Gabriel A Agbor, Joe A Vinson, Julius E Oben, Jeanne Y Ngogang
{"title":"In vitro antioxidant activity of three Piper species.","authors":"Gabriel A Agbor, Joe A Vinson, Julius E Oben, Jeanne Y Ngogang","doi":"10.1300/j157v07n02_04","DOIUrl":"https://doi.org/10.1300/j157v07n02_04","url":null,"abstract":"<p><p>Reactive oxygen species are known to play a role in numerous pathological conditions, and antioxidants from plant sources have been of great help in modulating this effect. This study assesses the methanolic extracts of the leaves of three Piper species (Piper guineense Schum and Thonn., Piper nigrum L. and Piper umbellatum L.) (Piperaceae) for their polyphenolic concentration and free radical scavenging activity. The Folin-Ciocalteu method was used to assess the polyphenolic concentration while the reducing power, 1,1-diphenyl-2-picrylhydrazyl (DPPH), superoxide radical, hydroxyl radical, nitric oxide scavenging and metal chelating activities were employed in studying the radical scavenging activity of the extracts. All three spices exhibited a marked polyphenolic concentration and dose dependent free radical scavenging activity. The free polyphenolic concentration of the three spices was in the order P. umbellatum (15.9 +/- 1.9 mg/g) > P. guineense (12.6 +/- 0.3 mg/g) > P. nigrum (9.8 +/- 0.8). The three Piper extracts exhibited a 79.8-89.9% scavenging effect on DPPH, an 85.1-97.9% scavenging effect on nitric oxide at a dose level of 10 mg/ml and a 47.1-51.6% scavenging effect on superoxide radical at a dose level of 8 mg/ml extraction. Piper extracts also exhibited a 57-76.1% scavenging effect on hydroxyl radical at 5 mg/ml, a 0.4-0.6 reducing power and an 88.3-93.9% metal chelating activity at a dose level of 8 mg/ml of extract. Thus, these Piper species can play a role in the modulation of free radical induced disorders.</p>","PeriodicalId":73776,"journal":{"name":"Journal of herbal pharmacotherapy","volume":"7 2","pages":"49-64"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27274024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ilko N Getov, Alexandra Tv Tzenova, Mile S Ristoff, Toncho V Todorov, Guenka I Petrova
{"title":"Safety assessment of newly marketed herbal medicines--methodological approach (Ginkgo biloba example in Bulgaria).","authors":"Ilko N Getov, Alexandra Tv Tzenova, Mile S Ristoff, Toncho V Todorov, Guenka I Petrova","doi":"10.1080/15228940802153040","DOIUrl":"https://doi.org/10.1080/15228940802153040","url":null,"abstract":"<p><p>This study presents a proposal for the methodological approach for postmarketing safety profile assessment based on sales data and information for adverse drug reactions of newly introduced herbal medicinal products in the market. The study covers all herbal medicinal products containing dry extract of Ginkgo biloba leaves allowed for sale in Bulgaria. The methodological approach we create should be used for the establishment of the national herbal drugs policy complying with the recent European regulatory changes and specificity of the therapeutic practice in the country.</p>","PeriodicalId":73776,"journal":{"name":"Journal of herbal pharmacotherapy","volume":"7 3-4","pages":"239-57"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/15228940802153040","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27797666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Luz María Sánchez Perera, Lino Varcalcel, Arturo Escobar, Mario Noa
{"title":"Polyphenol and phytosterol composition in an antibacterial extract from Rhizophora mangle L. bark.","authors":"Luz María Sánchez Perera, Lino Varcalcel, Arturo Escobar, Mario Noa","doi":"10.1080/15228940802142720","DOIUrl":"https://doi.org/10.1080/15228940802142720","url":null,"abstract":"<p><p>Rhizophora mangle L. bark aqueous extract has antimicrobial, wound healing and antiulcerogenic properties. These properties could be associated with its chemical composition. To test this hypothesis, gravimetric, colorimetric, gas chromatography techniques were used to determine the preliminary chemical composition of this extract. Sephadex LH-20 Exclusion Chromatography was used by the fractionation of total extract and fractionation of low molecular weight polyphenols by liquid/liquid extraction. High Performance Liquid Chromatography was used to perform the composition in this low molecular weigh polyphenols fraction. The extract presented polyphenolic structures (54.78%) and other structural components (45.22%). Polymeric tannins were the major polyphenolic component (80%) and 20% were hydrolysable tannins. Epicatechin, catechin, chlorogenic acid, gallic acid and ellagic acid were monomeric structures determined in this extract. Phytosterols (0.0285%): stigmasterol, beta-sitosterol and campesterol were also present.</p>","PeriodicalId":73776,"journal":{"name":"Journal of herbal pharmacotherapy","volume":"7 3-4","pages":"107-28"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/15228940802142720","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27797756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hanada G Shkukani, Abdulazim S Salhab, Ahmad M Disi, Maha S Shomaf, Farouk Al Quadan
{"title":"Antifertility effect of ethanolic extract of Juniperus phoenica (L.) in male albino rats.","authors":"Hanada G Shkukani, Abdulazim S Salhab, Ahmad M Disi, Maha S Shomaf, Farouk Al Quadan","doi":"10.1080/15228940802152463","DOIUrl":"https://doi.org/10.1080/15228940802152463","url":null,"abstract":"<p><p>The plant Juniperus phoenica (L.) (Cupressaceae) is widely growing on the rocky soils of the Mediterranean regions. In Jordan, the plant is distributed in different locations and is used as a folk medicine to treat rheumatism, edema, and urinary tract diseases. This study aimed to investigate the antifertility effect of J. phoenica in male albino rats. Animals were administered single daily intraperitoneal injections of 400 or 800 mg/kg of J. phoenica cones ethanol extract or the vehicle (dimethyl sulfoxide) for 21 consecutive days. A marked dose-dependent decrease in the counts and motility of the sperms collected from the cauda epididymis of treated rats was observed compared with the control. Furthermore, pregnancy rate in females markedly reduced by 60% and 80% after mating with males treated with 400 or 800 mg/kg, respectively. At the same time, significant decreases were detected in seminal vesicles and testicular weight of rats that received 800 mg/kg as compared with control rats. Testosterone levels were decreased significantly in both treated groups as compared with control. Histologically, seminiferous tubules of treated rats showed marked arrests of spermatogenesis and a marked decrease in the number of mature sperms. Therefore, the results of this study suggest that the ethanolic extract of the cones of J. phoenica possesses potential antifertility effects.</p>","PeriodicalId":73776,"journal":{"name":"Journal of herbal pharmacotherapy","volume":"7 3-4","pages":"179-89"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/15228940802152463","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27797759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Y S Biradar, R Singh, K Sharma, K Dhalwal, S L Bodhankar, K R Khandelwal
{"title":"Evaluation of anti-diarrhoeal property and acute toxicity of Triphala Mashi, an Ayurvedic formulation.","authors":"Y S Biradar, R Singh, K Sharma, K Dhalwal, S L Bodhankar, K R Khandelwal","doi":"10.1080/15228940802152869","DOIUrl":"https://doi.org/10.1080/15228940802152869","url":null,"abstract":"<p><p>The anti-diarrhoeal effect of aqueous and alcoholic extracts of Triphala and Triphala Mashi were studied employing castor oil-induced-diarrhoeal model in rats. The gastrointestinal transit rate was expressed as the percentage of the longest distance travelled by the charcoal divided by the total length of the small intestine. All the extracts, at various doses 200, 400 and 800 mg/kg displayed remarkable anti-diarrhoeal activity as evidenced by a significant increase in first defecation time, cumulative fecal weight and intestinal transit time. Aqueous and alcoholic extracts of Triphala and Triphala Mashi were considered safe up to a dose of 1750 mg/kg when evaluated for acute oral toxicity in accordance with the OECD (Organization for Economic Cooperation and Development) guidelines. In conclusion, the remarkable anti-diarrhoeal effect of Triphala and Triphala Mashi extracts against castor oil-induced diarrhoea suggest its potential for application in a wide range of diarrhoeal states.</p>","PeriodicalId":73776,"journal":{"name":"Journal of herbal pharmacotherapy","volume":"7 3-4","pages":"203-12"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/15228940802152869","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27797761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Puri, T. Khaliq, S. Rajendran, G. Bhatia, R. Chandra, T. Narender
{"title":"Antidyslipidemic Activity of Indigofera tinctoria","authors":"A. Puri, T. Khaliq, S. Rajendran, G. Bhatia, R. Chandra, T. Narender","doi":"10.1080/J157v07n01_05","DOIUrl":"https://doi.org/10.1080/J157v07n01_05","url":null,"abstract":"Indigofera tinctoria is a perennial shrub, which belongs to the family Papilionaceae. As a part of our drug discovery program we have investigated the antidyslipidemic activity of the alcoholic extract from Indigofera tinctoria as well as its three other components, that is, chloroform, butanol and aqueous fractions in dyslipidemic hamsters that were fed a high fat diet. The chloroform fraction showed a significant decrease in the plasma triglycerides (TG, 52%) (P < 0.001), total cholesterol (TC, 29%) (P < 0.05), glycerol (Gly, 24%) and free fatty acids (FFA, 14%). This decrease was also accompanied by an increase in high density lipoproteins (HDL) by 9% and an increased HDL-C/TC ratio of 52% at the dose of 250 mg/kg of body weight.","PeriodicalId":73776,"journal":{"name":"Journal of herbal pharmacotherapy","volume":"7 1","pages":"57 - 64"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/J157v07n01_05","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"60735335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D P Singh, S Maurya, S P Singh, Mandavi Singh, U P Singh
{"title":"Chemotaxonomic variability in Zizyphus mouritiana varieties and its pharmacological properties in relation to human health.","authors":"D P Singh, S Maurya, S P Singh, Mandavi Singh, U P Singh","doi":"10.1080/15228940802152968","DOIUrl":"https://doi.org/10.1080/15228940802152968","url":null,"abstract":"<p><p>Twenty varieties of ber (Zizyphus mouritiana), namely umaran, katha, bilayati, kaithli, ZG-3, gola, safeda rohtak, takadi, tikari, banarasi karaka, seo, sonaur-2, sonaur-3, ilaichi, mundia murahra, pathan, kakrola gola, seb, golden yellow and chhuhara, were investigated for the presence of phenolic acids in stem bark, leaves and fruits using high performance liquid chromatograph. Results indicated the presence of tannic (retention time (Rt.) 2.76 min), gallic (Rt. 2.86 min), caffeic (Rt. 3.12 min), vanillic (Rt. 3.26 min), ferulic (Rt. 3.42 min), chlorogenic (Rt. 4.16 min) and cinnamic acids (Rt. 4.45 min) in varying amounts in different parts in of these varieties. In fruits of seven varieties, namely, kaithly, sonaur-2, sonaur-3, mundia murahra, pathan, golden yellow and chhuhara, oxalic acid (Rt. 3.00 min) was also detected. Pharmacological properties of phenolic acids of fruits in relation to human health and the possible implications of different phenolic acids in chemotaxonomy of different varieties of ber are discussed.</p>","PeriodicalId":73776,"journal":{"name":"Journal of herbal pharmacotherapy","volume":"7 3-4","pages":"229-37"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/15228940802152968","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27797665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Catherine Ulbricht, Jennifer Armstrong, Ethan Basch, Samuel Basch, Steve Bent, Cynthia Dacey, Sean Dalton, Ivo Foppa, Nicole Giese, Paul Hammerness, Catherine Kirkwood, David Sollars, Shaina Tanguay-Colucci, Wendy Weissner
{"title":"An evidence-based systematic review of Aloe vera by the natural standard research collaboration.","authors":"Catherine Ulbricht, Jennifer Armstrong, Ethan Basch, Samuel Basch, Steve Bent, Cynthia Dacey, Sean Dalton, Ivo Foppa, Nicole Giese, Paul Hammerness, Catherine Kirkwood, David Sollars, Shaina Tanguay-Colucci, Wendy Weissner","doi":"10.1080/15228940802153339","DOIUrl":"https://doi.org/10.1080/15228940802153339","url":null,"abstract":"<p><p>An evidence-based systematic review including written and statistical analysis of scientific literature, expert opinion, folkloric precedent, history, pharmacology, kinetics/dynamics, interactions, adverse effects, toxicology, and dosing.</p>","PeriodicalId":73776,"journal":{"name":"Journal of herbal pharmacotherapy","volume":"7 3-4","pages":"279-323"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/15228940802153339","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27797669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
David Keifer, Catherine Ulbricht, Tracee Rae Abrams, Ethan Basch, Nicole Giese, Mary Giles, Catherine DeFranco Kirkwood, Michelle Miranda, Jen Woods
{"title":"Peppermint (Mentha piperita): an evidence-based systematic review by the Natural Standard Research Collaboration.","authors":"David Keifer, Catherine Ulbricht, Tracee Rae Abrams, Ethan Basch, Nicole Giese, Mary Giles, Catherine DeFranco Kirkwood, Michelle Miranda, Jen Woods","doi":"10.1300/j157v07n02_07","DOIUrl":"https://doi.org/10.1300/j157v07n02_07","url":null,"abstract":"<p><p>An evidence-based systematic review including written and statistical analysis of scientific literature, expert opinion, folkloric precedent, history, pharmacology, kinetics/dynamics, interactions, adverse effects, toxicology and dosing.</p>","PeriodicalId":73776,"journal":{"name":"Journal of herbal pharmacotherapy","volume":"7 2","pages":"91-143"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27274027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Echinacea: an effective alternative to antibiotics.","authors":"Michael Tierra","doi":"10.1300/j157v07n02_06","DOIUrl":"https://doi.org/10.1300/j157v07n02_06","url":null,"abstract":"<p><p>Echinacea is one of the most popular herbs in modern Europe and United States marketplaces. Unfortunately, most of the Echinacea consumed is misused, based on its misrepresentation as an effective cold and flu remedy. Throughout the later part of the nineteenth century and the first thirty years of the twentieth century, Echinacea was the preferred treatment for infections. The introduction of antibiotics resulted in the eclipse of Echinacea, along with the professional medical doctors, known as the \"Eclectics,\" who based their treatment on the use of herbs.</p>","PeriodicalId":73776,"journal":{"name":"Journal of herbal pharmacotherapy","volume":"7 2","pages":"79-89"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27274026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}