Journal of clinical & experimental immunology最新文献

{"title":"Therapeutic Monoclonal Antibodies Approved by FDA in 2022","authors":"","doi":"10.33140/jcei.08.01.03","DOIUrl":"https://doi.org/10.33140/jcei.08.01.03","url":null,"abstract":"Compared with the annual record high, 17 therapeutic monoclonal antibodies (mAb) approved in 2017, this year total 16 therapeutic mAb were approved by FDA, interestingly 4 of them targeted at VEGF (Vascular Endothelial Growth Factor), two indicated for solid tumor, two for Neovascular (Wet) Age-Related Macular Degeneration [1]. Monoclonal antibody technique was created by Georges Köhler, César Milstein, and Niels Kaj Jerne in 1975 by using a mouse x mouse hybridoma. In 1984 they were awarded the Nobel Prize in Medicine for the discovery. Eight years later, in 1992 US FDA approved the first therapeutic mAb muromonab","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":"134 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135585513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors, Contributing to Set up Effective Experimental Research","authors":"","doi":"10.33140/jcei.07.01.02","DOIUrl":"https://doi.org/10.33140/jcei.07.01.02","url":null,"abstract":"Imagine how to start a new research department and you will find many suggestions: how to find the right expertise, how to find investment, how to organise an effective research system. When you have the right contacts, you will surely get the opportunity to build up a constructive beginning. A new idea might be in bringing existing research laboratories together facing the same goal and subject looking for ways to ameliorate the working conditions and results. Organizing a new company formed by complementary laboratories and co-operative agents with different disciplines would be an exciting challenge.","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":"69 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77509041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Food Allergy among Patients Affected by Delta and Omicron Variants-A Case Study","authors":"","doi":"10.33140/jcei.07.01.04","DOIUrl":"https://doi.org/10.33140/jcei.07.01.04","url":null,"abstract":"Background: The variants of SARS-CoV-2 have been affecting people globally since 2020. The Delta variant, mainly in India and the omicron variant in multiple countries since Nov 2021, has infected millions of people; many died out of them. Amongst all factors, food allergy is one factor that also accelerates many infected people’s comorbidities and overall health status during the pandemic. Aims: The study aimed to assess the role of some common food allergies in Delta and Omicron infected people in the Indian population. Methods: The study was designed with 50 covid positive home-isolated patients (out of 62) infected by both the mentioned variants from April 2021 until 15th January 2022. However, they were not severely ill but had comorbidities such as diabetes, obesity, hepatomegaly, etc. After the negative test result, each participant was requested to attend a telephonic interview for 15 minutes. Further, they were offered free online diet consultation considering the fatigue and some allergic symptoms. ATLAS-Ti-9 software was used for the fundamental analysis. Results: Based on their self-referred serological allergy test (SAT), we found that 23 samples of milk (46%), 14 (28%) samples of citrus fruits, 12 (24%) patients were allergic due to mustard oil and other detections too based on the positive interpretation (+ to +++) of specific IgE (IU/ml). The patients were facing type-1 hypersensitivity but no other severe allergic issues. Conclusions: Food allergy accelerated respiratory syndromes and comorbidities, mainly among the infected (Delta and Omicron) patients who could also have a high chance of hypersensitivity due to some common ingesting allergens.","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77394248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Prayer from a Vegan Doctor","authors":"","doi":"10.33140/jcei.07.01.03","DOIUrl":"https://doi.org/10.33140/jcei.07.01.03","url":null,"abstract":"Lord please save us from the poor choices of food we pile on our plates. We are often unaware of how it determines our fate. With all the meat, fish, and eggs prepped with butter. Is it the saturated fat on our brains that blinds us to the fact that millions of animals suffer? We’re anxious, we’re angry, we have such low mood. Is it possible it’s because of our unhealthy food? “Oh no don’t take away my cheese, I’ll risk it all.” Those are the words from a victim of high cholesterol.","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78696682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between parvovirus B19 virus and childhood acute lymphoblastic leukemia: A cross-sectional study in Tehran; Iran","authors":"","doi":"10.33140/jcei.07.01.01","DOIUrl":"https://doi.org/10.33140/jcei.07.01.01","url":null,"abstract":"Objective: The propose of study was to determine the viral load of Parvovirus B19 in children with proven acute lymphoblastic leukemia (ALL) Methods: A cross-sectional study designed in pediatric ward of Rasoul-e-Akram Hospital (educational, third referral) in Tehran, Iran (2015 – 2016). Sixty-nine children (mean age: 6.57 ± 4.25 years) in preservative phase of ALL selected. BMA had done, and the viral load for Parvovirus B19 determined by quantitative PCR. Results: Type of ALL was Pre B cell: 76.8%; Pro B cell: 14.5% and T-cell type: 7.8%. Low viral load determined in 18.8% (n=13); intermediate in 39.1% (n=27). High and very high viral load observed in 27.1% 15 (n=15) and 20.3% (n=1) of cases respectively. Viral load was related to Pro B cell type (p = 0.050) and lymphadenopathy (p = 0.040), but not related to gender (p = 0.350) and severity of ALL (p = 0.403); like hepatosplenomegaly, anemia, thrombocytopenia or need to transfusion. Conclusion: Parvovirus B19 is a common viral infection in young Iranian population. Near one-third of childbearing age, women in Iran are at risk for primary Parvovirus B19 infection. Here, to evaluate the possible role of parvovirus B19 Infection in the etiology of ALL, 42 % of ALL cases had high and very high viral load (21.7% and 20.3); the low or intermediate viral load is detectable in all cases. The viral load was related to Pro B cell type of ALL (p = 0.050) and the presence of lymphadenopathy. However, there is no relationship observed between Parvovirus B19 viral load and the severity of ALL and gender. It probably might be due to viral detection in the early stages of the ALL","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":"13 6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82618451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of a Clinical Case for A Female Patient with Type 2 Diabetes Using the 2021 Consensus Report on Type 2 Diabetes Remission Discussions Sponsored by American Diabetes Association Based on GH-Method: math-physical medicine (No. 506)","authors":"","doi":"10.33140/jcei.06.06.07","DOIUrl":"https://doi.org/10.33140/jcei.06.06.07","url":null,"abstract":"This 73-year-old female patient has suffered from type 2 diabetes (T2D), hypertension, and hyperlipidemua for over 20 years. She started taking Metformin in 1999 and ceased taking it on 1/7/2019. As of 4/3/2019, her HbA1C level was at 6.6%. Since 4/4/2019, she implemented a lifestyle management program which not only focuses on diet and exercise but also factors in sleep, stress, life routines and habits, as well as environmental factors. In this article, the author applies the final conclusions from the American Diabetes Association (ADA) 2021 consensus report regarding “T2D Remission”. For this clinical case, he analyzes the patient’s present conditions to determine if she satisfies the criteria of “T2D remission” or not. The defined criteria of “remission” include timespan of at least one year, HbA1C level less than 6.5%, fasting plasma glucose (FPG) level less than 126 mg/dL, and estimated HbA1C (eA1C) values based on the mean continuous glucose monitoring (CGM) glucose data less than 6.5%. In conclusion, according to the ADA 2021 consensus report, this female patient is in “remission” for T2D. In summary, over the past year from 9/5/2020 to 9/5/2021, her average lab-A1C is 6.3%, mean CGM FPG value is 102 mg/dL, and CGM eAG is 5.7%. First, the selected one year satisfies the timespan requirement cited in the 2021 consensus report. Her set of glucose data has been collected over ~3 years, after post-Metformin (started on 1/7/2019) and her initiation of lifestyle management program that began on 4/4/2019. Second, all of her A1C values, both lab-tested and CGM eA1C, are less than 6.5% and her mean CGM FPG level is less than 126 mg/dL. Finally, she keeps a regular routine with quarterly medical examinations to monitor various diabetes complications, including macrovascular, micro- vascular, neural, and hormonal systems. The author understands and agrees with the consensus report that diabetes is non-curable and at most is “controllable” or “partially reversible”. Nevertheless, this female patient has also adopted a similar lifestyle improvement program as the author in order to deal with the root causes of her multiple metabolic disorders, particularly T2D, instead of suppressing the external symptoms of diabetes through medication intervention.","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78238709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of Food and Relative Risk Probability of Having Five Different Diseases, Including Diabetes Using Collected Food Data Over A 6.5-Year Period Based on GHMethod: Math-Physical Medicine (No. 492)","authors":"","doi":"10.33140/jcei.06.06.02","DOIUrl":"https://doi.org/10.33140/jcei.06.06.02","url":null,"abstract":"The author is a professionally trained mathematician, physicist and engineer. His view of health and medicine is similar to his past experience on designing a physical object, such as a building structure or a working machine, which he calls an “object”. The object’s strength or its expected lifespan is similar to the health conditions and longevity of a human being based on the following three key factors: (1) The original strength of the object’s material which is similar to the genetic factors of a human body. (2) The engineering design and site construction of this object are similar to the fundamental influential causes, including lifestyle details, life-long habits, and environmental factors, on the human health. Among those external causes, if the author has to pick up one category which has the most influence above of all that is the “food”. (3) The object endures different operational problems due to external forces or impacts which are similar to various diseases suffered by humans. After the object experiences external forces or impacts, we use some structural reinforcements to fix the building’s damaged cracks or replace the malfunctioned part of the machine. These engineering actions are similar to the “medical treatments” doctors provide patients. The medical treatments, including medication interventions (oral drugs or biochemical injections), necessary surgeries, or certain organ transplants are similar to the engineering repair of the damaged object. This article emphasizes the relationship between causes and results such as symptoms of diseases. It particularly addresses the inter-relationship of 5 selected diseases: cancers, cardiovascular diseases (CVD), chronic kidney diseases (CKD), diabetic retinopathy (DR), and type 2 diabetes (T2D), where the most important cause for most diseases is “food”. This food category in his study contains 25 defined elements include input data of food are collected via the developed iPhone APP. There are 5 elements for “Food Quantity”: breakfast amount, lunch amount, dinner amount, amount of between-meals snacks and fruits, and the average daily food consumption amount. In addition, there are 20 selected elements for “Food Quality” (see Figure 1). The combined Food score is the average value of both food quantity score and food quality score.","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73071370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Change in Health Biomarkers for Bodyweight and Glucoses Between the PreVirus Period and COVID-19 Period Based on GH-Method: Math-Physical Medicine (No. 468)","authors":"","doi":"10.33140/jcei.06.06.06","DOIUrl":"https://doi.org/10.33140/jcei.06.06.06","url":null,"abstract":"This paper describes the author’s quantitative improvements on his weight and glucose resulting from lifestyle modifications. Special attention has been placed on both the pre-virus period from 5/5/2018 to 1/18/2020 (total 624 days with 1,934 meals and snacks) and the COVID-19 quarantined period from 1/19/2020 to 6/16/2021 (total 514 days with 1,536 meals). This article emphasizes on bodyweight, glucoses, and glucose fluctuations (GF) during the two compared periods. In general, his health conditions of weight and glucoses in the COVID-19 period (514 days) are better than his health conditions in the pre-virus period (624 days). The COVID-19 pandemic is more than 100 times worse than SARS that occurred in 2003, in terms of its spreading speed, fatality number, and emotional impact on the world population. People belonging to the “vulnerable” groups” such as the elderly, with existing chronic diseases and history of complications, require special attention to their health conditions and lifestyle management during this COVID-19 quarantine period. In this particular period, the author achieved better results on both his diabetes control and overall metabolism management. The knowledge and experience he has gained in the past 11 years of medical research and his developed metabolism index (MI) model along with his four diabetes prediction tools assisted him in many ways. During the quarantine period, he has stopped traveling and suffered no jet-lag, eating home-cooked meals, maintaining nutritional balance, continuing his daily walking exercise of 16,000 steps (~10.7 km or 6.7 miles each day), sleeping 7.2 hours each night, living a stressfree life, avoiding negative news of politics and the pandemic, and keeping a regular daily life routine. The author enjoys conducting medical research, which is his obsessive hobby, and does not need to make a living off his work. Therefore, he feels no pressure at all to continuously perform research over the past 11 years. As a result, he has actually turned the COVID-19 crisis into his health advantage!","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":"84 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72966692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of Expected Longevity Using Medical Conditions and Lifestyle Details to Calculate A Female Patient’S Health Age Based on GH-Method: Math-Physical Medicine (No. 490)","authors":"","doi":"10.33140/jcei.06.06.04","DOIUrl":"https://doi.org/10.33140/jcei.06.06.04","url":null,"abstract":"The author was a mathematician and an engineer. His view of longevity is similar to his past experience on designing and building a structure or a machine which he calls an “object”. The expected lifespan of an object is similar to the longevity of a human being based on the following three factors: (1) The availability of good and strong building materials that are similar to the genetic factors of a human body health conditions. (2) The engineering design and site construction of this object are similar to the lifestyle, life-long habits, and environmental factors which are related to the health of the human body. (3) The building’s damaged cracks or the machine’s malfunctioned parts under external forces are similar to the medical conditions and symptoms of disease in the human body. If the object suffers from operational problems due to external forces that is similar to the human body being affected by various diseases, then we can repair the object such as adopting the reinforcement of the building structural part or replacing the operational part of the machine. They are similar to the medical treatments including medication interventions, different surgeries, or organ transplants. Once the author understood the analogy and similarity between an engineering object and a human body, he can then distinguish the differences among genetic reason, lifestyle maintenance, disease control, and medical treatments. It is extremely difficult, almost impossible at present time, to change our genes because we cannot select our biological parents; however, we can focus on our daily lifestyle management to either prevent from having diseases or controlling the progression of existing diseases.","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":"59 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84601776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Histobulin (Immunoglobulin/Histamine Complex) on Depression and Anxiety in Chronic Urticaria: Psychiatric Manifestations or Psychiatric Comorbidities of Chronic Urticaria?: A Case Report","authors":"","doi":"10.33140/jcei.06.06.03","DOIUrl":"https://doi.org/10.33140/jcei.06.06.03","url":null,"abstract":"Background: Psychiatric comorbidities of chronic urticaria (CU) have been reported and examined recently. The prevalence of mental disorders and emotional distress is high in patients with CU. This is a case report in which Histobulin was found to be effective for psychiatric manifestations in chronic spontaneous urticaria (CSU). Case Presentation: Three cases of CSU accompanying psychiatric manifestations (PMs) were treated with Histobulin. One patient with CSU with severe depression showed clinical changes in depressive symptoms in parallel to changes in allergic symptoms during treatment. Histobulin clearly improved not only CSU but also the accompanying PMs in one patient and slightly improved them in another patient. The PMs were not improved by an antihistamine (H1 blocker) in any case. Histobulin is effective not only for allergic manifestations (AMs) but also for PMs of CSU. Conclusions: PMs as well as AMs of CSU were improved by Histobulin therapy. PMs were suspected to be a part of the clinical manifestations in CSU, possibly through histamine-mediated mechanisms. These conditions were suggested to be ‘allergic psychiatric manifestations (APMs)’ or ‘histamine-mediated psychiatric manifestations (HPMs)’. Further study of PMs based on histamine-mediated mechanisms, including allergies, may be necessary. Accordingly, it should be clarified whether the PMs of CSU are a part of the clinical manifestations of CSU or are psychiatric comorbidities of CSU.","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88631858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}