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Journal of clinical & experimental immunology最新文献

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Features of Pathogens, Epidemiology, and Diagnosis of COVID-19 and Reliable Suggestion: Aiming to Solve the Confusion in Clinical Practice 新冠肺炎病原学、流行病学、诊断特点及可靠建议:旨在解决临床实践中的困惑
Journal of clinical & experimental immunology Pub Date : 2020-09-01 DOI: 10.33140/jcei.05.05.03
{"title":"Features of Pathogens, Epidemiology, and Diagnosis of COVID-19 and Reliable Suggestion: Aiming to Solve the Confusion in Clinical Practice","authors":"","doi":"10.33140/jcei.05.05.03","DOIUrl":"https://doi.org/10.33140/jcei.05.05.03","url":null,"abstract":"In past several months, the worldwide outbreak of COVID-19 infection is unstoppable, which results in millions of people infected and thousands of people dead. However, there are still something controversial in the virus mechanism, the epidemiological feature and the diagnose criterion of COVID-19, while we also have some consensus. The structure of SARS-CoV-2, the pathogen of COVID-19, is roughly similar with other coronavirus such as SARS-CoV and bat-CoV, but by sequencing the amino acid, recombination of virus particles, and observation in Electron microscope, it is obvious to find the some slight difference between the protein of SARS-CoV-2 and others’. The spike protein of SARSCoV-2 has a stronger ability to binding ACE2 than SARS-CoV. The carrier of SARS-CoV-2 is just as other respiratory viruses, like droplet, aerosol and surface, and the fecal-oral transmission is proved to be an efficient pathway. In clinical practice, the elder and the patients with comorbidity are more susceptible to infection and have poorer prognosis, while pediatric patients is the very opposite of it. Nucleic acid test represented by RT-PCR is a helpful method for diagnose, yet it has weaknesses of false negative in suspicious patient and resurgence in discharge patient. Serological and immunological test, reported not suitable for diagnose alone in early period, can be another reliable method that benefit the accuracy of diagnosis criterion when combined with RT-PCR.","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85655996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
What is on a mouth’s mind? 嘴巴在想什么?
Journal of clinical & experimental immunology Pub Date : 2020-09-01 DOI: 10.33140/jcei.05.05.06
{"title":"What is on a mouth’s mind?","authors":"","doi":"10.33140/jcei.05.05.06","DOIUrl":"https://doi.org/10.33140/jcei.05.05.06","url":null,"abstract":"In time, the wrong choice of words, along with faulty behavioural settings (errors), can influence one’s emotional and physical responses negatively. Lifestyle errors can act like bad sectors or clusters. The terms “bad sector” and “bad cluster” refer to a specific section of a digital storage device that has been rendered unusable for reading and writing data. When a computer says it has found bad sectors or clusters, it means that it has identified part of a connected storage medium that it can’t access. The computer can attempt to recover data that is stored on bad sectors and clusters, but there is a chance the data is lost forever.","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86289475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
HDFx and Methylated DNA; With Histones Upregulated in Macrophages/Monocytes Derived From Animal Survivors Subjected to Traumatic, Endotoxin,and Hemorrhagic Shock: Importance of Epigenesis and Potential Reasons forResistance to Bacterial, Fungal and Viral Infections HDFx和甲基化DNA;创伤、内毒素和失血性休克动物幸存者巨噬细胞/单核细胞中组蛋白上调:表观发生的重要性和对细菌、真菌和病毒感染的抗性的潜在原因
Journal of clinical & experimental immunology Pub Date : 2020-08-08 DOI: 10.33140/jcei.05.04.07
{"title":"HDFx and Methylated DNA; With Histones Upregulated in Macrophages/\u0000Monocytes Derived From Animal Survivors Subjected to Traumatic, Endotoxin,\u0000and Hemorrhagic Shock: Importance of Epigenesis and Potential Reasons for\u0000Resistance to Bacterial, Fungal and Viral Infections","authors":"","doi":"10.33140/jcei.05.04.07","DOIUrl":"https://doi.org/10.33140/jcei.05.04.07","url":null,"abstract":"Each year approximately 60,000 people die from hemorrhagic\u0000shock in the U.S.A. with about two million deaths worldwide [1].\u0000Deaths from traumatic shock, worldwide, has been difficult to\u0000estimate, due to battles/wars in many countries, but is thought to\u0000be more than two million victims/year [1]. Many reasons for these\u0000large numbers of deaths are known [for review, see1], for example,\u0000inadequate therapeutic measures, unavailability of adequate blood/\u0000plasma/fluid replacement, seeing the patient too late, and\u0000unavailability of trained ER personnel, among the major reasons\u0000[for recent review, see1]. Another predominant reason for large\u0000numbers of hemorrhagic and traumatic shock deaths is the risk of\u0000sepsis in many of these victims, resulting in septic shock having\u0000mortalities in excess of 40- 75%, depending upon locality, with the\u0000lower numbers in the U.S.A. Lastly, and most important is “natural\u0000resistance of the body to infectious microorganisms” (i.e, bacteria,\u0000funguses, viruses, parasitic organisms, etc.). What is responsible\u0000for “natural resistance” has been studied for more than 150 years.\u0000We know that the “innate” and “adaptive” immune systems are\u0000key elements in defense against infectious microorganisms [2, 3].\u0000But, which elements of these systems make-up major aspects of\u0000“resistance” and “host defense” still remains to be worked out.\u0000Using starfish, more than 140 years ago, the pioneer/father of\u0000immunology, and Nobel Laureate, Elie Metchnikoff, believed that\u0000white blood cells and macrophages were key to host-defense [4].\u0000He also believed the body develops molecules/substances, which\u0000are key to resistance to infectious microorganisms [4].","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91392936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A1C Variance Study and PPG Prediction Methodology over Six Periods Using GH-Method: Math-Physical Medicine 采用GH-Method:数学-物理医学的六期糖化血红蛋白方差研究及PPG预测方法
Journal of clinical & experimental immunology Pub Date : 2020-07-01 DOI: 10.33140/jcei.05.04.01
{"title":"A1C Variance Study and PPG Prediction Methodology over Six Periods Using GH-Method: Math-Physical Medicine","authors":"","doi":"10.33140/jcei.05.04.01","DOIUrl":"https://doi.org/10.33140/jcei.05.04.01","url":null,"abstract":"In this case study, the author analyzed, predicted, and interpreted a type 2 diabetes (T2D) patient’s hemoglobin A1C variances based on six periods data utilizing the GH-Method: math-physical medicine approach by applying mathematics, physics, engineering modeling, and computer science (big data analytics and AI). He believes in “prediction” and has developed five models, including metabolism index, weight, fasting plasma glucose (FPG), postprandial plasma glucose (PPG), and hemoglobin A1C. All prediction models have reached to 95% to 99% accuracy. His focus is on preventive medicine, especially on diabetes control via lifestyle management.","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":"02 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86245108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
To Acu or not to Puncture? Acu还是不穿刺?
Journal of clinical & experimental immunology Pub Date : 2020-07-01 DOI: 10.33140/jcei.05.04.05
{"title":"To Acu or not to Puncture?","authors":"","doi":"10.33140/jcei.05.04.05","DOIUrl":"https://doi.org/10.33140/jcei.05.04.05","url":null,"abstract":"Even though acupuncture and its reputed role in Traditional Chinese Medicine appears as a true value in East & West, from heart’s “perspective” it feels really as a false value. Acupuncture behaves as a stressor. Its way of approaching the skin, and especially the sensitive mechanoreceptors, fits more in challenging the nociceptors (pain receptors), rather than any other kind of basic skin receptors, such as haptic-stretch-pressure & vibration. This kindling mechanism, this external source of algorithmical conglomerative stress onto the skin, and consequently to other biological systems of the organism which are connected/entangled with it from the embryological phase of the three germ layers, has inevitably a direct link with the autonomic nervous system; the hypothalamic-pituitary-adrenal (HPA) axis with cortisol production, and the sympathoadrenal medullary (SAM) axis which activate the sympathetic nervous system, which dedicates energy to more relevant bodily systems to acute adaptation to stress. The above-mentioned neurobiological mechanisms are the basic major systems that respond to stress, and by extension they can affect through it (stress caused by acupuncture) the immune system.","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89728426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Escaping Cytokine Storm for the Poor 为穷人逃离细胞因子风暴
Journal of clinical & experimental immunology Pub Date : 2020-07-01 DOI: 10.33140/jcei.05.04.03
{"title":"Escaping Cytokine Storm for the Poor","authors":"","doi":"10.33140/jcei.05.04.03","DOIUrl":"https://doi.org/10.33140/jcei.05.04.03","url":null,"abstract":"Since the Covid 19 broke out, people are all looking for the cure. Many people died from this fat al disease; and cytokine storm is one of the most dangerous complications. For some low-income people, they are not eligible to be tested for Covid; and they might not get the proper medical care. In these cases, self-care procedures, such as exercise, clear the airway, handwashing, wearing mask, taking meds on time, and proper diet become crucial in deciding the prognoses. This research is about a case study of a patient who is not eligible for a Covid 19 lab test; and how she dealt with a severe flu-like disease.","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86449812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Building up fundamental strength to fight against COVID-19 for patients with chronic diseases and complications 为慢性病和并发症患者增强抗疫基础力量
Journal of clinical & experimental immunology Pub Date : 2020-06-30 DOI: 10.33140/jcei.05.04.02
Gerald C. Hsu
{"title":"Building up fundamental strength to fight against COVID-19 for patients with chronic diseases and complications","authors":"Gerald C. Hsu","doi":"10.33140/jcei.05.04.02","DOIUrl":"https://doi.org/10.33140/jcei.05.04.02","url":null,"abstract":"This paper describes qualitatively and quantitatively the actions to protect some patients with chronic diseases and complications during this COVID-19 period.","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87874174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Effective age resulting from Metabolic Changes 代谢变化导致的有效年龄
Journal of clinical & experimental immunology Pub Date : 2020-06-03 DOI: 10.33140/jcei.05.03.06
{"title":"Effective age resulting from Metabolic Changes","authors":"","doi":"10.33140/jcei.05.03.06","DOIUrl":"https://doi.org/10.33140/jcei.05.03.06","url":null,"abstract":"In this research note, the author reviewed his past 8-years data\u0000from 2012 through 2019 by focusing on the relationship between\u0000his metabolism and overall health conditions. He decided to write\u0000this paper regarding his “Effective Age” using the GH-Method:\u0000math-physical medicine approach.","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":"78 3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89974538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Evolutive Immunologic and Toxicologic Approach in Some Neuroinflamatory andDegenerative Disease like SM, DA, PD 一些神经炎症和退行性疾病如SM, DA, PD的进化免疫和毒理学方法
Journal of clinical & experimental immunology Pub Date : 2020-05-18 DOI: 10.33140/jcei.05.03.04
{"title":"Evolutive Immunologic and Toxicologic Approach in Some Neuroinflamatory and\u0000Degenerative Disease like SM, DA, PD","authors":"","doi":"10.33140/jcei.05.03.04","DOIUrl":"https://doi.org/10.33140/jcei.05.03.04","url":null,"abstract":"In order to better, understand some neurologic process is fundamental to use an evolutionary approach. Imaging can\u0000help in measuring efficiency of brains wasting system in the various subject. The brain glimphatic systems is well\u0000studied today but an accurate measure of the real efficiency of the system is needed. Aim of this work is to submit to the\u0000researcher a working method to measure this parameter to verify if possible to use the brain glymphatic system as new\u0000therapeutics strategy","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":"115 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87028775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lived Experiences of Individual Living with Human Immunodeficiency Virus Ages18-30 in Dasmariñas City Cavite Dasmariñas市18-30岁人类免疫缺陷病毒感染者的生活经历
Journal of clinical & experimental immunology Pub Date : 2020-05-08 DOI: 10.33140/jcei.05.03.02
{"title":"Lived Experiences of Individual Living with Human Immunodeficiency Virus Ages\u000018-30 in Dasmariñas City Cavite","authors":"","doi":"10.33140/jcei.05.03.02","DOIUrl":"https://doi.org/10.33140/jcei.05.03.02","url":null,"abstract":"An undergraduate thesis presented to the faculty of College of Nursing, Cavite State University, Indang Cavite, in partial fulfillment\u0000of the requirements for the degree of Bachelor of Science in Nursing, with Contribution no. SP CON NO.__________. Prepared\u0000under the supervision of Dr. Evelyn M. Del Mundo.","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82204948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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