Journal of molecular and cellular cardiology plus最新文献

{"title":"Apolipoprotein A-I mimetic peptide promotes angiogenesis by increasing MARK3 expression in hypercholesterolemic ischemic heart","authors":"Jingsong Ou , Zui Liu , Yang Cao , Zhi-Jun Ou , Yan Li , Mary G. Sorci-Thomas","doi":"10.1016/j.jmccpl.2025.100508","DOIUrl":"10.1016/j.jmccpl.2025.100508","url":null,"abstract":"","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"15 ","pages":"Article 100508"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147538247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Platelet membrane microbubbles as ultrasound imaging-trackable colloidal agents for clot targeting and detection","authors":"Mark Louis Vidallon , Mitchell Moon , Haikun Liu , Yuyang Song , Simon Crawford , Boon Mian Teo , James McFadyen , Alexis Bishop , Rico Tabor , Karlheinz Peter , Xiaowei Wang","doi":"10.1016/j.jmccpl.2025.100534","DOIUrl":"10.1016/j.jmccpl.2025.100534","url":null,"abstract":"","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"15 ","pages":"Article 100534"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147538759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selective ROCK2 inhibition reduces microvascular obstruction but does not reduce myocardial infarction after ischaemia and reperfusion","authors":"Lucie Pearce,&nbsp;David He,&nbsp;Derek M. Yellon,&nbsp;Sean M. Davidson","doi":"10.1016/j.jmccpl.2026.100836","DOIUrl":"10.1016/j.jmccpl.2026.100836","url":null,"abstract":"<div><h3>Introduction</h3><div>Myocardial ischaemia/reperfusion (I/R) injury causes infarction, microvascular obstruction (MVO), and haemorrhage. MVO, often driven by vasospasm, lacks effective therapy. The non-selective ROCK inhibitor fasudil, used for cerebral vasospasm, limits infarct size after myocardial I/R, but the roles of individual ROCK isoforms in limiting infarction and MVO remain unclear.</div></div><div><h3>Aims</h3><div>To determine the contribution of ROCK2 to myocardial and microvascular obstruction and to assess the vasodilatory potential of ROCK2 inhibition.</div></div><div><h3>Methods</h3><div>ROCK1/2 expression was analysed in rat hearts by RNAscope. Vascular myography assessed arterial responses to ROCK inhibitors. Rats underwent 30 min coronary occlusion and 180 min reperfusion, with ROCK2 inhibitor KD025 (100 mg/kg i.p.) or vehicle administered before reperfusion. Infarct size (%AAR) and MVO (%AAR) were quantified by TTC and Thioflavin S staining, respectively. Infarct size was also compared in WT and ROCK2⁺/⁻ mice.</div></div><div><h3>Results</h3><div>ROCK2 mRNA was more highly expressed than ROCK1 in both myocardium and coronary vasculature. The dual ROCK1/2 inhibitor, fasudil (10 mg/kg), reduced infarct size (34.5 ± 5.7 vs 55.8 ± 4.7%, P = 0.02, n = 6), whereas the ROCK2-selective KD025 (100 mg/kg) had no effect (43.7 ± 5.5 vs 48.3 ± 4.9%, P = 0.87, n = 8) and also showed no vasodilation ex vivo. ROCK2⁺/⁻ mice were similar to WT. However, KD025 reduced MVO% in rats (21.8 ± 2.5 vs 32.2 ± 1.8%, P = 0.04, n = 8), as did 3 mg/kg fasudil (19.2 ± 4.1 vs 32.2 ± 1.8%, P = 0.01, n = 6).</div></div><div><h3>Conclusion</h3><div>Dual ROCK1/2 inhibition protects myocardium from I/R injury, whereas selective ROCK2 inhibition or deficiency does not, implicating ROCK1 in infarct limitation. In contrast, ROCK2 inhibition reduced MVO, identifying ROCK2 as a potential microvascular target.</div></div>","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"15 ","pages":"Article 100836"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146173564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phosphorylation of Bcl2-L-13 by AMPKα2 activates mitophagy in pressure-overloaded heart","authors":"Tomokazu Murakawa ,&nbsp;Yasushi Sakata ,&nbsp;KInya Otsu","doi":"10.1016/j.jmccpl.2025.100554","DOIUrl":"10.1016/j.jmccpl.2025.100554","url":null,"abstract":"","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"15 ","pages":"Article 100554"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147536960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic Landscape and Prognostic Factors in Pediatric Mitochondrial Cardiomyopathy: A 20-Year Comprehensive Study","authors":"Atsuko Okazaki ,&nbsp;Yukiko Yatsuka ,&nbsp;Takuya Fushimi ,&nbsp;Akira Ohtake ,&nbsp;Kei Murayama ,&nbsp;Yasushi Okazaki","doi":"10.1016/j.jmccpl.2025.100584","DOIUrl":"10.1016/j.jmccpl.2025.100584","url":null,"abstract":"","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"15 ","pages":"Article 100584"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147537678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting C42 in PKGIα limits diastolic dysfunction in HFpEF","authors":"Jie Su,&nbsp;Joseph Burgoyne","doi":"10.1016/j.jmccpl.2025.100557","DOIUrl":"10.1016/j.jmccpl.2025.100557","url":null,"abstract":"","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"15 ","pages":"Article 100557"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147537687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Specific Regulatory Changes in Breast Cancer-Induced Cardiac Injury Unraveled by Single Nucleus RNA-seq and Spatial Transcriptomics","authors":"Lan Wu ,&nbsp;Wanqing Wu ,&nbsp;Xi Zhai ,&nbsp;Jingkai Zhang ,&nbsp;Xinyu Chen ,&nbsp;Xiao Xiao ,&nbsp;Zhifang Yang ,&nbsp;Gang Huang","doi":"10.1016/j.jmccpl.2025.100542","DOIUrl":"10.1016/j.jmccpl.2025.100542","url":null,"abstract":"","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"15 ","pages":"Article 100542"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147537871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The decrease in blood pressure and the improvement in glucose tolerance do not delay the progression of heart failure with preserved ejection fraction in mice.","authors":"Madara Grunda ,&nbsp;Helena Cirule ,&nbsp;Olga Zharkova-Malkova ,&nbsp;Maija Dambrova ,&nbsp;Reinis Vilskersts","doi":"10.1016/j.jmccpl.2025.100596","DOIUrl":"10.1016/j.jmccpl.2025.100596","url":null,"abstract":"","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"15 ","pages":"Article 100596"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147538604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting intracellular Na to reverse metabolic reprogramming and energetic dysfunction in heart failure","authors":"Zoe Hoare ,&nbsp;Yu Jin Chung ,&nbsp;Thomas R. Eykyn ,&nbsp;Svenja M. Kiehn ,&nbsp;Tobias Bruegmann ,&nbsp;Michael J. Shattock","doi":"10.1016/j.jmccpl.2025.100524","DOIUrl":"10.1016/j.jmccpl.2025.100524","url":null,"abstract":"","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"15 ","pages":"Article 100524"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147536736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circular RNA hsa-ZBTB44_0001 as a pre-natal diagnostic marker for Hypoplastic left heart syndrome","authors":"Neha Rawal ,&nbsp;Snigdha Kumari ,&nbsp;Ajay Bahl ,&nbsp;Anupam Mittal","doi":"10.1016/j.jmccpl.2025.100553","DOIUrl":"10.1016/j.jmccpl.2025.100553","url":null,"abstract":"","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"15 ","pages":"Article 100553"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147537870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}