Journal of intensive medicine最新文献

{"title":"Methodological development of the remote ventilate view platform for real-time monitoring of patient-ventilator asynchrony and respiratory parameters in severe pneumonia patients","authors":"Xiangyu Chen ,&nbsp;Siyi Yuan ,&nbsp;Elias Baedorf Kassis ,&nbsp;Song Zhang ,&nbsp;Yi Chi ,&nbsp;Shengjun Liu ,&nbsp;Fuhong Cai ,&nbsp;Yue Ma ,&nbsp;Yan Li ,&nbsp;Longxiang Su ,&nbsp;Yun Long","doi":"10.1016/j.jointm.2025.07.003","DOIUrl":"10.1016/j.jointm.2025.07.003","url":null,"abstract":"<div><h3>Background</h3><div>Patient-ventilator asynchrony (PVA) is common in critically ill patients undergoing mechanical ventilation and may adversely affect clinical outcomes. Traditional bedside assessment methods are subjective and intermittent. We developed a real-time digital platform to continuously monitor ventilator waveforms and quantify overall asynchrony burden of severe pneumonia patients.</div></div><div><h3>Methods</h3><div>The study retrospectively analyzed mechanically ventilated coronavirus disease 2019 (COVID-19 patients admitted to the Department of Critical Care Medicine of Peking Union Medical College Hospital (PUMCH) from December 2022 to August 2023. Ventilator waveforms were continuously collected and processed using the remote ventilate view platform, which automatically identified eight PVA subtypes and calculated the Overall Asynchrony Index (OAI) across the full ventilation course. Respiratory mechanics were also extracted. Primary outcomes included intensive care unit (ICU) mortality and 28-day ventilator-free days (VFDs), while secondary outcomes included the length of ICU stay and duration of mechanical ventilation. The study used R, Jamovi, and Python for statistical analysis.</div></div><div><h3>Results</h3><div>Twenty-three mechanically ventilated COVID-19 patients admitted to the ICU at Peking Union Medical College Hospital were included in this study. No correlation was found between the index and ventilatory parameters, compliance, and disease severity. Patients with an OAI ≥10 % were more likely to have fewer 28-day VFDs (1.3 days <em>vs</em>. 11.4 days, <em>P</em> = 0.027) and were demonstrated to have a higher ICU mortality (66.7 % <em>vs</em>. 18.2 %, <em>P</em> = 0.036). Among eight types of PVA, flow insufficiency was found to be associated with prognosis (<em>P</em> = 0.012). OAI correlated with the prognosis of COVID-19 patients. Patients with an OAI ≥10 % were more likely to have fewer 28-day VFDs and higher ICU mortality.</div></div><div><h3>Conclusions</h3><div>A higher OAI and increased flow insufficiency were associated with worse outcomes in COVID-19 patients receiving mechanical ventilation. This study demonstrates the feasibility and clinical potential of a real-time, platform-based approach for automated detection and longitudinal monitoring of PVA.</div></div>","PeriodicalId":73799,"journal":{"name":"Journal of intensive medicine","volume":"5 4","pages":"Pages 367-376"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145335065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seeing Artery and VEin Simultaneously in the long axis (SAVES) for ultrasound-guided infraclavicular axillary/subclavian vein cannulation: A retrospective analysis","authors":"Ruyuan Zhang,&nbsp;Lei Li,&nbsp;Yaoqing Tang,&nbsp;Dechang Chen","doi":"10.1016/j.jointm.2025.05.002","DOIUrl":"10.1016/j.jointm.2025.05.002","url":null,"abstract":"<div><h3>Background</h3><div>The anatomical configuration of the anterior scalene muscle, inserting between the subclavian vein and artery, creates a space between them. By placing an ultrasound probe in the infraclavicular area, an optimal longitudinal view of both the proximal part of the axillary and the distal part of the subclavian vein and artery can be obtained, while the pleura is out of view. This Seeing Artery and VEin Simultaneously in the long axis (SAVES) method for ultrasound-guided infraclavicular axillary/subclavian vein cannulation offers theoretical advantages because it may avoid iatrogenic pneumothorax and reduce the risk of arterial damage. The objective of the present study was, to our knowledge, for the first time, to determine the safety and efficacy of the SAVES method for ultrasound-guided infraclavicular axillary/subclavian vein cannulation in adult critically ill patients.</div></div><div><h3>Methods</h3><div>A retrospective study was performed on consecutive adult critically ill patients who underwent ultrasound-guided infraclavicular axillary/subclavian vein cannulation performed by the same physician in a medical/surgical intensive care unit (12 beds) between 20 August 2021 and 20 December 2024. The overall success rate, the first-pass success rate, the access time and number of attempts, the incidence of difficulty with insertion of the guidewire/dilator/catheter, and the mechanical complication rate were analyzed.</div></div><div><h3>Results</h3><div>A total of 111 adult critically ill patients required 142 ultrasound-guided infraclavicular axillary/subclavian vein punctures using the SAVES method. The overall success rate was 100%, and the first-pass success rate was 75.4%. The access time was 38.5 (interquartile range: 21.5–80.0) s. The proportions of different numbers (1, 2, and 3) of attempted catheterizations were 88.7%, 9.2%, and 2.1%, respectively. The incidence of difficulty with guidewire insertion was 15.5%, while no difficulty with insertion of the dilator or catheter was experienced. No instance of pneumothorax, hemothorax, arterial puncture, brachial plexus injury, or cardiac tamponade was recorded. The incidence of hematoma formation was 2.1%. The occurrence rate of posterior venous wall penetration was 3.5%. The catheter malposition rate was 5.6%.</div></div><div><h3>Conclusions</h3><div>The SAVES technique may be a safe and effective approach for ultrasound-guided infraclavicular axillary/subclavian vein cannulation. A larger controlled prospective study is warranted to confirm these findings.</div></div>","PeriodicalId":73799,"journal":{"name":"Journal of intensive medicine","volume":"5 4","pages":"Pages 350-358"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145335105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"History of the Chinese medical association-Chinese society of critical care medicine","authors":"Dechang Chen","doi":"10.1016/j.jointm.2025.08.005","DOIUrl":"10.1016/j.jointm.2025.08.005","url":null,"abstract":"","PeriodicalId":73799,"journal":{"name":"Journal of intensive medicine","volume":"5 4","pages":"Pages 295-297"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145332369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Practice pattern of aerosol drug therapy in ARDS patients: A secondary analysis of the Aero-in-ICU study","authors":"Sanjay Singhal ,&nbsp;Sai Saran ,&nbsp;Krupal Joshi ,&nbsp;Mohan Gurjar ,&nbsp;Parnandi Bhaskar Rao ,&nbsp;Jyoti Narayan Sahoo ,&nbsp;Ruchi Dua ,&nbsp;Alok Kumar Sahoo ,&nbsp;Ankur Sharma ,&nbsp;Sonika Agarwal ,&nbsp;Arun Sharma ,&nbsp;Pralay Shankar Ghosh ,&nbsp;Nikhil Kothari ,&nbsp;Kunal Deokar ,&nbsp;Sudipta Mukherjee ,&nbsp;Prakhar Sharma ,&nbsp;BPS Sreedevi ,&nbsp;Prakash Sivaramakrishnan ,&nbsp;Umadri Singh ,&nbsp;Dhivya Sundaram ,&nbsp;Avinash Agrawal","doi":"10.1016/j.jointm.2025.05.003","DOIUrl":"10.1016/j.jointm.2025.05.003","url":null,"abstract":"<div><h3>Background</h3><div>The potential role of aerosol drug therapy (ADT) in patients with acute respiratory distress syndrome (ARDS) remains uncertain. The objective of this study is to determine the prevalence and practice patterns of ADT in patients with ARDS.</div></div><div><h3>Methods</h3><div>This secondary analysis of a prospective observational multi-centric cohort study done in critically ill patients to know the ADT practice pattern was conducted in nine participating intensive care units (ICUs) across India between November 2022 and March 2023. The study recruited newly admitted adult patients (age &gt;18 years) who had an artificial airway and required mechanical ventilation (invasive or non‑invasive). These patients were followed up for the next 14 days or until ICU discharge or death. This secondary analysis collected data about screened patients with ARDS, related to each aerosol therapy including ongoing respiratory support, type of drug, and aerosol‑generating device, including ongoing respiratory support, type of drug, and aerosol‑generating device.</div></div><div><h3>Results</h3><div>Fifty-three (24.3%) of the 218 patients had ARDS, with a mean age of (60.2±14.8) years. At admission, the acute physiology and chronic health evaluation (APACHE II) and sequential organ failure assessment (SOFA) score of the recruited patients were 17.4±7.1 and 7.7±4.0, respectively. Respiratory support was provided with invasive mechanical ventilation (IMV) alone, non-invasive ventilation (NIV) alone, or both in 45.3%, 24.5%, and 30.2% of patients, respectively. The mean duration of the ICU stay was (6.4 ± 4.0) days. Of the 53 patients with ARDS, 51 (96.2%) received 1285 aerosol sessions during follow-up for 330 patient days. Of all patients with ARDS who received aerosol therapy, 71.4% were prescribed while on IMV and 25.7% on NIV. A single drug was used in 60.7% of the aerosol sessions used a single drug, and 39.3% were prescribed combination drugs. Shorter-acting bronchodilators were the predominant drugs, with jet nebulizers (55.4%) being the most commonly used aerosol generators. These were followed by ultrasonic (23.1%) and vibrating-mesh nebulizers (21.5 %). During IMV, only in 50.1% of aerosol sessions (460 out of 918) was an aerosol generator placed at the optimum position (15–30 cm away from the Y-junction).</div></div><div><h3>Conclusions</h3><div>Aerosol therapy is frequently used in ARDS, with bronchodilators being the most common drug. The jet nebulizer is the most familiar aerosol-generating device, but only half of the aerosol sessions are at the optimum position during invasive mechanical ventilation.</div></div>","PeriodicalId":73799,"journal":{"name":"Journal of intensive medicine","volume":"5 4","pages":"Pages 385-391"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145335067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Videoart in the intensive care unit: A prospective observational study","authors":"Tomer Arad ,&nbsp;Sabina Kalinchuk ,&nbsp;Dina Grinas ,&nbsp;Moran Hellerman-Itzhaki ,&nbsp;Guy Fishman ,&nbsp;Itai Bendavid ,&nbsp;Liran Statlender ,&nbsp;Ilya Kagan ,&nbsp;Pierre Singer","doi":"10.1016/j.jointm.2025.02.001","DOIUrl":"10.1016/j.jointm.2025.02.001","url":null,"abstract":"<div><h3>Background</h3><div>This study sought to evaluate the role of videoart in decreasing the risk of stress symptoms in patients hospitalized in the intensive care unit (ICU).</div></div><div><h3>Methods</h3><div>This is a prospective observational cohort study conducted in a general ICU in which 8 of 18 rooms are equipped with a videoart system. Competent patients who spent at least 48 h in the ICU were asked to complete an Impact of Events Scale (IES) questionnaire during hospitalization and at least 1 year after discharge. Patients were recruited from April 2017 until June 2020, and follow-up phone calls were made from June to August 2021. The primary outcome was an IES score indicative of significant stress symptoms during hospitalization. Secondary outcomes were IES scores indicative of significant stress symptoms after discharge and clinical parameters during hospital stay. The cut-off value for high-risk stress symptoms was 26. However, because there is uncertainty in the literature regarding the desired cut-off value, two other values were also analyzed. Outcomes that were found statistically significant were further examined using a logistic regression model for the control of confounders.</div></div><div><h3>Results</h3><div>Eighty-one patients completed the questionnaire during hospital stay and 24 patients after discharge. At home, patients who were exposed to videoart had a marginally lower mean IES score (median=6 [interquartile range: 0–18] <em>vs.</em> median=32 [interquartile range:10–45], <em>P</em> = 0.054) and a significantly lower rate of high-risk stress symptoms using the primary cut-off value (11.8 % <em>vs.</em> 57.1 %, <em>P</em>=0.038; odds ratio=10.00 95 % CI: 1.22 to 81.80, <em>P</em>=0.03). However, statistical significance was lost after adjustment for confounders (odds ratio=12.00, 95 % CI: 0.67 to 222.00, <em>P</em>=0.09) . There was no difference in the mean IES score, significant stress symptoms rate, or in any of the other endpoints examined during the hospital stay.</div></div><div><h3>Conclusions</h3><div>There is a trend toward the beneficial effect of videoart for the alleviation of stress symptoms among ICU patients. However, further study is needed to examine the role of this technology.</div></div>","PeriodicalId":73799,"journal":{"name":"Journal of intensive medicine","volume":"5 4","pages":"Pages 400-406"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145335104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ICU readmission and mortality risk prediction: Generalizability of a multi-hospital model","authors":"Tariq A. Dam ,&nbsp;Daan de Bruin ,&nbsp;Giovanni Cinà ,&nbsp;Patrick J. Thoral ,&nbsp;Paul W.G. Elbers ,&nbsp;Corstiaan A. den Uil ,&nbsp;Reinier F. Crane","doi":"10.1016/j.jointm.2025.03.007","DOIUrl":"10.1016/j.jointm.2025.03.007","url":null,"abstract":"<div><h3>Background</h3><div>Inadvertent intensive care unit (ICU) readmission is associated with longer length of stay and increased mortality. Conversely, delayed ICU discharge may represent inefficient use of resources. To better inform discharge timing, several hospitals have implemented machine learning models to predict readmission risk following discharge. However, these models are typically created locally and may not generalize well to other hospitals or patient populations. A single multi-hospital-based model might provide more accurate predictions and insight into features that are applicable across diverse clinical settings.</div></div><div><h3>Methods</h3><div>This study involved a retrospective multi-center cohort from one academic hospital (Amsterdam University Medical Center [AUMC]) and two large teaching hospitals (Maasstad Ziekenhuis [MSZ] and OLVG). Data from the latter two hospitals were combined to create a pooled model, which was tested on the academic hospital dataset. Data relating to all adult ICU patients were included, starting from the implementation of the electronic health record system until the commencement of model development for each hospital. An XGBoost model was trained to predict a composite outcome of readmission or mortality within 7 days and an autoencoder was used as an out-of-distribution (OOD) detector to capture dataset heterogeneity.</div></div><div><h3>Results</h3><div>In total, 44,837 patients were available for analysis across the three hospitals. The average readmission rates were 7.1 %, 6.9 %, and 5.9 % for MSZ, OLVG, and AUMC, respectively. Performance evaluation of the local models on AUMC data demonstrated weighted area under the receiver operating characteristic curves of 69.7 %±0.8 %, 70.5 %±0.5 %, and 76.5 %±1.9 %, respectively, whereas the pooled model achieved a weighted area under the receiver operating characteristic curves of 71.1 %±0.7 %. The difference between internal and external performance was reduced when cardiac surgery patients were excluded. The key features across models were albumin levels and the use of oxygen therapy.</div></div><div><h3>Discussion</h3><div>A single, multi-hospital-based model performed comparably on external datasets, especially when cardiac surgery patients were excluded. However, when applied externally, model predictions risk being uncalibrated for specific patient subgroups and require careful calibration before implementation. While external models were more stable than local ones over OOD scores, their performance was comparable after excluding cardiac surgery patients. Although pooling data marginally improved performance on external datasets, the incorporation of data from diverse hospitals is likely to provide greater benefits.</div></div>","PeriodicalId":73799,"journal":{"name":"Journal of intensive medicine","volume":"5 4","pages":"Pages 377-384"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145335068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The international, prospective CytOSorbⓇ treatMent Of critically ill patientS (COSMOS) registry: Interim results from the first 150 patients","authors":"Ricard Ferrer ,&nbsp;Matthias Thielmann ,&nbsp;Andreas Kribben ,&nbsp;Moritz Unglaube ,&nbsp;Bartosz Tyczynski ,&nbsp;Julian Kreutz ,&nbsp;Andreas Baumann ,&nbsp;Ulf Guenther ,&nbsp;Dietrich Henzler ,&nbsp;Thomas Kirschning ,&nbsp;Aschraf El-Essawi ,&nbsp;Thomas Günther ,&nbsp;Martin Bellgardt ,&nbsp;Gabriella Bottari ,&nbsp;Filippo Aucella ,&nbsp;Jorge Hidalgo ,&nbsp;Jean-Louis Teboul ,&nbsp;Dana Tomescu ,&nbsp;Teresa Klaus ,&nbsp;Weihong Fan ,&nbsp;Fabio Silvio Taccone","doi":"10.1016/j.jointm.2025.05.001","DOIUrl":"10.1016/j.jointm.2025.05.001","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;The CytOSorb&lt;sup&gt;Ⓡ&lt;/sup&gt; treatMent Of critically ill patientS (COSMOS) registry is an observational, prospective, multicenter, international real-world data collection platform executed in countries where the CytoSorb&lt;sup&gt;Ⓡ&lt;/sup&gt; (CS) 300 mL device is approved and routinely used in everyday clinical practice. This study aims to investigate utilization patterns of the hemoadsorption device and associated outcomes in critical care.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;Since July 2022, patients who were treated with CS as part of their intensive care treatment were enrolled from 16 sites in Germany, Italy, and Spain in the registry. After informed consent, real-world clinical data are systematically collected at multiple intervals, including 24 h before CS start, during CS treatment, and 24 h post-CS treatment, as well as at discharge from intensive care unit (ICU) and hospital discharge, and final follow-up on day 90. Vital status was assessed as ICU survival, 30-day survival, overall hospital survival, and 90-day survival. We compared details on the type of extracorporeal circuit used, device flow rate, anticoagulation regimen, vasopressor requirements, fluid balance, ratio of partial pressure of oxygen in arterial blood to the fraction of inspiratory oxygen concentration (P/F ratio), myoglobin in the rhabdomyolysis cohort and bilirubin in the liver failure cohort before and after CS treatment. Safety of the device was assessed by investigator-reported device-related adverse effects. Data were presented as either mean ± standard deviation or as median with interquartile range (IQR).&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;A total of 150 patients were enrolled, 23 patients did not have any data entry by the time of the data readout for this interim analysis conducted and therefore had to be excluded from the analysis (33 % female, mean age [59±17] years). CS indications included septic shock (57.6 %), cardiogenic shock (12.9 %), and rhabdomyolysis (10.6 %). CS was mainly integrated with renal replacement therapy (82.8 %). Median Acute Physiology and Chronic Health Evaluation II score was 23 (IQR: 17–29), Sequential Organ Failure Assessment score 12 (IQR: 9–15), and ICU stay 20 (IQR: 11–33) days. Median interleukin-6 decreased significantly from 862.4 (IQR: 142–97,457) pg/mL in the 24 h before CS treatment to 202.8 (IQR: 42–3247) pg/mL in the 24 h post-CS treatment (&lt;em&gt;P&lt;/em&gt; &lt;0.0001). Post-CS, lactate and creatinine levels significantly decreased, fluid balance improved from 1386 (IQR: 220–3168) mL to 275 (IQR: -768–1846) mL (&lt;em&gt;P&lt;/em&gt; &lt;0.0001) and median P/F ratio increased from 132 (IQR: 68–208) mmHg to 189 (IQR: 115–260) mmHg (&lt;em&gt;P&lt;/em&gt; &lt;0.0001). Norepinephrine requirements reduced from 0.30 (IQR: 0.18–0.46) µg/(kg·min) to 0.19 (IQR: 0.10–0.33) µg/(kg·min) (&lt;em&gt;P&lt;/em&gt;=0.0003). In rhabdomyolysis patients, myoglobin decreased from 18,976 (IQR: 1934–34,275) to 835 (IQR: 623–5925) µg/L (&lt;em&gt;P&lt;/em&gt;=0.0273). Obser","PeriodicalId":73799,"journal":{"name":"Journal of intensive medicine","volume":"5 4","pages":"Pages 392-399"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145335066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Joint application of multiplex drop-off digital PCR, droplet digital PCR, and metagenomic next-generation sequencing for the diagnosis of suspected infectious diseases: A retrospective cohort study","authors":"Shanshan Jin ,&nbsp;Shiyu Meng ,&nbsp;Qiuping Huang ,&nbsp;Hui Xie ,&nbsp;Jingjing Zheng ,&nbsp;Ruilan Wang","doi":"10.1016/j.jointm.2025.03.006","DOIUrl":"10.1016/j.jointm.2025.03.006","url":null,"abstract":"<div><h3>Background</h3><div>Critically ill patients in ICUs are highly vulnerable to infectious diseases. Early and accurate identification of pathogens is vital for initiating appropriate antimicrobial therapy. To evaluate the diagnostic effectiveness in patients with suspected infectious diseases; three different molecular technologies and conventional microbiological tests were used.</div></div><div><h3>Methods</h3><div>A total of 97 individuals suspected of having infectious diseases were retrospectively enrolled from July 2023 to January 2024 at Shanghai General Hospital. Samples were collected for metagenomic next-generation sequencing (mNGS), droplet digital polymerase chain reaction (ddPCR), multiplex drop-off digital polymerase chain reaction (MDO-dPCR), and conventional microbiological tests (CMTs) for suspected pathogen detection. The diagnostic efficacies of the three molecular technologies and CMTs were compared, and the effects of their joint application on clinical outcomes were evaluated. Intergroup comparisons were performed using the Kruskal–Wallis test, with a <em>P</em>-value &lt;0.05 considered statistically significant.</div></div><div><h3>Results</h3><div>Joint detection exhibited a high negative predictive value. The sensitivity of MDO-dPCR, ddPCR, and mNGS was 52.6%, 48.5%, and 96.6%, respectively; and the corresponding specificity was 72.5%, 73.3%, and 50.0%. A positive correlation was observed between pathogen copies detected using MDO-dPCR and procalcitonin (Pearson’s <em>ρ</em>=0.21, <em>P</em>=0.039), acute physiology and chronic health evaluation II (Pearson’s <em>ρ</em>=0.24, <em>P</em> =0.018), and sequential organ failure assessment (Pearson’s <em>ρ</em>=0.25, <em>P</em>=0.012). Therapeutic regimens were adjusted in 51.5% of the patients (50/97) based on the results of the combination tests.</div></div><div><h3>Conclusions</h3><div>In the present study, we highlighted the significance of molecular technologies for the early diagnosis of patients with suspected infections. These technologies can serve as a complement to CMTs and should be implemented promptly to guide clinicians in providing timely and effective anti-infective treatments. Future studies should aim to confirm these findings in large-scale clinical trials to refine diagnostic protocols, while also incorporating cost-utility analyses.</div></div>","PeriodicalId":73799,"journal":{"name":"Journal of intensive medicine","volume":"5 4","pages":"Pages 407-418"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145335103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe invasive Streptococcus pyogenes infections: A 15-year observational study with molecular characterization of isolates among intensive care adults","authors":"Loreto Vidaur ,&nbsp;Izaskun Azkarate ,&nbsp;Estibaliz Salas ,&nbsp;Iñigo Ansa ,&nbsp;Diego Vicente ,&nbsp;Jordi Rello ,&nbsp;Milagrosa Montes","doi":"10.1016/j.jointm.2025.06.001","DOIUrl":"10.1016/j.jointm.2025.06.001","url":null,"abstract":"<div><h3>Background</h3><div>Improving outcomes among patients with invasive group A <em>Streptococcus pyogenes</em> (iGAS) infections is an unmet clinical need. The main objective of this study was to analyze epidemiological and outcome differences in adults admitted to the intensive care unit (ICU) with iGAS infection over a 15-year period and to evaluate the impact of M1uk isolates and clindamycin optimization on patient outcomes.</div></div><div><h3>Methods</h3><div>This was a single-center observational study conducted at the ICU of Donostia University Hospital, located in Donostia, Spain. The recruitment of all consecutive adult patients admitted to the ICU by iGAS was carried out from January 2010 to May 2024 and divided into three periods: pre-pandemic (January 2010–2019), pandemic (2020–2021), and post-pandemic (May 2022–2024). The main outcome variables were ICU length of stay, hospital length of stay, and ICU mortality. Data were analyzed using the Statistical Package for the Social Sciences (SPSS) software (version 25; SPSS Inc., Chicago, IL, USA). A significance level of <em>P</em> &lt;0.05 was considered for all analyses.</div></div><div><h3>Results</h3><div>Sixty-eight adults were enrolled, with a crude mortality in pre- and post-pandemic periods being 25.5% and 10.0% (<em>P</em>=0.200), respectively. Twenty (29.4%) were respiratory and 29 (41.2%) were soft tissue infections. The incidence had valleys (&lt;1/100,000) in 2020 and 2021 and peaks (&gt;4/100,000 inhabitants) in 2014, 2019, and 2023. Pre-pandemic patients were significantly younger (median: 58.0 <em>vs.</em> 67.5 years, <em>P</em> &lt;0.050), had lower Charlson scores (median: 0 <em>vs.</em> 2, <em>P</em>=0.009), and required more renal replacement therapy (48.9% <em>vs.</em> 15.0%, <em>P</em>=0.013). <em>Emm1</em> type was the most frequent isolated strain, with the M1uk lineage being represented in 6 out of 7 <em>Emm1</em> isolates in post-pandemic period. M1uk-infected patients were older (median: 67.0 <em>vs.</em> 50.0 years, <em>P</em>=0.073) but mortality was similar. Most patients (86.6%) received β-lactams plus clindamycin. Interestingly, time to clindamycin administration was earlier (median: 1 h <em>vs.</em> 24 h; <em>P</em> &lt;0.050) in the post-pandemic period with a 5-fold increase in ICU mortality (5.6% to 26.5%, OR=6.14, 95% CI: 0.74 to 50.85; <em>P</em>=0.090) among those adults who did not receive clindamycin in the emergency department.</div></div><div><h3>Conclusions</h3><div>The incidence of iGAS infections requiring ICU admission showed no significant increase post-Coronavirus Disease-19 pandemic. The highly toxigenic M1uk strain became predominant, but it was not associated with worse mortality among adult ICU patients.</div></div>","PeriodicalId":73799,"journal":{"name":"Journal of intensive medicine","volume":"5 4","pages":"Pages 336-343"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145335149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing outcomes in pediatric populations with continuous renal replacement therapy: Current multidisciplinary strategies and innovations","authors":"Flora R. Gallegos ,&nbsp;Parth Shirode ,&nbsp;Max Gilliland ,&nbsp;Jieji Hu ,&nbsp;Amanda Osagie-Ogbeide ,&nbsp;Sidharth Kumar Sethi ,&nbsp;Rupesh Raina","doi":"10.1016/j.jointm.2025.03.005","DOIUrl":"10.1016/j.jointm.2025.03.005","url":null,"abstract":"<div><div>Continuous renal replacement therapy (CRRT) is critical in managing several conditions in critically ill pediatric patients. The clinical and economic impact of CRRT is profound and diverse, similar to the patients and conditions it is used to treat. Although much medical literature surrounds CRRT in adults, there remains a gap in research for pediatric populations. This article provides a brief review of current kidney replacement therapies, focusing on CRRT indications, prescribing practices, and modality comparisons. We aim to evaluate the current practical considerations and effectiveness of these therapies and highlight recent advances and future directions, especially in relation to the pediatric patient population. We analyzed recent literature and clinical guidelines on CRRT for critically ill pediatric patients. Key considerations include prescription strategies and comparison of different CRRT modalities, and essential considerations include anticoagulation, settings, and complications. We also explore recent advances in CRRT technologies and their role in clinical management. CRRT offers significant benefits for patients with severe kidney impairments by providing continuous support and improving outcomes. Discussing current recommendations and uses of CRRT and recent advancements will improve its safety and efficacy. Advances in technology and clinical practice are enhancing the use of CRRT, though further research is needed to optimize treatment and address ongoing challenges.</div></div>","PeriodicalId":73799,"journal":{"name":"Journal of intensive medicine","volume":"5 4","pages":"Pages 323-332"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145334922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}