脉动流条件下拉格朗日磁粒子通过狭窄动脉的跟踪

Sayan Bose, A. Datta, R. Ganguly, M. Banerjee
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引用次数: 11

摘要

给药技术是生物医学领域的一个重要领域。靶向给药的目的是通过指导或捕获体内所需部位附近的活性剂来减少药物使用的不良副作用。这在癌症化疗中尤其有益,因为一般(全身)给药的副作用可能很严重。本文对功能化磁微球在部分闭塞血管中的非定常磁性药物靶向(MDT)进行了数值研究,考虑了颗粒-流体耦合对磁性颗粒运输和捕获的影响。利用ansys fluent软件,采用欧拉-拉格朗日方法求解流体动力学流动和流体中磁性颗粒的运动。使用可植入的圆柱形永磁体来产生所需的磁场。磁性粒子在部分闭塞血管中的定向输送与在正常通畅血管中的定向输送明显不同。进行了参数化研究,报告了流量Re、磁片直径及其径向和轴向位置对“瞄准效率”的影响。分析表明,存在一个最佳的操作参数制度,在该制度下,携带药物的磁性颗粒在预先指定的靶区沉积在部分闭塞的血管壁上可以最大化。该结果为研究MDT在血管狭窄中的作用提供了有益的设计依据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Lagrangian Magnetic Particle Tracking Through Stenosed Artery Under Pulsatile Flow Condition
Drug delivery technologies are an important area within biomedicine. Targeted drug delivery aims to reduce the undesired side effects of drug usage by directing or capturing the active agents near a desired site within the body. This is particularly beneficial in, for instance, cancer chemotherapy, where the side effects of general (systemic) drug administration can be severe. Herein, a numerical investigation of unsteady magnetic drug targeting (MDT) using functionalized magnetic microspheres in partly occluded blood vessels is presented considering the effects of particle-fluid coupling on the transport and capture of the magnetic particles. An Eulerian–Lagrangian technique is adopted to resolve the hemodynamic flow and the motion of the magnetic particles in the flow using ansys fluent. An implantable cylindrical permanent magnet insert is used to create the requisite magnetic field. Targeted transport of the magnetic particles in a partly occluded vessel differs distinctly from the same in a regular unblocked vessel. Parametric investigation is conducted and the influence of the flow Re, magnetic insert diameter, and its radial and axial position on the “targeting efficiency” is reported. Analysis shows that there exists an optimum regime of operating parameters for which deposition of the drug-carrying magnetic particles in a predesignated target zone on the partly occluded vessel wall can be maximized. The results provide useful design bases for in vitro set up for the investigation of MDT in stenosed blood vessels.
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