Journal of medical research and innovation最新文献

{"title":"3D Printing and its Future in Medical World","authors":"Sanjay Sharma, S. Goel","doi":"10.15419/JMRI.141","DOIUrl":"https://doi.org/10.15419/JMRI.141","url":null,"abstract":"Since the time of its inception, 3D printing has not only fascinated the researchers but also health professionals. Though the process is exciting, it involves meticulous coordination and selection process to achieve a desirable product. This review article discusses about the history of evolution of 3 D printers, their current application and future trends. Emphasis has also been laid to recognize the best suitable product and ways to prevent its misuse.","PeriodicalId":73819,"journal":{"name":"Journal of medical research and innovation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41805179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editors and Reviewers Acknowledgement, 2(2), July-December, 2018","authors":"Editorial Team","doi":"10.15419/jmri.144","DOIUrl":"https://doi.org/10.15419/jmri.144","url":null,"abstract":"The Journal of Medical Research and Innovation would like to thank each and every one who has helped us to review and edit the articles. As a small token of appreciation, we would like to mention the names of all the editors and reviewers in random order here who have edited or reviewed the articles for the July, 2018 issue. The list will be updated as when more reviewers review the articles.","PeriodicalId":73819,"journal":{"name":"Journal of medical research and innovation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46532203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Markers of Poor Prognosis in Non-ST Segment Elevation Acute Coronary Syndromes Without Revascularization: A 3-Year Survival Analysis","authors":"A. Parkhomenko, N. Dovgan, Y. Lutay, S. Kozhukhov","doi":"10.15419/JMRI.139","DOIUrl":"https://doi.org/10.15419/JMRI.139","url":null,"abstract":"Introduction: The non-ST elevation acute coronary syndrome (NSTE-ACS) account for more than 50% of the total number of patients with ACS. The mortality rates after NSTEMI are not significantly different when compared with patients with ST-segment elevation myocardial infarction. Aim: The aim of the present study was to investigate whether the assessment of clinical, laboratory and instrumental data during hospital stay provide any additional independent information in predicting the 3-year major cardiac events after NSTE-ACS. Methods: We observed 490 consecutive patients, who were admitted to the emergency cardiology department with NSTE-ACS. The patients' baseline characteristics, blood analysis, left ventricle (LV) and renal function data were assessed and analyzed. The median follow‑up time was 36 months. The endpoint was cardiovascular death. Results: The results of our study show that the risk of cardiovascular death during the three years follow-up after multivariate adjustment increases with older age (> 64 years), history of diabetes, prior myocardial infarction and history of angina pectoris, lower ejection fraction (<50%), degree of myocardial hypertrophy (the thickness of the interventricular septum >1.25 mm) of the LV and the degree of diastolic dysfunction (E-wave deceleration time (DT) < 150 ms), silent myocardial ischemia during first 24-hours, high pulse pressure on Day 1 (>49 mm Hg), glucose level > 7.5 mmol/l on admission and moderate kidney dysfunction (CrCl <60 ml/min). Conclusion: In patients with NSTE-ACS, we report the cardiovascular death risk factors within the 3-year follow-up period in the present study. We thus conclude that it is important to identify the patients with high risk of future cardiovascular complications.","PeriodicalId":73819,"journal":{"name":"Journal of medical research and innovation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43526210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydroelectrophoresis for Transdermal Administration of Verapamil or of Hyaluronic Acid in Peyronie's Disease: A Prospective, Open Label, Multicenter Study","authors":"G. Cavallini, C. Maretti","doi":"10.15419/JMRI.119","DOIUrl":"https://doi.org/10.15419/JMRI.119","url":null,"abstract":"Aim & Objective: To assess the efficacy of a new electromotive system for the transcutaneous delivery of verapamil or of hyaluronic acid to improve the symptoms of Peyronie' s disease (PD) in patients with a curvature deformity of < 30° at the beginning of therapy. \u0000Methods & Materials: Sixty-one PD patients were studied. Thirty were randomly assigned to receive verapamil 10 mg/session (Isoptin®, BGP Products, Rome-Italy), (Group 1, median age 56 years, range 49-62), and 31 were randomly assigned to receive hyaluronic acid 8 mg/session (Sinovial®, IBSA, Lodi-Italy) (Group 2, median age 58 years, range 51-56). There were ten sessions, 2 sessions/week for each drug. Each drug was transdermally administered using the hydroelectrophoresis technique and carried out using a Hydro4and apparatus (Swiss4Med SA, Morbio Inferiore, Switzerland). With respect to the efficacy of the drugs studied, the endpoints were: side effects, pain, erectile function, penile deviations and plaque area (cm2) before, and 3 and 6 months after drug administration. The differences were assessed using the Mann-Whitney Rank test (unmatched groups) or using the Wilcoxon Signed Rank test (matched groups). The differences between the groups in terms of side effects were assessed using the chi-square test. \u0000Results: No significant difference emerged among the baseline values of the two groups. Pain, erectile function, plaque area and penile deformity significantly improved in both groups after treatment, but a notably higher improvement occurred in the patients in whom hyaluronic acid was administered. Only a few negligible side effects occurred in the Group 1 patients treated with Verapamil, with no significant difference between the groups. \u0000Conclusion: Administration of both hyaluronic acid and verapamil using the Hydro4and apparatus is a safe and efficient method for PD therapy.","PeriodicalId":73819,"journal":{"name":"Journal of medical research and innovation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45313684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aneurysmal Bone Cyst of Talus","authors":"D. Shrestha, Bishnu Babu Thapa, D. Maharjan, Kumar Basnet, Prabeen Ghimire, Sijan Karki","doi":"10.15419/JMRI.122","DOIUrl":"https://doi.org/10.15419/JMRI.122","url":null,"abstract":"Aneurysmal bone cyst (ABC) of talus is rare benign, expansile and osteolytic bone growth. Cyst contains bloody fluid lined with variable amount of osteolytic giant cells. This is common in epiphyseal ends of long bone and rare in small bones like talus. Here a 20 years’ male with aneurysmal bone cyst of talus managed with wide intralesional curettage with autologous bone graft mixed with synthetic bone graft been presented.","PeriodicalId":73819,"journal":{"name":"Journal of medical research and innovation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47773161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dyke-Davidoff-Masson Syndrome: A Delayed Diagnosis of an Acquired Variant","authors":"T. Kumar, Abhijit Vipul, R. Yadav","doi":"10.15419/jmri.121","DOIUrl":"https://doi.org/10.15419/jmri.121","url":null,"abstract":"Dyk-Davidof-Masson Syndrome (DDMS) is an important cause of intractable and drug-resistant seizures. It has varied clinical presentation and history with distinct neuroimaging features. Here, we describe a female patient presented with recurrent intractable convulsion, mental retardation, hemiparesis, and characteristic neuroimaging features of cerebral hemiatrophy, calvarial thickening, and ipsilateral hyperpneumatization of the frontal sinuses which is suggestive of DDMS. Early institution of neuroimaging in patients with intractable epilepsy will make early diagnosis and better outcome.","PeriodicalId":73819,"journal":{"name":"Journal of medical research and innovation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46108926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Evaluation of Efficacy of Ritodrine Versus Nifedipine in Prevention of Preterm Labour in Direct Head to Head Randomized Control Trials: A Systematic Review","authors":"Viraj R. Panchal, N. Darji, D. Rana","doi":"10.32892/JMRI.153","DOIUrl":"https://doi.org/10.32892/JMRI.153","url":null,"abstract":"Aims and Objectives: To compare the efficacy of ritodrine versus nifedipine in prevention of preterm labour at day two and seven. \u0000Methodology: All randomised control trials which follows PRISMA guidelines 2009 and in which Ritodrine and Nifedipine was compared head to head for the treatment of Pre-term labour. Clinical trial registries,MEDLINE, SCOPUS, EMBASE database were searched for MeSH terms Ritodrine, Nifedipine, pre-term labour and having primary outcome as number of delivery at day 2 and 7. Observational studies, unpublished studies, RCTs not following PRISMA guidelines were excluded. Data was analyzed using RevMan 5.3 version® and Odd’s Ratio was calculated to determine the difference at day 2 and 7. Both fixed effect and Random effect model was utilized to calculate the difference. P value less than 0.05 was considered as statistically significant. The I2 will be used to measure the heterogeneity between studies and a value > 30.0 will be considered to reflect heterogeneity. \u0000Results: A total of 6 Head to head RCTs were included in the studies. At day 2, according to fixed effect model, statistically ritodrine was having more likelihood for delivery as compared to nifedipine(Odd’s ratio=1.492, CI=1.013-2.197, P=0.043) but according to random effect model the difference was not statistically significant(Odd’s ratio=1.468, CI=0.919-2.344, P=0.108). At day 7, according to fixed effect model, ritodrine was having more likelihood for delivery as compared to nifedipine(Odd’s ratio=1.196, CI=0.852-1.679, P=0.302) and according to random effect model the difference was not statistically significant(Odd’s ratio=1.143, CI=0.720-1.815, P=0.572). \u0000Conclusion: Ritodrine causes more deliveries at day 2 and 7, so nifedipine is a better tocolytic as compared to ritodrine.","PeriodicalId":73819,"journal":{"name":"Journal of medical research and innovation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49279960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Study of Oral Hygiene Among Urban and Urban Slum Dwellers of Ahmedabad","authors":"K. Solanki, Harshdeep Joshi, Alpesh Patel, D. Bala","doi":"10.32892/JMRI.152","DOIUrl":"https://doi.org/10.32892/JMRI.152","url":null,"abstract":"Aims and Objectives: To compare the oral hygiene practices and study the proportion of dental problems among urban and urban slum areas. Methodology: An observational, cross sectional study was carried out in 150 people in urban and urban slum areas. The study duration was four months (June 2015 to September 2015). The data was collected in a pre-designed proforma. The knowledge of the community was considered with regards to oral hygiene and harmful effects of bad food habits and tobacco consumption. The oral problems and hygiene was assessed by using mouth mirror and probe. The data was analyzed using SPSS version 24.0 Software. Results: Out of the total data collected, 75 of the data entries were obtained from urban area and urban slum area each. The age wise distribution was done as well in both the areas. Among them, most common age group was 20-45 years (50.7% in urban while 48.0% in urban slum) followed by 10-19 years, 46-60 years, 1-9 years and 60and above age group. The common symptoms observed like broken teeth (28%), gingivitis (13.30%), caries (21.10%) etc. were more in urban as compared to urban slum areas. Most common brushing practice was using paste (90%) followed by powder (10%) and salt (1%). More number of people in urban area (28%) consumes carbonated drinks as compared to urban slum (6.7%) (P value = 0.001). The proportion of sensitive teeth was more in urban (36%) as compared to urban slum (26.7%) (P value = 0.126). Most of the people in urban as well as urban slum area (97.3%) change their brush within 15 days-3 months. Conclusion: The proportion of gingivitis, dental illness, grinding teeth, sensitive teeth are more commonly seen in urban areas as compared to that of the urban slums. However, the proportion of bleeding gums, awareness regarding dental problems, frequency of brushing teeth and pattern of brushing were almost similar in both of the areas.","PeriodicalId":73819,"journal":{"name":"Journal of medical research and innovation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42197983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A study of cases of Diphtheria diagnosed at Civil Hospital, Ahmedabad, India","authors":"Binda Pipaliya, P. Shah, M. Vegad, S. Soni, A. Goswami, Khusbhu Vagadiya","doi":"10.32892/JMRI.156","DOIUrl":"https://doi.org/10.32892/JMRI.156","url":null,"abstract":"Aims and Objectives: Most of the vaccine preventable diseases have shown a decline with advent of National immunization schedule but Diphtheria is still present in some region of India. The purpose of this study is to diagnose cases of Diphtheria. \u0000Methods and Materials: This study was performed during August- 2017 to October- 2017 at Bacteriology Laboratory of Microbiology Department, Civil Hospital, Ahmedabad. Two throat swab received from each suspected patient with detailed clinical and immunization history. One swab was inoculated in selective and enrichment culture media while another was used for microscopic examination for isolation of Corynebacterium diphtheria. \u0000Results: Out of total 118 samples, Corynebacterium diphtheriae was isolated in 35 samples. Among 35 cases, 16 patients belong to under 5 yr, while 19 belonged to 6-20 yr of age group. \u0000Conclusion: The majority of cases are reported from children who were non- immunized or partially immunized against Diphtheria. Persistance or resurgence of Diphtheria is mainly due to low coverage of primary immunization as well as booster doses and inaccessible areas. Targeted immunization coverage is required specifically in inaccessible areas.","PeriodicalId":73819,"journal":{"name":"Journal of medical research and innovation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45445620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Evaluation of Efficacy and Safety of Monotherapy with Carbamazepine and Phenytoin In Epilepsy : A Meta-Analysis","authors":"Aashka Shah, D. Rana, S. Malhotra","doi":"10.32892/jmri.154","DOIUrl":"https://doi.org/10.32892/jmri.154","url":null,"abstract":"Aims and Objectives \u0000 \u0000To review and analyse statistically the evidence from existing randomised controlled trials. \u0000To compare the efficacy and safety of carbamazepine and phenytoin when used as monotherapy treatments. \u0000To assess the effectiveness of the drug at controlling seizures and to evaluate tolerability with regard to side effects of these drugs. \u0000 \u0000Methodology: A systemic review with the comparative evaluation of efficacy and safety of monotherapy with Carbamazepine and Phenytoin in epilepsy was carried out. Seven studies with Randomised Controlled Trials of carbamazepine and phenytoin as monotherapy were taken up for Meta Analysis based on the inclusion and exclusion criteria. Time to withdrawal of allocated treatment (retention time) was chosen as the primary outcome. Secondary outcomes included Time to achieve 12-month remission (seizure-free period), Time to achieve six-month remission (seizure-free period), Time to first seizure post-randomisation, Adverse events (including adverse events relating to treatment withdrawal. The data was entered in the MedCalc Statistical Software version 17.5.5 and analysed. The principal summary measure were the Odd’s Ratio And Hazard Ratio (HR) (at 95% Confidence Interval). Funnel Plot and Forest Plot were plotted. \u0000Results: The overall pooled odd‘s ratio for the primary outcome (for 862 participants) was 0.882(fixed effect model) and 0.877(random effect model) (95% confidence interval (CI)0.63 to 1.22, P = 0.3643). The P value was 0.3643 which proved the statistically insignificant difference in the efficacy of the two drugs(0.05 is considered as significant p value). As for the adverse effects ; rash, dysmorphic and idiosyncratic side effects include gum hypertrophy , hirsutism , acne etc. are more frequently associated with phenytoin. Drowsiness, Tiredness, Fatigue and sedation are more associated with carbamazepine as compared to phenytoin. The overall pooled odd’s ratio for “Time to achieve 6 month remission” (for 232 participants) was 1.232(fixed) and 1.272(random) (95% confidence interval (CI) 0.732 to 2.073(fixed), P = 0.0910), indicating an advantage for phenytoin for the 6 month remission outcome. \u0000Conclusion: The study concluded that there was no statistically significant difference achieved between the two treatment arms. Hence the neurophysician is compelled to rely on the individual patient characteristics for dispensing the drug. Hence the study provides a robust evidence that the two treatments are equally efficacious.","PeriodicalId":73819,"journal":{"name":"Journal of medical research and innovation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46615998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}