Journal of clinical & experimental immunology最新文献_第3页

Mesenchymal stem cells-derived Extracellular Vesicles: A Promising COVID-19 Therapy?” 间充质干细胞来源的细胞外囊泡:一种有希望的COVID-19治疗方法?

Journal of clinical & experimental immunology Pub Date : 2021-11-29 DOI: 10.33140/jcei.06.06.05

引用次数: 0

Pre-Solid-Organ-Transplant COVID-19 Vaccination 固体器官移植前COVID-19疫苗接种

Journal of clinical & experimental immunology Pub Date : 2021-08-26 DOI: 10.33140/jcei.06.04.02

{"title":"Pre-Solid-Organ-Transplant COVID-19 Vaccination","authors":"","doi":"10.33140/jcei.06.04.02","DOIUrl":"https://doi.org/10.33140/jcei.06.04.02","url":null,"abstract":"Vaccine such as influenza vaccine, is administered in stable transplant recipients, although live attenuated virus vaccines are contraindicated, generally due to risk of disseminated infection [1, 2]. Neither efficacy, safety, nor durability are well known in transplant recipients due to exclusion of them from recent COVID-19 vaccine trials [1, 2]. Currently, there are no SARS-CoV-2 vaccine platforms using attenuated live virus approved in phase III trials. Nevertheless, if they are approved for use, concerns, including potential decrease in efficacy in immunocompromised patients, potential for vaccine-related allograft rejection, unknown durability of the immune response, and long-term safety data still exist. Due to experience with neither the influenza vaccine nor the adjuvant recombinant zoster vaccine having been related to allograft rejection, successful administration of influenza and adjuvanted recombinant zoster vaccines to stable transplant recipients, and unanticipated vaccine-related adverse events to the allograft having not borne out, the influenza and adjuvanted recombinant zoster vaccines are able to be extrapolated to COVID-19 vaccines [2, 3]. In immunocompromised host, concerns for adenoviral vector vaccines are focused on a viral infection, but these concerns have no scientific evidence. Although newly approved adenoviral-vector use for vaccination, this vaccine platform has been used for decades for gene therapy for cancer and other rare diseases. Inactivated virus and protein subunit vaccine platforms that have been used in transplant recipients for other infections, such as human papilloma virus, pertussis, and hepatitis A and B, are currently under investigation for SARS-CoV-2 (COVID-19) infection in transplant recipients [2].","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91276910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Clinical Study on Pancytopenia in Pregnancy in Women of Rural Haryana 哈里亚纳邦农村妇女妊娠全血细胞减少症的临床研究

Journal of clinical & experimental immunology Pub Date : 2021-06-09 DOI: 10.33140/jcei.06.03.04

引用次数: 0

Objectivity and Practice of Peripheral Blood Smear Examination for Childhood Anemia Diagnosis in Benghazi Children Hospital /Libya 利比亚班加西儿童医院外周血涂片检查诊断儿童贫血的客观性与实践

Journal of clinical & experimental immunology Pub Date : 2021-06-09 DOI: 10.33140/jcei.06.03.03

{"title":"Objectivity and Practice of Peripheral Blood Smear Examination for Childhood Anemia Diagnosis in Benghazi Children Hospital /Libya","authors":"","doi":"10.33140/jcei.06.03.03","DOIUrl":"https://doi.org/10.33140/jcei.06.03.03","url":null,"abstract":"Introduction: Anemia is a common disease in children. Peripheral Blood Smear (PBS) require effort and human resource. In this study, we will evaluate objectivity of PBS ordering practice in Benghazi Children Hospital/Libya. Method: A retrospective study of PBS reports of 318 child in 2015 was conducted. Data collected include cause of PBS request, along with other relevant demographic, clinical and laboratory details. Kappa statistic was used for analyzing degree of agreement of results between PBS and Complete Blood Count (CBC) in anemia diagnosis. Results: Our study showed that Hematologists and 88.7% by general pediatricians requested only 6.9% of PBS. Anemia was main cause of request in 36.2%. Only 33.7 % of OPD cases referred with suspect of anemia were revealed to be anemic upon PBS examination and 45.4 % referred with no suspect of anemia were revealed to be anemic upon examination in total study population, but not in Neonate. In 65.1%, there was an agreement between diagnosis of anemia by CBC and PBS. There was accordance of 76.6% between exclusion of anemia by CBC and PBS. Hypochromic microcytic anemia was diagnosed in 93 cases (29.2%), macrocytic anemia was diagnosed in 5%, and 65.7% were not anemic. Conclusions: PBS examination is none objectively ordered and over utilized by Pediatricians in outpatient settings and for routine practice with less yield. Establishing laboratory guidelines for improving utility of PBS, careful and complete justified requests, discussion with laboratory staff, and continuous auditing practice are noticeable needs in the Benghazi Children Hospital.","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85460525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tamoxifen for Five Years 服用他莫昔芬5年

Journal of clinical & experimental immunology Pub Date : 2021-06-09 DOI: 10.33140/jcei.06.03.01

Xu Chen

引用次数: 0

What Do All Autoimmune Diseases Have in Common? 所有自身免疫性疾病有什么共同之处?

Journal of clinical & experimental immunology Pub Date : 2021-06-09 DOI: 10.33140/jcei.06.03.02

引用次数: 4

Red Tide: Why a Biologic, HDFx, and Magnesium Could be used to allay Inflammatory and Lung Problems Caused by Algal Blooms: Hypothesis 赤潮:为什么一种生物制剂、HDFx和镁可以用来减轻由藻华引起的炎症和肺部问题:假设

Journal of clinical & experimental immunology Pub Date : 2021-01-21 DOI: 10.33140/jcei.06.01.03

引用次数: 1

What we learned from the Covid-19 Outbreak in 2020 我们从2020年的Covid-19疫情中学到了什么

Journal of clinical & experimental immunology Pub Date : 2021-01-21 DOI: 10.33140/jcei.06.01.02

引用次数: 0

Cytokines: The Game Changer in Pathogenesis of Covid-19 细胞因子:改变Covid-19发病机制的游戏规则

Journal of clinical & experimental immunology Pub Date : 2021-01-21 DOI: 10.33140/jcei.06.01.01

{"title":"Cytokines: The Game Changer in Pathogenesis of Covid-19","authors":"","doi":"10.33140/jcei.06.01.01","DOIUrl":"https://doi.org/10.33140/jcei.06.01.01","url":null,"abstract":"A small particle of the size about 100 micrometers (SARS-V2) has shaken the world. In some Covid-19 patients a severe immune reaction was found in which cells release too many cytokines into the blood too quickly. Cytokines are regulators of host responses to infection, immune responses, inflammation, and trauma. In addition, cytokines activate those cells, stimulating them to produce more cytokines. Normally, this feedback loop is kept in check by the body. Some cytokines act to make disease worse. Cytokine storms might explain why some people have a severe reaction to corona viruses while others only experience mild symptoms. They could also be the reason why younger people are less affected, as their immune systems are less developed and so produce lower levels of inflammation-driving cytokines. Since, in early 2020, Covid -19 became pandemic, globally multi-pronged research started to get rid of corona virus 2 (SARSCoV-2) [1, 2]. For such a task, it was necessary to understand the pathogenesis of covid-19, due to the fact that SARS-CoV-2, is new and its mechanism of action and its interrelationship with the human body organs is not fully known yet. Nevertheless, it is known that all viruses and bacteria when invade the body interact with the immune system, inflammation starts and if the immune system cannot get rid of the invaders, pathogenesis starts.","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":"13 42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80561045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

COVID-19 Perceptional Disparity Among Dental Practitioners in Tricity (Chandigarh, Panchkula and Mohali) 三邦(昌迪加尔、潘切库拉和莫哈里)牙医对COVID-19的认知差异

Journal of clinical & experimental immunology Pub Date : 2021-01-21 DOI: 10.33140/jcei.06.01.04

{"title":"COVID-19 Perceptional Disparity Among Dental Practitioners in Tricity (Chandigarh, Panchkula and Mohali)","authors":"","doi":"10.33140/jcei.06.01.04","DOIUrl":"https://doi.org/10.33140/jcei.06.01.04","url":null,"abstract":"Background: Coronavirus (SARS-CoV-2) made the headlines after its initial breakout in Wahan, China in December 2019. Viral by genome, lethal by nature, strongly contagious by character succeeded in making a new chapter in everyone’s life in a very short span making it a pandemic Objectives: The aim of this study was to assess perceptional disparity among dental practitioners regarding the Coronavirus Disease 2019 (COVID-2019) pandemic. Material and methods: A total of 300 participating dentists were randomly included in this cross sectional survey. A self structured, closed ended questionnaire was administered to each participant to record demographic and professional characteristics followed by their knowledge regarding corona virus. Statistical analysis was performed using SPSS Version 20 and Multivariable linear regression analysis was carried out Results: It was found that only 33.3% of the clinicians had high knowledge regarding corona virus and only 38.5% of the respondents know the correct incubation period. About 65 % of the practitioners did not know about the diagnostic test available for corona virus and only 4.3 % of them gained knowledge rom journals or print media The above responses indicate a low knowledge among the dental practitioners regarding corona virus. Conclusions: The knowledge and practice scores were found to be worrisome, which is important to combat COVID-19. They are advised to follow the Centers of Disease Control and Prevention (CDC) and World Health Organization (WHO) guidelines in their clinics, and sensitize their staff so that no stone is left unturned in defeating this pandemic.","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90711603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0