Journal of neuro and oncology research最新文献

Stereotactic Radiosurgery in the Management of Intractable Seizure Due to Hypothalamic Hamartoma 立体定向放射外科手术治疗下丘脑滨状瘤引起的顽固性癫痫发作

Journal of neuro and oncology research Pub Date : 2024-07-22 DOI: 10.46889/jnor.2024.4206

J. H. Wijaya

{"title":"Stereotactic Radiosurgery in the Management of Intractable Seizure Due to Hypothalamic Hamartoma","authors":"J. H. Wijaya","doi":"10.46889/jnor.2024.4206","DOIUrl":"https://doi.org/10.46889/jnor.2024.4206","url":null,"abstract":"The occurrence of severe seizure is almost always present in hypothalamic hamartomas (HH) cases and surgery is an option to control the condition. Stereotactic radiosurgery (SRS) is among of alternative treatments. Our objective is to provide current evidence for seizure treatment with SRS in HHs patients. From EuroPMC, PubMed, ScienceDirect and the Cochrane Library, each author carried out literature searches on seizure treatment for HH using SRS between 1971 and 2021 using the following terms: stereotactic radiosurgery, radiosurgery, CyberKnife, Gamma Knife, linear accelerator, radiotherapy and hypothalamic hamartoma. We included any patients with seizure onset less than 18 years of age, regardless of age when SRS was performed. This systematic review included 17 out of 31 studies, three of which were observational studies. The study included 131 individuals, with a median age of onset of 7.4 years old and a male-to-female ratio of 34.3% (n=45). The isodose at the margin was 19 Gy. The median lesion volume at the time of diagnosis was 0.8 mL (0.1 – 48.3 mL). The median follow-up after SRS was 34.3 months (3 – 77 months). Only eight of the 90 HHs had a change in MR and 12 patients, SRS had no effect on the seizure frequency. The authors concluded that SRS is beneficial for the treatment of HH. However, the authors could not deny that current evidence is too early to construct a systematic review and a more prospective study design is required.","PeriodicalId":73853,"journal":{"name":"Journal of neuro and oncology research","volume":"23 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141814404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pilot Testing of CAN Digital Apps to Improve the Quality of Life of Cancer and Benign Brain Tumor Survivors 提高癌症和良性脑肿瘤幸存者生活质量的 CAN 数字应用程序试点测试

Journal of neuro and oncology research Pub Date : 2024-06-11 DOI: 10.46889/jnor.2024.4204

Claudia Rebola

{"title":"Pilot Testing of CAN Digital Apps to Improve the Quality of Life of Cancer and Benign Brain Tumor Survivors","authors":"Claudia Rebola","doi":"10.46889/jnor.2024.4204","DOIUrl":"https://doi.org/10.46889/jnor.2024.4204","url":null,"abstract":"Objective: Vestibular Schwannoma (VS) and breast cancer patients experience negative Quality of Life (QoL) impacts. VS patients struggle with mood disorders, whereas breast cancer patients experience treatment-related cognitive impairment. Improving QoL in these patient populations is the objective of these digital app technologies involving music, art and robotic pet therapies.\u0000\u0000Methods: Active Receptive Music for Cancer (ARMCan) recruited ten breast cancer patients who were randomized into an interactive music therapy group and a receptive music therapy group, occurring daily for 15 minutes over 6 months. The primary endpoint was Functional Assessment of Cancer Therapy – Cognitive Function (FACT-Cog) scores. Sensory Integrative Therapy with Art and Robots (SITAR) recruited ten VS patients to undergo art therapy alone or art therapy and robotic companion therapy weekly for twelve weeks. One patient in each group completed the study. The primary endpoint was Mental Health Quality of Life Questionnaire (MHQOL) surveys with a secondary endpoint of Hamilton Depression scale (HAM-D).\u0000\u0000Results: For ARMCan, integrative music therapy led to an increase in FACT-Cog scores of 44.2% and 12.4% for the interactive (n = 3) and receptive music (n = 3) groups, respectively. For SITAR, there were 106% and 63.6% increases in MHQOL scores for the art intervention (n = 1) and combined therapy groups (n = 1), respectively. There was an average decrease of 80% in HAM-D scores.\u0000\u0000Conclusion: This pilot study primarily demonstrates feasibility for digital applications to improve QoL in breast cancer and VS patients. There is preliminary data to support that integrative music therapy can improve treatment-induced cognitive impairment in breast cancer patients. Similarly, art and robotic animal companion therapy may improve overall QoL and reduce depressive symptoms in vestibular schwannoma patients.","PeriodicalId":73853,"journal":{"name":"Journal of neuro and oncology research","volume":"35 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141355568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plueral Effusion and Ovarian Cancer 浆膜腔积液与卵巢癌

Journal of neuro and oncology research Pub Date : 2024-04-23 DOI: 10.46889/jnor.2024.4106

Mohammad Haydar

{"title":"Plueral Effusion and Ovarian Cancer","authors":"Mohammad Haydar","doi":"10.46889/jnor.2024.4106","DOIUrl":"https://doi.org/10.46889/jnor.2024.4106","url":null,"abstract":"Pleural effusion, the pathological accumulation of fluid in the pleural space, is very common. Its causes vary widely, ranging from fairly harmless effusions accompanying viral pleuritis to prognostically highly relevant ones due to congestive heart failure or malignances. Pleural effusions are classified by their biochemical properties into exudative and transudative effusions but can also be due to blood, pus and chyle. Applying Light’s criteria may be helpful to diagnose an exudative effusion.\u0000\u0000Exudative effusions are commonly caused by infection, malignancy and inflammatory disorders, such as rheumatoid arthritis.\u0000\u0000In this case we presented 39 women that was admentes with only short of breath and Pleural effusion, During the hospitalization, a pleural fluid puncture was performed and a cytological result was obtained for ovarian cancer and CA-125 was high in the pleural fluid, the patient underwent chemotherapy and her condition improved hourly.\u0000\u0000In this case, we present a rare case in which the patient complained of shortness of breath without surgical or gynecological complaints and was finally diagnosed with ovarian cancer, which raises the importance of ruling out malignancy every time a new pleural fluid is aspirated.","PeriodicalId":73853,"journal":{"name":"Journal of neuro and oncology research","volume":"37 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140671647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effect of Ketogenic Metabolic Therapy on Recurrent High-Grade Gliomas: Case Series 生酮代谢疗法对复发性高级别胶质瘤的影响：病例系列

Journal of neuro and oncology research Pub Date : 2024-04-14 DOI: 10.46889/jnor.2024.4103

{"title":"The Effect of Ketogenic Metabolic Therapy on Recurrent High-Grade Gliomas: Case Series","authors":"","doi":"10.46889/jnor.2024.4103","DOIUrl":"https://doi.org/10.46889/jnor.2024.4103","url":null,"abstract":"High-grade gliomas represent the most prevalent primary malignant brain tumors in the adult population. Despite extensive efforts dedicated to advance in therapeutic modalities, treatment options remain very limited in this field, leading to a worse prognosis for affected patients. Moreover, a considerable number of cases exhibit refractory disease following the initial management. Ketogenic Metabolic Therapy (KMT) has emerged as a promising adjunctive approach for recurrent high-grade gliomas, offering them a synergistic effect enhancement of the effectiveness of conventional therapies against this type of cancer. The underlying hypothesis relies on the use of high-fat, low-carbohydrate diet, with adequate protein content can potentially induce metabolic reprogramming in cancer cells. Currently, the use of KMT is on the rise and has shown positive effects on the control of selected neurological symptoms and improvements in patient’s quality of life. This is a descriptive observational multicenter study (case series) that includes patients with recurrent high-grade gliomas who underwent Ketogenic Metabolic Therapy (KMT) and were supplemented with a liquid ketogenic formula (in a 3:1 ratio) as a complementary treatment to the ongoing medical regimen for recurrence. The results show a positive impact on seizure control, as well as significant improvements in cognition, memory and functionality, as reported by patients and/or their families (caregivers). Regarding the disease status, assessed by the RANO criteria, the 12-month follow-up evaluation indicated stable disease in 55% and a partial response in 20% of cases. Although the results of this work are promising, more conclusive clinical data are still needed to support the use of KMT in the treatment of high-grade gliomas.","PeriodicalId":73853,"journal":{"name":"Journal of neuro and oncology research","volume":"202 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140704699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Scrotal Migration of The Distal End of The Ventriculoperitoneal Shunt: Is There a Role for Early Closure of Patent Processus Vaginalis in The Pediatric Population? 脑室腹腔分流术远端阴囊移位：早期关闭阴道前突在儿科人群中是否有作用？

Journal of neuro and oncology research Pub Date : 2024-02-23 DOI: 10.46889/jnor.2024.4102

Houssein Darwish

{"title":"Scrotal Migration of The Distal End of The Ventriculoperitoneal Shunt: Is There a Role for Early Closure of Patent Processus Vaginalis in The Pediatric Population?","authors":"Houssein Darwish","doi":"10.46889/jnor.2024.4102","DOIUrl":"https://doi.org/10.46889/jnor.2024.4102","url":null,"abstract":"Background: Ventriculoperitoneal shunt (VP) insertion is one of the surgical treatments for patients with hydrocephalus. Infection, malfunction, catheter migration, hernia development, equipment failure, CSF subcutaneous collection and peritoneal pseudocyst formation are considered to be the main complications of this procedure.\u0000\u0000Case Description: A 6-months-old boy known to have congenital aqueductal stenosis with VP shunt insertion at the age of 1 month, presented with scrotal swelling and generalized hypotonia. He was found to have catheter migration into the scrotum.\u0000\u0000Conclusion: Scrotal migration of the distal end of the ventriculoperitoneal shunt is a rare but threatening complication that can present with either signs of hydrocephalus or scrotal swelling or hydrocele. Accordingly, we recommend performing a scrotal exam with an ultrasound early upon evaluation of any infant presenting with scrotal swelling or hydrocele after VP shunt insertion. There haven’t been clear recommendations in the literature concerning closure of patent processus vaginalis upon placing a VP shunt in patients below the age of 3 months. Thus, we question whether early closure could help reduce the complications of catheter migration in infants.","PeriodicalId":73853,"journal":{"name":"Journal of neuro and oncology research","volume":"26 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140435690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Osimertinib in Combination with Bevacizumab for EGFR Mutated Recurrent Glioblastoma (GBM): A Case Report 奥希替尼联合贝伐单抗治疗表皮生长因子受体（EGFR）突变的复发性胶质母细胞瘤（GBM）：病例报告

Journal of neuro and oncology research Pub Date : 2024-01-16 DOI: 10.46889/jnor.2024.4101

Soma Sengupta

引用次数: 0

Diagnosis and Minimally-Invasive Treatment of Posterior Fossa Dural Arteriovenous Fistula Presenting Clinically as A Carotid-Cavernous Fistula 临床表现为颈动脉-海绵状静脉瘘的后窝硬脑膜动静脉瘘的诊断与微创治疗

Journal of neuro and oncology research Pub Date : 2023-12-31 DOI: 10.46889/jnor.2023.3304

O. Algın

引用次数: 0

Breast Cancer Awareness 关注乳腺癌

Journal of neuro and oncology research Pub Date : 2023-12-18 DOI: 10.46889/jnor.2023.3303

引用次数: 0

Behavioral Medicine: A New Perspective in the Field of Health 行为医学:健康领域的新视角

Journal of neuro and oncology research Pub Date : 2023-08-31 DOI: 10.46889/jnor.2023.3204

P. Theofilou

引用次数: 0

Cannabis-Based Products and Medical Propaganda: It Cuts Both Ways 以大麻为基础的产品和医疗宣传:有利有弊

Journal of neuro and oncology research Pub Date : 2023-05-25 DOI: 10.46889/jnor.2023.3203

P. Mei

引用次数: 0