Journal of nanotechnology in engineering and medicine最新文献_第10页

Lagrangian Magnetic Particle Tracking Through Stenosed Artery Under Pulsatile Flow Condition 脉动流条件下拉格朗日磁粒子通过狭窄动脉的跟踪

Journal of nanotechnology in engineering and medicine Pub Date : 2013-08-01 DOI: 10.1115/1.4026839

Sayan Bose, A. Datta, R. Ganguly, M. Banerjee

{"title":"Lagrangian Magnetic Particle Tracking Through Stenosed Artery Under Pulsatile Flow Condition","authors":"Sayan Bose, A. Datta, R. Ganguly, M. Banerjee","doi":"10.1115/1.4026839","DOIUrl":"https://doi.org/10.1115/1.4026839","url":null,"abstract":"Drug delivery technologies are an important area within biomedicine. Targeted drug delivery aims to reduce the undesired side effects of drug usage by directing or capturing the active agents near a desired site within the body. This is particularly beneficial in, for instance, cancer chemotherapy, where the side effects of general (systemic) drug administration can be severe. Herein, a numerical investigation of unsteady magnetic drug targeting (MDT) using functionalized magnetic microspheres in partly occluded blood vessels is presented considering the effects of particle-fluid coupling on the transport and capture of the magnetic particles. An Eulerian–Lagrangian technique is adopted to resolve the hemodynamic flow and the motion of the magnetic particles in the flow using ansys fluent. An implantable cylindrical permanent magnet insert is used to create the requisite magnetic field. Targeted transport of the magnetic particles in a partly occluded vessel differs distinctly from the same in a regular unblocked vessel. Parametric investigation is conducted and the influence of the flow Re, magnetic insert diameter, and its radial and axial position on the “targeting efficiency” is reported. Analysis shows that there exists an optimum regime of operating parameters for which deposition of the drug-carrying magnetic particles in a predesignated target zone on the partly occluded vessel wall can be maximized. The results provide useful design bases for in vitro set up for the investigation of MDT in stenosed blood vessels.","PeriodicalId":73845,"journal":{"name":"Journal of nanotechnology in engineering and medicine","volume":"4 1","pages":"031006"},"PeriodicalIF":0.0,"publicationDate":"2013-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1115/1.4026839","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63484116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Size-Dependent Nanoparticle Margination and Adhesion Propensity in a Microchannel 纳米颗粒在微通道中的边沿和粘附倾向

Journal of nanotechnology in engineering and medicine Pub Date : 2013-08-01 DOI: 10.1115/1.4025609

Patrick L. Jurney, Rachit Agarwal, Vikramjit Singh, K. Roy, S. Sreenivasan, Li Shi

{"title":"Size-Dependent Nanoparticle Margination and Adhesion Propensity in a Microchannel","authors":"Patrick L. Jurney, Rachit Agarwal, Vikramjit Singh, K. Roy, S. Sreenivasan, Li Shi","doi":"10.1115/1.4025609","DOIUrl":"https://doi.org/10.1115/1.4025609","url":null,"abstract":"Intravenous injection of nanoparticles as drug delivery vehicles is a common practice in clinical trials of therapeutic agents to target speciﬁc cancerous or pathogenic sites. The vascular ﬂow dynamics of nanocarriers (NCs) in human microcapillaries play an impor- tant role in the ultimate efﬁcacy of this drug delivery method. This article reports an experimental study of the effect of nanoparticle size on their margination and adhesion propensity in microﬂuidic channels of a half-elliptical cross section. Spherical polysty- rene particles ranging in diameter from 60 to 970nm were ﬂown in the microchannels and individual particles adhered to either the top or bottom wall of the channel were imaged using ﬂuorescence microscopy. When the number concentration of particles in the ﬂow was kept constant, the percentage of nanoparticles adhered to the top wall increased with decreasing diameter (d), with the number of particles adhered to the top wall following a d (cid:2) 3 trend. When the volume concentration of particles in solution was kept constant, no discernible trend was found. This experimental ﬁnding is explained by the competition between the Brownian force promoting margination and repulsive parti-cle–particle electrostatic forces retarding adhesion to the wall. The 970 nm particles were found to adhere to the bottom wall much more than to the top wall for each of the","PeriodicalId":73845,"journal":{"name":"Journal of nanotechnology in engineering and medicine","volume":"4 1","pages":"031002"},"PeriodicalIF":0.0,"publicationDate":"2013-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1115/1.4025609","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63481289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Gen-3 Thermal Management Technology: Role of Microchannels and Nanostructures in an Embedded Cooling Paradigm 第三代热管理技术:微通道和纳米结构在嵌入式冷却范例中的作用

Journal of nanotechnology in engineering and medicine Pub Date : 2013-05-01 DOI: 10.1115/1.4023898

A. Bar-Cohen

引用次数: 61

Fabrication and Testing of Planar Stent Mesh Designs Using Carbon-Infiltrated Carbon Nanotubes 碳渗透碳纳米管平面支架网状结构的制备与测试

Journal of nanotechnology in engineering and medicine Pub Date : 2013-05-01 DOI: 10.1115/1.4025598

Kristopher N. Jones, B. Jensen, A. Bowden

{"title":"Fabrication and Testing of Planar Stent Mesh Designs Using Carbon-Infiltrated Carbon Nanotubes","authors":"Kristopher N. Jones, B. Jensen, A. Bowden","doi":"10.1115/1.4025598","DOIUrl":"https://doi.org/10.1115/1.4025598","url":null,"abstract":"This paper explores and demonstrates the potential of using pyrolitic carbon as a material for coronary stents. Stents are commonly fabricated from metal, which has worse biocompatibilty than many polymers and ceramics. Pyrolitic carbon, a ceramic, is currently used in medical implant devices due to its preferrable biocompatibility properties. It can be created by growing carbon nanotubes, and then filling the space between with amorpheous carbon via chemical vapor deposition. We prepared multiple samples of two different stent-like flexible geometry designs out of carbon infiltrated carbon nanotubes. Tension loads were applied to expand the samples and we recorded the forces at brittle failure. These data were then used in conjunction with a nonlinear FEA model of the stent geometry to determine Youngs modulus and maximum fracture strain for each sample. Additionally, images were recorded of the samples before, during, and at failure. These images were used to measure an overall percent elongation for each sample. The highest fracture strain observed was 1.4% and Youngs modulus values confirmed the the material was the similar to that used in previous carbon infiltrated carbon nanotube work. The average percent elongation was 86% and reached as high as 145%. This exceeds a typical target of 66%.Copyright © 2013 by ASME","PeriodicalId":73845,"journal":{"name":"Journal of nanotechnology in engineering and medicine","volume":"4 1","pages":"020903"},"PeriodicalIF":0.0,"publicationDate":"2013-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1115/1.4025598","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63481282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Wireless Underground Sensor Networks: System in Support of Future Agriculture 无线地下传感器网络:支持未来农业的系统

Journal of nanotechnology in engineering and medicine Pub Date : 2013-05-01 DOI: 10.1115/1.4024767

M. Vuran, Xin Dong, K. Preston

引用次数: 1

Finding of Optimum Effective Parameters on Sweetening of Methane Gas by Zinc Oxide Nanoparticles 氧化锌纳米颗粒脱硫甲烷气体的最佳有效参数研究

Journal of nanotechnology in engineering and medicine Pub Date : 2013-05-01 DOI: 10.1115/1.4025467

F. Farahbod, S. Farahmand, M. Fard, Mohammad Nikkhahi

{"title":"Finding of Optimum Effective Parameters on Sweetening of Methane Gas by Zinc Oxide Nanoparticles","authors":"F. Farahbod, S. Farahmand, M. Fard, Mohammad Nikkhahi","doi":"10.1115/1.4025467","DOIUrl":"https://doi.org/10.1115/1.4025467","url":null,"abstract":"Nanocatalysts are adapted in this research to remove H 2 S as the toxic, corrosive, and pyrophoric contaminant. The important feature which is considered is to enhance the adsorption efficiency of hydrogen sulfide from hydrocarbon fuels such as methane gas by applying the zinc oxide nanocatalyst. In general, the optimum conditions to eliminate the hydrogen sulfide from methane gas are evaluated in this paper, experimentally. In this study, zinc oxide nanoparticles are synthesized and are contacted with flow of sour methane. The synthesized nanoparticles are characterized by SEM. The process performance of H 2 S removal from methane gas on zinc oxide nanoparticles is illustrated by the ratio of outlet concentration per feed concentration. The effects of operating conditions such as operating temperature, pressure, the occupied volume of bed, the amount of H 2 S concentration in feed stream, feed superficial velocity, size of nanocatalyst, and the bed height are studied in this paper. Also, the cost estimations are presented for different operating pressures and temperatures. This work studies the adsorption of H 2 S from natural gas with an emphasis on the influence of the operating parameters on process efficiency and cost evaluation. Finally, results introduce the amount of pressure 15 atm, temperature 300 °C, bed height 70 cm, and 35 nm in diameter nano zinc oxide as the optimum properties. Therefore, the amount of C/C 0 is decreased to 0.022. In addition, this is confirmed that the increase in the feed concentration of H 2 S and feed superficial velocity, also the decrease in the diameter of zinc oxide catalyst enhances the process efficiency.","PeriodicalId":73845,"journal":{"name":"Journal of nanotechnology in engineering and medicine","volume":"4 1","pages":"021003"},"PeriodicalIF":0.0,"publicationDate":"2013-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1115/1.4025467","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63480869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Viscosity and Friction Factor of Aluminum Oxide–Water Nanofluid Flow in Circular Tubes 氧化铝-水纳米流体在圆管内流动的粘度和摩擦系数

Journal of nanotechnology in engineering and medicine Pub Date : 2013-05-01 DOI: 10.1115/1.4025540

Clement C. Tang, S. Tiwari, Matthew W. Cox

引用次数: 18

Particle Manipulation in Insulator Based Dielectrophoretic Devices 基于绝缘体的介电装置中的粒子操纵

Journal of nanotechnology in engineering and medicine Pub Date : 2013-05-01 DOI: 10.1115/1.4025368

Aytug Gencoglu, D. Olney, Alexandra Lalonde, Karuna S. Koppula, B. Lapizco-Encinas

引用次数: 11

Micro and Nanofluidics: Historical Perspectives and Challenges 微纳米流体学:历史展望与挑战

Journal of nanotechnology in engineering and medicine Pub Date : 2013-05-01 DOI: 10.1115/1.4025463

A. Conlisk

引用次数: 1

Fabrication of Centimeter Long, Ultra-Low Aspect Ratio Nanochannel Networks in Borosilicate Glass Substrates 在硼硅玻璃衬底上制备厘米长、超低纵横比纳米通道网络

Journal of nanotechnology in engineering and medicine Pub Date : 2013-05-01 DOI: 10.1115/1.4025366

M. Pinti, Tanuja Kambham, Bowen Wang, S. Prakash

{"title":"Fabrication of Centimeter Long, Ultra-Low Aspect Ratio Nanochannel Networks in Borosilicate Glass Substrates","authors":"M. Pinti, Tanuja Kambham, Bowen Wang, S. Prakash","doi":"10.1115/1.4025366","DOIUrl":"https://doi.org/10.1115/1.4025366","url":null,"abstract":"Nanofluidic devices have a broad range of applications resulting from the dominance of surface-fluid interactions. Examples include molecular gating, sample preconcentration, and sample injection. Manipulation of small fluid samples is ideal for micro total analysis systems or lab on chip devices which perform multiple unit operations on a single chip. In this paper, fabrication procedures for two different ultra-low aspect ratio (ULAR) channel network designs are presented. The ULAR provides increased throughput compared to higher aspect ratio features with the same critical dimensions. Channel network designs allow for integration between microscale and nanoscale fluidic networks. A modified calcium assisted glass–glass bonding procedure was developed to fabricate chemically uniform, all glass nanochannels. A polydimethylsiloxane (PDMS)-glass adhesive bonding procedure was also developed as adhesive bonding allows for more robust fabrication with lower sensitivity to surface defects. The fabrication schemes presented allow for a broad array of available parameters for facile selection of device fabrication techniques depending on desired applications for lab on chip devices.","PeriodicalId":73845,"journal":{"name":"Journal of nanotechnology in engineering and medicine","volume":"4 1","pages":"020905"},"PeriodicalIF":0.0,"publicationDate":"2013-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1115/1.4025366","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63481105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16