Journal of oncology research and therapy最新文献

{"title":"DNA Methylation Studies and Molecular Therapy of Helicobacter pylori Strain for the Treatment of Gastric Cancer","authors":"","doi":"10.29011/2574-710x.010106","DOIUrl":"https://doi.org/10.29011/2574-710x.010106","url":null,"abstract":"","PeriodicalId":73876,"journal":{"name":"Journal of oncology research and therapy","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77671169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemoprevention: A Promising Prophylaxis to Risk of Leukemia in Polluted Environments and Indication for Creative Health Education","authors":"","doi":"10.29011/2574-710x.001092","DOIUrl":"https://doi.org/10.29011/2574-710x.001092","url":null,"abstract":"","PeriodicalId":73876,"journal":{"name":"Journal of oncology research and therapy","volume":"160 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76627916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacokinetics of Six-Carbon Analogues of L-Glucose in Tumour-Bearing Humans (Series I: Ascorbate)","authors":"","doi":"10.29011/2574-710x.010100","DOIUrl":"https://doi.org/10.29011/2574-710x.010100","url":null,"abstract":"","PeriodicalId":73876,"journal":{"name":"Journal of oncology research and therapy","volume":"100 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78108635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pro-Inflammatory Milieu in Human Kidney Perfusates Treated with Hypothermic Pulsatile Machine Perfusion.","authors":"Emmett Ratigan, Sashi Kasimsetty, Jeffrey Cohen, Alana Shigeoka, Lisa Stocks, Kristin Mekeel, Robert Steiner, Dianne B McKay","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Hypothermic Machine Perfusion (HMP) has been shown to decrease Delayed Graft Function (DGF) and improve outcomes of deceased donor kidney transplants. Although the mechanisms of protection afforded by HMP have not yet been defined, this study tested the hypothesis that HMP improves transplant outcomes by clearing pro-inflammatory molecules from the allograft during pumping. Here we report on 26 allografts preserved via pulsatile HMP at our organ procurement organization that were prospectively evaluated for the time-dependent clearance of cytokines, chemokines and injury markers during their time on pump. Of the cytokines and chemokines measured, IL-1RA, IL-6, IL-18, INFγ, and MCP-1 were increased in the pump perfusate over time and were correlated with markers of kidney injury. Over time on pump, the 'Danger' molecule HMGB1 appeared in the perfusate, and perfusate samples activated T-cells <i>ex vivo</i>. The data from this prospective study show that HMP is associated with a time-dependent clearance of pro-inflammatory cytokines, chemokines and danger molecules from donor allografts during the process of pumping, which may in part explain the beneficial effects of HMP.</p>","PeriodicalId":73876,"journal":{"name":"Journal of oncology research and therapy","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11566414/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in Brain Cancer: Creating Monoallelic Single Point Mutation in IDH1 by Single Base Editing.","authors":"Sagar R Shah, Alfredo Quinones-Hinojosa, Shuli Xia","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Mutations in the Isocitrate Dehydrogenase 1 (IDH1) gene occur in 70% of grade II and grade III gliomas, 10% of acute myeloid leukemia, as well as cholangiocarcinomas, melanomas, and chondrosarcomas. Numerous mechanisms have been proposed to illustrate the biological function of mutant IDH1. Most functional studies of mutant IDH1 have been conducted in exogenous overexpression systems with the IDH1 wild type background. This mini-review comments on recent publication by Wei et al, in which a highly efficient \"single base editing\" approach was employed to generate monoallelic IDH1 R132H mutation without the induction of a double strand break in the IDH1 gene.</p>","PeriodicalId":73876,"journal":{"name":"Journal of oncology research and therapy","volume":"5 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6641564/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141285494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Anterolateral Thigh Flap for Hemiglossectomy Defect","authors":"K. Nguyen, T. Bui, C. Nguyen, T. A. Nguyen","doi":"10.29011/2574-710x.000076","DOIUrl":"https://doi.org/10.29011/2574-710x.000076","url":null,"abstract":"Since Song, et al. introduced the Anterolateral Thigh Flap (ALTF) in 1984, the ALTF has gained popularity for reconstruction for head and neck defects. Thirteen consecutive patients with carcinoma of the tongue underwent surgical resection and reconstruction with the ALTF. There was only one complete flap failure, the resultant flap success rate is 92%. Preliminary assessment of recovering tongue function was acceptable and donor site complications were minimal. Therefore, we believe that the ALTF is a reliable flap for hemiglossectomy defect reconstruction. Patients and Methods From March 2018 to December 2018 at the 5th Surgical Department of Ho Chi Minh City Oncology Hospital, 13 consecutive patients with squamous cell carcinoma of the tongue requiring hemiglossectomy underwent resection and reconstruction with ALTF. The histologic type of all tumors were squamous cell carcinoma. The research method is a case series report. The function of postoperative tongue is evaluated by three doctors Tables 1,2. Never understandable; may use written communication 1 Difficult to understand 2 Usually understandable; face-to-face contact necessary 3 Understandable most of the time; occasional repetition necessary 4 Always understandable Table 1: Understandability of speech [2]. Introduction Tongue cancer is the most common cancer of the oral cavity. Surgery is the main treatment modality for this neoplasm. With small and superficial defects, resection surgeries do not affect the function of the tongue. However, if the large lesions invade deeply, the procedures will leave large defects that require reconstruction to restore the functions of the tongue, the most important of which are speech and deglutition. Tongue reconstruction objectives include not only the recovery of tongue volume, but also the movement of the tongue. Currently, free flap is the ideal choice for tongue reconstruction. The Radial Forearm Flap (RFF) and Anterolateral Thigh Flap (ALTF) are the two most widely used flaps. RFF was introduced in 1981 and has gained popularity for reconstruction the oral cavity. This flap shows several advantages, but it also has disadvantages concerning the scar of donor site [1]. The ALTF is now widely used for reconstruction in Asia; this flap has some significant advantages for reconstruction of head and neck. It can be raised as a subcutaneous flap, a fasciocutaneous flap or a myocutaneous flap and can resurface large defects in head and neck. In addition, it is pliable and suitable for three dimensional defects of the tongue and the floor of the mouth. Another advantage is that it has a large and long vascular pedicle; donor site can be closed primarily and functional loss of donor site is minimal. Citation: Nguyen KA, Bui TX, Nguyen CQ, Nguyen TA (2019) The Anterolateral Thigh Flap for Hemiglossectomy Defect. J Oncol Res Ther 4: 176. DOI: 10.29011/2574710X.000176 2 Volume 4; Issue 01 J Oncol Res Ther, an open access journal ISSN: 2574-710X Level Descri","PeriodicalId":73876,"journal":{"name":"Journal of oncology research and therapy","volume":"384 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77682163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Significance of Using SYPRO Ruby against CBB R-250 for Visualizing Haematoxylin Stained Proteins in Gels.","authors":"Noor Feuza Hussain,&nbsp;Sulma Ibrahim Mohammed","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Laser Capture Micro-dissection (LCM) is a technique that is used to isolate specific tumor cells from a heterogeneous tumor tissue sample.To aid in identifying and dissecting pure tumor cells from other parts of the tissues such as the stroma, tissues are stained with Haematoxylin and Eosin. The cells are then used for protein, RNA or DNA extraction. However, the effect of Haematoxylin and Eosin or other different stains routinely used in the laboratories on the recovery, quantity and quality of proteins especially for down stream application such as 2-dimenssional gel electrophoresis (2-DE) and MS not known. This study, determined the effect of Haematoxylin staining on the detection methods used in 1-D SDS-PAGE for protein quantification. A series of concentration of proteins were obtained from human pancreatic whole tissue and was run on a SDS-PAGE parallel with the proteins obtained from Haematoxylin stained and unstained tissues.The protein band intensities were measured with a densitometer after separately stained with SYPRO Ruby or CBB R-250.The protein band intensity ratios of the whole tissue and Haematoxylin stain/ Haematoxylin unstained tissue were calculated. According to the ratios,there was an intensity loss in the Haematoxylin stained proteins when detecting through CBB R -250 but not from SYPRO Ruby. This was due to the structure and reactivity of these two stains towards proteins in the presence of Haematoxylin. The study recommends the use of SYPRO Ruby instead of CBB R-250 to visualize proteins in 2-DE gels when tissues were stained with Haematoxylin.</p>","PeriodicalId":73876,"journal":{"name":"Journal of oncology research and therapy","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6498853/pdf/nihms-1002087.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37216511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral Squamous Cell Carcinomas are Associated with Poorer Outcome with Increasing Ages.","authors":"Tarinee Lubpairee,&nbsp;Catherine F Poh,&nbsp;Denise M Laronde,&nbsp;Miriam P Rosin,&nbsp;Lewei Zhang","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objectives: </strong>1.1.Although oral cancers traditionally occur in people between the age of 50 and 70, there are increasing incidences of this disease in younger and very old people. Objectives: to compare the demographics, habits, clinicopathological features, treatment and outcome of oral cancer in three age groups of patients: Young (≤ 45), Traditional (46 to 75), and Old (> 75).</p><p><strong>Subjects: </strong>1.2.Primary oral cancers (393 patients) in a longitudinal study were used.</p><p><strong>Results: </strong>1.3.Significant differences were noted in ethnicity (fewer Caucasian patients in Young), tobacco habit (more non-smokers in Young), location of cancer (more at tongue for Young and more at low-risk sites for Old) and treatment (more surgery for Young). Compared to Young (univariate analysis), Traditional and Old showed a 3- and 4.5-fold increase in local recurrences respectively; 1.9- and 2.7-fold increase in regional metastasis; 3.1- and 5.4-fold increase in death due to disease; and a 3.4- and 6.6-fold decrease in overall survival. Compared to Young (multivariate analysis), Traditional and Old showed a 2.4- and 3.3-fold increase in local recurrence; 2.7- and 5.4-fold increase in disease-specific survival; and 2.8- and 6.5-fold decrease in overall survival.</p><p><strong>Conclusion: </strong>1.4.Oral cancer in different age groups showed differing ethnicity, habit, location, treatment and outcome.</p>","PeriodicalId":73876,"journal":{"name":"Journal of oncology research and therapy","volume":"3 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6498857/pdf/nihms-1002090.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37216510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}