Journal of molecular and cellular cardiology plus最新文献

{"title":"Corrigendum to “Sex-specific human electromechanical multiscale in-silico models for virtual therapy evaluation” [J Mol Cell Cardiol Plus 13 (2025) 100479]","authors":"Maxx Holmes , Zhinuo Jenny Wang , Ruben Doste , Julia Camps , Hector Martinez-Navarro , Hannah Smith , Jakub Tomek , Blanca Rodriguez","doi":"10.1016/j.jmccpl.2025.100832","DOIUrl":"10.1016/j.jmccpl.2025.100832","url":null,"abstract":"","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"15 ","pages":"Article 100832"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147537559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exercise has differential effects on cardiometabolic health in male and female mice on a high fat diet","authors":"Lauren Watson , Marco Annandale , Caitlin MacRae , Jayd Dayaram , Neave Burgess , Thaize Chometon , Christopher Puliuvea , Christopher Hedges , Randall D'Souza , Troy Merry , Kimberley Mellor","doi":"10.1016/j.jmccpl.2025.100573","DOIUrl":"10.1016/j.jmccpl.2025.100573","url":null,"abstract":"","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"15 ","pages":"Article 100573"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147537560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lamin A/C deficiency-mediated ROS elevation contributes to pathogenic phenotypes of dilated cardiomyopathy in iPSC model","authors":"Hangyuan Qiu , Yaxun Sun , Xiaochen Wang , Tingyu Gong , Jun Su , Jiaxi Shen , Jingjun Zhou , Jiafeng Xia , Hao Wang , Xiangfu Meng , Guosheng Fu , Donghui Zhang , Chenyang Jiang , Ping Liang","doi":"10.1016/j.jmccpl.2025.100501","DOIUrl":"10.1016/j.jmccpl.2025.100501","url":null,"abstract":"","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"15 ","pages":"Article 100501"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147537879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Innovative cell therapy with sustained mesenchymal stem cell secretome for long-term cardioprotection","authors":"Andrew Kompa , David Greening , Jarmon Lees , Anne Kong , Jonathon Cross , Ashley Nowland , Jack Phang , Saba Naghipour , Yali Deng , Jack Darby , Lina Mariana , Cameron Kos , Tanya Hall , James Chong , Rebecca Ritchie , Janna Morrison , Klearchos Papas , Kilian Kelly , Derek Hausenloy , Thomas Loudovaris , Shiang Lim","doi":"10.1016/j.jmccpl.2025.100523","DOIUrl":"10.1016/j.jmccpl.2025.100523","url":null,"abstract":"","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"15 ","pages":"Article 100523"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147537940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Macrophage FOXK2 Promotes Cardiac Repair in Non-diabetic Myocardial Infarction with Stress Hyperglycemia","authors":"Lv Huizhen , Liu Zening , Feng Suli , Liu Wennan , Bao Kaiwen , Shen Xilin , Shi Lei , Li Yongle , Zhou Xin , Yang Qing , Ai Ding","doi":"10.1016/j.jmccpl.2025.100540","DOIUrl":"10.1016/j.jmccpl.2025.100540","url":null,"abstract":"","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"15 ","pages":"Article 100540"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147538425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gene therapy targeting RIPK3 with the N-terminus of murine cytomegalovirus M45 prevents cardiac necroptosis and improves myocardial function in mouse models of doxorubicin-induced cardiotoxicity","authors":"Rui Ni , Xiaoyun Ji , Zhuxu Zhang , Guo-Chang Fan , Zhaoliang Su , Tianqing Peng","doi":"10.1016/j.jmccpl.2025.100513","DOIUrl":"10.1016/j.jmccpl.2025.100513","url":null,"abstract":"","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"15 ","pages":"Article 100513"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147538242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the molecular mechanisms of altered calcitonin receptor signalling in atrial fibroblasts in patients with atrial fibrillation","authors":"Aaron Michael Johnston , Chi Him Kendrick Yiu , Lucia Margarida Moreira , Daniel John McAlea , Paul Robinson , Ileana Badi , Vivek Srivastava , Rana Sayeed , George Krasopoulos , Nicholas Ralph Henry Walcot , Priya Sastry , Antonios Kourliouros , Nicola Smart , Svetlana Reilly","doi":"10.1016/j.jmccpl.2025.100546","DOIUrl":"10.1016/j.jmccpl.2025.100546","url":null,"abstract":"","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"15 ","pages":"Article 100546"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147538432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sedentary Ageing Remodels the Structure-Function Relationships that Underlie Calcium Signalling at Super-resolution Scales in the Heart","authors":"Miriam Hurley, Moza Al-Owais, Liam McCormick, Alan Benson, Michael Colman","doi":"10.1016/j.jmccpl.2025.100591","DOIUrl":"10.1016/j.jmccpl.2025.100591","url":null,"abstract":"","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"15 ","pages":"Article 100591"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147538607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypophosphorylation of the cMyBP-C M-domain is associated with detyrosination and acetylation of microtubules in hypertrophic cardiomyopathy","authors":"Sila Algül , Inez Duursma , Jennifer Hesson , Akhil Baby , Sakthivel Sadayappan , Julie Mathieu , Michael Regnier , Diederik W.D. Kuster , Jolanda van der Velden","doi":"10.1016/j.jmccpl.2025.100588","DOIUrl":"10.1016/j.jmccpl.2025.100588","url":null,"abstract":"","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"15 ","pages":"Article 100588"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147538750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response of human iPSC-cardiomyocytes to adrenergic drugs assessed by high-throughput pericellular oxygen measurements and computational modeling","authors":"Weizhen Li ,&nbsp;M. Amin Forouzandehmehr ,&nbsp;David McLeod ,&nbsp;Maria R. Pozo ,&nbsp;Yuli W. Heinson ,&nbsp;Matthew W. Kay ,&nbsp;Zhenyu Li ,&nbsp;Stefano Morotti ,&nbsp;Emilia Entcheva","doi":"10.1016/j.jmccpl.2026.100834","DOIUrl":"10.1016/j.jmccpl.2026.100834","url":null,"abstract":"<div><div>Rate- and contractility-modulating drugs, such as adrenergic agonists and antagonists, are widely used in the treatment of cardiovascular conditions. Preclinical assessment of new modulators of rate, inotropy and metabolism can be aided by high-throughput (HT) methods for chronic measurements, coupled with scalable human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). Here, we evaluate the utility of long-term optical (label-free) measurements of pericellular oxygen in a HT format (96-well plates) for the assessment of the effectiveness of adrenergic drugs in hiPSC-CMs. Quantitative oxygen consumption metrics were derived and correlated to measurements performed in the same samples using all-optical electrophysiology. Adrenergic agonists significantly increased oxygen consumption rate (OCR), best seen in the kinetics of initial depletion of pericellular oxygen, i.e. time to reach 5%. Adrenergic antagonists decreased OCR, best quantified using steady-state values for pericellular oxygen after at least 5 h. OCR-based drug type identification correlated well with the acute spontaneous rate measurements in the same samples. Direct rate modulation with chronic optogenetic pacing sped up OCR in hiPSC-CMs. Blebbistatin, an excitation-contraction uncoupler, significantly reduced OCR. Computational modeling helped interpret our results by capturing the effects of pacing rate, adrenergic stimulation, and blebbistatin on oxygen consumption, thereby highlighting the key contribution of inotropy and mechanical contraction to OCR in hiPSC-CMs. We conclude that HT label-free optical oxygen measurements and the comprehensive in silico hiPSC-CM models, constrained by such measurements, represent valuable human-based approaches for non-invasive assessment of rate- and metabolism-modulating drugs in preclinical studies.</div></div>","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"15 ","pages":"Article 100834"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146173563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}