cell membrane, and are central molecules in the sphingolipid signalling pathway.</p><p><strong>Methods: </strong>Our lab has targeted the ceramide signaling pathway for potential pharmacological intervention in the treatment of breast cancer. Previously, we have shown that certain ceramide analogs have therapeutic potential in the treatment of chemo-sensitive and multidrug-resistant breast cancers. Using the most active analog from our previous studies as the lead compound, new analogs containing a flavone moiety were designed and synthesized. In general, flavone derivatives often show interesting pharmacological properties, and compounds based on these molecules have been found useful in many different therapeutic areas including anti-tumor, anti-coagulants, and anti-HIV therapy.</p><p><strong>Results: </strong>Synthesis and biological evaluation of five new flavonoid ceramide analogs are reported here. These compounds were also shown to be self-fluorescent, which can be useful when investigating their distribution and action in cancer cells.</p><p><strong>Conclusion: </strong>Four out of the five flavone ceramide analogs in this study showed significant anti-proliferation activities in the three cell lines studied, MDA-MB-232, MCF-7, and MCF-7TN-R; some showing varying degrees of selectivity. The mechanisms involved in cell proliferation inhibition are complicated and further studies are needed.</p>","PeriodicalId":73876,"journal":{"name":"Journal of oncology research and therapy","volume":"8 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10399632/pdf/nihms-1914530.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10412926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Suppressive Effects of Tyrosine (Y129) Phosphorylation of Profilin I on Breast Cancer Progression Tyrosine (Y129)磷酸化Profilin I对乳腺癌进展的抑制作用
Journal of oncology research and therapy Pub Date : 2022-12-29 DOI: 10.29011/2574-710x.10155
{"title":"Suppressive Effects of Tyrosine (Y129) Phosphorylation of Profilin I on Breast Cancer Progression","authors":"","doi":"10.29011/2574-710x.10155","DOIUrl":"https://doi.org/10.29011/2574-710x.10155","url":null,"abstract":"","PeriodicalId":73876,"journal":{"name":"Journal of oncology research and therapy","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76821293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between Isoflavones and Colorectal Cancer Risk: A Case-Control Study in Japanese 异黄酮与结直肠癌风险的关系:日本的一项病例对照研究
Journal of oncology research and therapy Pub Date : 2022-12-27 DOI: 10.29011/2574-710x.10152
{"title":"Association between Isoflavones and Colorectal Cancer Risk: A Case-Control Study in Japanese","authors":"","doi":"10.29011/2574-710x.10152","DOIUrl":"https://doi.org/10.29011/2574-710x.10152","url":null,"abstract":"","PeriodicalId":73876,"journal":{"name":"Journal of oncology research and therapy","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89197983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endoplasmic Reticulum Stress in Osteosarcoma: IRE1α-XBP1 Inhibition Exerts Anti-Tumor Activity 骨肉瘤内质网应激:IRE1α-XBP1抑制发挥抗肿瘤活性
Journal of oncology research and therapy Pub Date : 2022-12-27 DOI: 10.29011/2574-710x.10157
{"title":"Endoplasmic Reticulum Stress in Osteosarcoma: IRE1α-XBP1 Inhibition Exerts Anti-Tumor Activity","authors":"","doi":"10.29011/2574-710x.10157","DOIUrl":"https://doi.org/10.29011/2574-710x.10157","url":null,"abstract":"","PeriodicalId":73876,"journal":{"name":"Journal of oncology research and therapy","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90710058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hypoxia Mediated Glycoprotein-170 Expression: Role in Cancer Cells Chemo Resistance 缺氧介导的糖蛋白170表达:在癌细胞化疗耐药中的作用
Journal of oncology research and therapy Pub Date : 2022-12-22 DOI: 10.29011/2574-710x.10153
{"title":"Hypoxia Mediated Glycoprotein-170 Expression: Role in Cancer Cells Chemo Resistance","authors":"","doi":"10.29011/2574-710x.10153","DOIUrl":"https://doi.org/10.29011/2574-710x.10153","url":null,"abstract":"","PeriodicalId":73876,"journal":{"name":"Journal of oncology research and therapy","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80493450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Piper nigrum: Therapeutic Potential of Leaves Extract in HNSCC 黑椒叶提取物治疗HNSCC的潜力
Journal of oncology research and therapy Pub Date : 2022-10-29 DOI: 10.29011/2574-710x.10150
{"title":"Piper nigrum: Therapeutic Potential of Leaves Extract in HNSCC","authors":"","doi":"10.29011/2574-710x.10150","DOIUrl":"https://doi.org/10.29011/2574-710x.10150","url":null,"abstract":"","PeriodicalId":73876,"journal":{"name":"Journal of oncology research and therapy","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84983435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Survivorship Endpoints in Pet Dogs with Naturally Occurring Cancer as Models for Human Cancer 宠物狗自然发生的癌症作为人类癌症模型的生存终点
Journal of oncology research and therapy Pub Date : 2022-10-06 DOI: 10.29011/2574-710x.10148
Mairin Miller, S. Stewart, K. Wendelburg, F. Lew, John Berg, Arata Matsuyama, A. Mutsaers, S. Kahn, Craig Clifford, Gary Clark, C. Khanna
{"title":"Survivorship Endpoints in Pet Dogs with Naturally Occurring Cancer as Models for Human Cancer","authors":"Mairin Miller, S. Stewart, K. Wendelburg, F. Lew, John Berg, Arata Matsuyama, A. Mutsaers, S. Kahn, Craig Clifford, Gary Clark, C. Khanna","doi":"10.29011/2574-710x.10148","DOIUrl":"https://doi.org/10.29011/2574-710x.10148","url":null,"abstract":"Endpoints in Pet Dogs with Naturally Occurring Cancer as Models for Human Cancer. Abstract Pet dogs with cancer have been valuable models for human cancer drug development (Comparative Oncology). Despite strong similarities, the false perception that survivorship in veterinary cancer patients does not exist creates a challenge in translation of efficacy signals, from dog studies to humans, and constrains innovation in veterinary oncology. Until now veterinary oncology has been unique in its focus on the median when reporting","PeriodicalId":73876,"journal":{"name":"Journal of oncology research and therapy","volume":"112 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80745630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhanced Progression-Free Survival in a Phase 2 Trial of Personal Dendritic Cell Vaccines in Patients with Newly Diagnosed Glioblastoma 在新诊断的胶质母细胞瘤患者中，个人树突状细胞疫苗的2期试验提高了无进展生存期
Journal of oncology research and therapy Pub Date : 2022-09-30 DOI: 10.29011/2574-710x.010149
DE Piccioni, CM Duma, RV LaRocca, R. Aiken, TH Taylor, JA Carrillo, GI Nistor, HS Keirstead, Robert O. Dillman, DA Bota, Robert O. Dillman
{"title":"Enhanced Progression-Free Survival in a Phase 2 Trial of Personal Dendritic Cell Vaccines in Patients with Newly Diagnosed Glioblastoma","authors":"DE Piccioni, CM Duma, RV LaRocca, R. Aiken, TH Taylor, JA Carrillo, GI Nistor, HS Keirstead, Robert O. Dillman, DA Bota, Robert O. Dillman","doi":"10.29011/2574-710x.010149","DOIUrl":"https://doi.org/10.29011/2574-710x.010149","url":null,"abstract":"Standard therapy of aggressive glioblastoma (GBM), which includes maximum safe surgical resection and concurrent radiation/temozolomide (RT/TMZ) followed by maintenance TMZ, is associated with poor progression-free survival (PFS) and overall","PeriodicalId":73876,"journal":{"name":"Journal of oncology research and therapy","volume":"49 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74613828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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