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Journal of molecular and cellular cardiology plus最新文献

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10005: SREBP2 Depletion Protects against Hyperlipidemia and Atherosclerosis by Regulating ANGPTL3-LPL Axis
Journal of molecular and cellular cardiology plus Pub Date : 2024-12-01 DOI: 10.1016/j.jmccpl.2024.100127
Yifan Wang, Jia You Sarafina Choe, Yu Shi, Thi Tun Thi, Kai Yan Cheng, Yang Hu, Hui Li, Xiaoyun Cao, Yang Ji, Yan Liu, Matthew Ackers-Johnson, Yujia Shen, Haojie Yu
{"title":"10005: SREBP2 Depletion Protects against Hyperlipidemia and Atherosclerosis by Regulating ANGPTL3-LPL Axis","authors":"Yifan Wang, Jia You Sarafina Choe, Yu Shi, Thi Tun Thi, Kai Yan Cheng, Yang Hu, Hui Li, Xiaoyun Cao, Yang Ji, Yan Liu, Matthew Ackers-Johnson, Yujia Shen, Haojie Yu","doi":"10.1016/j.jmccpl.2024.100127","DOIUrl":"10.1016/j.jmccpl.2024.100127","url":null,"abstract":"","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"10 ","pages":"Article 100127"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143175536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
10048: Empagliflozin ameliorates the pathological phenotype in human induced pluripotent stem cell-derived cardiomyocytes generated from patients with diabetic heart failure
Journal of molecular and cellular cardiology plus Pub Date : 2024-12-01 DOI: 10.1016/j.jmccpl.2024.100170
Shuo Cong, Fan Yu, En Ping Yap, Valerie Ho, Myu Mai Ja Kp, Derek Hausenloy, Chrishan Ramachandra
{"title":"10048: Empagliflozin ameliorates the pathological phenotype in human induced pluripotent stem cell-derived cardiomyocytes generated from patients with diabetic heart failure","authors":"Shuo Cong, Fan Yu, En Ping Yap, Valerie Ho, Myu Mai Ja Kp, Derek Hausenloy, Chrishan Ramachandra","doi":"10.1016/j.jmccpl.2024.100170","DOIUrl":"10.1016/j.jmccpl.2024.100170","url":null,"abstract":"","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"10 ","pages":"Article 100170"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143175916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
10051: A novel therapeutic peptide to inhibit reperfusion injury during acute myocardial infarction
Journal of molecular and cellular cardiology plus Pub Date : 2024-12-01 DOI: 10.1016/j.jmccpl.2024.100173
Prisca Boisguérin, Aurélie Covinhes, Laura Gallot, Christian Barrere, Anne Vincent, Christophe Piot, Joël Nargeot, Stéphanie Barrère-Lemaire
{"title":"10051: A novel therapeutic peptide to inhibit reperfusion injury during acute myocardial infarction","authors":"Prisca Boisguérin, Aurélie Covinhes, Laura Gallot, Christian Barrere, Anne Vincent, Christophe Piot, Joël Nargeot, Stéphanie Barrère-Lemaire","doi":"10.1016/j.jmccpl.2024.100173","DOIUrl":"10.1016/j.jmccpl.2024.100173","url":null,"abstract":"","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"10 ","pages":"Article 100173"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143127799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
10023: Polyphenol-Rich Extract Of Roselle Calyx (Hpe) Limit Progression Of Cardiac Dysfunction And Structural Changes In Diabetic Rat Model
Journal of molecular and cellular cardiology plus Pub Date : 2024-12-01 DOI: 10.1016/j.jmccpl.2024.100145
Siti Balkis Budin, Fatin Farhana Jubaidi, Nur Liyana Mohammed Yusof, Satirah Zainalabidin, Izatus Shima Taib, Zariyantey Abdul Hamid
{"title":"10023: Polyphenol-Rich Extract Of Roselle Calyx (Hpe) Limit Progression Of Cardiac Dysfunction And Structural Changes In Diabetic Rat Model","authors":"Siti Balkis Budin, Fatin Farhana Jubaidi, Nur Liyana Mohammed Yusof, Satirah Zainalabidin, Izatus Shima Taib, Zariyantey Abdul Hamid","doi":"10.1016/j.jmccpl.2024.100145","DOIUrl":"10.1016/j.jmccpl.2024.100145","url":null,"abstract":"","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"10 ","pages":"Article 100145"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143128721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
10014: Diagnostic Test for Myosin Binding Protein-C (cMyBP-C) in Patients with Acute Coronary Syndrome (ACS)
Journal of molecular and cellular cardiology plus Pub Date : 2024-12-01 DOI: 10.1016/j.jmccpl.2024.100136
Raja Iqbal Mulya Harahap, Bejo Ropii, Nida Suraya, Tiene Rostini
{"title":"10014: Diagnostic Test for Myosin Binding Protein-C (cMyBP-C) in Patients with Acute Coronary Syndrome (ACS)","authors":"Raja Iqbal Mulya Harahap, Bejo Ropii, Nida Suraya, Tiene Rostini","doi":"10.1016/j.jmccpl.2024.100136","DOIUrl":"10.1016/j.jmccpl.2024.100136","url":null,"abstract":"","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"10 ","pages":"Article 100136"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143130625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
10004: Association Between Bisphenol Exposure and Metabolic Syndrome Components in A Malaysian Population
Journal of molecular and cellular cardiology plus Pub Date : 2024-12-01 DOI: 10.1016/j.jmccpl.2024.100126
Sarah Zulkifli, Mohd Danial Mohd Efendy Goon, Atiqah Auni Razali, Jazlan Jamaluddin, Normala Abd Latip, Sharaniza Ab Rahim, Suraya Abdul Razak, Thuhairah Abdul Rahman, Nur Amirah Shibraumalisi, Zaliha Ismail, Siti Hamimah Sheikh Abdul Kadir
{"title":"10004: Association Between Bisphenol Exposure and Metabolic Syndrome Components in A Malaysian Population","authors":"Sarah Zulkifli, Mohd Danial Mohd Efendy Goon, Atiqah Auni Razali, Jazlan Jamaluddin, Normala Abd Latip, Sharaniza Ab Rahim, Suraya Abdul Razak, Thuhairah Abdul Rahman, Nur Amirah Shibraumalisi, Zaliha Ismail, Siti Hamimah Sheikh Abdul Kadir","doi":"10.1016/j.jmccpl.2024.100126","DOIUrl":"10.1016/j.jmccpl.2024.100126","url":null,"abstract":"","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"10 ","pages":"Article 100126"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143175535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
10001: Calciseptine isolated from the black mamba toxin selectively blocks cardiac Cav1.2 (alpha1C) versus Cav1.3 (alpha1D) L-type calcium channels
Journal of molecular and cellular cardiology plus Pub Date : 2024-12-01 DOI: 10.1016/j.jmccpl.2024.100123
Pietro Mesirca, Jean Chemin, Christian Barrère, Eleonora Torre, Laura Gallot, Mélanie Faure, Arnaud Monteil, Isabelle Bidaud, Sylvie Diochot, Michel Lazdunski, TuckWah Soong, Stéphanie Barrere-Lemaire, Matteo E. Mangoni, Joël Nargeot
{"title":"10001: Calciseptine isolated from the black mamba toxin selectively blocks cardiac Cav1.2 (alpha1C) versus Cav1.3 (alpha1D) L-type calcium channels","authors":"Pietro Mesirca, Jean Chemin, Christian Barrère, Eleonora Torre, Laura Gallot, Mélanie Faure, Arnaud Monteil, Isabelle Bidaud, Sylvie Diochot, Michel Lazdunski, TuckWah Soong, Stéphanie Barrere-Lemaire, Matteo E. Mangoni, Joël Nargeot","doi":"10.1016/j.jmccpl.2024.100123","DOIUrl":"10.1016/j.jmccpl.2024.100123","url":null,"abstract":"","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"10 ","pages":"Article 100123"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143176435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
10058: Cardiovascular Impact of Global BCAA Catabolic Regulation
Journal of molecular and cellular cardiology plus Pub Date : 2024-12-01 DOI: 10.1016/j.jmccpl.2024.100180
Yunxia Liu, Shuxun Ren, Meng Wang, Zhao Liu, Norihiko Morisawa, Liping Sun, Jens Marc Titze, Haipeng Sun, Chen Gao, Yibin Wang
{"title":"10058: Cardiovascular Impact of Global BCAA Catabolic Regulation","authors":"Yunxia Liu, Shuxun Ren, Meng Wang, Zhao Liu, Norihiko Morisawa, Liping Sun, Jens Marc Titze, Haipeng Sun, Chen Gao, Yibin Wang","doi":"10.1016/j.jmccpl.2024.100180","DOIUrl":"10.1016/j.jmccpl.2024.100180","url":null,"abstract":"","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"10 ","pages":"Article 100180"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143176445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
10008: Integrative analysis revealed circRNA-miRNA-mRNA regulatory network in pulmonary arterial hypertension related to congenital heart disease
Journal of molecular and cellular cardiology plus Pub Date : 2024-12-01 DOI: 10.1016/j.jmccpl.2024.100130
Fajri Marindra Siregar, Anggoro Budi Hartopo, Sofia Mubarika Haryana
{"title":"10008: Integrative analysis revealed circRNA-miRNA-mRNA regulatory network in pulmonary arterial hypertension related to congenital heart disease","authors":"Fajri Marindra Siregar, Anggoro Budi Hartopo, Sofia Mubarika Haryana","doi":"10.1016/j.jmccpl.2024.100130","DOIUrl":"10.1016/j.jmccpl.2024.100130","url":null,"abstract":"","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"10 ","pages":"Article 100130"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143176628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Modeling immune checkpoint inhibitor associated myocarditis in vitro and its therapeutic implications 免疫检查点抑制剂相关心肌炎的体外建模及其治疗意义
Journal of molecular and cellular cardiology plus Pub Date : 2024-11-20 DOI: 10.1016/j.jmccpl.2024.100122
Garrett Jensen , Xinjie Wang , Jacob Kuempel , Zhishi Chen , Wei Yu , Nicolas Palaskas , Mary Sobieski , Nghi Nguyen , Reid T. Powell , Clifford Stephan , Weijia Luo , Jiang Chang
{"title":"Modeling immune checkpoint inhibitor associated myocarditis in vitro and its therapeutic implications","authors":"Garrett Jensen ,&nbsp;Xinjie Wang ,&nbsp;Jacob Kuempel ,&nbsp;Zhishi Chen ,&nbsp;Wei Yu ,&nbsp;Nicolas Palaskas ,&nbsp;Mary Sobieski ,&nbsp;Nghi Nguyen ,&nbsp;Reid T. Powell ,&nbsp;Clifford Stephan ,&nbsp;Weijia Luo ,&nbsp;Jiang Chang","doi":"10.1016/j.jmccpl.2024.100122","DOIUrl":"10.1016/j.jmccpl.2024.100122","url":null,"abstract":"<div><div>Immune checkpoint inhibitor-associated myocarditis is the most lethal side effect of immune checkpoint blockade. Myocarditis leads to persistently increased mortality and lacks effective treatments. The development of patient-relevant disease models may enable disease prediction, increased understanding of disease pathophysiology, and the development of effective treatment strategies. Here, we report a new method to model immune checkpoint inhibitor-associated myocarditis <em>in vitro</em> via a co-culture of activated primary human immune cells, human induced pluripotent stem cell-derived cardiomyocytes, and FDA-approved immune checkpoint inhibitors to recapitulate myocarditis <em>in vitro</em>. Significant cardiomyocyte necrosis, arrhythmia development, and sarcomere destruction occur, replicating clinical findings from myocarditis. This tissue culture myocarditis phenotype may rely on an induced pluripotent stem cell-derived cardiomyocyte antigen-specific CD8<sup>+</sup> T cell response. The administration of dexamethasone rescued cardiomyocyte viability, morphology, and electrophysiology and suppressed inflammatory cytokine production. In conclusion, we detail how this platform can effectively model and provide critical information about the morphological and electrophysiological changes induced by immune checkpoint inhibitor-associated myocarditis. We have also validated the ability of this platform to screen potential medications to treat immune checkpoint inhibitor-associated myocarditis. This work establishes a robust, scalable model for identifying new therapies and risk factors, which is valuable in delineating the nature of interactions between the immune system and the heart during myocarditis.</div></div>","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"10 ","pages":"Article 100122"},"PeriodicalIF":0.0,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142700843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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