Journal of clinical & experimental immunology最新文献_第2页

Investigation of Expected Longevity Using Medical Conditions and Lifestyle Details to Calculate A Female Patient’S Health Age Based on GH-Method: Math-Physical Medicine (No. 490) 基于h-法计算女性患者健康年龄的医疗条件和生活方式细节的预期寿命调查:数学-物理医学(490号)

Journal of clinical & experimental immunology Pub Date : 2021-11-29 DOI: 10.33140/jcei.06.06.04

{"title":"Investigation of Expected Longevity Using Medical Conditions and Lifestyle Details to Calculate A Female Patient’S Health Age Based on GH-Method: Math-Physical Medicine (No. 490)","authors":"","doi":"10.33140/jcei.06.06.04","DOIUrl":"https://doi.org/10.33140/jcei.06.06.04","url":null,"abstract":"The author was a mathematician and an engineer. His view of longevity is similar to his past experience on designing and building a structure or a machine which he calls an “object”. The expected lifespan of an object is similar to the longevity of a human being based on the following three factors: (1) The availability of good and strong building materials that are similar to the genetic factors of a human body health conditions. (2) The engineering design and site construction of this object are similar to the lifestyle, life-long habits, and environmental factors which are related to the health of the human body. (3) The building’s damaged cracks or the machine’s malfunctioned parts under external forces are similar to the medical conditions and symptoms of disease in the human body. If the object suffers from operational problems due to external forces that is similar to the human body being affected by various diseases, then we can repair the object such as adopting the reinforcement of the building structural part or replacing the operational part of the machine. They are similar to the medical treatments including medication interventions, different surgeries, or organ transplants. Once the author understood the analogy and similarity between an engineering object and a human body, he can then distinguish the differences among genetic reason, lifestyle maintenance, disease control, and medical treatments. It is extremely difficult, almost impossible at present time, to change our genes because we cannot select our biological parents; however, we can focus on our daily lifestyle management to either prevent from having diseases or controlling the progression of existing diseases.","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":"59 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84601776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mesenchymal stem cells-derived Extracellular Vesicles: A Promising COVID-19 Therapy?” 间充质干细胞来源的细胞外囊泡:一种有希望的COVID-19治疗方法?

Journal of clinical & experimental immunology Pub Date : 2021-11-29 DOI: 10.33140/jcei.06.06.05

引用次数: 0

Pre-Solid-Organ-Transplant COVID-19 Vaccination 固体器官移植前COVID-19疫苗接种

Journal of clinical & experimental immunology Pub Date : 2021-08-26 DOI: 10.33140/jcei.06.04.02

{"title":"Pre-Solid-Organ-Transplant COVID-19 Vaccination","authors":"","doi":"10.33140/jcei.06.04.02","DOIUrl":"https://doi.org/10.33140/jcei.06.04.02","url":null,"abstract":"Vaccine such as influenza vaccine, is administered in stable transplant recipients, although live attenuated virus vaccines are contraindicated, generally due to risk of disseminated infection [1, 2]. Neither efficacy, safety, nor durability are well known in transplant recipients due to exclusion of them from recent COVID-19 vaccine trials [1, 2]. Currently, there are no SARS-CoV-2 vaccine platforms using attenuated live virus approved in phase III trials. Nevertheless, if they are approved for use, concerns, including potential decrease in efficacy in immunocompromised patients, potential for vaccine-related allograft rejection, unknown durability of the immune response, and long-term safety data still exist. Due to experience with neither the influenza vaccine nor the adjuvant recombinant zoster vaccine having been related to allograft rejection, successful administration of influenza and adjuvanted recombinant zoster vaccines to stable transplant recipients, and unanticipated vaccine-related adverse events to the allograft having not borne out, the influenza and adjuvanted recombinant zoster vaccines are able to be extrapolated to COVID-19 vaccines [2, 3]. In immunocompromised host, concerns for adenoviral vector vaccines are focused on a viral infection, but these concerns have no scientific evidence. Although newly approved adenoviral-vector use for vaccination, this vaccine platform has been used for decades for gene therapy for cancer and other rare diseases. Inactivated virus and protein subunit vaccine platforms that have been used in transplant recipients for other infections, such as human papilloma virus, pertussis, and hepatitis A and B, are currently under investigation for SARS-CoV-2 (COVID-19) infection in transplant recipients [2].","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91276910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Clinical Study on Pancytopenia in Pregnancy in Women of Rural Haryana 哈里亚纳邦农村妇女妊娠全血细胞减少症的临床研究

Journal of clinical & experimental immunology Pub Date : 2021-06-09 DOI: 10.33140/jcei.06.03.04

引用次数: 0

What Do All Autoimmune Diseases Have in Common? 所有自身免疫性疾病有什么共同之处?

Journal of clinical & experimental immunology Pub Date : 2021-06-09 DOI: 10.33140/jcei.06.03.02

引用次数: 4

Red Tide: Why a Biologic, HDFx, and Magnesium Could be used to allay Inflammatory and Lung Problems Caused by Algal Blooms: Hypothesis 赤潮:为什么一种生物制剂、HDFx和镁可以用来减轻由藻华引起的炎症和肺部问题:假设

Journal of clinical & experimental immunology Pub Date : 2021-01-21 DOI: 10.33140/jcei.06.01.03

引用次数: 1

COVID-19 Perceptional Disparity Among Dental Practitioners in Tricity (Chandigarh, Panchkula and Mohali) 三邦(昌迪加尔、潘切库拉和莫哈里)牙医对COVID-19的认知差异

Journal of clinical & experimental immunology Pub Date : 2021-01-21 DOI: 10.33140/jcei.06.01.04

{"title":"COVID-19 Perceptional Disparity Among Dental Practitioners in Tricity (Chandigarh, Panchkula and Mohali)","authors":"","doi":"10.33140/jcei.06.01.04","DOIUrl":"https://doi.org/10.33140/jcei.06.01.04","url":null,"abstract":"Background: Coronavirus (SARS-CoV-2) made the headlines after its initial breakout in Wahan, China in December 2019. Viral by genome, lethal by nature, strongly contagious by character succeeded in making a new chapter in everyone’s life in a very short span making it a pandemic Objectives: The aim of this study was to assess perceptional disparity among dental practitioners regarding the Coronavirus Disease 2019 (COVID-2019) pandemic. Material and methods: A total of 300 participating dentists were randomly included in this cross sectional survey. A self structured, closed ended questionnaire was administered to each participant to record demographic and professional characteristics followed by their knowledge regarding corona virus. Statistical analysis was performed using SPSS Version 20 and Multivariable linear regression analysis was carried out Results: It was found that only 33.3% of the clinicians had high knowledge regarding corona virus and only 38.5% of the respondents know the correct incubation period. About 65 % of the practitioners did not know about the diagnostic test available for corona virus and only 4.3 % of them gained knowledge rom journals or print media The above responses indicate a low knowledge among the dental practitioners regarding corona virus. Conclusions: The knowledge and practice scores were found to be worrisome, which is important to combat COVID-19. They are advised to follow the Centers of Disease Control and Prevention (CDC) and World Health Organization (WHO) guidelines in their clinics, and sensitize their staff so that no stone is left unturned in defeating this pandemic.","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90711603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glyceryl tribenzoate: A food additive with unique properties to be a substitute for cinnamon. 三苯甲酸酯:一种具有独特性能的食品添加剂，可以代替肉桂。

Journal of clinical & experimental immunology Pub Date : 2021-01-01 Epub Date: 2021-10-20 DOI: 10.33140/jcei.06.05.04

Swarupa Pahan, Sridevi Dasarathi, Kalipada Pahan

{"title":"Glyceryl tribenzoate: A food additive with unique properties to be a substitute for cinnamon.","authors":"Swarupa Pahan, Sridevi Dasarathi, Kalipada Pahan","doi":"10.33140/jcei.06.05.04","DOIUrl":"https://doi.org/10.33140/jcei.06.05.04","url":null,"abstract":"<p><p>Cinnamon is a regularly used natural seasoning and flavoring material throughout the world for eras. Recent laboratory studies have demonstrated that oral cinnamon may be beneficial for different neuroinflammatory and neurodegenerative disorders such as multiple sclerosis (MS), Parkinson's disease (PD), Alzheimer's disease (AD), and Lewy body diseases (LBD). However, cinnamon's certain limitations (e.g. unavailability of true Ceylon cinnamon throughout the world, impurities in ground cinnamon, etc.) have initiated an interest among researchers to find an alternate of cinnamon that can potentially deliver the same efficacy in the diseases mentioned above. Glyceryl tribenzoate (GTB) is a U.S. Food and Drug Administration (FDA)-approved flavoring ingredient that is used in food and food packaging industries. It has been found that similar to cinnamon, oral GTB is capable of upregulating regulatory T cells and suppressing the autoimmune disease process of experimental autoimmune encephalomyelitis, an animal model of MS. Moreover, both GTB and cinnamon metabolite sodium benzoate (NaB) have the potency to attenuate neurodegenerative pathology in a mouse model of Huntington disease (HD). Here, we have also demonstrated anti-inflammatory property of GTB in astrocytes and macrophages, a property that is also seen with cinnamon and its metabolite sodium benzoate (NaB). Therefore, here, we have made a sincere attempt to discuss the similarities and dissimilarities between cinnamon and GTB with a focus whether GTB has the potential to be considered as a substitute of cinnamon for neuroinflammatory and neurodegenerative disorders.</p>","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":"6 5","pages":"367-372"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8555914/pdf/nihms-1749969.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39581006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

From Coral to Coal 从珊瑚到煤

Journal of clinical & experimental immunology Pub Date : 2020-12-09 DOI: 10.33140/jcei.05.06.03

{"title":"From Coral to Coal","authors":"","doi":"10.33140/jcei.05.06.03","DOIUrl":"https://doi.org/10.33140/jcei.05.06.03","url":null,"abstract":"From coral to coal. A course from life to decay; from fluid plasticity to sedimentary rigidity; from tropical reef polyps expansion to combustible oxidative free radicals reaction; from expression to suppression; from flourish to perish. All these contrasting dynamics, this vivid antithesis of an integer ecosystem to a compressed peat bog, this endless colorful miracle of delight to a blackish stratum shell of scorn, get to be defined by a single letter; an “r”. The reflection that stands in between and makes all the difference; the reflection that stands in between and as a pivotal criterion reverberates opposed conditions and qualities; the reflection that stands in between and as a sword decides and divides. Which way it will be: light or darkness, real or unreal, allostasis or allostatic load, neuroinflammation or neuroprotection, progressive neurodegeneration or cell control and communication, gamma synchrony or hyperexcitability, well-being or mind-body infirmity, is determined by a serious consideration and careful thought. The conceptual operation of inverting a system or event with respect to a plane. A level of existence and cogitation, or development in accordance with a vectoring, a direction, orientation and attention. And for all the above, the mind-eye mirror connection which perceives and interprets, and creates a neuronal abstract substrate of bound distinct circuits that form as a whole memory, undoubtedly holds the key.","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78949882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transcutaneous Vagus Nerve Stimulation is Associated with Lower Mechanical Ventilation and Mortality in COVID-19 Patients: An interim Safety Analysis 经皮迷走神经刺激与COVID-19患者低机械通气和死亡率相关:一项临时安全性分析

Journal of clinical & experimental immunology Pub Date : 2020-11-23 DOI: 10.33140/jcei.05.06.02

P. Nemechek

{"title":"Transcutaneous Vagus Nerve Stimulation is Associated with Lower Mechanical Ventilation and Mortality in COVID-19 Patients: An interim Safety Analysis","authors":"P. Nemechek","doi":"10.33140/jcei.05.06.02","DOIUrl":"https://doi.org/10.33140/jcei.05.06.02","url":null,"abstract":"Objective: To evaluate the safety and efficacy of transcutaneous vagus nerve stimulation in preventing respiratory failure and improving survival in hospitalized COVID-19 patients. Design, Setting, and Participants: Interim analysis of an ongoing single-arm, uncontrolled open-label, observational trial to assess the transcutaneous vagus nerve stimulation (tVNS) in hospitalized SARS-CoV-2 infected subjects. Eligible subjects are 18 years old or older requiring hospitalization for COVID-19pneumonia. Results: The 25 subjects enrolled with a mean age of 52.2 (22-80). Mechanical ventilation was required in only 2 (8%) cases. One survived and 1 one died. Although 4 (16%) of the 25 hospitalized subjects died, only 1 (4%) was attributed to respiratory failure. Relative to other reported COVID-19 hospitalization outcomes data, our mortality rate of 16% (4 of 25) is lower than many other reported cohorts 10.2% – 50%. Only 8% (2 of 25) of subjects required mechanical ventilation comparing favorably to 7.4%-79% of subjects requiring mechanical ventilation in other cohorts. Adverse events associated with tVNS occurred in only 2 subjects (8%) and consisted of reversible oral paresthesia and orthostatic hypotension. Conclusion and Relevance: In this interim report of tVNS in COVID-19 pneumonia, patients had a low rate of adverse events, infrequent use of mechanical ventilation, and a high rate of survival. Several other studies have shown a wide range of in hospital mortality (14-50%) and the requirement of mechanical ventilation (7-79%). The interim analysis found the mortality rate and the frequency of mechanical ventilation to be less than almost all other large COVID-19 cohorts. Only mild and self-limiting adverse events tVNS occurred in 2 subjects highlighting the safety of vagus stimulation. The study is slated to enroll a minimum of 50 subjects. Trial Registration: ClinicalTrials.gov Identifier: NTC04379037.","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75272720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2