Advances in protein chemistry and structural biology最新文献_第7页

Tau-Cytoskeleton and their interaction with other neurodegenerative proteins. tau细胞骨架及其与其他神经退行性蛋白的相互作用。

3区生物学

Advances in protein chemistry and structural biology Pub Date : 2026-01-01 Epub Date: 2025-11-20 DOI: 10.1016/bs.apcsb.2025.10.032

Surajita Sahu, Nagaraj Rangappa, Subashchandrabose Chinnathambi, Monalisa Mishra

{"title":"Tau-Cytoskeleton and their interaction with other neurodegenerative proteins.","authors":"Surajita Sahu, Nagaraj Rangappa, Subashchandrabose Chinnathambi, Monalisa Mishra","doi":"10.1016/bs.apcsb.2025.10.032","DOIUrl":"10.1016/bs.apcsb.2025.10.032","url":null,"abstract":"A wide range of neurological conditions known as Tauopathies are distinguished by a peculiar accumulation of Tau protein and its effect on the central nervous system (CNS) and beyond. In Tauopathies, Tau aggregation has a primary role in the neurodegenerative process. Clinically, individuals exhibit various symptoms, such as cognitive or behavioural anomalies, mobility issues, memory loss, and language problems. The major Tau isoforms (3R, 4R, or an equal 3R:4R ratio) identified in the inclusion bodies of the brain are used to classify Tauopathies pathologically. We address various Tauopathies, differentiating between primary and secondary forms, the involvement of Tau isoforms, the affected brain areas, and the corresponding neuropathological features. This review emphasizes the pathological and physiological role of Tau protein, providing a comprehensive analysis of the molecular processes enabling Tau aggregation and its subsequent effect on neuronal structure and function. Additionally, the review highlights the complex interactions that exist between Tau and other neurodegenerative proteins, including amyloid-beta in Alzheimer's disease, alpha-synuclein in Parkinson's disease, huntingtin protein in Huntington's disease, and how these relationships worsen Tau pathology and advance neurodegeneration. The organ-specific impact of Tauopathy, including the brain and other peripheral organs, has been discussed. The significance of these findings for future treatment techniques aiming at addressing Tau disease and mitigating its organ-specific repercussions.","PeriodicalId":7376,"journal":{"name":"Advances in protein chemistry and structural biology","volume":"150 ","pages":"489-517"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147571845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cytoskeletal disintegration in cardiovascular disease-related neurodegeneration. 心血管疾病相关神经退行性变中的细胞骨架解体。

3区生物学

Advances in protein chemistry and structural biology Pub Date : 2026-01-01 Epub Date: 2025-11-19 DOI: 10.1016/bs.apcsb.2025.10.030

Erdem Atasever, Tamer Cebe, Şeydanur Turgut, Gülnur Andican, Ufuk Çakatay

{"title":"Cytoskeletal disintegration in cardiovascular disease-related neurodegeneration.","authors":"Erdem Atasever, Tamer Cebe, Şeydanur Turgut, Gülnur Andican, Ufuk Çakatay","doi":"10.1016/bs.apcsb.2025.10.030","DOIUrl":"10.1016/bs.apcsb.2025.10.030","url":null,"abstract":"Neurodegenerative diseases, such as Alzheimer's disease, vascular dementia, Parkinson's disease, frontotemporal dementia, and cognitive decline associated with stroke, have a similar clinical trait involving the alteration of microtubule dynamics and cytoskeletal integrity. The neuronal cytoskeleton is essential for facilitating axonal transport, synaptic connections, and providing structural support. In Alzheimer's disease and vascular dementia, tau protein undergoes hyperphosphorylation and dissociates from microtubules, forming insoluble aggregates that obstruct intracellular transport and destabilize microtubule structure. Additionally, region-specific posttranslational changes of tubulin are modified, further impairing cytoskeletal control. In Parkinson's disease, the aggregation of α-synuclein induces oxidative damage and directly impairs microtubule polymerization, especially in the dopaminergic neurons of the substantia nigra. Stroke induces acute ischemia and reperfusion injury, resulting in surges of reactive oxygen and nitrogen species, disruption of the blood-brain barrier, and neuroinflammatory cascades that rapidly destroy cytoskeletal proteins and alter microglial phenotypes. Cardiovascular conditions, including hypertension, heart failure, and atherosclerosis, lead to persistent cerebral hypoperfusion, which promotes progressive neuronal damage and alters tubulin expression and organization. Cardiovascular complications intensify oxidative stress and impair neurovascular coupling, establishing a detrimental cycle that accelerates cytoskeletal disintegration and neural impairment. Collectively, such conditions demonstrate a heart-brain axis in which cardiovascular problems directly lead to microtubule disintegration and dementia. Understanding these pathways provides a unified framework for cytoskeletal biomarkers and novel therapeutic approaches to preserve neuronal structure in various neurological conditions.","PeriodicalId":7376,"journal":{"name":"Advances in protein chemistry and structural biology","volume":"150 ","pages":"141-180"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147571783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Introduction to alternative proteins. 介绍替代蛋白质。

3区生物学

Advances in protein chemistry and structural biology Pub Date : 2026-01-01 Epub Date: 2026-08-25 DOI: 10.1016/bs.apcsb.2026.08.015

Harshita Shrivastava, Meenakshi Kandpal, Himanshi Jindal, Sunil Kumar, Hem Chandra Jha, Rajan Kumar Pandey

{"title":"Introduction to alternative proteins.","authors":"Harshita Shrivastava, Meenakshi Kandpal, Himanshi Jindal, Sunil Kumar, Hem Chandra Jha, Rajan Kumar Pandey","doi":"10.1016/bs.apcsb.2026.08.015","DOIUrl":"https://doi.org/10.1016/bs.apcsb.2026.08.015","url":null,"abstract":"Currently, one-third of the global grain supply is utilized as animal feed that eventually leads to global food shortage and increased food demand. A shift towards alternative proteins (APs) has several benefits which could assist in access expansion towards dietary protein and staple crop price reduction. Alternative proteins thus present a sustainable solution towards global food security. This chapter provides a comprehensive overview of alternative proteins, detailing their various types such as plant-based, microbial, insect-derived, and cultured meat proteins. It delves into the structural characteristics, functional attributes, and production technologies of these AP sources. A comparative description of the different types of APs is also presented to focus on their respective advantages, limitations, and challenges. The chapter additionally focuses on the potential health benefits associated with APs including their medicinal values and bioactive properties. The current food safety considerations surrounding APs are discussed to inform future improvements in production and regulation. The chapter concludes with an analysis of the key obstacles and opportunities for APs as a critical component of the future food supply.","PeriodicalId":7376,"journal":{"name":"Advances in protein chemistry and structural biology","volume":"154 ","pages":"1-31"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149007797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigating the immune-modulatory association of miRNAs in HPV-associated HNSCC individuals: A bioinformatics approach. 研究hpv相关HNSCC个体中mirna的免疫调节关联：生物信息学方法。

3区生物学

Advances in protein chemistry and structural biology Pub Date : 2026-01-01 Epub Date: 2026-03-31 DOI: 10.1016/bs.apcsb.2026.02.005

Ankur Datta, M Muthu Meenakshi, Susanna Daniels, B Varshaa, George Priya Doss C

{"title":"Investigating the immune-modulatory association of miRNAs in HPV-associated HNSCC individuals: A bioinformatics approach.","authors":"Ankur Datta, M Muthu Meenakshi, Susanna Daniels, B Varshaa, George Priya Doss C","doi":"10.1016/bs.apcsb.2026.02.005","DOIUrl":"10.1016/bs.apcsb.2026.02.005","url":null,"abstract":"Head and Neck Squamous Cell Carcinoma (HNSCC) diagnosis remains a challenge for clinicians, with human papillomavirus (HPV) status long associated with HNSCC prognosis and response to therapy. Small non-coding molecules, such as microRNAs (miRNAs), significantly alter gene expression, particularly of immune-modulatory genes. In the current study, an effort to map the interaction patterns between miRNAs and their target genes was carried out using diverse computational tools. A microarray-based study was retrieved and analysed using GEO2R to identify ubiquitously expressed miRNAs in HPV-associated HNSCC samples, with HPV-negative samples used as controls. Seven miRNAs were identified, namely hsa-miR-150-5p, hsa-miR-142-5p, hsa-miR-142-3p, hsa-miR-1-3p, hsa-miR-133b, hsa-miR-206, and hsa-miR-1260b. Functional annotation using miRNet identified numerous significant signalling pathways dysregulated by the aforementioned miRNAs. miRDB was used to map miRNA target genes, which were visualised in Cytoscape; among these, key immune-modulatory genes were analysed in a comprehensive meta-analysis. Furthermore, the GEPIA2 tool was used to perform survival analysis and generate Kaplan-Meier plots correlating survival percentages in HNSCC patients with gene expression patterns. The viral infectious cycle was dysregulated by miR-1260b expression. DKK1, STC2, SPOCK1, and TP53 were among the genes whose aberrant expression was associated with a significant reduction in survival in HNSCC-affected individuals. This report elucidates the pivotal role of miRNAs in modulating the expression of key immune-modulatory genes, thereby influencing the prognosis of HNSCC and HPV infection.","PeriodicalId":7376,"journal":{"name":"Advances in protein chemistry and structural biology","volume":"152 ","pages":"55-76"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148004435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuroinflammation- molecular target based therapeutic approach. 神经炎症-基于分子靶标的治疗方法。

3区生物学

Advances in protein chemistry and structural biology Pub Date : 2026-01-01 Epub Date: 2026-05-20 DOI: 10.1016/bs.apcsb.2026.04.006

Deepraj Paul

{"title":"Neuroinflammation- molecular target based therapeutic approach.","authors":"Deepraj Paul","doi":"10.1016/bs.apcsb.2026.04.006","DOIUrl":"https://doi.org/10.1016/bs.apcsb.2026.04.006","url":null,"abstract":"Chronic neuroinflammation has become a major concern due to its ability to propagate into multiple neurodegenerative disorders which severely reduce the life expectancy of the patients. Many molecular targets have been identified which include amyloid beta (Aβ) peptides and oligomers, protofibrils, tau proteins, MID1/ TRIM18, Beclin1 protein, Puma, NMDA receptors, RyanR2, 5-HT2B, α7nAChR, TLR4, ERRα, CysLT(1)R, PDGFβR, DRD1, β2-AR, caspases, calpain, cytochrome c, CDK5, p38-MAPK, BACE1, γ-secretase, 5-lipoxygenase, NADPH oxidase 2 and 4, JNK, MMPs, NLRP3, GSAP, PARP-1, PARG, TRPM2, H2O2, NO (excess), LTB4, LTD4, NF-κB (NF-kBp50/RelA dimers and NF-κB p65), TNF-α,IL-1β, IL-6, IL-10, ApoE2, ApoE4, Bax,Bcl-2, miR-9, miR-29, miR-29a/b-1, miR-101, miR-124, miR-107, miR-298, miR-149, miR-328, miR-34a-5p, miR-15b, miR-16, miR-125b-5p, miR-124, and miR-374b-5p, miR-181c-5p, linc00507, LncRNA 51A, LncRNA 17A, LncRNA BC200, LncRNA NDM29, LncRNA NEAT1, LncRNA EBF3-AS, LncRNA NAT-Rad18, LcRNA TUG1, LncRNA MALAT1, LncRNA WT1-AS, LncRNA MAGI2-AS3, XBP-1, SERCA, Na+/Ca2+exchanger, plasma-membrane Ca2+-ATPase, HSP27, mtHSP60/HSPD1-mtHSP10/HSPE1, HSPD1, HSPE1, HSP70, Hsp90, Sirt1, Sirt3, TIMP-123 (composite of TIMP-1, TIMP-2, and TIMP-3), TIMP-4, AChEI, BDNF. Identification of the molecular targets enabled the identification of phytoconstituents which could modulate majority of these molecular targets. A herbal formulation which is expected to alleviate neuroinflammation includes many phytoconstituents such as curcumin, (-)-epigallocatechin-3-gallate, baicalein, baicalin, resveratrol, cis-resveratrol, berberine, quercetin, apigenin, corosolic acid, ursolic acid, oleanolic acid, luteolin, albigenin, withanolide A, celastrol, gallotannin, nobotanin B, kaempferol, naringenin, rutin, withaferin A, crocetin, katsumain H, geranylgeranylacetone and huperzine. A compatibility study with different phytoconstituents will determine the suitability of the formulation.","PeriodicalId":7376,"journal":{"name":"Advances in protein chemistry and structural biology","volume":"153 ","pages":"211-284"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148443816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting kinases in neurodegenerative diseases and cancer: Structural insights and therapeutic strategies. 靶向激酶在神经退行性疾病和癌症：结构见解和治疗策略。

3区生物学

Advances in protein chemistry and structural biology Pub Date : 2026-01-01 Epub Date: 2026-05-08 DOI: 10.1016/bs.apcsb.2026.04.008

Anas Shamsi, Saleha Anwar, Khuzin Dinislam

{"title":"Targeting kinases in neurodegenerative diseases and cancer: Structural insights and therapeutic strategies.","authors":"Anas Shamsi, Saleha Anwar, Khuzin Dinislam","doi":"10.1016/bs.apcsb.2026.04.008","DOIUrl":"https://doi.org/10.1016/bs.apcsb.2026.04.008","url":null,"abstract":"Protein kinases play a key role in cellular signalling and are key drivers of neoplasia. In comparison, their role in neurodegenerative diseases used to be considered as secondary or downstream effects of neuronal damage. A growing body of data based on genetics, biochemistry, structural biology, and systems-level analysis has completely changed this view and placed kinase dysregulation as a common and unifying pathogenic pathway throughout cancer and neurodegeneration. The current chapter summarizes the recent progress that places kinases in a context-dependent state of molecular switches with disease-specific outcomes determined by structural conformation, spatiotemporal regulation, and network integration as opposed to kinase identity. The structural insights of high-resolution have changed the classical models that were based on pathways into models based on conformation and have shown that pathological kinase signalling is often caused by stabilisation of individual states of activity or regulation. These structural concepts describe the efficacy and drawbacks of first-generation ATP-competitive inhibitors, thereby leading to the development of allosteric, covalent, multi-target, and network-directed therapeutic approaches. The chapter also contrasts oncogenic kinase activation with oncogenic kinase dysfunction in post-mitotic neurons to demonstrate how the same signalling modules can be used to drive cell proliferation, cell survival, or cell degeneration depending on cellular context and microenvironment. The chapter also applies the knowledge in oncology, including mechanisms of resistance, adaptive signalling rewiring, and precision medicine, to neurodegenerative studies, but highlights the need for disease-specific adaptation due to the susceptibility and longevity of neurons.","PeriodicalId":7376,"journal":{"name":"Advances in protein chemistry and structural biology","volume":"153 ","pages":"95-134"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148443848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deciphering antimicrobial peptide (AMP) resistance mechanisms in Enterococcus faecalis through integrated RNA-Seq and hub genes identification. 通过整合RNA-Seq和枢纽基因鉴定解读粪肠球菌抗菌肽（AMP）耐药机制。

3区生物学

Advances in protein chemistry and structural biology Pub Date : 2026-01-01 Epub Date: 2025-05-30 DOI: 10.1016/bs.apcsb.2024.11.014

J Deepika, Aishwarya C Shetty, DhanushKumar T, Karthick Vasudevan

{"title":"Deciphering antimicrobial peptide (AMP) resistance mechanisms in Enterococcus faecalis through integrated RNA-Seq and hub genes identification.","authors":"J Deepika, Aishwarya C Shetty, DhanushKumar T, Karthick Vasudevan","doi":"10.1016/bs.apcsb.2024.11.014","DOIUrl":"10.1016/bs.apcsb.2024.11.014","url":null,"abstract":"Antimicrobial resistance (AMR) remains a critical global health threat, necessitating innovative approaches to combat drug-resistant bacteria. This study investigates the genetic basis of resistance in Enterococcus faecalis, a Gram-positive bacterium, in response to the antibiotic Teixobactin, with potential importance on the development of antimicrobial peptides (AMPs). Leveraging whole transcriptome RNA-Seq analysis and advanced bioinformatics tools, we identified ten central hub genes: guaA, guaB, lepA, der, secA, ftsH, obg, nusG, dnaA, and ffh. These genes demonstrate significant upregulation and robust interactions within the bacterial genome. Our comprehensive analysis reveals the involvement of these genes in crucial cellular functions linked to AMP resistance, including purine metabolism, protein export, stress response, transcriptional regulation, and ribosomal activities. These findings provide vital insights into the complex molecular mechanisms underlying Enterococcus faecalis' resistance to AMPs, these genes reflect an adaptive response to antibiotic exposure, which is critical for understanding the overall resistance mechanisms in E. faecalis. As the global battle against AMR intensifies, the identified hub genes present promising opportunities for the discovery of novel antibiotics, reinforcing efforts to combat drug-resistant bacterial infections.","PeriodicalId":7376,"journal":{"name":"Advances in protein chemistry and structural biology","volume":"149 ","pages":"353-374"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146045821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Processing and structural modifications of insect proteins for alternative proteins. 昆虫蛋白的加工与结构修饰。

3区生物学

Advances in protein chemistry and structural biology Pub Date : 2026-01-01 Epub Date: 2026-09-03 DOI: 10.1016/bs.apcsb.2026.08.020

Chiranjiv Pradhan

{"title":"Processing and structural modifications of insect proteins for alternative proteins.","authors":"Chiranjiv Pradhan","doi":"10.1016/bs.apcsb.2026.08.020","DOIUrl":"https://doi.org/10.1016/bs.apcsb.2026.08.020","url":null,"abstract":"The rapid growth of global population is intensifying the demand for higher protein production. To satisfy the protein demand edible insects are emerging as a promising alternative protein source. Insect proteins exhibit high nutritional quality, favorable amino acid profiles, and significant functional versatility. However, their incorporation in the food requires a lot of processing to break it in to powder or other forms such as protein concentrate and isolate. The processing often applies thermal and non-thermal treatments which bring many structural modifications and alters the secondary, tertiary or quaternary structure and exposes the different amino acids. The structural modification of protein influences the techno-functional characteristics of the proteins in terms of solubility, emulsion, water holding capacity, oil holding capacity, foaming and gelation and bioavailability. This chapter also discusses nutritional and safety implications, including allergenicity and antinutritional factors. Finally, key challenges, knowledge gaps, and future research directions related to structure-function relationships, process standardization, and consumer acceptance are highlighted. Overall, this chapter highlights the effect of controlled protein structural modification on utilization efficiency of insect proteins as functional ingredients in sustainable food systems.","PeriodicalId":7376,"journal":{"name":"Advances in protein chemistry and structural biology","volume":"154 ","pages":"525-565"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149007588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The science of alternative proteins: Comparing animal and plant-based sources. 替代蛋白质的科学：比较动物和植物来源。

3区生物学

Advances in protein chemistry and structural biology Pub Date : 2026-01-01 Epub Date: 2026-08-25 DOI: 10.1016/bs.apcsb.2026.08.009

Ashokkumar Sibiya

{"title":"The science of alternative proteins: Comparing animal and plant-based sources.","authors":"Ashokkumar Sibiya","doi":"10.1016/bs.apcsb.2026.08.009","DOIUrl":"https://doi.org/10.1016/bs.apcsb.2026.08.009","url":null,"abstract":"The very basic concepts of components regarding dietary food upholds providing reinforcement to the cells, tissues, organs for physiological activities. Each dietary food type gives unique nutrition, strength and serves chemical compound required for the organism to perform any different function such as metabolism (catabolism and anabolism), growth, development and senescence. Protein is one of the dietary foods among dietary food types i.e. carbohydrates, lipids, fats and essential oil. Plant proteins consumption rate are very less when compared to the consumption of animal protein as food. Now a days, plant protein researches are undergoing, with the advancements especially high throughput extrusion technology with pharmacy analysis. Based on the structure and composition variation in plant and animal based dietary, their digestion and absorption rate differ significantly. Meanwhile, the functional uniqueness of the both protein basis is astounding to the biological world. A Plant protein can't be replaced by animal protein and vice versa. This article review confers the evolution of dietary proteins derived from the plant and animal as existing applications to the large-scale sustainable production in significance with the biotechnology advancements.","PeriodicalId":7376,"journal":{"name":"Advances in protein chemistry and structural biology","volume":"154 ","pages":"73-92"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149007650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alternative proteins: Structure and functional properties. 替代蛋白：结构和功能特性。

3区生物学

Advances in protein chemistry and structural biology Pub Date : 2026-01-01 Epub Date: 2026-09-18 DOI: 10.1016/bs.apcsb.2026.08.005

Saranya Nallusamy, Sathyaseelan Chakkarai, Caroline Ravikumar

{"title":"Alternative proteins: Structure and functional properties.","authors":"Saranya Nallusamy, Sathyaseelan Chakkarai, Caroline Ravikumar","doi":"10.1016/bs.apcsb.2026.08.005","DOIUrl":"https://doi.org/10.1016/bs.apcsb.2026.08.005","url":null,"abstract":"The speedy growth of population and continued deterioration of the environment put the world under not completely relying on conventional protein sources. The study of alternative proteins has emerged as a transformative avenue in addressing the growing demand for sustainable food sources amidst environmental, economic, and health challenges. Thus, it has remained the focus of many academics and the industry for research into the possibility of using plants, algae, fungi, and insect-based proteins, which may be more viable, inexpensive, and friendly to the environment. The glycinin, beta-conglycinin, legumin, albumins, glutenins, globulins, and oryzenin from plant sources, phycobiliproteins, phycoerythrin and rubisco from algae sources, mycoprotein from fungi sources, and, vitellogenin and troponins from insect sources are some of the alternative proteins that are shown to have nutritional values. Most of these sources also possess high protein content and overall good amino acid composition; they are, therefore, rated as nutritious and healthy protein sources. These alternative novel proteins though superior in nutritional aspects, are at a preliminary stage on various aspects of research about structure and their function, especially insect algae, bacteria, and fungi proteins. The investigation into their molecular architecture and physicochemical interactions will reveal their function in a variety of food systems. Exploring the protein solubility, emulsification, gelation, and foaming properties will influence their application in the formulation of novel food products. Thus, this book chapter will provide a comprehensive overview of the structural and functional properties of various alternative proteins.","PeriodicalId":7376,"journal":{"name":"Advances in protein chemistry and structural biology","volume":"154 ","pages":"331-355"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149007824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0