J. Nicandro, C. Tsourounis, L. Frassetto, B. Guglielmo
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In vivo effect of I'm-Yunity on hepatic cytochrome P450 3A4.
The inhibition or induction of hepatic cytochrome P450 3A4 (CYP3A4) enzyme associated with herbal medicines such as I'm-Yunity™ (Coriolus versicolor) can result in clinically significant herb-drug interactions. The active ingredient of I'm-Yunity™ is believed to be polysaccharopeptide polymer (PSP). Drug interactions between I'm-Yunity™ and other medications or supplements are yet to be investigated. The objective of this single-treatment, one-period, three-phase, open-labeled study was to evaluate the ability of I'm-Yunity™ to inhibit or induce CYP3A4 in 12 healthy adult volunteers (8 women and 4 men) aged between 23 and 54 years through the use of a CYP3A4-specific assay, the erythromycin breath test (EBT). EBT measurements are reported as percentage of 14C-Erythromycin metabolized/hr. Participants were given a 14-day supply of I'm-Yunity™ and instructed to take 1200 mg, three times daily with meals. Comparisons of all subjects' mean CYP3A4 activities were performed with the EBT before and after taking ...
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