Journal of medical research and innovation最新文献

{"title":"Epidemiological Burden of Lower Limb Spasticity in Adults: A Systematic Review","authors":"Mamoona Javed, Muhammad Ali","doi":"10.32892/jmri.195","DOIUrl":"https://doi.org/10.32892/jmri.195","url":null,"abstract":"Objective: The objective of this study was to investigate the burden of disease associated with lower limb spasticity (LLS) and its complications in adults. \u0000Methods: A systematic search of MEDLINE and EMBASE identified 9 studies published between November 2012 and July 2019 that assessed the epidemiological burden associated with LLS. \u0000Results: LLS was found to occur in one-third of adults after neuromyelitis optica spectrum disorder (NMOSD), one quarter to one third with multiple sclerosis, one quarter to half with Parkinson’s disease and roughly half with stroke. LLS reduces mobility and diminishes the quality of life. LLS complications, especially injuries following falls are a common occurrence. \u0000Conclusion: Given the high prevalence among adults with common disorders, such as stroke; the evidence on the burden of LLS is somewhat finite. Further research is needed to explore the trends over time and across different geographical regions in the incidence and prevalence of LLS. The dearth of high-quality evidence for LLS suggests a lack of awareness of the problem and interest in it, and hence, the unmet need among patients and their carers.","PeriodicalId":73819,"journal":{"name":"Journal of medical research and innovation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48057160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Embalica Officinalis: A miracle multipurpose plant","authors":"R. Anbesse","doi":"10.32892/jmri.199","DOIUrl":"https://doi.org/10.32892/jmri.199","url":null,"abstract":"Plants are a major source of nutrition and health care. Embalicalofficinalis is one of the most widely used in traditional Indian medicine in different form and believed to alleviate against several disease. This article summarizes multipurpose and medicinal value of Embalicaofficinalis (EO). I reviewed the application of EO in antioxidant, antidiabetic, anticancer, antiulcer, cardioprotective activity, cytoprotective, antitussive, immunomodualation, chelating agent, and respiratory problems.","PeriodicalId":73819,"journal":{"name":"Journal of medical research and innovation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41651802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"To Evaluate Anti-HLA Antibodies Sensitization in Pre- and Post-renal Transplant Patient’s Serum: A Retrospective Case Series","authors":"N. Agarwal, Sanjeev Goswami","doi":"10.32892/jmri.187","DOIUrl":"https://doi.org/10.32892/jmri.187","url":null,"abstract":"Introduction: In India, patients of renal failure are dependent on live related or unrelated donor. Because of poor financial condition patients do not go for DSA (Donor Specific Antibody) detection using Luminex. In absence of screening of de-novo production of DSA and don’t get proper management. As a result of which patient undergo acute rejection. \u0000Case Series: Here we are presenting 5 acute rejection cases comparing there DSA in pre-transplant and post-transplant sera using solid-phase assays.5 renal transplanted patients undergone acute and hyperacute rejection (Banff's classification) were considered for presented case series. Collected serum (pre and post-transplant on day of rejection) from each patient was subjected to detection of anti-HLA antibody using Luminex-PRA. \u0000Conclusion: Presence of donor-specific anti-HLA antibody with their titer was detected in pre and post-transplant serum. It is found that the strength of DSA is directly proportional to graft life.","PeriodicalId":73819,"journal":{"name":"Journal of medical research and innovation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48819965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroticism polygenic risk score predicts 20-year burden of depressive symptoms for Whites but not Blacks.","authors":"S. Assari, A. Javanbakht, Mohammed Saqib, H. Helmi, M. Bazargan, Jennifer A. Smith","doi":"10.32892/jmri.183","DOIUrl":"https://doi.org/10.32892/jmri.183","url":null,"abstract":"Background\u0000Black-White differences are reported in social, psychological, behavioral, medical, and biological correlates of depression. This study was conducted to compare Black and White older adults for the association between neuroticism polygenic risk score (N-PRS) and chronicity of depressive symptoms over 20 years.\u0000\u0000\u0000Methods\u0000Data came from the Health and Retirement Study (HRS), 1990 - 2012, a nationally representative sample of Americans above age 50. Current analysis followed 9,249 individuals (7,924 Whites and 1,325 Blacks) for up to 22 years. Depressive symptoms were measured every two years between 1992 and 2012 using the 8-item Center for Epidemiological Studies-Depression Scale (CES-D-8). The independent variable was N-PRS. The dependent variable was average depressive symptoms between 1992 and 2012. Linear regression was used for data analysis.\u0000\u0000\u0000Results\u0000In the pooled sample, higher N-PRS was associated with higher average depressive symptoms over the 20-year follow up period [b=0.01, 95%CI=0.00 to 0.04], net of all covariates. We also found an interaction between race and N-PRS [b=-0.02, 95%CI=-0.03 to 0.00], suggesting a stronger effect of N-PRS on 20-year average depressive symptoms for Whites than Blacks. Based on our race-specific linear regression models, higher N-PRS was associated with higher depressive symptoms from 1992 to 2012 for Whites [b=0.01, 95%CI=0.01 to 0.02] but not Blacks [b=0.00, 95%CI=-0.02 to 0.02].\u0000\u0000\u0000Conclusion\u0000Black and White older adults may differ in the salience of the existing N-PRS for depressive symptoms, which better reflects the burden of depression for Whites than Blacks. This may be because the existing PRSs are derived from mostly or exclusively White samples, limiting their applicability in other race groups. Racial variation in psychosocial, clinical, and biological correlates of depression needs further research.","PeriodicalId":73819,"journal":{"name":"Journal of medical research and innovation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46406404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Program schedule of 3rd International Conference on Clinical Orthopedics & Spine Biomechanics","authors":"Editorial Team","doi":"10.32892/jmri.190","DOIUrl":"https://doi.org/10.32892/jmri.190","url":null,"abstract":"The program schedule of 3rd International Conference on Clinical Orthopedics & Spine Biomechanics held at ISIC, New Delhi, India.","PeriodicalId":73819,"journal":{"name":"Journal of medical research and innovation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42511437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abstracts Presented at 3rd International Conference on Clinical Orthopedics & Spine Biomechanics","authors":"Editorial Team","doi":"10.32892/jmri.191","DOIUrl":"https://doi.org/10.32892/jmri.191","url":null,"abstract":"Abstracts Presented at 3rd International Conference on Clinical Orthopedics & Spine Biomechanics held at ISIC, New Delhi, India.","PeriodicalId":73819,"journal":{"name":"Journal of medical research and innovation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41879882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcatheter aortic valve replacement in Bicuspid Aortic Valve Disease: An Insight","authors":"Varshil Mehta, Nikhil Nalluri, Varun Kumar, Nileshkumar J Patel, V. Atti, Arvin Narula, Mauricio G. Cohen","doi":"10.32892/JMRI.180","DOIUrl":"https://doi.org/10.32892/JMRI.180","url":null,"abstract":"As per the current scenario, role of Transcatheter aortic valve replacement (TAVI) is controversial in bicuspid aortic valve stenosis. All the randomized clinical trials comparing outcomes of TAVI with surgery till date, have excluded patients with bicuspid aortic valve. Some of the observational studies have reported outcomes of TAVI in bicuspid aortic valve stenosis patients who are not surgical candidate. The recent advances in TAVI and its expansion into intermediate groups, which includes younger age groups sparks a debate on the efficacy and safety of TAVI in Bicsuspid aortic valve (BAV). The purpose of the present article is to review the available literature regarding the feasibility, safety and outcomes of TAVI in bicuspid aortic valve stenosis.","PeriodicalId":73819,"journal":{"name":"Journal of medical research and innovation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41495968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metformin Inhibits Growth of Breast Cancer Cell T47 through Decreasing Expression of Protein P53, BCL2 and Cyclin D1","authors":"Irma Yanti Rangkuti, P. Hasibuan, T. Widyawati, Y. Siregar","doi":"10.32892/JMRI.164","DOIUrl":"https://doi.org/10.32892/JMRI.164","url":null,"abstract":"Breast cancer is a disease that afflicts women only 0.5 to 1 % are male breast cancers.Breast cancer has several variants and requires a different therapeutic approach, and until now the therapy has not been satisfactory due to the emergence of resistance. Metformin as the main choice drug type 2 diabetes mellitus which is known to have a cytotoxic effect for breast cancer. This study aimed to analyze metformin cytotoxic mechanisms covering the cell cycle , apoptosis, expression of p53, bcl-2 and cyclin D1 T47D cells which exposed to metformin HCl. The study was conducted invitro on T47D breast cancer cells which exposed to metformin concentrations of 1738.2 µg / mL and 3476.4 µg / mL and doxorubicin concentrations of 0.1µg / mL and 0.2µg / mL for 24 hours. Cell cycle testing and apoptosis using the flowsitometry method and expression test of p53 protein, bcl-2 dancycline D1 in T47D cells with immunocytochemistry. Data was analyzed by one way Anova with Bonferroni's advanced test. The results showed that metformin inhibited the G0-G1 phase of the T47D cell cycle, triggered T47D cell apoptosis, significantly reduced p53, bcl-2 and cyclin D1 protein expression (p <0.05). Conclusion of the study, metformin inhibits T47D cells through inhibition of the cell cycle G0-G1 phase, reducing protein expression p53, bcl-2 and cyclin D1.","PeriodicalId":73819,"journal":{"name":"Journal of medical research and innovation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46840717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge, Attitude and Practice of Preventing the Occurrence of Work-Related Musculoskeletal Disorders Among Doctors in University of Port-Harcourt Teaching Hospital","authors":"B. Ephraim-Emmanuel, Ronami S. Ogbomade, Blackman Nabai Idumesaro, I. Ugwoke","doi":"10.32892/JMRI.161","DOIUrl":"https://doi.org/10.32892/JMRI.161","url":null,"abstract":"Background: Musculoskeletal disorders affecting medical personnel should never be treated lightly. It has thus become necessary to strictly infuse ergonomics in medical practice in order to tackle the occurrence of musculoskeletal system disorders. This would ensure better productivity among the medical personnel. This research was conducted to determine the knowledge, attitude and practice of the prevention of work-related musculoskeletal disorders among doctors working at the University of Port-Harcourt Teaching Hospital.Methods: A descriptive, cross-sectional study design was employed in carrying out this study among doctors working at the University of Port Harcourt Teaching Hospital. Multistage sampling was utilized in selecting a sample population of 223 doctors for this study. Data collection was done using a semi-structured self-administered questionnaire. Ethical approval to conduct this study was gotten from the University of Port-Harcourt research ethics committee. Consent, confidentiality, privacy and beneficence were ensured in this study. For test of associations, statistical significance was set at 0.05.Results: Majority of the respondents had good knowledge and attitude towards musculoskeletal disorders’ prevention at work. The practice of ergonomic principles was however not satisfactory. Occurrence of work-related musculoskeletal disorders among study respondents was significantly associated with the knowledge and practice of ergonomic principles required to prevent the occurrence of these disorders.Conclusion: Despite the significant proportion of doctors in this study having good knowledge and attitude towards prevention of musculoskeletal system disorders at work, only few of these doctors satisfactorily practiced the necessary preventive measures necessary to prevent these disorders. This inadvertently resulted in the high prevalence of these disorders found in this study. It is recommended that a re-orientation of doctors to be more involved in the actual application of ergonomics while working no matter the compulsion or desire to get the work done should be done.","PeriodicalId":73819,"journal":{"name":"Journal of medical research and innovation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44510107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-Spinal Causes of Back Pain: An ‘undiagnosed’ diagnosis","authors":"S. Goel","doi":"10.32892/JMRI.172","DOIUrl":"https://doi.org/10.32892/JMRI.172","url":null,"abstract":"Low back pain is a common ailment affecting individuals all around the globe. Majority of Disability Adjusted Life Years lost amongst working population is due to low back pain. Though majority of surgeons/physicians keep only spinal causes in mind while treating such an ailments, a number of other causes exist for such a pathology. This editorial aims to make the readers aware about such non spinal causes of low back pain.","PeriodicalId":73819,"journal":{"name":"Journal of medical research and innovation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45904975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}