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Journal of Experimental Pathology最新文献

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The antagonistic effect of interferon-beta on the interferon-gamma-induced expression of HLA-DR antigen in a squamous cell carcinoma line. 干扰素- β对干扰素- γ诱导的鳞状细胞癌HLA-DR抗原表达的拮抗作用。
Journal of Experimental Pathology Pub Date : 1992-01-01
Y Naito, T Baba, H Suzuki, K Uyeno
{"title":"The antagonistic effect of interferon-beta on the interferon-gamma-induced expression of HLA-DR antigen in a squamous cell carcinoma line.","authors":"Y Naito,&nbsp;T Baba,&nbsp;H Suzuki,&nbsp;K Uyeno","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We examined the effect of type I interferon (IFN) on IFN-gamma-induced HLA-DR antigen expression in A431 cells, a human squamous cell carcinoma line. A431 cells expressed HLA-DR antigen when stimulated with IFN-gamma, but not with IFN-beta. Simultaneous addition of IFN-gamma and IFN-beta to A431 cells resulted in significantly decreased HLA-DR antigen expression when compared to treatment with IFN-gamma alone. Kinetic studies revealed that IFN-beta was required concomitantly or prior to stimulation with IFN-gamma in order to down-regulate expression of HLA-DR antigens. IFN-alpha also inhibited IFN-gamma-induced HLA-DR antigen expression in A431 cells. Analysis of cytoplasmic mRNA showed that simultaneous treatment of A431 cells with IFN-gamma and IFN-beta resulted in a marked decrease of the level of DR alpha specific mRNA when compared to a level reached after treatment with IFN-gamma alone. These results suggest that type I IFN antagonize the IFN-gamma-induced HLA-DR antigen expression in human keratinocyte system, and that this antagonistic effect of type I IFN is confirmed as evidenced by a change in HLA-DR mRNA levels.</p>","PeriodicalId":73745,"journal":{"name":"Journal of Experimental Pathology","volume":"6 1-2","pages":"75-87"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12791849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Modulation of alpha interferon levels by AZT treatment in HIV-seropositive patients. AZT治疗对hiv血清阳性患者α干扰素水平的调节作用。
Journal of Experimental Pathology Pub Date : 1992-01-01
E Buimovici-Klein, G F McKinley, M Lange, J A Sonnabend, V Mohan, M H Grieco, L Z Cooper
{"title":"Modulation of alpha interferon levels by AZT treatment in HIV-seropositive patients.","authors":"E Buimovici-Klein,&nbsp;G F McKinley,&nbsp;M Lange,&nbsp;J A Sonnabend,&nbsp;V Mohan,&nbsp;M H Grieco,&nbsp;L Z Cooper","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The effect of AZT on serum HIV p24 antigen and endogenous serum alpha interferon levels was studied in AIDS and ARC patients. Following administration of AZT there was a rapid decline in the serum levels of both HIV p24 antigen and alpha interferon. When AZT treatment was interrupted, the levels of both HIV p24 antigen and of interferon rapidly increased. These findings suggest that HIV or some other AZT sensitive microorganism is the inducer of interferon which is characteristically found in the serum of AIDS and symptomatic HIV infected patients. They also suggest that the rapid decline in interferon levels may underlie some of the symptomatic benefit that follows administration of AZT.</p>","PeriodicalId":73745,"journal":{"name":"Journal of Experimental Pathology","volume":"6 1-2","pages":"31-9"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12791304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stimulation of IFN-alpha production in HLA-DR+, light density peripheral blood mononuclear cells by human immunodeficiency virus. 人免疫缺陷病毒对HLA-DR+、轻密度外周血单个核细胞ifn - α生成的刺激。
Journal of Experimental Pathology Pub Date : 1990-01-01
J F Toso, J J Ferbas, G Rappocciolo, J A Armstrong, M Ho, C R Rinaldo
{"title":"Stimulation of IFN-alpha production in HLA-DR+, light density peripheral blood mononuclear cells by human immunodeficiency virus.","authors":"J F Toso,&nbsp;J J Ferbas,&nbsp;G Rappocciolo,&nbsp;J A Armstrong,&nbsp;M Ho,&nbsp;C R Rinaldo","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":73745,"journal":{"name":"Journal of Experimental Pathology","volume":"5 3","pages":"123-5"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13250544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Response of rat myocardial mast cells to experimental ischemia. 大鼠心肌肥大细胞对实验性缺血的反应。
Journal of Experimental Pathology Pub Date : 1990-01-01
P G Krüger, T Ellingsen, T S Saetersdal
{"title":"Response of rat myocardial mast cells to experimental ischemia.","authors":"P G Krüger,&nbsp;T Ellingsen,&nbsp;T S Saetersdal","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The effects of ischemia on mast cells in the rat heart were studied. After 5 hours morphological signs of mediator release: granule dissolution, were observed. After 4 weeks the number of mast cells was significantly increased in comparison with nonischemic. Furthermore, 4 weeks after ischemia there was an increased number of regenerating mast cells. An increase in the number of mast cells and morphological signs of granule synthesis in the ventricular or septal muscle of the sham operated controls indicates that the surgical procedure itself can affect the mast cells of the heart generally. Morphological signs of granule synthesis were observed within mast cells of all experimental groups, and the figure was highly increased after 4 weeks of ischemia.</p>","PeriodicalId":73745,"journal":{"name":"Journal of Experimental Pathology","volume":"5 1","pages":"29-38"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13546266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
2',5'-Oligoadenylate (2-5A) binding protein (RNase L) changes in AIDS and mammalian cells/tissues. 2'，5'-寡腺苷酸(2- 5a)结合蛋白(RNase L)在艾滋病和哺乳动物细胞/组织中的变化。
Journal of Experimental Pathology Pub Date : 1990-01-01
J M Wu, C C Chang, J W Chiao, C H Wang
{"title":"2',5'-Oligoadenylate (2-5A) binding protein (RNase L) changes in AIDS and mammalian cells/tissues.","authors":"J M Wu,&nbsp;C C Chang,&nbsp;J W Chiao,&nbsp;C H Wang","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":73745,"journal":{"name":"Journal of Experimental Pathology","volume":"5 2","pages":"79-88"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13246353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interferon action on membrane-associated viruses: a minireview. 干扰素对膜相关病毒的作用综述。
Journal of Experimental Pathology Pub Date : 1990-01-01
R M Friedman
{"title":"Interferon action on membrane-associated viruses: a minireview.","authors":"R M Friedman","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":73745,"journal":{"name":"Journal of Experimental Pathology","volume":"5 2","pages":"49-51"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12873150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Translational regulation by HIV leader RNA, TAT, and interferon-inducible enzymes. HIV领导RNA、TAT和干扰素诱导酶的翻译调控。
Journal of Experimental Pathology Pub Date : 1990-01-01
R H Silverman, D N Sengupta
{"title":"Translational regulation by HIV leader RNA, TAT, and interferon-inducible enzymes.","authors":"R H Silverman,&nbsp;D N Sengupta","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Every step in the replication cycle of HIV provides unique opportunities for controlling the progression of AIDS. In this regard, virus protein synthesis should be an important target for limiting HIV multiplication in cells. Molecular mechanisms in the regulation of HIV protein synthesis were therefore investigated in the context of interferon action. The interferon-inducible enzymes, 2-5A synthetase and dsRNA-dependent protein kinase, which can inhibit translation were activated by HIV-1 leader RNA. In cell-free systems, leader RNA and Tat protein of HIV inhibited and enhanced translation, respectively. An intriguing interplay of these viral and host factors were shown to influence the rate of translation in vitro. A model describing opposing actions of HIV Tat protein and interferon in HIV replication is represented.</p>","PeriodicalId":73745,"journal":{"name":"Journal of Experimental Pathology","volume":"5 2","pages":"69-77"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12873152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Jack fruit lectin binding pattern in carcinoma of the uterine cervix. 杰克果凝集素在子宫颈癌中的结合模式。
Journal of Experimental Pathology Pub Date : 1990-01-01
P Remani, A Joy, K K Vijayan, A Ravindran, V M Haseena Beevi, D M Vasudevan, T Vijayakumar
{"title":"Jack fruit lectin binding pattern in carcinoma of the uterine cervix.","authors":"P Remani,&nbsp;A Joy,&nbsp;K K Vijayan,&nbsp;A Ravindran,&nbsp;V M Haseena Beevi,&nbsp;D M Vasudevan,&nbsp;T Vijayakumar","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A lectin was isolated and purified from the seeds of Jack Fruit (Artocarpus integrifolia) using a column of immobilized N-acetyl D-Galactosamine. The Jack Fruit lectin (JFL) was conjugated to horse radish peroxidase (HRP). The purified conjugate was used to study the binding properties of tissues from carcinomas of the uterine cervix. The binding to cancer tissues was compared with that of normal controls. The carcinomatous cells showed varying degrees of binding towards JFL in contrast to normal controls which generally had uniform binding. The nature and intensity of binding of the lectin with the cancer tissues suggest that this lectin may be used as a diagnostic marker in carcinoma of uterine cervix.</p>","PeriodicalId":73745,"journal":{"name":"Journal of Experimental Pathology","volume":"5 3","pages":"89-96"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13250545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immunohistochemical demonstration of a thiamine diphosphate-binding protein in the brain of the adult rat. 成年大鼠脑中硫胺素二磷酸结合蛋白的免疫组织化学证明。
Journal of Experimental Pathology Pub Date : 1990-01-01
H Yoshioka, K Nishino, G Ohshio, T Kimura, T Sugiyama, T Kita
{"title":"Immunohistochemical demonstration of a thiamine diphosphate-binding protein in the brain of the adult rat.","authors":"H Yoshioka,&nbsp;K Nishino,&nbsp;G Ohshio,&nbsp;T Kimura,&nbsp;T Sugiyama,&nbsp;T Kita","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We recently purified a new thiamine diphosphate-binding protein (ThDP-BP) prepared from rat liver, and found immunoreactivity for ThDP-BP in neurons and other neuronal tissues. In this study, we examined the distribution of ThDP-BP in the rat neurons by the avidin-biotin complex technique. Strong immunoreactivity for ThDP-BP was found in the cerebral cortex, hippocampus, ependymal cells, nucleus III, nucleus V, and medial vestibular nucleus. Moderate immunoreactivity was noted in the olfactorius nucleus anterior and weak activity in the nucleus ruber. ThDP-BP may be useful in clarifying the pathogenesis of Wernicke encephalopathy and Leigh's disease.</p>","PeriodicalId":73745,"journal":{"name":"Journal of Experimental Pathology","volume":"5 4","pages":"155-68"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13256715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Relation of alpha and gamma interferon levels to development of AIDS in homosexual men. α和γ干扰素水平与男同性恋者艾滋病发展的关系。
Journal of Experimental Pathology Pub Date : 1990-01-01
C R Rinaldo, J A Armstrong, L A Kingsley, S Zhou, M Ho
{"title":"Relation of alpha and gamma interferon levels to development of AIDS in homosexual men.","authors":"C R Rinaldo,&nbsp;J A Armstrong,&nbsp;L A Kingsley,&nbsp;S Zhou,&nbsp;M Ho","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Homosexual men who were human immunodeficiency virus (HIV) seropositive at enrollment into the Pittsburgh portion of the Multicenter AIDS Cohort Study had elevated titers of serum alpha and gamma interferon (IFN) within 24 months prior to development of AIDS. In contrast, subjects who developed AIDS relatively early after seroconversion to HIV during this study did not have increased levels of alpha or gamma IFN.</p>","PeriodicalId":73745,"journal":{"name":"Journal of Experimental Pathology","volume":"5 3","pages":"127-32"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13284015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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