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Journal of molecular and cellular cardiology plus最新文献

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Discovery of long-acting angiotensin 1-7, apelin-13, and bispecific mimetics for the treatment of cardiovascular and metabolic diseases 发现治疗心血管和代谢疾病的长效血管紧张素1-7、apelin-13和双特异性模拟物
Journal of molecular and cellular cardiology plus Pub Date : 2025-06-01 DOI: 10.1016/j.jmccpl.2025.100308
Weike Bao , Hannah Bolt , Nicholas Bhagroo , Kevin Minton , Fiona Shilliday , Ashot Sargsyan , Marie Persson , Elise Bernard , Petra Thulin , Pia Davidsson , Anders Cavallin , Claudio Colombo , Yasunori Aoki , Ulrik Jurva , Gabor Foldes , Liang Guo , Sarah Will , Regina Fritsche Danielson , Qing-Dong Wang , Kenny Hansson
{"title":"Discovery of long-acting angiotensin 1-7, apelin-13, and bispecific mimetics for the treatment of cardiovascular and metabolic diseases","authors":"Weike Bao , Hannah Bolt , Nicholas Bhagroo , Kevin Minton , Fiona Shilliday , Ashot Sargsyan , Marie Persson , Elise Bernard , Petra Thulin , Pia Davidsson , Anders Cavallin , Claudio Colombo , Yasunori Aoki , Ulrik Jurva , Gabor Foldes , Liang Guo , Sarah Will , Regina Fritsche Danielson , Qing-Dong Wang , Kenny Hansson","doi":"10.1016/j.jmccpl.2025.100308","DOIUrl":"10.1016/j.jmccpl.2025.100308","url":null,"abstract":"","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"12 ","pages":"Article 100308"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144471376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
JMCC plus - Celebrating milestones and looking ahead in our third year JMCC plus -庆祝我们的里程碑，展望我们的第三年
Journal of molecular and cellular cardiology plus Pub Date : 2025-06-01 DOI: 10.1016/j.jmccpl.2025.100286
Davor Pavlovic , Rebekah Gundry
{"title":"JMCC plus - Celebrating milestones and looking ahead in our third year","authors":"Davor Pavlovic , Rebekah Gundry","doi":"10.1016/j.jmccpl.2025.100286","DOIUrl":"10.1016/j.jmccpl.2025.100286","url":null,"abstract":"","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"12 ","pages":"Article 100286"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144270328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Isoform switch of T-cell factor7L2 during mouse heart development 小鼠心脏发育过程中t细胞因子7l2的异构体开关
Journal of molecular and cellular cardiology plus Pub Date : 2025-06-01 DOI: 10.1016/j.jmccpl.2025.100458
Bo Ye , Lu Xiao , Yuyong Xu , Haodong Xu , Faqian Li
{"title":"Isoform switch of T-cell factor7L2 during mouse heart development","authors":"Bo Ye ,&nbsp;Lu Xiao ,&nbsp;Yuyong Xu ,&nbsp;Haodong Xu ,&nbsp;Faqian Li","doi":"10.1016/j.jmccpl.2025.100458","DOIUrl":"10.1016/j.jmccpl.2025.100458","url":null,"abstract":"<div><div>Canonical WNT signaling plays critical, often opposing roles in heart development and disease, but its context-dependent mechanisms remain unclear. We hypothesized that alternative splicing of Tcf7l2, a key nuclear partner of β-catenin, contributes to WNT signaling specificity in the heart. To investigate this, we cloned and sequenced 53 Tcf7l2 transcripts in ventricular tissues from embryonic day 17.5 (E17.5, 24/53) and postnatal day 8 (P8, 29/53) mice, identifying 32 distinct isoforms. Among 18 potential exons, exons 6 and 17 were absent, and over 80 % of transcripts lacked exon 4. Alternative splicing was prominent in the C-terminal exons (14, 15, and 16), with exon 14 inclusion significantly higher in P8 hearts (64.3 %) than E17.5 hearts (34.8 %). Variations in exon 15 and 16 combinations, along with reading frame shifts caused by the adenine insertion and deletion (indel) near the beginning of exon 18, affected C-terminal structures, altering the presence of the E-tail, C-clamp, and CtBP-binding motifs. Notably, exon 14 insertion introduced a redox-switch domain spanning the NLS and C-clamp regions in E and S isoforms, while adenine indels altered isoform lengths, driving transitions between E, S, and M isoforms. RT-PCR validation across multiple developmental stages confirmed these splicing patterns. Our findings suggest that a postnatal redox-sensitive isoform switch in Tcf7l2 modulates WNT signaling, potentially influencing cardiomyocyte maturation during the transition from proliferation to hypertrophy.</div></div>","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"12 ","pages":"Article 100458"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144189693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CD36-Retinoic Acid- FABP5- PPARδ Signaling Axis Primes Neonatal Cardiomyocytes to Spontaneously Proliferate cd36 -维甲酸- FABP5- PPARδ信号轴启动新生儿心肌细胞自发增殖
Journal of molecular and cellular cardiology plus Pub Date : 2025-06-01 DOI: 10.1016/j.jmccpl.2025.100321
Abou Bakr Salama , Qinghui Ou , Riham Abouleisa , Tamer Mohamed , Marc Dwenger , Collin Wells , Ahmad Gebreil , Jessica Miller , Kamal Abou Farraj , Reham Wahid , Hania Abdelhafez , Momo Arai , Sameeha Abdulwali , Yazan Almasry , Muzammil Dastagir , Mohamed Salman , Pretty Mathew , Nourhan Baraka , Sarah Bench , Livia Eberlin , Bradford Hill
{"title":"CD36-Retinoic Acid- FABP5- PPARδ Signaling Axis Primes Neonatal Cardiomyocytes to Spontaneously Proliferate","authors":"Abou Bakr Salama ,&nbsp;Qinghui Ou ,&nbsp;Riham Abouleisa ,&nbsp;Tamer Mohamed ,&nbsp;Marc Dwenger ,&nbsp;Collin Wells ,&nbsp;Ahmad Gebreil ,&nbsp;Jessica Miller ,&nbsp;Kamal Abou Farraj ,&nbsp;Reham Wahid ,&nbsp;Hania Abdelhafez ,&nbsp;Momo Arai ,&nbsp;Sameeha Abdulwali ,&nbsp;Yazan Almasry ,&nbsp;Muzammil Dastagir ,&nbsp;Mohamed Salman ,&nbsp;Pretty Mathew ,&nbsp;Nourhan Baraka ,&nbsp;Sarah Bench ,&nbsp;Livia Eberlin ,&nbsp;Bradford Hill","doi":"10.1016/j.jmccpl.2025.100321","DOIUrl":"10.1016/j.jmccpl.2025.100321","url":null,"abstract":"","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"12 ","pages":"Article 100321"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144470293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gdf10-mediated Fibroblast-Cardiomyocyte Crosstalk during Postnatal Heart Development 出生后心脏发育中gdf10介导的成纤维细胞-心肌细胞串扰
Journal of molecular and cellular cardiology plus Pub Date : 2025-06-01 DOI: 10.1016/j.jmccpl.2025.100312
Maria Uscategui Calderon , Maria Spaeth , Marissa Granitto , Brittany Gonzalez , Christina Alfieri , Leah Kottyan , Matt Weirauch , Katherine Yutzey
{"title":"Gdf10-mediated Fibroblast-Cardiomyocyte Crosstalk during Postnatal Heart Development","authors":"Maria Uscategui Calderon ,&nbsp;Maria Spaeth ,&nbsp;Marissa Granitto ,&nbsp;Brittany Gonzalez ,&nbsp;Christina Alfieri ,&nbsp;Leah Kottyan ,&nbsp;Matt Weirauch ,&nbsp;Katherine Yutzey","doi":"10.1016/j.jmccpl.2025.100312","DOIUrl":"10.1016/j.jmccpl.2025.100312","url":null,"abstract":"","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"12 ","pages":"Article 100312"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144470405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fibrotic Remodeling of Myxomatous Mitral Valves in a Mouse Model of Marfan Syndrome 马凡氏综合征小鼠模型粘液瘤二尖瓣纤维化重塑
Journal of molecular and cellular cardiology plus Pub Date : 2025-06-01 DOI: 10.1016/j.jmccpl.2025.100316
Brittany A. Gonzalez , Cassandra L. Clift , Gabrielle Bogut , Taku Kasai , Sasha A. Singh , Elena Aikawa , Katherine E. Yutzey
{"title":"Fibrotic Remodeling of Myxomatous Mitral Valves in a Mouse Model of Marfan Syndrome","authors":"Brittany A. Gonzalez ,&nbsp;Cassandra L. Clift ,&nbsp;Gabrielle Bogut ,&nbsp;Taku Kasai ,&nbsp;Sasha A. Singh ,&nbsp;Elena Aikawa ,&nbsp;Katherine E. Yutzey","doi":"10.1016/j.jmccpl.2025.100316","DOIUrl":"10.1016/j.jmccpl.2025.100316","url":null,"abstract":"","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"12 ","pages":"Article 100316"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144470408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The mitochondrial calcium efflux regulator TMEM65 is essential to the function of the adult heart 线粒体钙外排调节剂TMEM65对成人心脏功能至关重要
Journal of molecular and cellular cardiology plus Pub Date : 2025-06-01 DOI: 10.1016/j.jmccpl.2025.100404
Joanne F. Garbincius , Oniel Salik , Henry M. Cohen , Carmen Choya-Foces , Adam S. Mangold , Angelina D. Makhoul , Anna E. Schmidt , Dima Y. Khalil , Joshua J. Doolittle , Adyson B. Johnson , Anya S. Wilkinson , Emma K. Murray , Michael P. Lazaropoulos , Alycia N. Hildebrand , Kenneth C. Bedi Jr. , Kenneth B. Margulies , Dhanendra Tomar , John W. Elrod
{"title":"The mitochondrial calcium efflux regulator TMEM65 is essential to the function of the adult heart","authors":"Joanne F. Garbincius ,&nbsp;Oniel Salik ,&nbsp;Henry M. Cohen ,&nbsp;Carmen Choya-Foces ,&nbsp;Adam S. Mangold ,&nbsp;Angelina D. Makhoul ,&nbsp;Anna E. Schmidt ,&nbsp;Dima Y. Khalil ,&nbsp;Joshua J. Doolittle ,&nbsp;Adyson B. Johnson ,&nbsp;Anya S. Wilkinson ,&nbsp;Emma K. Murray ,&nbsp;Michael P. Lazaropoulos ,&nbsp;Alycia N. Hildebrand ,&nbsp;Kenneth C. Bedi Jr. ,&nbsp;Kenneth B. Margulies ,&nbsp;Dhanendra Tomar ,&nbsp;John W. Elrod","doi":"10.1016/j.jmccpl.2025.100404","DOIUrl":"10.1016/j.jmccpl.2025.100404","url":null,"abstract":"","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"12 ","pages":"Article 100404"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144470673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Myocardial Endothelial-to-Mesenchymal transition in Diabetic Cardiomyopathy as a surrogate marker for prevention and assess disease severity 糖尿病性心肌病中心肌内皮向间质转化作为预防和评估疾病严重程度的替代标志物
Journal of molecular and cellular cardiology plus Pub Date : 2025-06-01 DOI: 10.1016/j.jmccpl.2025.100309
Uma Nahar Saikia, Chandni Kashyap, Vibhuti Sharma, Ajay Bahl
{"title":"Myocardial Endothelial-to-Mesenchymal transition in Diabetic Cardiomyopathy as a surrogate marker for prevention and assess disease severity","authors":"Uma Nahar Saikia,&nbsp;Chandni Kashyap,&nbsp;Vibhuti Sharma,&nbsp;Ajay Bahl","doi":"10.1016/j.jmccpl.2025.100309","DOIUrl":"10.1016/j.jmccpl.2025.100309","url":null,"abstract":"","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"12 ","pages":"Article 100309"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144470823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Modeling Cardiorenal Syndrome Type 1: A Time Course Evaluation of Myocardial Infarction-Induced Kidney Injury 1型心肾综合征模型：心肌梗死所致肾损伤的时间过程评价
Journal of molecular and cellular cardiology plus Pub Date : 2025-06-01 DOI: 10.1016/j.jmccpl.2025.100341
Sophia M. Sears, Richa A. Singhal, Mamata Chaudhari, Daniel C. Nguyen, Kenneth R. Brittian, Bradford G. Hill, Yibing Nong, Steven P. Jones
{"title":"Modeling Cardiorenal Syndrome Type 1: A Time Course Evaluation of Myocardial Infarction-Induced Kidney Injury","authors":"Sophia M. Sears,&nbsp;Richa A. Singhal,&nbsp;Mamata Chaudhari,&nbsp;Daniel C. Nguyen,&nbsp;Kenneth R. Brittian,&nbsp;Bradford G. Hill,&nbsp;Yibing Nong,&nbsp;Steven P. Jones","doi":"10.1016/j.jmccpl.2025.100341","DOIUrl":"10.1016/j.jmccpl.2025.100341","url":null,"abstract":"","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"12 ","pages":"Article 100341"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144470906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stage-specific Alternative RNA Splicing Attunes Cardiomyocyte Proliferation and Contraction. 阶段特异性选择性RNA剪接调节心肌细胞增殖和收缩。
Journal of molecular and cellular cardiology plus Pub Date : 2025-06-01 DOI: 10.1016/j.jmccpl.2025.100317
Peiheng Gan
{"title":"Stage-specific Alternative RNA Splicing Attunes Cardiomyocyte Proliferation and Contraction.","authors":"Peiheng Gan","doi":"10.1016/j.jmccpl.2025.100317","DOIUrl":"10.1016/j.jmccpl.2025.100317","url":null,"abstract":"","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"12 ","pages":"Article 100317"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144471208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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