Journal of hazardous materials advances最新文献

{"title":"A review of current trends, challenges, and future perspectives in machine learning applications to water resources in Nepal","authors":"Shishir Chaulagain ,&nbsp;Manoj Lamichhane ,&nbsp;Urusha Chaulagain","doi":"10.1016/j.hazadv.2025.100678","DOIUrl":"10.1016/j.hazadv.2025.100678","url":null,"abstract":"<div><div>Nepal faces frequent hazards like floods, droughts, sedimentation, glacial melting, and landslides that threaten lives and infrastructure, making effective risk assessment and sustainable management essential. Recently machine learning (ML) approaches have gained popularity worldwide in the water resources sector as it can capture complex relationship between predictors and predictand variables. We reviewed 34 papers published from 2010 to 2025 to identify the current status, challenges and future perspectives in the applications of ML in flood forecasting, streamflow prediction, water quality assessment, groundwater mapping, and landslide susceptibility. The review indicates that the application of ML in water resources in Nepal is on increasing trends. Our study shows that both classical ML and deep learning models consistently achieve higher accuracy than traditional empirical and processed based models. In addition, deep learning and hybrid models outperformed classical ML models in solving water resources problems. Key challenges include sparse observed data, limited computational resources, and insufficient local expertise to train and validate the ML models. Future research should focus on hybrid models and transfer learning to further enhance prediction accuracy and support sustainable water management in Nepal. By providing insights into the current status and future opportunities of ML applications in water resources, this study serves as a valuable resource for novice researchers and practitioners aiming to contribute to this evolving field.</div></div>","PeriodicalId":73763,"journal":{"name":"Journal of hazardous materials advances","volume":"18 ","pages":"Article 100678"},"PeriodicalIF":5.4,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143642605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining the impact of different scales on COVID-19 monitoring in sewerage catchment areas: Insights from Latvia","authors":"Brigita Dejus ,&nbsp;Dita Gudra ,&nbsp;Sandis Dejus ,&nbsp;Roberts Ozols ,&nbsp;Juris Laicans ,&nbsp;Martins Strods ,&nbsp;Davids Fridmanis ,&nbsp;Maija Ustinova ,&nbsp;Ance Roga ,&nbsp;Janis Grabis ,&nbsp;Vineta Minkevica ,&nbsp;Talis Juhna","doi":"10.1016/j.hazadv.2025.100676","DOIUrl":"10.1016/j.hazadv.2025.100676","url":null,"abstract":"<div><div>The spread and transmission of coronavirus, SARS-CoV-2, have become a significant global concern. As the SARS-CoV-2 virus can be released into the environment through various human excretions, it provides a possibility for early detection and identification within a population through the use of wastewater-based epidemiology (WBE). With the rapid progress in the application of WBE during the COVID-19 pandemic, researchers have been able to provide evidence of SARS-CoV-2 shedding in wastewater and aid in decision-making for public health measures. However, there is a lack of research on potential trends and correlations between different levels of wastewater sample analysis, from building-level to municipality-level. Therefore, this study aims to fill this gap and also explore the use of metagenomic analysis in addition to the amount of viral RNA concentration in wastewater samples for COVID-19 monitoring at different levels. Results from monitoring indicated consistent patterns of COVID-19 and variants at the building, community, and municipality levels. However, there was a statistical difference in transmission dynamics at the building level during the spring season, possibly due to localized factors. Thus, the comparison of monitoring data from COVID-19 across different sewage catchment areas plays a crucial role in understanding the geographical spread of COVID-19. Metagenome analysis revealed a predominance of gut-associated microbes in wastewater, but no significant seasonal variations were observed. Further research is necessary to fully understand the relationship between changes in the gut microbiome and the distribution of COVID-19.</div></div>","PeriodicalId":73763,"journal":{"name":"Journal of hazardous materials advances","volume":"18 ","pages":"Article 100676"},"PeriodicalIF":5.4,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143594128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A collagen-hydrolyzing halotolerant protease for enhanced dye decolorization and toxicity reduction in high-salinity textile tannery wastewater","authors":"Shohreh Ariaeenejad,&nbsp;Seyedeh Fatemeh Sadeghian Motahar","doi":"10.1016/j.hazadv.2025.100669","DOIUrl":"10.1016/j.hazadv.2025.100669","url":null,"abstract":"<div><div>In this study, PersiProtease1, a halotolerant alkaline protease, was derived from tannery metagenome and used to hydrolyze collagen in textile tannery wastewater. Beyond its primary role, PersiProtease1 also demonstrated significant potential for the decolorization of azo, anthraquinone, and triphenylmethane dyes. PersiProtease1 was tested under various environmental conditions, showing a superior dye removal efficiency of 52–89 % under 200 g/L salinity within 60 min, following second-order kinetics, is significantly higher than that of other reported proteases that typically achieve below 60 % efficiency under similar conditions. Additionally, compared to other proteases reported in high-salinity environments, PersiProtease1 exhibited a degree of hydrolysis (DH) of 43.08 %, surpassing the typical DH values of &lt;30 % reported in previous studies for similar conditions, for collagen degradation in a 5 mg/mL solution of textile tannery wastewater after 120 min. In addition to its collagen-degrading capabilities, protease achieved 80 % decolorization in textile tannery wastewater containing a mixture of dyes at 250 ppm, outperforming enzymes such as laccases, which typically achieve approximately 60 % decolorization under similar conditions. The enzyme was also capable of decolorizing high concentrations (500 ppm) of azo, anthraquinone, and triphenylmethane dyes, achieving &gt; 85 % efficiency within 60 min. Phytotoxicity and microbial toxicity tests were also conducted to evaluate the detoxification efficacy of PersiProtease1. These findings demonstrated reduced dye toxicity through increased plant germination rates and enhanced bacterial growth rates, indicating the potential of the enzyme to mitigate the harmful effects of dyes by promoting both plant and microbial growth. These results demonstrate PersiProtease1′s versatility as a biocatalyst for the treatment of high-salinity textile and tannery wastewater, making it an effective tool for pollution control and sustainable waste management.</div></div>","PeriodicalId":73763,"journal":{"name":"Journal of hazardous materials advances","volume":"18 ","pages":"Article 100669"},"PeriodicalIF":5.4,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143600570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study of the toxicity of Fe3O4 nanoparticles on Pacific white leg shrimp (Litopenaeus vannamei) and the antibacterial efficacy against Vibrio harveyi","authors":"Suharyadi ,&nbsp;Uun Yanuhar ,&nbsp;Maheno Sri Widodo ,&nbsp;Abdul Rahem Faqih ,&nbsp;Heru Suryanto ,&nbsp;Nico Rahman Caesar","doi":"10.1016/j.hazadv.2025.100674","DOIUrl":"10.1016/j.hazadv.2025.100674","url":null,"abstract":"<div><div>Nanotechnology has rapidly developed in various fields. The unique, specific, and very small dimensions of nanoparticles have many functions in technical and biological advancements, such as drug delivery and antibacterial applications. This study investigates the potential antibacterial properties of chitosan-stabilized Fe₃O₄ nanoparticles (Fe₃O₄ NPs) to inhibit the growth of <em>Vibrio harveyi</em> bacteria and evaluates their toxicity towards white leg shrimp (<em>Litopenaeus vannamei</em>). The characterization results of the Fe₃O₄ NPs synthesis show an average crystallite size of 21.41 nm. The antibacterial activity of chitosan-capped Fe₃O₄ NPs colloidal (Cs/Fe₃O₄ NPs) was found at a chitosan concentration of 15,000 mg/L, with an inhibition zone against V<em>. harveyi</em> of 6.12 ± 0.02 mm, and Fe₃O₄ NPs colloidal without chitosan capping at 6.17 ± 0.01 mm. Both treatments showed significantly greater antibacterial activity (<em>P</em> &lt; 0.05, <em>n</em> = 3) compared to the treatment with Fe₃O₄ NPs colloid capped with chitosan at 5,000 and 10,000 mg/L. The toxicity test was conducted on white leg shrimp at 48 h and 96 h of exposure, with the highest mortality occurring at a concentration of 125 mg/L, resulting in 5 % mortality (<em>P</em> &gt; 0.05) with an LC₅₀ value of 338.84 mg/L. Fe₃O₄ NPs have the potential to be developed as therapeutic agents or as bacterial growth inhibitors in the field of aquaculture by coating feed as a supplement (nano feed) due to their antibacterial properties and low toxicity levels towards cultured organisms.</div></div>","PeriodicalId":73763,"journal":{"name":"Journal of hazardous materials advances","volume":"18 ","pages":"Article 100674"},"PeriodicalIF":5.4,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143579274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of adsorption and ozonation as quaternary treatment of WWTP effluent for the removal of contaminants of emerging concern: Results from laboratory scale experiments","authors":"Agostina Chiavola ,&nbsp;Camilla Di Marcantonio ,&nbsp;Andrea Noè Porretti ,&nbsp;Sara Scagnetti ,&nbsp;Veronica Ciuchi ,&nbsp;Maria Rosaria Boni ,&nbsp;Sacha Micoli ,&nbsp;Marco Lazzazzara ,&nbsp;Simone Leoni ,&nbsp;Alessandro Frugis ,&nbsp;Valentina Gioia","doi":"10.1016/j.hazadv.2025.100665","DOIUrl":"10.1016/j.hazadv.2025.100665","url":null,"abstract":"<div><div>European legislation introduces the need for quaternary treatment processes to reduce the risk associated with residual concentrations of Contaminants of Emerging Concern (CECs) present in the final effluent of Wastewater Treatment Plants. Among the various processes evaluated for this purpose, adsorption and ozonation have demonstrated the highest removal efficiencies. This study investigated the efficiency of these processes at laboratory scale, targeting four representative CECs commonly detected in wastewater: Carbamazepine (CBZ, antiepileptic), Sulfamethoxazole (SMX, antibiotic), 1H-Benzotriazole (BTR) and 5-Methyl-1H-Benzotriazole (MBTR) (corrosion inhibitors). Experiments were conducted under different operating conditions and treatment configurations. Overall, ozonation efficiently removed all the target CECs. CBZ and SMX exhibited similar reduction trends, achieving 90% removal within the first 5 min of treatment and complete removal after 15 min, at typical ozone dosages. MBTR was also effectively degraded but at a slower rate: the complete removal was observed only after 30 min. BTR required 60 min to reach a 50% concentration reduction. The removal patterns of these CECs in the mixture closely resembled those observed in the tests where they were present alone; only MBTR degradation rate decreased appreciably. Adsorption experiments, both in batch and continuous flow applications, revealed an inverse removal affinity: BTR&gt;MBTR&gt;&gt;CBZ&gt;SMX. The Freundlich isotherm model always provided the best fitting of the batch experimental data. The Freundlich constant, K_F, for benzotriazole compounds was significantly higher than for pharmaceuticals: 74.13 for BTR, 97.09 for MBTR, 18.90 for CBZ and 18.65 for SMX.</div><div>This study provides valuable insights into the comparative performance of ozonation and adsorption for CECs removal, offering critical data to support decision-making in the upgrading of wastewater treatment plants.</div></div>","PeriodicalId":73763,"journal":{"name":"Journal of hazardous materials advances","volume":"18 ","pages":"Article 100665"},"PeriodicalIF":5.4,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143579272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Generational impact of exposure to volatile organic compounds from automobile paint spray on reproductive hormonal response in Wistar rats from parents to their filial generation (f1)","authors":"Ogbodo John Onyebuchi ,&nbsp;Onwurah Ikechukwu Emmanuel ,&nbsp;Njoku Obioma Uzoma ,&nbsp;Egba Simeon Ikechukwu","doi":"10.1016/j.hazadv.2025.100675","DOIUrl":"10.1016/j.hazadv.2025.100675","url":null,"abstract":"<div><div>This study evaluated the composition of volatile organic compounds (VOCs) in a branded automobile spray paint and their possible toxic effects, using albino rats as an experimental model. A total of 60 albino rats comprising both males and females were used for this study. This work was divided into two phases. They were exposed to these inhalants for 8 weeks and 15 min daily using an automated inhalation exposure chamber. An automated digital air quality sampler was used to determine the actual dose of the VOCs in each exposure chamber, while Gas Chromatography Mass Spectrometry (GCMS) was used to analyze the composition of VOCs content in the exposed paint solution. Hormonal assay was carried out using standard Enzyme-linked immunosorbent assay (ELISA) protocol. The GCMS analysis of the exposed paint solution used for this study showed xylene (21.98 %), toluene (17.35 %), ethanol (34.61 %) and different isomers of benzenes (26.06 %) at different concentration peaks. There was a significant (<em>p</em> &lt; 0.05) increase in total air quality across the groups: G2 (686.00 ± 460.48), G3 (692.66 ± 411.47), G4 (790.00 ± 497.97), G5 (805.66 ± 507.53) compared to the control (805.66 ± 507.53). There were significant (<em>p</em> &lt; 0.05) decreases in the concentrations of progesterone (PRO), luteinizing hormone (LH), follicle-stimulating hormone (FSH), estrogen (E2) and testosterone (TET) both in stock parent and F1 of the exposed experimental rats especially group 1 when compared to the control (<em>p</em> &lt; 0.05). This work has demonstrated that these organic compounds have adverse effects on the reproductive system of exposed rats and can also be transferred to the F1 (offspring) of the exposed experimental rats.</div></div>","PeriodicalId":73763,"journal":{"name":"Journal of hazardous materials advances","volume":"18 ","pages":"Article 100675"},"PeriodicalIF":5.4,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143562252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sustainable treatment of oil produced water using novel methods – A review","authors":"Fathi Al Jabri ,&nbsp;L. Muruganandam ,&nbsp;Natarajan Rajamohan","doi":"10.1016/j.hazadv.2025.100658","DOIUrl":"10.1016/j.hazadv.2025.100658","url":null,"abstract":"<div><div>Oil Produced water (OPW) is a highly undesirable discharge from oil exploration and petroleum industries. The composition of produced water is highly heterogeneous, comprising distinct organic and inorganic compounds, including heavy metals and sulphate-reducing bacteria. The characteristics of the OPW depend on the age of the rigs, depth, and geochemistry. The contamination of ecosystems by produced water from oil fields poses a substantial risk to public health, highlighting the urgent need for innovative treatment strategies to clean this effluent before its discharge into aquatic systems. This review explores emerging approaches for the remediation of produced water, focusing on the associated environmental hazards, advanced oxidation processes, and membrane-based removal techniques that leverage graphene aerogel composites. The exceptional properties of graphene aerogels, including their expansive surface area, hydrophobic and oleophilic nature, and proficient electron transfer capabilities significantly enhance the efficacy of produced water treatment. For example, a Polybenzimidazole polymer membrane, modified with graphene oxide and reduced graphene oxide, successfully treated 99.9 % of the produced water. Likewise, a porous graphene aerogel, synthesized through a hydrothermal method, demonstrated an impressive adsorption capacity of 223 g/g for oil and organic solvents present in the produced water.</div></div>","PeriodicalId":73763,"journal":{"name":"Journal of hazardous materials advances","volume":"18 ","pages":"Article 100658"},"PeriodicalIF":5.4,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143534831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of Black Carbon (BC) concentration distribution in relation to Lung-Deposited Surface Area (LDSA) measured in the operational drift of the underground metalliferous mine","authors":"Sergei Sabanov ,&nbsp;Jurgen Brune ,&nbsp;Liang Wang ,&nbsp;Ruslana Korshunova ,&nbsp;Abdullah R. Qureshi ,&nbsp;Nursultan Kuzembayev","doi":"10.1016/j.hazadv.2025.100672","DOIUrl":"10.1016/j.hazadv.2025.100672","url":null,"abstract":"<div><div>The assessment of air quality in underground metalliferous mines is crucial due to the high occupational exposure risks posed by diesel particulate matter (DPM) as a by-product of diesel engine emissions. This study presents the results of the analysis of black carbon (BC), as a surrogate of DPM, concentration distribution in relation to Lung-Deposited Surface Area (LDSA). The measurements were produced at the working diesel engine equipment within two sections (planes) of the mine drift, where for each plane the nine sampling points were used. Correlation factors between BC, LDSA, PMs, and airflow velocity were produced, and relationships of particle number concentration (PNC), BC, and LDSA to particle diameter were elaborated. BC at an average concentration of 2591 µg/m³ with a particle diameter of 90 nm had the worst dilution factor (0.13) within the 9 meters length between the measured points of two planes compared to LDSA (0.29) at concentration 4017 µm²/cm³ and PM₁ (0.34) at concentration 2982 µg/m³. Monte Carlo modelling analysed the concentrations distribution range of BC to PM_0.3, PM₁ and PM_2.5 considering the instruments' accuracy, and demonstrated reasonable confidence regions of BC and LDSA concentrations between each measurement point during their distribution from Plane 1 to Plane 2. Developed risk assessment produced the event tree analysis by demonstrating LDSA high exposure zones considering toxic effect timing. This study offers an integrated, spatial-temporal characterization of diesel exhaust and LDSA, thereby contributing novel insights into the dispersion of the health-relevant aerosol exposure of underground miners.</div></div>","PeriodicalId":73763,"journal":{"name":"Journal of hazardous materials advances","volume":"18 ","pages":"Article 100672"},"PeriodicalIF":5.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143551514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plastic pollution in food packaging systems: impact on human health, socioeconomic considerations and regulatory framework","authors":"Hana Najahi ,&nbsp;Mohamed Banni ,&nbsp;Mantoura Nakad ,&nbsp;Rami Abboud ,&nbsp;Jean Claude Assaf ,&nbsp;Luigi Operato ,&nbsp;Malika Belhassen ,&nbsp;Leonardo Gomes ,&nbsp;Wael Hamd","doi":"10.1016/j.hazadv.2025.100667","DOIUrl":"10.1016/j.hazadv.2025.100667","url":null,"abstract":"<div><div>Global plastic production surpasses 400 million metric tons annually. With only 9 % being recycled, 50 % directly landfilled, and an additional 20 % mismanaged, plastic waste represents a major challenge facing our planet today. The repercussions of plastic pollution are extensive, affecting the future of sustainability globally, by not only the environment and human health but also socioeconomic and sociocultural factors. This review examines the effects of macro and microplastics on various human organs and systems, including the liver, brain, stem cells, respiratory, reproductive, immune, and neurological systems. It also investigates the different routes of microplastic uptake, such as digestion, inhalation, and dermal contact. These routes highlight how microplastics with size ranges less than 3 µm can infiltrate the body, causing oxidative stress, inflammation, and cellular dysfunction as well as differentiation shift of stem cells, which may lead to chronic health conditions. Moreover, this study highlights the urgent need for implementing sustainable practices, policies, and regulations to address the health risks, economic losses, diminished quality of life, disruption of traditional practices, and impacts on cultural heritage and community well-being. By emphasizing the interconnectedness of environmental, health, and societal factors, this review highlights the urgency of adopting a comprehensive approach to mitigate the impacts of plastic pollution. Addressing this global challenge is crucial not only to safeguard public health but also to ensure the sustainability of our planet's future.</div></div>","PeriodicalId":73763,"journal":{"name":"Journal of hazardous materials advances","volume":"18 ","pages":"Article 100667"},"PeriodicalIF":5.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143579273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Naringenin reduces cadmium-induced depression and memory deficits via the remediation of neuroinflammation, glutamate excitotoxicity, and DNA fragmentation","authors":"Zehra Batool ,&nbsp;Asia Afzal ,&nbsp;Maha Shahid ,&nbsp;Zaid Abdul Razzak ,&nbsp;Shabana U Simjee ,&nbsp;Sadia Sadir ,&nbsp;Sidrah Shahzad ,&nbsp;Tuba Sharf Batool ,&nbsp;Laraib Liaquat ,&nbsp;Irfan Sajid ,&nbsp;Sarwat Yusuf ,&nbsp;Rabbia Fatima ,&nbsp;Saara Ahmad ,&nbsp;Saida Haider","doi":"10.1016/j.hazadv.2025.100671","DOIUrl":"10.1016/j.hazadv.2025.100671","url":null,"abstract":"<div><div>Cadmium (Cd) is a heavy metal with negligible biodegradability and extended biological half-life and its use is ubiquitously increased in modern-day life. Exposure to Cd affects every biological system, including the brain and nervous system. Neurotoxicity induced by Cd exposure produces major health impacts since it exerts behavioral dysfunctions that can affect daily routine life. Because of its unavoidable use, it is necessary to search the dietary components that can combat Cd-induced neurotoxicity. Naringenin is the main flavonoid found in grapefruits and oranges, and low amounts of naringenin are found in tomatoes as well. Its antioxidant and anti-inflammatory effects have been described repeatedly. It has also been reported to reduce Cd-induced renal dysfunction and testicular toxicity. This study was conducted to evaluate the mitigating effects of naringenin in animal model of Cd-induced neurotoxicity. Cd neurotoxicity was determined by behavioral analysis in terms of depressive behavior and memory function. We found that Cd toxicity exerted depression-like behavior and memory dysfunction in rats, which was attenuated by the pre-treatment of naringenin. To determine the insight of these effects of naringenin, we identified some biomarkers affiliated with the neurotoxicity. We found increased glutamate excitotoxicity, inflammation, and increased DNA fragmentation in rat brain exposed to Cd. These biomarkers were significantly attenuated by naringenin pre-treatment, which was also reflected by reduced depression-like symptoms and improved memory performance in Cd-exposed rats treated with naringenin. Here, we suggest that consumption of naringenin can be adopted to protect brain function from Cd-induced neurotoxicity.</div></div>","PeriodicalId":73763,"journal":{"name":"Journal of hazardous materials advances","volume":"18 ","pages":"Article 100671"},"PeriodicalIF":5.4,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143594135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}