Medicinal chemistry-based novel herapeutics for Tauopathies in Alzheimer's disease.

Abstract

Research on the Alzheimer's disease (AD) has been going on for over 100 years, but there is yet to be found an effective cure that has passed all the clinical trials. However, many compounds have been explored for their effects on AD patients, compounds that could help ease the disease symptoms or help slow down the disease progression or reverse the effects of the disease. Small molecules like toluidine blue and melatonin are seen to be useful against AD. Natural compounds were seen to have an exceptional potential as therapeutics for AD. Highly branched polymers, dendrimers were also seen to be effective Tau and AD therapeutics as drug-delivery systems and on their own. Metal complexes and metal nanoparticles also showed success against AD. Synthesis of a bifunctional compound that was an effective chelating agent for Cu, useful against Tau and Amyloid-β (Aβ) and was catalysed by excess Cu metal present in association with Aβ was also done. It is necessary to take forward the effective therapeutics to further levels of clinical trials.