Journal of ocular biology, diseases, and informatics最新文献_第6页

Spectral-domain optical coherence tomography in healed ocular toxoplasmosis. 眼弓形虫病愈合后的光谱域光学相干断层扫描。

Journal of ocular biology, diseases, and informatics Pub Date : 2010-09-01 Epub Date: 2011-08-10 DOI: 10.1007/s12177-011-9062-x

Sandeep Saxena, Ramit A K Rastogi, Kuldeep Vishvkarma, Sanjiv Hansraj, Carsten H Meyer

引用次数: 9

Tumor necrosis factor-α-mediated severity of idiopathic retinal periphlebitis in young adults (Eales' disease): implication for anti-TNF-α therapy. 肿瘤坏死因子-α介导的年轻人特发性视网膜外周炎(Eales病)的严重程度:抗tnf -α治疗的意义

Journal of ocular biology, diseases, and informatics Pub Date : 2010-07-16 DOI: 10.1007/s12177-010-9053-3

Sandeep Saxena, Aditya B Pant, Vinay K Khanna, Kamlesh Singh, Rajendra K Shukla, Carsten H Meyer, Vijay K Singh

{"title":"Tumor necrosis factor-α-mediated severity of idiopathic retinal periphlebitis in young adults (Eales' disease): implication for anti-TNF-α therapy.","authors":"Sandeep Saxena, Aditya B Pant, Vinay K Khanna, Kamlesh Singh, Rajendra K Shukla, Carsten H Meyer, Vijay K Singh","doi":"10.1007/s12177-010-9053-3","DOIUrl":"https://doi.org/10.1007/s12177-010-9053-3","url":null,"abstract":"Tumor necrosis factor-alpha (TNF-α) is a pleiotropic inflammatory cytokine. Tumor necrosis factor-alpha was evaluated in the serum samples of patients with idiopathic retinal periphlebitis in young adults (Eales' disease). Retinal periphlebitis was graded according to a new grading system based on severity of inflammation (grade 1-4). Quantification of the TNF-α levels was carried out using ELISA kit in the serum samples of young adults with idiopathic retinal periphlebitis (n = 17) and healthy controls (n = 17) of similar age. Tumor necrosis factor-α level was found to be significantly raised in cases with retinal periphlebitis as compared with controls (p < 0.001). Higher levels of TNF-α were found to be associated with increased severity of retinal periphlebitis. Tumor necrosis factor-α represents a novel target for controlling inflammatory activity in idiopathic retinal periphlebitis. Higher levels of TNF-α, in association with the increased severity of retinal periphlebitis, have implications for early anti-TNF-α therapy.","PeriodicalId":73873,"journal":{"name":"Journal of ocular biology, diseases, and informatics","volume":"3 1","pages":"35-8"},"PeriodicalIF":0.0,"publicationDate":"2010-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12177-010-9053-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29520180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

The need for validation of large administrative databases: Veterans Health Administration ICD-9CM coding of exudative age-related macular degeneration and ranibizumab usage. 验证大型管理数据库的需要:退伍军人健康管理局的ICD-9CM编码的渗出性年龄相关性黄斑变性和雷尼单抗的使用。

Journal of ocular biology, diseases, and informatics Pub Date : 2010-07-09 DOI: 10.1007/s12177-010-9052-4

Paul Latkany, Mona Duggal, Joseph Goulet, Hyung Paek, Michael Rambo, Philip Palmisano, Woody Levin, Joseph Erdos, Amy Justice, Cynthia Brandt

{"title":"The need for validation of large administrative databases: Veterans Health Administration ICD-9CM coding of exudative age-related macular degeneration and ranibizumab usage.","authors":"Paul Latkany, Mona Duggal, Joseph Goulet, Hyung Paek, Michael Rambo, Philip Palmisano, Woody Levin, Joseph Erdos, Amy Justice, Cynthia Brandt","doi":"10.1007/s12177-010-9052-4","DOIUrl":"https://doi.org/10.1007/s12177-010-9052-4","url":null,"abstract":"We performed a validation study by chart review of data for exudative age-related macular degeneration (eAMD) and, because of the Veterans Administration (VA) therapy policy, ranibizumab usage in the largest electronic medical record system in the USA. We reviewed 5,854 distinct patients who visited an ophthalmology clinic within VA Connecticut from January 2006-December 2008. We randomly selected 98 of 138 distinct eAMD patients and 265 of 5,588 non-eAMD patients who did not receive ranibizumab. International Classification of Diseases, Ninth Revision, Clinical Modification coding of eAMD had an excellent positive predictive value of 97.8% (95% confidence interval (CI), 93.5-99.4%). The national Decision Support System (DSS) had an excellent positive predictive value of 100% (95% CI, 79.9-100%) for ranibizumab. However, the negative predictive value of the DSS dispensed ranibizumab decreased to 67.5 (95% CI, 62.1-72.4) because of a change in the way local values were stored that led to errors. Therefore, validation of clinical information over time in large databases is necessary.","PeriodicalId":73873,"journal":{"name":"Journal of ocular biology, diseases, and informatics","volume":"3 1","pages":"30-4"},"PeriodicalIF":0.0,"publicationDate":"2010-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12177-010-9052-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29520179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Association of contrast sensitivity with LogMAR visual acuity and glycosylated hemoglobin in non-insulin dependent diabetes mellitus. 非胰岛素依赖型糖尿病患者对比敏感度与LogMAR视力和糖化血红蛋白的关系。

Journal of ocular biology, diseases, and informatics Pub Date : 2010-06-01 Epub Date: 2010-11-03 DOI: 10.1007/s12177-010-9056-0

Shaili Misra, Sandeep Saxena, Poonam Kishore, Shashi K Bhasker, Arvind Misra, Carsten H Meyer

{"title":"Association of contrast sensitivity with LogMAR visual acuity and glycosylated hemoglobin in non-insulin dependent diabetes mellitus.","authors":"Shaili Misra, Sandeep Saxena, Poonam Kishore, Shashi K Bhasker, Arvind Misra, Carsten H Meyer","doi":"10.1007/s12177-010-9056-0","DOIUrl":"https://doi.org/10.1007/s12177-010-9056-0","url":null,"abstract":"A tertiary care center-based prospective case-control study was undertaken to evaluate the association of contrast sensitivity with LogMAR visual acuity and glycosylated hemoglobin (HbA1c) in 205 cases of non-insulin dependent diabetes mellitus and 115 controls. LogMAR visual acuity and contrast sensitivity were scored using ETDRS and Pelli-Robson charts, respectively. Bivariate correlation between contrast sensitivity and LogMAR visual acuity showed significant inverse correlation in cases without retinopathy (r = -0.466) and with non-proliferative retinopathy (r = -0.307). In a multivariate model, on applying linear regression analysis, LogMAR visual acuity (p < 0.001) and HbA1c (p = 0.002) had significant association with contrast sensitivity. Significant difference in contrast sensitivity was not observed between cases without diabetic retinopathy and with non-proliferative diabetic retinopathy, implying no association with retinal microvascular changes. Contrast sensitivity dysfunction observed in diabetes mellitus results from changes in retinal function secondary to alteration in carbohydrate metabolism depicted in glycosylated hemoglobin.","PeriodicalId":73873,"journal":{"name":"Journal of ocular biology, diseases, and informatics","volume":" ","pages":"60-3"},"PeriodicalIF":0.0,"publicationDate":"2010-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12177-010-9056-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40125473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 24

Matrix metalloproteinase 9 expression: new regulatory elements. 基质金属蛋白酶9的表达:新的调控元件。

Journal of ocular biology, diseases, and informatics Pub Date : 2010-06-01 Epub Date: 2010-08-05 DOI: 10.1007/s12177-010-9054-2

Irina Surgucheva, Kumaravel Chidambaram, David A Willoughby, Andrei Surguchov

引用次数: 25

Comparative modeling of PON2 and analysis of its substrate binding interactions using computational methods. PON2的比较建模及其底物结合相互作用的计算方法分析。

Journal of ocular biology, diseases, and informatics Pub Date : 2010-06-01 Epub Date: 2011-02-09 DOI: 10.1007/s12177-011-9057-7

Subramanian Barathi, Muralidaran Charanya, Shivashanmugam Muthukumaran, Narayanasamy Angayarkanni, Vetrivel Umashankar

{"title":"Comparative modeling of PON2 and analysis of its substrate binding interactions using computational methods.","authors":"Subramanian Barathi, Muralidaran Charanya, Shivashanmugam Muthukumaran, Narayanasamy Angayarkanni, Vetrivel Umashankar","doi":"10.1007/s12177-011-9057-7","DOIUrl":"https://doi.org/10.1007/s12177-011-9057-7","url":null,"abstract":"Paraoxonase (PON) constitutes a family of calcium-dependent mammalian enzymes comprising of PON1, PON2, and PON3. PON family shares ~60% sequence homology. These enzymes exhibit multiple activities like paraoxonase, arylesterase, and lactonase in a substrate dependent manner. Decreased PON activity has been reported in diseases like cardiovascular disease, atherosclerosis, and diabetes. Even though, PON2 is the oldest member of the family, PON1 is the only member studied in silico. In this study, the structure of PON2 was modeled using MODELLER 9v7 and its interactions with relevant ligands and it's physiological substrate homocysteine thiolactone was performed using AutoDock 4.0. The results reveal that PON1 and PON2 share common ligand binding patterns for arylesterase and lactonase activity, whereas in case of paraoxon binding, the residues involved in the interactions were different. Interestingly, the substrate HCTL was found to have the lowest free energy of binding (ΔG) and highest affinity for PON2 than PON1.","PeriodicalId":73873,"journal":{"name":"Journal of ocular biology, diseases, and informatics","volume":"3 2","pages":"64-72"},"PeriodicalIF":0.0,"publicationDate":"2010-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12177-011-9057-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30446833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

CFH, VEGF, and PEDF genotypes and the response to intravitreous injection of bevacizumab for the treatment of age-related macular degeneration. CFH、VEGF 和 PEDF 基因型与玻璃体内注射贝伐珠单抗治疗老年性黄斑变性的反应。

Journal of ocular biology, diseases, and informatics Pub Date : 2010-06-01 Epub Date: 2010-07-28 DOI: 10.1007/s12177-010-9055-1

Daisuke Imai, Keisuke Mori, Kuniko Horie-Inoue, Peter L Gehlbach, Takuya Awata, Satoshi Inoue, Shin Yoneya

{"title":"CFH, VEGF, and PEDF genotypes and the response to intravitreous injection of bevacizumab for the treatment of age-related macular degeneration.","authors":"Daisuke Imai, Keisuke Mori, Kuniko Horie-Inoue, Peter L Gehlbach, Takuya Awata, Satoshi Inoue, Shin Yoneya","doi":"10.1007/s12177-010-9055-1","DOIUrl":"10.1007/s12177-010-9055-1","url":null,"abstract":"We determined whether there is an association between complement factor H (CFH), high-temperature requirement A-1 (HTRA1), vascular endothelial growth factor (VEGF), and pigment epithelium-derived factor (PEDF) genotypes and the response to treatment with a single intravitreous injection of bevacizumab for age-related macular degeneration (AMD). Eighty-three patients with exudative AMD treated by bevacizumab injection were genotyped for three single nucleotide polymorphisms (SNPs; rs800292, rs1061170, rs1410996) in the CFH gene, a rs11200638-SNP in the HTRA1 gene, three SNPs (rs699947, rs1570360, rs2010963) in the VEGF gene, and four SNPs (rs12150053, rs12948385, rs9913583, rs1136287) in the PEDF gene using a TaqMan assay. The CT genotype (heterozygous) of CFH-rs1061170 was more frequently represented in nonresponders in vision than TT genotypes (nonrisk allele homozygous) at the time points of 1 and 3 months, while there was no CC genotype (risk allele homozygous) in our study cohort (p = 7.66 × 10(-3), 7.83 × 10(-3), respectively). VEGF-rs699947 was also associated with vision changes at 1 month and PEDF-rs1136287 at 3 months (p = 5.11 × 10(-3), 2.05 × 10(-2), respectively). These variants may be utilized for genetic biomarkers to estimate visual outcomes in the response to intravitreal bevacizumab treatment for AMD.","PeriodicalId":73873,"journal":{"name":"Journal of ocular biology, diseases, and informatics","volume":"3 2","pages":"53-9"},"PeriodicalIF":0.0,"publicationDate":"2010-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3148139/pdf/12177_2010_Article_9055.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30051056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of surgeon-individual treatment profiles to support the provision of an optimum treatment service for cataract patients. 确定外科医生个人治疗概况，以支持为白内障患者提供最佳治疗服务。

Journal of ocular biology, diseases, and informatics Pub Date : 2010-06-01 Epub Date: 2011-04-13 DOI: 10.1007/s12177-011-9058-6

Thomas Neumuth, Renate Wiedemann, Christian Foja, Petra Meier, Juliane Schlomberg, Dayana Neumuth, Peter Wiedemann

{"title":"Identification of surgeon-individual treatment profiles to support the provision of an optimum treatment service for cataract patients.","authors":"Thomas Neumuth, Renate Wiedemann, Christian Foja, Petra Meier, Juliane Schlomberg, Dayana Neumuth, Peter Wiedemann","doi":"10.1007/s12177-011-9058-6","DOIUrl":"https://doi.org/10.1007/s12177-011-9058-6","url":null,"abstract":"One objective of ophthalmological departments is the optimization of patient treatment services. A strategy for optimization is the identification of individual potential for advanced training of surgeons based on their daily working results. The objective of this feasibility study was the presentation and evaluation of a strategy for the computation of surgeon-individual treatment profiles (SiTPs). We observed experienced surgeons during their standard daily performance of cataract procedures in the Ophthalmological Department of the University Medical Center Leipzig, Germany. One hundred five cases of cataract procedures were measured as Surgical Process Models (SPMs) with a detailed-to-the-second resolution. The procedures were performed by three different surgeons during their daily work. Subsequently, SiTPs were computed and analyzed from the SPMs as statistical 'mean' treatment strategies for each of the surgeons. The feasibility study demonstrated that it is possible to identify differences in surgeon-individual treatment profiles beyond the resolution of cut-suture times. Surgeon-individual workflows, activity frequencies and average performance durations of surgical activities during cataract procedures were analyzed. Highly significant (p < 0.001) workflow differences were found between the treatment profiles of the three surgeons. Conclusively, the generation of SiTPs is a convenient strategy to identify surgeon-individual training potentials in cataract surgery. Concrete recommendations for further education can be derived from the profiles.","PeriodicalId":73873,"journal":{"name":"Journal of ocular biology, diseases, and informatics","volume":"3 2","pages":"73-83"},"PeriodicalIF":0.0,"publicationDate":"2010-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12177-011-9058-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30572275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Hypoxia-inducible factor and vascular endothelial growth factor in the neuroretina and retinal blood vessels after retinal ischemia. 视网膜缺血后神经视网膜和视网膜血管中的缺氧诱导因子和血管内皮生长因子。

Journal of ocular biology, diseases, and informatics Pub Date : 2010-05-27 DOI: 10.1007/s12177-010-9050-6

Gisela Håkansson, Bodil Gesslein, Lotta Gustafsson, Ulrica Englund-Johansson, Malin Malmsjö

{"title":"Hypoxia-inducible factor and vascular endothelial growth factor in the neuroretina and retinal blood vessels after retinal ischemia.","authors":"Gisela Håkansson, Bodil Gesslein, Lotta Gustafsson, Ulrica Englund-Johansson, Malin Malmsjö","doi":"10.1007/s12177-010-9050-6","DOIUrl":"https://doi.org/10.1007/s12177-010-9050-6","url":null,"abstract":"Retinal ischemia arises from circulatory failure. As the retinal blood vessels are key organs in circulatory failure, our aim was to study the retinal vasculature separately from the neuroretina to elucidate the role of hypoxia-inducible factor (HIF) 1α and 1β and vascular endothelial growth factor (VEGF) in retinal ischemia. Retinal ischemia was induced in porcine eyes by applying an intraocular pressure, followed by 12 h of reperfusion. HIF-1α mRNA expression was not affected by ischemia, while immunofluorescence staining was higher after ischemia in the neuroretina. HIF-1β immunoreactivity and mRNA expression were unaffected. VEGF protein levels in the vitreous humor and VEGF staining in the neuroretina were more pronounced in eyes subjected to ischemia than in the sham eyes. VEGF may be activated downstream of HIF-1 and is known to stimulate retinal neovascularization, which causes sight-threatening complications. These results emphasize the need for pharmacological treatment to block the HIF and VEGF signaling pathways in retinal ischemia.","PeriodicalId":73873,"journal":{"name":"Journal of ocular biology, diseases, and informatics","volume":"3 1","pages":"20-9"},"PeriodicalIF":0.0,"publicationDate":"2010-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12177-010-9050-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29520178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Erratum to: A case of amniotic membrane transplantation in non-healing Nocardia asteroides keratitis. 羊膜移植治疗未愈合的小行星诺卡菌角膜炎1例。

Journal of ocular biology, diseases, and informatics Pub Date : 2010-04-07 DOI: 10.1007/s12177-010-9049-z

Firoozeh Rahimi, Masoud Aghsaei Fard, Reza Soltani Mogaddam

引用次数: 0