Enhancing outcomes in pediatric populations with continuous renal replacement therapy: Current multidisciplinary strategies and innovations

Abstract

Continuous renal replacement therapy (CRRT) is critical in managing several conditions in critically ill pediatric patients. The clinical and economic impact of CRRT is profound and diverse, similar to the patients and conditions it is used to treat. Although much medical literature surrounds CRRT in adults, there remains a gap in research for pediatric populations. This article provides a brief review of current kidney replacement therapies, focusing on CRRT indications, prescribing practices, and modality comparisons. We aim to evaluate the current practical considerations and effectiveness of these therapies and highlight recent advances and future directions, especially in relation to the pediatric patient population. We analyzed recent literature and clinical guidelines on CRRT for critically ill pediatric patients. Key considerations include prescription strategies and comparison of different CRRT modalities, and essential considerations include anticoagulation, settings, and complications. We also explore recent advances in CRRT technologies and their role in clinical management. CRRT offers significant benefits for patients with severe kidney impairments by providing continuous support and improving outcomes. Discussing current recommendations and uses of CRRT and recent advancements will improve its safety and efficacy. Advances in technology and clinical practice are enhancing the use of CRRT, though further research is needed to optimize treatment and address ongoing challenges.