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Experimental neurodegeneration in hippocampus and its phytoremidation. 海马实验性神经退行性变及其植物修复。
Journal of herbal pharmacotherapy Pub Date : 2005-01-01
Maheep Bhatnagar, Sunil Dutt Shukla, Rekha Bhatnagar
{"title":"Experimental neurodegeneration in hippocampus and its phytoremidation.","authors":"Maheep Bhatnagar,&nbsp;Sunil Dutt Shukla,&nbsp;Rekha Bhatnagar","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Present study reports cytological and biochemical changes associated with stress induced neurodegeneration in hippocampal subregion of the brain in animals subjected to physical stressors such as immobilization or swimming stress for specific period of time. Studies also demonstrate neuroprotective activity of herbal extract in brain.</p>","PeriodicalId":73776,"journal":{"name":"Journal of herbal pharmacotherapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2005-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25665826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of long-term oral administration of green tea extract on weight gain and glucose tolerance in Zucker diabetic (ZDF) rats. 长期口服绿茶提取物对Zucker糖尿病(ZDF)大鼠体重增加和葡萄糖耐量的影响
Journal of herbal pharmacotherapy Pub Date : 2005-01-01
Elsa M Janle, Carla Portocarrero, Yongxin Zhu, Qin Zhou
{"title":"Effect of long-term oral administration of green tea extract on weight gain and glucose tolerance in Zucker diabetic (ZDF) rats.","authors":"Elsa M Janle,&nbsp;Carla Portocarrero,&nbsp;Yongxin Zhu,&nbsp;Qin Zhou","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>There have been some claims that green tea reduces weight and lowers blood glucose in diabetes. Intraperitoneal injections of green tea catechins in diabetic rats have shown beneficial effects. To determine if oral administration of green tea would prevent development of diabetes, young Zucker diabetic rats were dosed with green tea extract containing 50-125 mg/kg of Epigallocatechin gallate (EGCG) starting at 7 weeks of age, before the appearance of excessive weight gain and glucose elevation. While there was a trend toward lower weight gain and average daily glucose, there was no statistically significant difference.</p>","PeriodicalId":73776,"journal":{"name":"Journal of herbal pharmacotherapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2005-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25891998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Some compaction characteristics of the hot water leaf extract og Nauclea latifiola: a potential antimalarial agent. 一种潜在的抗疟剂——乳核仁热水叶提取物的一些压实特性。
Journal of herbal pharmacotherapy Pub Date : 2005-01-01
M O Emeje, C Y Isimi, D A N Oqua, O O Kunle
{"title":"Some compaction characteristics of the hot water leaf extract og Nauclea latifiola: a potential antimalarial agent.","authors":"M O Emeje,&nbsp;C Y Isimi,&nbsp;D A N Oqua,&nbsp;O O Kunle","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This study aims to develop a suitable tablet dosage form of Nauclea latifolia, a potential antimalarial agent. The compaction characteristics of the oven dried water extract were studied using the Heckel equation. The mechanical properties of the compacts were also determined. This preliminary information will be useful in developing a suitable dosage form of the extract for use in the management of malaria. The results showed that N. latifolia extract exhibited high densification due to dye filling while the subsequent rearrangement of the granules did not contribute, significantly, to their densification. The granules had enhanced plasticity as shown by the low yield point, Py. The tablets produced from the extract had good mechanical properties, with hardness increasing via compression pressure while the friability decreased. However, the tablets had poor disintegration properties; it is concluded that while tablets of suitable physical properties can be produced from the extract, a disintegrant would need to be included in the formulation to ensure adequate drug release.</p>","PeriodicalId":73776,"journal":{"name":"Journal of herbal pharmacotherapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2005-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25991285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Comparison of the Hemostatic Effects of Notoginseng and Yun Nan Bai Yao to Placebo Control 三七与白云药与安慰剂对照止血效果的比较
Journal of herbal pharmacotherapy Pub Date : 2005-01-01 DOI: 10.1080/J157v05n02_01
Chengde Fan, Jessica C. Song, C. White
{"title":"A Comparison of the Hemostatic Effects of Notoginseng and Yun Nan Bai Yao to Placebo Control","authors":"Chengde Fan, Jessica C. Song, C. White","doi":"10.1080/J157v05n02_01","DOIUrl":"https://doi.org/10.1080/J157v05n02_01","url":null,"abstract":"Introduction: We previously demonstrated the hemostatic effects of notoginseng using a rat bleeding model. Yun Nan Bai Yao is a proprietary product for external use in China to treat bleeding but the hemostatic effects have not been proven. This study was conducted to compare the hemostatic effects of notoginseng to that of Yun Nan Bai Yao and placebo control. Methods: Rats (n = 37) were randomized into 3 groups and their tails were transected 5 mm from the tip in this blinded investigation. Group 1 received placebo (wheat flour, n = 17), group 2 received notoginseng (n = 10) and group 3 received the Yun Nan Bai Yao (n = 10). The total bleeding time was determined and compared among groups. Results: Bleeding time in minutes was 29.7% and 22.3% lower in the notoginseng and Yun Nan Bai Yao groups than the placebo group (p < 0.001 and p < 0.001, respectively). No significant difference was found between the two active groups (p = 0.418). Conclusions: When applied externally, both notoginseng and Yun Nan Bai Yao pro.","PeriodicalId":73776,"journal":{"name":"Journal of herbal pharmacotherapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2005-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/J157v05n02_01","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"60733467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 23
July, 2005 Edited Excerpts from 2005年7月编辑节选自
Journal of herbal pharmacotherapy Pub Date : 2005-01-01 DOI: 10.1080/J157v05n04_07
F. Brinker
{"title":"July, 2005 Edited Excerpts from","authors":"F. Brinker","doi":"10.1080/J157v05n04_07","DOIUrl":"https://doi.org/10.1080/J157v05n04_07","url":null,"abstract":"A great concern in medicine is consistency, to the extent that this can become considered as the standard of excellence of a product. A product that meets a certain minimal content standard is often assumed to be a product of quality, though it may be of minimum quality. The objective of achieving excellence in process, content, and activity has long been a goal in botanical manufacturing. Those who sought to achieve this superior quality were often at odds with standard practices described in pharmacopoeias, while they were attempting to advance the art and science of botanical pharmacy. To merely concentrate the most active components to the neglect of the balanced complexity of the whole was not always considered desirable by these innovators. Such was the opinion of John Uri Lloyd, Eclectic pharmacist, award winning researcher, inventor, and former president of the American Pharmaceutical Association who pioneered many advances still used today in the extraction of drugs [his preferred term for dried herbs] to maximize the therapeutic efficacy:","PeriodicalId":73776,"journal":{"name":"Journal of herbal pharmacotherapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2005-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/J157v05n04_07","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"60733883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
A preliminary investigation of the enzymatic inhibition of 5alpha-reduction and growth of prostatic carcinoma cell line LNCap-FGC by natural astaxanthin and Saw Palmetto lipid extract in vitro. 天然虾青素和锯棕榈脂提取物体外抑制前列腺癌细胞LNCap-FGC细胞5 α还原和生长的初步研究
Journal of herbal pharmacotherapy Pub Date : 2005-01-01
Mark L Anderson
{"title":"A preliminary investigation of the enzymatic inhibition of 5alpha-reduction and growth of prostatic carcinoma cell line LNCap-FGC by natural astaxanthin and Saw Palmetto lipid extract in vitro.","authors":"Mark L Anderson","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Unlabelled: </strong>Inhibition of 5alpha-reductase has been reported to decrease the symptoms of benign prostate hyperplasia (BPH) and possibly inhibit or help treat prostate cancer. Saw Palmetto berry lipid extract (SPLE) is reported to inhibit 5alpha-reductase and decrease the clinical symptoms of BPH. Epidemiologic studies report that carotenoids such as lycopene may inhibit prostate cancer. In this investigation the effect of the carotenoid astaxanthin, and SPLE were examined for their effect on 5alpha-reductase inhibition as well as the growth of prostatic carcinoma cells in vitro. These studies support patent #6,277,417 B1. The results show astaxanthin demonstrated 98% inhibition of 5alpha-reductase at 300 microg/mL in vitro. Alphastat, the combination of astaxanthin and SPLE, showed a 20% greater inhibition of 5alpha-reductase than SPLE alone n vitro. A nine day treatment of prostatic carcinoma cells with astaxanthin in vitro produced a 24% decrease in growth at 0.1 mcg/mL and a 38% decrease at 0.01 mcg/mL. SPLE showed a 34% decrease at 0.1 mcg/mL.</p><p><strong>Conclusions: </strong>Low levels of carotenoid astaxanthin inhibit 5alpha-reductase and decrease the growth of human prostatic cancer cells in vitro. Astaxanthin added to SPLE shows greater inhibition of 5alpha-reductase than SPLE alone in vitro.</p>","PeriodicalId":73776,"journal":{"name":"Journal of herbal pharmacotherapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2005-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25241434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Safety assurances for dietary supplements policy issues and new research paradigms. 膳食补充剂的安全保证政策问题和新的研究范式。
Journal of herbal pharmacotherapy Pub Date : 2005-01-01
Ethan M Basch, Julie C Servoss, Usha B Tedrow
{"title":"Safety assurances for dietary supplements policy issues and new research paradigms.","authors":"Ethan M Basch,&nbsp;Julie C Servoss,&nbsp;Usha B Tedrow","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Herbal therapies are used by more than 12% of the U.S. population each year, resulting in annual out-of-pocket expenses above $5 billion. Utilization rates are particularly high among patients with chronic diseases, and in patients frequently seen in clinic by physicians and nurse practitioners. Most physicians do not receive formal education regarding the safety of these therapies, and there is growing concern in the medical community about the potential risks to patients and the paucity of reliable information. Numerous adverse effects and interactions have been attributed to dietary supplements, based on variable levels of evidence ranging from historical use or anecdotes to pre-clinical research or high-quality clinical trials. Significant potential morbidity and costs have been indirectly associated with herb/supplement-drug interactions, including increased emergency room visits, outpatient clinic visits, and perioperative complications. However, most research has focused on efficacy rather than safety. Post-market surveillance is complicated by the uneven standardization of products between manufacturers, and in some cases between batches produced by the same manufacturer. To assure public safety around the use of dietary supplements within the framework of existing legislation and market realities, schema must evolve to more systematically monitor the safety of agents in the post-market environment; identify potentially dangerous supplements (and/or constituents); study the mechanism and potential hazards of these identified products; and clarify the process by which products may be considered for removal from the market. We discuss research and educational paradigms within this context which make use of existing surveillance mechanisms to more efficiently identify agents of particular concern. Specific examples are given.</p>","PeriodicalId":73776,"journal":{"name":"Journal of herbal pharmacotherapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2005-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25242190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Differential activity of lipoic acid enantiomers in cell culture. 硫辛酸对映体在细胞培养中的差异活性。
Journal of herbal pharmacotherapy Pub Date : 2005-01-01
Jerry Robert Smith, Harish V Thiagaraj, Benjamin Seaver, Keith K Parker
{"title":"Differential activity of lipoic acid enantiomers in cell culture.","authors":"Jerry Robert Smith,&nbsp;Harish V Thiagaraj,&nbsp;Benjamin Seaver,&nbsp;Keith K Parker","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>It is unclear whether the two enantiomeric forms (R & S) of lipoic acid (LA) share similar pharmacological activity and the exact cellular targets of LA are not well identified. We oxidatively stressed 3 cell culture systems representing different cell types. Mitochondrial metabolism was the primary endpoint. When C6 glioma was damaged by hydrogen peroxide (H2O2), all forms of LA protected. Racemic and S-LA were less effective than the R-isomer that was also protective in tertiary butyl hydroperoxide (TBHP)-damaged C6 glioma. In PC12 cells, little damage was produced by TBHP; R-LA increased mitochondrial metabolism above the level of non-damaged control. In H2O2 damaged PC12 cells, R-LA and racemic LA (but not S-LA) not only protected against damage, but increased mitochondrial metabolism above the non-damaged control level. When BAE cells were damaged with H2O2, R- and racemic LA protected while S-LA was ineffective.</p>","PeriodicalId":73776,"journal":{"name":"Journal of herbal pharmacotherapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2005-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25891997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Differential Activity of Lipoic Acid Enantiomers in Cell Culture 硫辛酸对映体在细胞培养中的差异活性
Journal of herbal pharmacotherapy Pub Date : 2005-01-01 DOI: 10.1080/J157v05n03_05
J. R. Smith, H. V. Thiagaraj, B. Seaver, K. Parker
{"title":"Differential Activity of Lipoic Acid Enantiomers in Cell Culture","authors":"J. R. Smith, H. V. Thiagaraj, B. Seaver, K. Parker","doi":"10.1080/J157v05n03_05","DOIUrl":"https://doi.org/10.1080/J157v05n03_05","url":null,"abstract":"It is unclear whether the two enantiomeric forms (R & S) of lipoic acid (LA) share similar pharmacological activity and the exact cellular targets of LA are not well identified. We oxidatively stressed 3 cell culture systems representing different cell types. Mitochondrial metabolism was the primary endpoint. When C6 glioma was damaged by hydrogen peroxide (H2O2), all forms of LA protected. Racemic and S-LA were less effective than the R-isomer that was also protective in tertiary butyl hydroperoxide (TBHP)-damaged C6 glioma. In PC12 cells, little damage was produced by TBHP; R-LA increased mito-chondrial metabolism above the level of non-damaged control. In H2O2damaged PC12 cells, R-LA and racemic LA (but not S-LA) not only protected against damage, but increased mitochondrial metabolism above the non-damaged control level. When BAE cells were damaged with H2O2, R- and racemic LA protected while S-LA was ineffective.","PeriodicalId":73776,"journal":{"name":"Journal of herbal pharmacotherapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2005-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/J157v05n03_05","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"60733064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 17
Screening of Some Medicinal Plants Used in South-West Nigerian Traditional Medicine for Anti-Salmonella typhi Activity 尼日利亚西南部一些传统药材抗伤寒沙门菌活性的筛选
Journal of herbal pharmacotherapy Pub Date : 2005-01-01 DOI: 10.1080/J157v05n01_06
K. Akinyemi, U. Mendie, S. T. Smith, A. Oyefolu, Akitoye O. Coker
{"title":"Screening of Some Medicinal Plants Used in South-West Nigerian Traditional Medicine for Anti-Salmonella typhi Activity","authors":"K. Akinyemi, U. Mendie, S. T. Smith, A. Oyefolu, Akitoye O. Coker","doi":"10.1080/J157v05n01_06","DOIUrl":"https://doi.org/10.1080/J157v05n01_06","url":null,"abstract":"Ten Nigerian medicinal plants used traditionally for the treatment of several ailments of both microbial and non-microbial origins were tested on multi-drug resistant S. typhi(MDR) strains of which six of them were active. The results revealed that both the aqueous and ethanol extracts of Terminalia avicennioides, Momordica balsamina, Combretum paniculatumand Trema guineensiswere effective on the MDR-S. typhistrains with minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values ranging from 9.60 to 14 mcg/ml and 24 to 33 mcg/ml, respectively. Whereas, only the aqueous extracts of Morinda lucidaand Ocimum gratissimumwere found to be active against this pathogen with MIC and MBC values of 9.60 and 24 mcg/ml for M. lucida, 40 and 55 mcg/ml for O. gratissimum, respectively. There was no statistical significant difference (P > 0.05) between the activity of each plant extract and the decoctions prepared from them. All the six active plants showed positive reactions to alkaloids, tannins, flavonoids and anthraquinones but in variable degrees. All but M. balsamina, indicated the presence of saponin.","PeriodicalId":73776,"journal":{"name":"Journal of herbal pharmacotherapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2005-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/J157v05n01_06","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"60733316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 69
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