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Journal of molecular and cellular cardiology plus最新文献

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Fibrotic Remodeling of Myxomatous Mitral Valves in a Mouse Model of Marfan Syndrome 马凡氏综合征小鼠模型粘液瘤二尖瓣纤维化重塑
Journal of molecular and cellular cardiology plus Pub Date : 2025-06-01 DOI: 10.1016/j.jmccpl.2025.100316
Brittany A. Gonzalez , Cassandra L. Clift , Gabrielle Bogut , Taku Kasai , Sasha A. Singh , Elena Aikawa , Katherine E. Yutzey
{"title":"Fibrotic Remodeling of Myxomatous Mitral Valves in a Mouse Model of Marfan Syndrome","authors":"Brittany A. Gonzalez , Cassandra L. Clift , Gabrielle Bogut , Taku Kasai , Sasha A. Singh , Elena Aikawa , Katherine E. Yutzey","doi":"10.1016/j.jmccpl.2025.100316","DOIUrl":"10.1016/j.jmccpl.2025.100316","url":null,"abstract":"","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"12 ","pages":"Article 100316"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144470408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The mitochondrial calcium efflux regulator TMEM65 is essential to the function of the adult heart 线粒体钙外排调节剂TMEM65对成人心脏功能至关重要
Journal of molecular and cellular cardiology plus Pub Date : 2025-06-01 DOI: 10.1016/j.jmccpl.2025.100404
Joanne F. Garbincius , Oniel Salik , Henry M. Cohen , Carmen Choya-Foces , Adam S. Mangold , Angelina D. Makhoul , Anna E. Schmidt , Dima Y. Khalil , Joshua J. Doolittle , Adyson B. Johnson , Anya S. Wilkinson , Emma K. Murray , Michael P. Lazaropoulos , Alycia N. Hildebrand , Kenneth C. Bedi Jr. , Kenneth B. Margulies , Dhanendra Tomar , John W. Elrod
{"title":"The mitochondrial calcium efflux regulator TMEM65 is essential to the function of the adult heart","authors":"Joanne F. Garbincius , Oniel Salik , Henry M. Cohen , Carmen Choya-Foces , Adam S. Mangold , Angelina D. Makhoul , Anna E. Schmidt , Dima Y. Khalil , Joshua J. Doolittle , Adyson B. Johnson , Anya S. Wilkinson , Emma K. Murray , Michael P. Lazaropoulos , Alycia N. Hildebrand , Kenneth C. Bedi Jr. , Kenneth B. Margulies , Dhanendra Tomar , John W. Elrod","doi":"10.1016/j.jmccpl.2025.100404","DOIUrl":"10.1016/j.jmccpl.2025.100404","url":null,"abstract":"","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"12 ","pages":"Article 100404"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144470673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Myocardial Endothelial-to-Mesenchymal transition in Diabetic Cardiomyopathy as a surrogate marker for prevention and assess disease severity 糖尿病性心肌病中心肌内皮向间质转化作为预防和评估疾病严重程度的替代标志物
Journal of molecular and cellular cardiology plus Pub Date : 2025-06-01 DOI: 10.1016/j.jmccpl.2025.100309
Uma Nahar Saikia, Chandni Kashyap, Vibhuti Sharma, Ajay Bahl
{"title":"Myocardial Endothelial-to-Mesenchymal transition in Diabetic Cardiomyopathy as a surrogate marker for prevention and assess disease severity","authors":"Uma Nahar Saikia, Chandni Kashyap, Vibhuti Sharma, Ajay Bahl","doi":"10.1016/j.jmccpl.2025.100309","DOIUrl":"10.1016/j.jmccpl.2025.100309","url":null,"abstract":"","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"12 ","pages":"Article 100309"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144470823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Modeling Cardiorenal Syndrome Type 1: A Time Course Evaluation of Myocardial Infarction-Induced Kidney Injury 1型心肾综合征模型：心肌梗死所致肾损伤的时间过程评价
Journal of molecular and cellular cardiology plus Pub Date : 2025-06-01 DOI: 10.1016/j.jmccpl.2025.100341
Sophia M. Sears, Richa A. Singhal, Mamata Chaudhari, Daniel C. Nguyen, Kenneth R. Brittian, Bradford G. Hill, Yibing Nong, Steven P. Jones
{"title":"Modeling Cardiorenal Syndrome Type 1: A Time Course Evaluation of Myocardial Infarction-Induced Kidney Injury","authors":"Sophia M. Sears, Richa A. Singhal, Mamata Chaudhari, Daniel C. Nguyen, Kenneth R. Brittian, Bradford G. Hill, Yibing Nong, Steven P. Jones","doi":"10.1016/j.jmccpl.2025.100341","DOIUrl":"10.1016/j.jmccpl.2025.100341","url":null,"abstract":"","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"12 ","pages":"Article 100341"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144470906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stage-specific Alternative RNA Splicing Attunes Cardiomyocyte Proliferation and Contraction. 阶段特异性选择性RNA剪接调节心肌细胞增殖和收缩。
Journal of molecular and cellular cardiology plus Pub Date : 2025-06-01 DOI: 10.1016/j.jmccpl.2025.100317
Peiheng Gan
{"title":"Stage-specific Alternative RNA Splicing Attunes Cardiomyocyte Proliferation and Contraction.","authors":"Peiheng Gan","doi":"10.1016/j.jmccpl.2025.100317","DOIUrl":"10.1016/j.jmccpl.2025.100317","url":null,"abstract":"","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"12 ","pages":"Article 100317"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144471208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
VWA7 Expression In The Mouse Heart Induces Maladaptation And Inflammatory Dependent Fibrosis VWA7在小鼠心脏中的表达诱导不适应和炎症依赖性纤维化
Journal of molecular and cellular cardiology plus Pub Date : 2025-06-01 DOI: 10.1016/j.jmccpl.2025.100356
Yasuhide Kuwabara , N. Scott Blair , Caitlin Keezer , Rajesh Kumar Kasam , Kathy Warrick , Suh-Chin Lin , Jeffery D. Molkentin
{"title":"VWA7 Expression In The Mouse Heart Induces Maladaptation And Inflammatory Dependent Fibrosis","authors":"Yasuhide Kuwabara , N. Scott Blair , Caitlin Keezer , Rajesh Kumar Kasam , Kathy Warrick , Suh-Chin Lin , Jeffery D. Molkentin","doi":"10.1016/j.jmccpl.2025.100356","DOIUrl":"10.1016/j.jmccpl.2025.100356","url":null,"abstract":"","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"12 ","pages":"Article 100356"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144471349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Isoform switch of T-cell factor7L2 during mouse heart development 小鼠心脏发育过程中t细胞因子7l2的异构体开关
Journal of molecular and cellular cardiology plus Pub Date : 2025-06-01 DOI: 10.1016/j.jmccpl.2025.100458
Bo Ye , Lu Xiao , Yuyong Xu , Haodong Xu , Faqian Li
{"title":"Isoform switch of T-cell factor7L2 during mouse heart development","authors":"Bo Ye ,&nbsp;Lu Xiao ,&nbsp;Yuyong Xu ,&nbsp;Haodong Xu ,&nbsp;Faqian Li","doi":"10.1016/j.jmccpl.2025.100458","DOIUrl":"10.1016/j.jmccpl.2025.100458","url":null,"abstract":"<div><div>Canonical WNT signaling plays critical, often opposing roles in heart development and disease, but its context-dependent mechanisms remain unclear. We hypothesized that alternative splicing of Tcf7l2, a key nuclear partner of β-catenin, contributes to WNT signaling specificity in the heart. To investigate this, we cloned and sequenced 53 Tcf7l2 transcripts in ventricular tissues from embryonic day 17.5 (E17.5, 24/53) and postnatal day 8 (P8, 29/53) mice, identifying 32 distinct isoforms. Among 18 potential exons, exons 6 and 17 were absent, and over 80 % of transcripts lacked exon 4. Alternative splicing was prominent in the C-terminal exons (14, 15, and 16), with exon 14 inclusion significantly higher in P8 hearts (64.3 %) than E17.5 hearts (34.8 %). Variations in exon 15 and 16 combinations, along with reading frame shifts caused by the adenine insertion and deletion (indel) near the beginning of exon 18, affected C-terminal structures, altering the presence of the E-tail, C-clamp, and CtBP-binding motifs. Notably, exon 14 insertion introduced a redox-switch domain spanning the NLS and C-clamp regions in E and S isoforms, while adenine indels altered isoform lengths, driving transitions between E, S, and M isoforms. RT-PCR validation across multiple developmental stages confirmed these splicing patterns. Our findings suggest that a postnatal redox-sensitive isoform switch in Tcf7l2 modulates WNT signaling, potentially influencing cardiomyocyte maturation during the transition from proliferation to hypertrophy.</div></div>","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"12 ","pages":"Article 100458"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144189693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interrogating the Effect of MYH7 R904H Dilated Cardiomyopathy Variant On Sarcomeric Dynamics 探讨MYH7 R904H扩张型心肌病变异对肌体动力学的影响
Journal of molecular and cellular cardiology plus Pub Date : 2025-06-01 DOI: 10.1016/j.jmccpl.2025.100385
Dania Ahmed , Alexander Loiben , Clayton Friedman , Wei-Ming Chien , Kai-Chun (Daniel) Yang
{"title":"Interrogating the Effect of MYH7 R904H Dilated Cardiomyopathy Variant On Sarcomeric Dynamics","authors":"Dania Ahmed ,&nbsp;Alexander Loiben ,&nbsp;Clayton Friedman ,&nbsp;Wei-Ming Chien ,&nbsp;Kai-Chun (Daniel) Yang","doi":"10.1016/j.jmccpl.2025.100385","DOIUrl":"10.1016/j.jmccpl.2025.100385","url":null,"abstract":"","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"12 ","pages":"Article 100385"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144469927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Mechanism of Coronary Collateral Growth in Adulthood Induced by Repetitive Ischemia 成人反复缺血诱导冠状动脉侧枝生长的机制
Journal of molecular and cellular cardiology plus Pub Date : 2025-06-01 DOI: 10.1016/j.jmccpl.2025.100334
Iyanuoluwa Ogunmiluyi, Molly Enrick, Yang Wang, Bevelyn Egleh, Jian Shi, James Gadd, Blessing Nagy, Liya Yin
{"title":"The Mechanism of Coronary Collateral Growth in Adulthood Induced by Repetitive Ischemia","authors":"Iyanuoluwa Ogunmiluyi,&nbsp;Molly Enrick,&nbsp;Yang Wang,&nbsp;Bevelyn Egleh,&nbsp;Jian Shi,&nbsp;James Gadd,&nbsp;Blessing Nagy,&nbsp;Liya Yin","doi":"10.1016/j.jmccpl.2025.100334","DOIUrl":"10.1016/j.jmccpl.2025.100334","url":null,"abstract":"","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"12 ","pages":"Article 100334"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144470082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mechanisms driving mechanical memory in adult rat and human Cardiomyocytes 驱动成年大鼠和人类心肌细胞机械记忆的机制
Journal of molecular and cellular cardiology plus Pub Date : 2025-06-01 DOI: 10.1016/j.jmccpl.2025.100381
Nesrine Bouhrira, Alexia Vite, Deborah Eaton, Kenneth Bedi, Kenneth Margulies
{"title":"Mechanisms driving mechanical memory in adult rat and human Cardiomyocytes","authors":"Nesrine Bouhrira,&nbsp;Alexia Vite,&nbsp;Deborah Eaton,&nbsp;Kenneth Bedi,&nbsp;Kenneth Margulies","doi":"10.1016/j.jmccpl.2025.100381","DOIUrl":"10.1016/j.jmccpl.2025.100381","url":null,"abstract":"","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"12 ","pages":"Article 100381"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144470101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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