Journal of herbal pharmacotherapy最新文献_第2页

Antihypertensive activity of the aqueous extract of Retama raetam Forssk. leaves in spontaneously hypertensive rats. 水提物的降压活性研究。自发性高血压大鼠的叶片。

Journal of herbal pharmacotherapy Pub Date : 2007-01-01 DOI: 10.1300/j157v07n02_05

M Eddouks, M Maghrani, L Louedec, M Haloui, J B Michel

{"title":"Antihypertensive activity of the aqueous extract of Retama raetam Forssk. leaves in spontaneously hypertensive rats.","authors":"M Eddouks, M Maghrani, L Louedec, M Haloui, J B Michel","doi":"10.1300/j157v07n02_05","DOIUrl":"https://doi.org/10.1300/j157v07n02_05","url":null,"abstract":"The antihypertensive and diuretic effects of the aqueous extract of Retama raetam Forssk. (RR) leaves were studied in both normotensive (WKY) and spontaneously hypertensive rats (SHR). In SHR rats, daily oral administration of RR (20 mg/kg) for three weeks exhibited a significant reduction in blood pressure. The systolic blood pressure decreased significantly from the seventh day (P < 0.01) and persisted through the end of treatment (P < 0.001) in SHR rats. The RR significantly enhanced the diuresis in WKY rats (P < 0.001). Furthermore, oral administration of RR at a dose of 20 mg/kg produced a significant increase on urinary excretion of sodium (P < 0.05), potassium (P < 0.01) and chlorides (P < 0.01) in SHR rats. In WKY rats, RR treatment induced a significant increase on urinary potassium elimination (P < 0.05) without affecting sodium and chloride excretion. Irbesartan (Avapro) 20 mg/kg (body weight), an angiotensin II receptor antagonist, was used as reference drug. No significant changes were noted in heart rate after RR treatment in SHR as well as in WKY rats. Glomerular filtration rate showed a significant increase after RR administration in WKY rats (P < 0.01) and a no significant increase in SHR rats. These results suggest that oral administration of aqueous RR extract exhibited antihypertensive and diuretic effects in SHR rats and diuretic action in WKY rats.","PeriodicalId":73776,"journal":{"name":"Journal of herbal pharmacotherapy","volume":"7 2","pages":"65-77"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27274025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Immunomodulatory Activity of Petroleum Ether Extract of Flower Heads of Sphaeranthus indicus Linn 球兰花头石油醚提取物的免疫调节作用

Journal of herbal pharmacotherapy Pub Date : 2007-01-01 DOI: 10.1080/J157v07n01_03

A. Bafna, MPharm S. H. Mishra

引用次数: 14

In vivo effect of I'm-Yunity on hepatic cytochrome P450 3A4. I'm-Yunity对肝细胞色素P450 - 3A4的体内影响。

Journal of herbal pharmacotherapy Pub Date : 2007-01-01 DOI: 10.1300/J157V07N01_04

J. Nicandro, C. Tsourounis, L. Frassetto, B. Guglielmo

引用次数: 3

In vivo Effect of I'm-Yunity™ on Hepatic Cytochrome P450 3A4 I'm-Yunity™对肝细胞色素P450 3A4的体内影响

Journal of herbal pharmacotherapy Pub Date : 2007-01-01 DOI: 10.1080/J157v07n01_04

J. Nicandro, C. Tsourounis, L. Frassetto, B. Guglielmo

{"title":"In vivo Effect of I'm-Yunity™ on Hepatic Cytochrome P450 3A4","authors":"J. Nicandro, C. Tsourounis, L. Frassetto, B. Guglielmo","doi":"10.1080/J157v07n01_04","DOIUrl":"https://doi.org/10.1080/J157v07n01_04","url":null,"abstract":"The inhibition or induction of hepatic cytochrome P450 3A4 (CYP3A4) enzyme associated with herbal medicines such as I'm-Yunity™ (Coriolus versicolor) can result in clinically significant herb-drug interactions. The active ingredient of I'm-Yunity™ is believed to be polysaccharopeptide polymer (PSP). Drug interactions between I'm-Yunity™ and other medications or supplements are yet to be investigated. The objective of this single-treatment, one-period, three-phase, open-labeled study was to evaluate the ability of I'm-Yunity™ to inhibit or induce CYP3A4 in 12 healthy adult volunteers (8 women and 4 men) aged between 23 and 54 years through the use of a CYP3A4-specific assay, the erythromycin breath test (EBT). EBT measurements are reported as percentage of 14C-Erythromycin metabolized/hr. Participants were given a 14-day supply of I'm-Yunity™ and instructed to take 1200 mg, three times daily with meals. Comparisons of all subjects' mean CYP3A4 activities were performed with the EBT before and after taking I'm-Yunity™. Results revealed a mean EBT change (SD) from baseline of 0.08% (0.56%) 14C-Erythromycin metabolized/hr, which was not significant (p = 0.63). Therefore, 14 days of exposure to I'm-Yunity™ was not associated with clinically significant CYP3A4 inhibition or induction, suggesting that short-term administration of I'm-Yunity™ with medications primarily metabolized by CYP3A4 is safe and not expected to be associated with significant herb-drug interactions. However, it is still unknown whether interactions exist between I'm-Yunity™ and other medications metabolized by other CYP450 isozymes or enzyme/transporter systems.","PeriodicalId":73776,"journal":{"name":"Journal of herbal pharmacotherapy","volume":"15 1","pages":"39 - 56"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/J157v07n01_04","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"60735326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Banaba (Lagerstroemia speciosa L.): an evidence-based systematic review by the Natural Standard research collaboration. Banaba (Lagerstroemia speciosa L.):自然标准研究合作的循证系统评价。

Journal of herbal pharmacotherapy Pub Date : 2007-01-01

Catherine Ulbricht, Chi Dam, Tamara Milkin, Erica Seamon, Wendy Weissner, Jen Woods

引用次数: 0

Evaluation of antidiabetic activity of Coldenia procumbens in alloxan-induced diabetes in rat. 原藜对四氧嘧啶诱导的糖尿病大鼠抗糖尿病活性的评价。

Journal of herbal pharmacotherapy Pub Date : 2007-01-01

Nita Patel, Sunant Raval, Harshad Goriya, Mayur Jhala, Bhola Joshi

引用次数: 0

Abstracts of the 13th Annual Symposium on Complementary Health Care. December 12-14, 2006. Exeter, United Kingdom. 第十三届补充卫生保健年度研讨会摘要。2006年12月12-14日。埃克塞特，英国。

Journal of herbal pharmacotherapy Pub Date : 2007-01-01

引用次数: 0

Evaluation of the stimulant content of dietary supplements marketed as "ephedra-free". 对标榜“不含麻黄”的膳食补充剂的兴奋剂含量进行评估。

Journal of herbal pharmacotherapy Pub Date : 2007-01-01 DOI: 10.1300/j157v07n01_06

Philip J. Gregory

引用次数: 4

Marine algae: screening for a potent antibacterial agent. 海藻:筛选一种有效的抗菌剂。

Journal of herbal pharmacotherapy Pub Date : 2007-01-01

Ratish Nair, Rajesh Chabhadiya, Sumitra Chanda

{"title":"Marine algae: screening for a potent antibacterial agent.","authors":"Ratish Nair, Rajesh Chabhadiya, Sumitra Chanda","doi":"","DOIUrl":"","url":null,"abstract":"This study was done to investigate the antimicrobial potentiality of the marine algae collected from different coastal regions of Gujarat and screened for the same. Twenty-six marine algae belonging to Rhodophyceae, Chlorophyceae and Phaeophyceae were screened for their potential antibacterial activity against five clinically important bacterial strains, namely Bacillus cereus, Micrococcus flavus, Citrobacter freundii, Klebsiella pneumoniae and Pseudomonas testosterone. Acetone and methanol were used for extraction; and the extracted yield was more when the solvent used was methanol. The antibacterial activity was done by both Agar disc diffusion method and Agar ditch method. The five bacterial strains showed varied response towards marine algal extracts. The most susceptible bacteria was B. cereus followed by K. pneumoniae and C. freundii while the most resistant bacteria were M. flavus and P. testosteroni. Among the 26 algae screened, E. intestinalis was the most potent alga and thus, this alga was selected for further studies. E. intestinalis was extracted in petroleum ether, 1,4-dioxan, acetone, methanol and DMF, and their antibacterial activity was studied against the above-stated five bacterial strains using agar disc method. Maximum extractive value of E. intestinalis was in methanol (2.05%) and minimum was in acetone (0.38%). The most susceptible bacteria was K. pneumoniae and maximum antibacterial activity was shown by petroleum ether extract and minimum was shown by 1,4-dioxan extract. The most resistant bacteria were M. flavus and C. freundii. The MIC values of E. intestinalis extracts ranged from 2500-9.765 microg/0.5 ml against B. cereus and K. pneumoniae. From these results it is concluded that the acetone extract of E. intestinalis is the most potent extract and can be used as a lead molecule in drug discovery in inhibiting some of the bacterial strains. E. intestinalis can be used as a promising novel marine antimicrobial agent in the coming years.","PeriodicalId":73776,"journal":{"name":"Journal of herbal pharmacotherapy","volume":"7 1","pages":"73-86"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26799373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analgesic and anti-inflammatory activities of the isomeric mixture of alpha- and beta-amyrin from Protium heptaphyllum (Aubl.) march. 七叶丙氨酸α -和β -amyrin异构体混合物的镇痛和抗炎活性。

Journal of herbal pharmacotherapy Pub Date : 2007-01-01 DOI: 10.1300/j157v07n02_03

Gislei Frota Aragão, Marta Cristhiany Cunha Pinheiro, Paulo Nogueira Bandeira, Telma Leda Gomes Lemos, Glauce S de Barros Viana

{"title":"Analgesic and anti-inflammatory activities of the isomeric mixture of alpha- and beta-amyrin from Protium heptaphyllum (Aubl.) march.","authors":"Gislei Frota Aragão, Marta Cristhiany Cunha Pinheiro, Paulo Nogueira Bandeira, Telma Leda Gomes Lemos, Glauce S de Barros Viana","doi":"10.1300/j157v07n02_03","DOIUrl":"https://doi.org/10.1300/j157v07n02_03","url":null,"abstract":"In the present work, we demonstrated that the mixture of alpha- and beta-amyrin (AMI) from Protium heptaphyllum has antinociceptive activity as was evident from the writhing and formalin tests in mice. AMI (10 and 50 mg/kg, i.p.) inhibited writhing in 73 and 94%, respectively, while preferentially inhibiting the 2nd phase of the response (37 and 51; and 60 and 73% inhibitions of the 1st and 2nd phases, respectively) to the formalin test. Naloxone, an opioid antagonist, did not reverse the antinociceptive effect. AMI (50 mg/kg, i.p.) was also active in the hot plate test, increasing the reaction time to thermal stimulus after 30 and 60 min, by 62 and 71%, respectively. A preventive antiedematogenic effect was observed in mice that had a carrageenan-induced paw edema. Paw volume was significantly and dose-dependently decreased by 39, 42 and 53%, three hours after administration of 10, 25 and 50 mg/kg doses, i.p., respectively. AMI (25 and 50 mg/kg, i.p.) was also able to reverse the edema already induced by carrageenan (curative effect). AMI (10 and 25 mg/kg, i.p.) was equally effective in the dextran- induced paw edema (preventive effect), reducing the paw volume by 50 and 60% at the 2nd hour, and by 63 and 73% at the third hour post-dose. AMI (50 mg/kg, i.p.) reverted the edema already formed after the dextran injection (curative effect). In conclusion, AMI demonstrated peripheral and central analgesic effects independent of the opioid system, and also showed a potent anti-inflammatory activity. The antiinflammatory activity was potentiated by both indomethacin and thalidomide, suggesting a potential involvement of prostaglandins and TNFalpha inhibitions.","PeriodicalId":73776,"journal":{"name":"Journal of herbal pharmacotherapy","volume":"7 2","pages":"31-47"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27274023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 29