Journal of molecular and cellular cardiology plus最新文献

{"title":"10023: Polyphenol-Rich Extract Of Roselle Calyx (Hpe) Limit Progression Of Cardiac Dysfunction And Structural Changes In Diabetic Rat Model","authors":"Siti Balkis Budin, Fatin Farhana Jubaidi, Nur Liyana Mohammed Yusof, Satirah Zainalabidin, Izatus Shima Taib, Zariyantey Abdul Hamid","doi":"10.1016/j.jmccpl.2024.100145","DOIUrl":"10.1016/j.jmccpl.2024.100145","url":null,"abstract":"","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"10 ","pages":"Article 100145"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143128721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"10014: Diagnostic Test for Myosin Binding Protein-C (cMyBP-C) in Patients with Acute Coronary Syndrome (ACS)","authors":"Raja Iqbal Mulya Harahap, Bejo Ropii, Nida Suraya, Tiene Rostini","doi":"10.1016/j.jmccpl.2024.100136","DOIUrl":"10.1016/j.jmccpl.2024.100136","url":null,"abstract":"","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"10 ","pages":"Article 100136"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143130625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"10004: Association Between Bisphenol Exposure and Metabolic Syndrome Components in A Malaysian Population","authors":"Sarah Zulkifli, Mohd Danial Mohd Efendy Goon, Atiqah Auni Razali, Jazlan Jamaluddin, Normala Abd Latip, Sharaniza Ab Rahim, Suraya Abdul Razak, Thuhairah Abdul Rahman, Nur Amirah Shibraumalisi, Zaliha Ismail, Siti Hamimah Sheikh Abdul Kadir","doi":"10.1016/j.jmccpl.2024.100126","DOIUrl":"10.1016/j.jmccpl.2024.100126","url":null,"abstract":"","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"10 ","pages":"Article 100126"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143175535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"10001: Calciseptine isolated from the black mamba toxin selectively blocks cardiac Cav1.2 (alpha1C) versus Cav1.3 (alpha1D) L-type calcium channels","authors":"Pietro Mesirca, Jean Chemin, Christian Barrère, Eleonora Torre, Laura Gallot, Mélanie Faure, Arnaud Monteil, Isabelle Bidaud, Sylvie Diochot, Michel Lazdunski, TuckWah Soong, Stéphanie Barrere-Lemaire, Matteo E. Mangoni, Joël Nargeot","doi":"10.1016/j.jmccpl.2024.100123","DOIUrl":"10.1016/j.jmccpl.2024.100123","url":null,"abstract":"","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"10 ","pages":"Article 100123"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143176435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"10058: Cardiovascular Impact of Global BCAA Catabolic Regulation","authors":"Yunxia Liu, Shuxun Ren, Meng Wang, Zhao Liu, Norihiko Morisawa, Liping Sun, Jens Marc Titze, Haipeng Sun, Chen Gao, Yibin Wang","doi":"10.1016/j.jmccpl.2024.100180","DOIUrl":"10.1016/j.jmccpl.2024.100180","url":null,"abstract":"","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"10 ","pages":"Article 100180"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143176445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"10008: Integrative analysis revealed circRNA-miRNA-mRNA regulatory network in pulmonary arterial hypertension related to congenital heart disease","authors":"Fajri Marindra Siregar, Anggoro Budi Hartopo, Sofia Mubarika Haryana","doi":"10.1016/j.jmccpl.2024.100130","DOIUrl":"10.1016/j.jmccpl.2024.100130","url":null,"abstract":"","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"10 ","pages":"Article 100130"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143176628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modeling immune checkpoint inhibitor associated myocarditis in vitro and its therapeutic implications","authors":"Garrett Jensen ,&nbsp;Xinjie Wang ,&nbsp;Jacob Kuempel ,&nbsp;Zhishi Chen ,&nbsp;Wei Yu ,&nbsp;Nicolas Palaskas ,&nbsp;Mary Sobieski ,&nbsp;Nghi Nguyen ,&nbsp;Reid T. Powell ,&nbsp;Clifford Stephan ,&nbsp;Weijia Luo ,&nbsp;Jiang Chang","doi":"10.1016/j.jmccpl.2024.100122","DOIUrl":"10.1016/j.jmccpl.2024.100122","url":null,"abstract":"<div><div>Immune checkpoint inhibitor-associated myocarditis is the most lethal side effect of immune checkpoint blockade. Myocarditis leads to persistently increased mortality and lacks effective treatments. The development of patient-relevant disease models may enable disease prediction, increased understanding of disease pathophysiology, and the development of effective treatment strategies. Here, we report a new method to model immune checkpoint inhibitor-associated myocarditis <em>in vitro</em> via a co-culture of activated primary human immune cells, human induced pluripotent stem cell-derived cardiomyocytes, and FDA-approved immune checkpoint inhibitors to recapitulate myocarditis <em>in vitro</em>. Significant cardiomyocyte necrosis, arrhythmia development, and sarcomere destruction occur, replicating clinical findings from myocarditis. This tissue culture myocarditis phenotype may rely on an induced pluripotent stem cell-derived cardiomyocyte antigen-specific CD8⁺ T cell response. The administration of dexamethasone rescued cardiomyocyte viability, morphology, and electrophysiology and suppressed inflammatory cytokine production. In conclusion, we detail how this platform can effectively model and provide critical information about the morphological and electrophysiological changes induced by immune checkpoint inhibitor-associated myocarditis. We have also validated the ability of this platform to screen potential medications to treat immune checkpoint inhibitor-associated myocarditis. This work establishes a robust, scalable model for identifying new therapies and risk factors, which is valuable in delineating the nature of interactions between the immune system and the heart during myocarditis.</div></div>","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"10 ","pages":"Article 100122"},"PeriodicalIF":0.0,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142700843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual calcium-voltage optical mapping of regional voltage and calcium signals in intact murine RyR2-R2474S hearts","authors":"Yangpeng Li ,&nbsp;Zhu Liu ,&nbsp;Christopher O'Shea ,&nbsp;Jianhong Li ,&nbsp;Xian Luo ,&nbsp;Tangting Chen ,&nbsp;Xianhong Ou ,&nbsp;Weichao Liu ,&nbsp;Guoliang Hao ,&nbsp;Christopher L.-H. Huang ,&nbsp;Davor Pavlovic ,&nbsp;Xiaoqiu Tan ,&nbsp;Ming Lei","doi":"10.1016/j.jmccpl.2024.100121","DOIUrl":"10.1016/j.jmccpl.2024.100121","url":null,"abstract":"<div><div>Abnormal regional variations in electrical and calcium homeostasis properties have been implicated in catecholaminergic polymorphic ventricular tachycardias (CPVT) attributable to abnormal RyR2-mediated store Ca²⁺ release, but their underlying mechanism have not been well explored in intact hearts.</div></div><div><h3>Methods</h3><div>We performed in vivo and ex vivo studies including high throughput mapping of Ca²⁺ transients (CaT) and transmembrane voltage (V_m) in murine wild-type (WT) and heterozygous <em>RyR2</em>-R2474S/+ hearts, before and during isoprenaline (ISO) challenge.</div></div><div><h3>Results</h3><div>ISO-challenged <em>RyR2</em>-R2474S/+ showed increased incidence of arrhythmia accompanied by abnormal Ca²⁺ transients compared to WT. CaT duration (CaTD) in the LV apex amongst regions studied both before and during ISO challenge in both WT and <em>RyR2</em>-R2474S/+ ventricles. <em>RyR2</em>-R2474S/+ ventricles showed prolonged CaTD, both before and during isoprenaline (ISO) challenge. Conversely, action potential durations (APD) were the same in WT and RyR2-R2474S/+ ventricles and identically reduced by ISO challenge. <em>RyR2</em>-R2474S/+ showed <em>V</em>_m-CaT latencies at time to half decay, but not rise time to peak, which were significantly prolonged compared to WT in all ventricular regions examined with ISO challenge. Following burst pacing, ventricular localized concordant alternans in CaT and APD were readily observed in <em>RyR2</em>-R2474S/+ but not in WT mice. Such CaT and APD alternans occurred mostly semiannually in specific regions of the ventricular pre-occurrence of VT.</div></div><div><h3>Conclusion</h3><div>The pro-arrhythmic <em>RyR2</em>-R2474S/+ phenotype in intact hearts thus directly parallels delayed regional CaT recovery properties and alteration of <em>V</em>_m-CaT latencies. Studies suggest that discordant localized calcium alternans are mechanistically responsible for action potential duration alternans and occurrence of VT in <em>RyR2</em>-R2474S/+ mice.</div></div>","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"10 ","pages":"Article 100121"},"PeriodicalIF":0.0,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142700844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Title page","authors":"","doi":"10.1016/S2772-9761(24)00059-X","DOIUrl":"10.1016/S2772-9761(24)00059-X","url":null,"abstract":"","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"10 ","pages":"Article 100119"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142747694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The influence of the endocannabinoid system on the profibrotic profile of cardiac fibroblasts associated with Duchenne Muscular Dystrophy","authors":"Lesia Savchenko ,&nbsp;Salwa Soussi ,&nbsp;Davide Rovina ,&nbsp;Martina Rabino ,&nbsp;Giulio Pompilio ,&nbsp;Angelo Parini ,&nbsp;Aoife Gowran ,&nbsp;Nathalie Pizzinat","doi":"10.1016/j.jmccpl.2024.100115","DOIUrl":"10.1016/j.jmccpl.2024.100115","url":null,"abstract":"","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"10 ","pages":"Article 100115"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142744817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}