Journal of neuro and oncology research最新文献

{"title":"Improving Mental Health in Older Adults","authors":"Virginia Lee","doi":"10.46889/jnor.2023.3201","DOIUrl":"https://doi.org/10.46889/jnor.2023.3201","url":null,"abstract":"There are significant mental health disparities in older people in underserved communities and disadvantaged racial and ethnic groups. Blacks are less inclined to have a mental diagnosis or receive mental health treatments [1]. Older Asian American women have higher rates of suicidal ideations and completions than women from other ethnic and racial groups. Blacks’ and Hispanics’ incidence of the disease is higher (2x and 1.5x respectively), but receiving a diagnosis is much lower [1]. There is a correlation between mental health conditions and cognitive impairment. Contributor factors are stress, disparities that put them at risk for cognitive impairments, ageism increased other forms of discrimination and mental health issues [1].","PeriodicalId":73853,"journal":{"name":"Journal of neuro and oncology research","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90171107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case Report of Conus Medullaris Tumor Causing a Diagnostic Dilemma","authors":"I. Chakraborty","doi":"10.46889/jnor.2023.3101","DOIUrl":"https://doi.org/10.46889/jnor.2023.3101","url":null,"abstract":"Intramedullary astrocytomas of the spinal cord are rarer than intracranial astrocytomas. Glioblastoma Multiforme (GBM) generally does not involve the spinal cord (1-5% of all GBM cases) and presents as only 1.5% of all spinal cord tumors. The ratio of low-grade to high-grade astrocytomas in the spinal cord is about 3:1.\u0000\u0000Case Report: We report a case of a 40-year-old male patient complaining of back pain. Insidious in onset, gradual in progression, deep-seated since 8 months. Walking has been difficult for 6 months due to associated foot drop in the left lower limb. There was no evidence of bowel or bladder involvement, and there were no complaints in the upper limbs or elsewhere. On examination, the motor system showed foot drop and EHL weakness in the left lower limb. Following that, he underwent D12-L1 laminectomy with subtotal excision of the lesion under neuromonitoring. Glioma was discovered on histopathology. Adjuvant radiation and chemotherapy were given.\u0000\u0000Conclusion: The rarity of this entity may have hampered the development of standardized regimens for optimal treatment. We believe that accumulated experience in the treatment of this lethal condition might contribute well to improving its therapeutic outcome.","PeriodicalId":73853,"journal":{"name":"Journal of neuro and oncology research","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80193736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stem Cell Implants: Emerging Innovation for Stroke Recovery.","authors":"Reid Colliander, Kaitlyn Alleman, Michael Diaz, Med Jimenez, Patrick King, Pranav Mirpuri, Christopher Cutler, Brandon Lucke-Wold","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Stroke is a debilitating neurovascular injury that those effects hundreds of thousands of Americans each year. Despite the high prevalence, disease morbidity and mortality, options for stroke intervention and rehabilitation are still limited. Stem cells have shown promise in stroke treatment due to their ability to self-renew and differentiate into different cell types. The primary sources of stem cells used today are bone marrow and fetal brain tissue, with mesenchymal stem cells, bone marrow stem cells and neural stem cells being particularly well-studied. By secreting therapeutic and neurogenic substances they are hypothesized to help foster recovery at the site of injury. Delivery mechanisms for stem cell therapy include intracerebral, intra-arterial, intraperitoneal, intravenous, intraventricular and intranasal routes with radiographic imaging now being used to monitor the progress of stem cell therapies. Stem cell implants have been found to be safe but optimal treatment strategies are still being established with several promising studies underway. Future efforts should continue to focus on improving efficacy, exploring alternative stem cell sources, enhancing migration capability and survival and educating stroke patients on the benefits and risks of stem cell therapy.</p>","PeriodicalId":73853,"journal":{"name":"Journal of neuro and oncology research","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9537583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Sleep and Brain Science of Lucid Dreaming: Insights into Therapeutic Applications","authors":"Berenika Maciejewicz","doi":"10.46889/jnor.2022.3303","DOIUrl":"https://doi.org/10.46889/jnor.2022.3303","url":null,"abstract":"Lucid dreaming is being conscious within one’s own dream. In recent years, dream lucidity has started to attract more attention not only from the broad neuroscience field but also from applied neurology, psychiatry, sports performance science, or art therapy areas. The aim of this research is to investigate and evaluate some of the therapeutic potentials of dream lucidity. The findings propose that the emergence of self-awareness during sleep could have various health and wellness benefits and applications. Analysis and evaluation of existing neuroscientific data on lucid dreaming was performed and combined with own investigations and methodological insights. In addition, virtual reality training and transcranial direct current stimulation areas of research were also investigated in the context of potential applications for inducing dream lucidity. Results show that various clinical and non-clinical applications of lucid dreaming techniques might be effectively employed in reducing nightmares, increasing mindfulness, or as an experimental treatment for individuals suffering from certain mental health disorders like narcolepsy or post-traumatic stress disorder. It’s further suggested that dream lucidity training might help with sleep quality while reducing daytime stress and anxiety. Nevertheless, further research and caution in this area are required to fully understand both the therapeutic benefits and potentially negative long term consequences of cultivating lucid dreaming.","PeriodicalId":73853,"journal":{"name":"Journal of neuro and oncology research","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87274800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contribution of Stereotaxic Biopsy in the Management of Brain Tumors: About 101 Cases","authors":"D. M","doi":"10.46889/jnor.2022.3302","DOIUrl":"https://doi.org/10.46889/jnor.2022.3302","url":null,"abstract":"Introduction: The advent of Stereotaxic Biopsy (STB) and the development of CT and MRI have improved the management of brain tumours. The aim of this study is to evaluate the role of STB in the management of brain tumors.\u0000\u0000Material and Methods: Retrospective study from 2000 to 2020 concerning 101 consecutive patients with brain tumours, having benefited from a STB, collected in the neurosurgery departments of the the public hospital establishment of AIT IDDIR and Mustapha and Mustapha BACHA university hospital center. The seat of the lesion is deep or functional (the Rolondic region, hemispherical, basal ganglia, lateral ventricles and brainstem and pineal region). STB was performed under CT guidance in all cases. For pineal tumours, arteriography with venographic time and preoperative MRI has been deemed useful to avoid hemorrhagic complications.\u0000\u0000Results: In 101 cases, the STB was conclusive on the first attempt (90%). The repetition of the STB made it possible to re-establish a precise diagnosis in (5.94%) It was malignant lesions (70% of the cases). The average age of the patients was 46 years (3 to 72) with a male predominance.\u0000\u0000The topography of the lesions is: 75.13% in the Rolondic region, Central Gray Nuclei, Brainstem and pineal region; 12.87% in the corpus callosum and lateral ventricles and 12.5% in the eloquent superficial lesion. Postoperative complications are dominated by mortality 5.9% followed by partial epileptic seizure 2.98% and severe neurological disorders 1.98%, bilateral ptosis 1.98% and hemiplegia 0.99%. Perioperative mortality fell from 10.45% before 2005 to 1% after 2006 (Chi-square; p = 0.010).\u0000\u0000Conclusion: STBs should be staged and repeated in case of inconclusive histology. For small deep lesions STB under MRI conditions is necessary. For pineal tumours, it must be performed by the transtemporal orthogonal approach.","PeriodicalId":73853,"journal":{"name":"Journal of neuro and oncology research","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86489731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term Methylphenidate Monotherapy for Parkinson’s: Biochemistry Analysis and 17 Year Case Study","authors":"R. Townsend","doi":"10.46889/jnor.2022.3301","DOIUrl":"https://doi.org/10.46889/jnor.2022.3301","url":null,"abstract":"Background: Information in this study can improve the health and quality of life of over ten million people with Parkinson’s. This paper presents long-term treatment of Parkinson’s with Methylphenidate that was found safe and effective to use instead of traditional anti-Parkinsonians such as Carbidopa-Levodopa and Pramipexole that cause augmentation (neural damage), excessive sedation, sudden passing out and slowed cognition. Methylphenidate strengthens and protects neural tissues and sustains normal alertness and cognition.\u0000\u0000Methods: This article analyzes the neurobiochemistry of Methylphenidate-therapy vs. AntiParkinsonian-therapy based on this author’s review of over 400 published studies and guidelines. This article also presents a Case Study involving a case-subject who has a very severe Parkinson’s disorder with a well-documented nine years of AntiParkinsonian-therapy followed by eight years of Methylphenidate-therapy. The case-subject is a 66 year-old male with a PhD who is a published Neurobiochemistry Researcher. At age-55 he was medically documented as disabled and needing medications to function. At age-58 his illness and the adverse effects of APs jointly caused total disability for which there was no known remedy. Thus he conceived and designed the world’s first long-term Methylphenidate treatment of Parkinson’s and implemented it with the cooperation of a prescribing Physician.\u0000\u0000Results: Adjunctive 30 mg doses of diurnal Methylphenidate overcame adverse effects of AntiParkinsonians. 20 mg doses of diurnal Methylphenidate monotherapy controlled Parkinson’s illness better than AntiParkinsonians. A 3-hour dosing schedule resulted in smooth and uninterrupted efficacy between and across doses of Methylphenidate. Sequential doses every three hours extended efficacy duration to 16 hours. Continued high-dose AntiParkinsonians at bedtime gave good sleep.\u0000\u0000Conclusion: This author recommends that clinicians use these findings to replace diurnal AntiParkinsonians with diurnal Methylphenidate in order to provide safer and more effective long-term treatment of Parkinson’s illnesses.","PeriodicalId":73853,"journal":{"name":"Journal of neuro and oncology research","volume":"84 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86466069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Universe and Multiverse Transportation Possibilities Using Consciousness and Thought Travelling","authors":"Md. Sadique Shaikh","doi":"10.46889/jnor.2022.2202","DOIUrl":"https://doi.org/10.46889/jnor.2022.2202","url":null,"abstract":"The dreams started to come true and journey started into reality when NASA succeed their mission to transport mankind on moon and reached on lunar surface on 20 July, 1969 at 20:17 UTC (Coordinated Universal Time) and after 6 hours and 39 minutes Armstrong became first person to step on lunar surface from Apollo Lunar Module Eagle on 21 July 1969 at 02:56 UTC. The amount of space time travel is affordable, bearable in this case with less advance technology only possible because of comparatively very near distance of Moon from planet Earth, but if mankind plan to establish journey from Earth to Mars or any other planet of our solar system or interstellar transportation including even today’s present very advanced Artificial intelligence based technologies of 2022 or ultra-advanced technologies in near future say 2030, 2040 human race might be successful or partially possible or possible with lots of obstacles, problems and risks. Several space analyst, scientists, astrophysicist, astronomers, quantum mechanics expert and researchers across world working on all these aspect with unique agenda how to minimise space time with increasing velocity of space shuttle to send mankind from planet Earth to other planets, stars and galaxies in deep Universe. Hence several scientists trying to match their space craft, space drive or space shuttle should be at least half to velocity of “Speed of Light” which is the ultimate speed of space transportation in known Universe, but unfortunately human civilization not succeeded in the same though several concepts proposed like “Warp drive, gravitational sling shots space shuttle, wormhole transport insertion from one surface and exit on another surface of bend or curvature space/ Universe using gravitational space drive and likewise. Hence globally conclude and accepted there is nothing more than of speed of light in known universe for fastest transportation and to explore and expand human civilization on another habitat planets, exoplanets and blanets come under habitable space zones and orbit having their energy stars or draft like Sun to have Earth-like environment. But as per my knowledge and experience “Everything is Vibrational Energy” with different frequencies. Even according to law of thermodynamics “Energy neither create nor destroyed, it’s only transform from one to another form” and it’s also relative by all universe sense according to Sir Albert Einstein whereas quantum mechanics also supports to all these phenomenon with the help of string theory, quantum entanglement and higher dimensions of space which also open to new door and direction to research for “Multiverse” and then after transport to it in far future. Therefore I am not challenging to any opinion but want put up my point of view regarding space transport and is “Speed of Consciousness and its generated output Thoughts has several times greater than speed of light and speed of light can’t be reached to speed of thoughts”. Why! Because everyth","PeriodicalId":73853,"journal":{"name":"Journal of neuro and oncology research","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80397080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does Exposure To Environmental Pollution Increase The Incidence Of CNS Tumors In Children?","authors":"K. Musiol","doi":"10.46889/jnor.2022.2201","DOIUrl":"https://doi.org/10.46889/jnor.2022.2201","url":null,"abstract":"Purpose: The postulated risk factor of CNS tumors might be air pollution. In Poland, especially in the Silesian voivodship, air quality is inferior compared to other European countries. The study aimed to evaluate the effect of selected air pollution parameters on the incidence of central nervous system tumors in children.\u0000\u0000Material and methods: A group of 460 children (251 boys, 209 girls) aged 0-18 (0.17-18.75) years, diagnosed with CNS cancer were included. The age Standardized Incidence Ratios (SIR) for CNS malignancies in children were calculated. Based on the data concerning air quality, the number and location of air quality monitoring stations for 2003-2016 published by the Regional Inspectorate for Environmental Protection in Katowice, the mean concentrations of benzene (C6H6), Nitrogen dioxide (NO2), benzoalphapyrene (BaP) and particulates matter with a diameter of 2.5 micrometers (PM 2.5) and 10 micrometers (PM10) were calculated.\u0000\u0000Results: The highest PM10 (50.62µg/m3), PM2.5 (36.14µg/m3), BaP (10.9ng/m3) and C6H6 (3.67µg/m3) concentrations were recorded in the Rybnik area. The highest age-standardized CNS tumor incidence ratio (n/100,000) was also demonstrated in the Rybnik area (3.24). The analysis showed a significant positive correlation between the SIR and the concentration of PM2.5 (r=0.89, p=0.039) and PM10 (r=0.93, p=0.007). There was no significant correlation between SIR and NO2 (r=0.41, p=0.41), BaP (r=0.56, p=0.24), C6H6 (r=0,79, p=0,2).\u0000\u0000Conclusion: Exposure to high concentrations of particulate matter may increase the risk of developing CNS cancers in children. Further research is needed, especially in the pediatric population.","PeriodicalId":73853,"journal":{"name":"Journal of neuro and oncology research","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82592844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Correction of Plagiocephaly","authors":"A. G. Martins","doi":"10.46889/jnor.2022.2103","DOIUrl":"https://doi.org/10.46889/jnor.2022.2103","url":null,"abstract":"Real Plagiocephaly is a rare form of craniosynostosis, resulting from the premature fusion of the coronal suture on one side, leading to a deformed head and to an apparently exteriorized homolateral eye. We present a simple and straightforward technique, based on removal of the involved suture, with the surgical incision prolonged to the orbital roof till near the ethmoide. After having sectioned the lateral border of the orbit at the junction of the zygomatic and frontal bones, a paramedian incision is made on the frontal bone, from the anterior fontanel (always carefully preserved), till the glabella. Then follows simple osteoclasia of the frontal bone and placement of a bone graft obtained from the adjacent parietal bone and that will maintain the forward projection of the frontal bone (but in slight hypercorrection). The grafts are simply fixed with silk sutures, placed through perforating holes in the bones, no metal being used. The transverse surgical wound, going almost from ear to ear, is closed in the usual way.","PeriodicalId":73853,"journal":{"name":"Journal of neuro and oncology research","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79342585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Review of Cervical Schwannomas: Presentation, Pathogenesis, Management, Complications and Future Directions.","authors":"Michael Goutnik, Emma Earl, Padmavathi Reddy, Brandon Lucke-Wold","doi":"10.46889/JNOR.2022.3304","DOIUrl":"10.46889/JNOR.2022.3304","url":null,"abstract":"<p><p>Cervical schwannomas are benign peripheral nerve sheath tumors, relatively uncommon pathologies. The purpose of this review is to summarize and expand on the existing literature on cervical schwannomas, focusing on clinical presentation, pathogenesis, surgical and radiologic management and innovative therapies including ultrasound-guided techniques. Pubmed and SCOPUS databases were searched using combinations of terms including \"cervical schwannoma\", \"surgery\", \"fusion\", \"complications\", \"radiosurgery\", and others. The findings regarding these unique clinical entities are presented below.</p>","PeriodicalId":73853,"journal":{"name":"Journal of neuro and oncology research","volume":"2 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10860156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}