Journal of chemical health & safety最新文献_第6页

Development of Safety Science and Engineering Disciplines in Mainland China 中国大陆安全科学与工程学科的发展

Journal of chemical health & safety Pub Date : 2024-03-07 DOI: 10.1021/acs.chas.3c00113

Jianfeng Yang, Feilong Zhang, Jianwen Zhang, Pengchao Wang, Siyu Peng, Qianlin Wang, Jinghai Li, Liangchao Chen and Zhan Dou*,

{"title":"Development of Safety Science and Engineering Disciplines in Mainland China","authors":"Jianfeng Yang, Feilong Zhang, Jianwen Zhang, Pengchao Wang, Siyu Peng, Qianlin Wang, Jinghai Li, Liangchao Chen and Zhan Dou*, ","doi":"10.1021/acs.chas.3c00113","DOIUrl":"10.1021/acs.chas.3c00113","url":null,"abstract":"Considering the growing emphasis on safety issues in mainland China, it is essential to identify the hurdles in the development of safety disciplines and to promote alignment between safety disciplines and society. To understand the current state of safety science and engineering disciplines in mainland China, we conducted a study while considering the geographical distribution level, as well as the power gap between universities. In terms of the geographical distribution, the spatial distribution characteristics of institutions with safety engineering enrollment in China were mapped out. To illustrate the development characteristics and existing safety discipline problems, the current situation of economic development and safety production in each region was integrated. In terms of power gaps, the Cingta database was used to study the disparity between different indicators and the competitiveness of safety disciplines in representative universities. Based on these findings, the development of chemical safety education is further discussed. Finally, development directions were provided for the effective reform of safety disciplines in each university at this stage. The study demonstrated that the current development status of safety disciplines in universities was related to social needs and social background. The development of safety disciplines in certain provinces of China did not match the current state of the local economy and safety products. There was a significant gap between the strengths and weaknesses of disciplines between universities and colleges.","PeriodicalId":73648,"journal":{"name":"Journal of chemical health & safety","volume":"31 3","pages":"238–252"},"PeriodicalIF":0.0,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140070250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemical Health Risk Assessment and Evaluation of Risk toward Ototoxicants among Workers at Palm Oil Mills 棕榈油厂工人的化学健康风险评估和耳毒性风险评价

Journal of chemical health & safety Pub Date : 2024-03-05 DOI: 10.1021/acs.chas.3c00090

Nornadiah Roslan, and , Mohamad Syazarudin Md Said*,

{"title":"Chemical Health Risk Assessment and Evaluation of Risk toward Ototoxicants among Workers at Palm Oil Mills","authors":"Nornadiah Roslan,  and , Mohamad Syazarudin Md Said*, ","doi":"10.1021/acs.chas.3c00090","DOIUrl":"10.1021/acs.chas.3c00090","url":null,"abstract":"Chemical and noise hazards are known to have a synergistic effect, where a variety of different chemical substances may worsen hearing damage in humans. These chemical substances are identified as ototoxicants that are toxic to the auditory system. This study evaluated the issue and created a framework in which these ototoxicants can be recognized early in the workplace. The approach involved hazard identification of chemicals hazardous to health, observation of tasks related to chemicals, identification of ototoxicants and noise exposure, evaluation of risks, and determination of the adequacy of control measures in accordance with the DOSH Malaysia Chemical Health Risk Assessment (CHRA) Third Edition Manual 2017 and the Industry Code of Practice for Management of Occupational Noise Exposure and Hearing Conservation 2019. The target subjects of this study involved 148 palm oil mill workers at two different locations who are exposed to both chemicals and noise throughout their daily tasks. Four work units (i.e., boiler operators and welders at palm oil mill A and laboratory analysts and welders at palm oil mill B) were concluded to have a significant risk of exposure to ototoxicants due to the high noise exposure, inadequacy of engineering control, and unsuitable use of PPE.","PeriodicalId":73648,"journal":{"name":"Journal of chemical health & safety","volume":"31 3","pages":"202–216"},"PeriodicalIF":0.0,"publicationDate":"2024-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140047170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Gist of the List 清单要点

Journal of chemical health & safety Pub Date : 2024-02-26 DOI: 10.1021/acs.chas.4c00014

Lauren Goulding,

引用次数: 0

Spotlights: Self-Heating Lunchboxes, Using Machine Learning to Predict Toxicity, and the Role of Sulfation in Skin Sensitization 聚焦：自加热饭盒、利用机器学习预测毒性以及硫酸盐化在皮肤过敏中的作用

Journal of chemical health & safety Pub Date : 2024-02-23 DOI: 10.1021/acs.chas.4c00013

Lauren Goulding*,

引用次数: 0

Progress on Tritium Toxicity and Detoxification Strategies 氚毒性和解毒策略方面的进展

Journal of chemical health & safety Pub Date : 2024-02-23 DOI: 10.1021/acs.chas.3c00091

Binghui Lu, Xinrui Yang, Jing Liu and Rong Li*,

{"title":"Progress on Tritium Toxicity and Detoxification Strategies","authors":"Binghui Lu, Xinrui Yang, Jing Liu and Rong Li*, ","doi":"10.1021/acs.chas.3c00091","DOIUrl":"10.1021/acs.chas.3c00091","url":null,"abstract":"Tritium is a radioactive isotope of hydrogen that emits β-rays. Ingesting large doses of tritium can result in significant internal radiation damage to tissues and organs, causing chromosome damage, genomic instability, and even cancer. Therefore, the efficient promotion of tritium excretion and detoxification has become a crucial concern due to the extensive utilization of tritium. Conventional approaches involve administering diuretics and increased water intake, which can shorten the effective half-excretion period by 4 to 6 days. However, diuretic usage may lead to adverse reactions. In recent years, traditional Chinese medicines, such as Paichuanpian and Chahuangjing, have garnered attention for their potential in tritium elimination, with demonstrated low toxicity in animal experiments. Nevertheless, given the limited number of clinical cases involving internal tritium pollution, uncertainties persist regarding their clinical effects and toxicity levels. Hydrogen-rich water provides a simple, safe, nontoxic solution that has demonstrated promising results in antiradiation therapy and the treatment of various diseases. Experimental evidence suggests that hydrogen-rich water can also enhance excretion and detoxification processes while offering antioxidant benefits in animal models exposed to internal tritium. Therefore, it holds potential as an innovative approach for promoting tritium excretion and detoxification. This paper aims to compare the advantages and disadvantages of different measures and medications to provide insights into the development and enhancement of drugs specifically designed for promoting tritium excretion.","PeriodicalId":73648,"journal":{"name":"Journal of chemical health & safety","volume":"31 2","pages":"144–152"},"PeriodicalIF":0.0,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139946793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Validity and Reliability of Survey Data: Key to Empowering Chemical Health and Safety Research 调查数据的有效性和可靠性：增强化学品健康与安全研究能力的关键

Journal of chemical health & safety Pub Date : 2024-02-13 DOI: 10.1021/acs.chas.3c00111

Qi Cui*, Jordan T. Harshman and Regis Komperda,

引用次数: 0

Nasal Drug Delivery System and Devices: An Overview on Health Effects 鼻腔给药系统和设备：健康影响概述

Journal of chemical health & safety Pub Date : 2024-02-09 DOI: 10.1021/acs.chas.3c00069

Pratik Katare, Tanvi Pawar Medhe, Akanksha Nadkarni, Mrudul Deshpande, Rakesh Kumar Tekade, Derajram Benival and Aakanchha Jain*,

{"title":"Nasal Drug Delivery System and Devices: An Overview on Health Effects","authors":"Pratik Katare, Tanvi Pawar Medhe, Akanksha Nadkarni, Mrudul Deshpande, Rakesh Kumar Tekade, Derajram Benival and Aakanchha Jain*, ","doi":"10.1021/acs.chas.3c00069","DOIUrl":"10.1021/acs.chas.3c00069","url":null,"abstract":"For centuries, intranasal administration has been a perennial fascination for humanity. In recent times, the realm of nanotechnology-based biomaterials has witnessed a notable resurgence. At its epicenter is the concept of “nose-to-brain” delivery, a pivotal strategy within the pharmaceutical landscape aimed at circumventing the challenges of first-pass metabolism and the reticular endothelium system. This innovative approach spans a spectrum of domains, encompassing drug delivery, diagnostics, theranostics, photothermal and photodynamic therapies, bioengineering, and biomedical engineering. To overcome its multifaceted challenges, the pioneering development of novel formulations is paramount, utilizing the potential of mucoadhesive polymers, sol–gel techniques, pH-dependent absorption, and advanced methodologies. The evolution of excipient technologies has, however, raised concerns surrounding nasal irritation, rapid drainage, and systemic toxicity, affecting both established and emerging formulations. Furthermore, the growing interest in comprehending, evaluating, and documenting the toxicity profiles of nanomaterials stems from their vast range of applications across industries. It sheds light on the various toxicological implications arising from the myriad variables in dosage form formulations, including the role of excipients. It is crucial to note that the mishandling of devices designed for nasal formulation administration can significantly contribute to toxicity concerns. Given these notable developments, this comprehensive review aims to provide an exhaustive examination of current knowledge regarding the physiological consequences of intranasal drug delivery systems within the human body.","PeriodicalId":73648,"journal":{"name":"Journal of chemical health & safety","volume":"31 2","pages":"127–143"},"PeriodicalIF":0.0,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139755938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Safety Guidance Document for Lithium Aluminum Hydride (LAH) Reduction: A Resource for Developing Specific SOPs on LAH Manipulations† 锂铝氢化物（LAH）还原安全指导文件：为制定有关 LAH 处理的具体 SOP 提供资源†。

Journal of chemical health & safety Pub Date : 2024-02-09 DOI: 10.1021/acs.chas.3c00102

Tilak Chandra*, and , Jeffrey P. Zebrowski,

{"title":"A Safety Guidance Document for Lithium Aluminum Hydride (LAH) Reduction: A Resource for Developing Specific SOPs on LAH Manipulations†","authors":"Tilak Chandra*,  and , Jeffrey P. Zebrowski, ","doi":"10.1021/acs.chas.3c00102","DOIUrl":"10.1021/acs.chas.3c00102","url":null,"abstract":"Strong reducing agents like lithium aluminum hydride (LiAlH4, LAH) are frequently employed by industry and academic laboratories in syntheses and other research applications. Due to LAH’s reactivity, several laboratory explosions and fires have been documented in the literature and on various EH&S webpages at universities. Some of the accidents were caused by incorrect handling of LAH or by improper chemical processes, such as weighing on regular paper, grinding, and creating friction, using contaminated solvents and glassware, and physically scraping the material during transfers. In many of these cases, researchers did not have access to a guidance document or an SOP for many of these incidents, and no thorough risk assessment was carried out. Academic laboratories can avoid similar accidents and associated property damage by developing a safety guidance document that identifies every facet of LAH manipulation in the experiment, including reaction setup, procedures for weighing and transferring material to the reaction vessel, heating, and cooling during the reaction, quenching the reaction, and waste disposal. This LAH guidance document can be used to produce a manipulation-specific SOP that covers best practices and precautions for a variety of substrates and reaction scales.","PeriodicalId":73648,"journal":{"name":"Journal of chemical health & safety","volume":"31 2","pages":"162–171"},"PeriodicalIF":0.0,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139756041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mitigation of Potential Risks in Chemical Laboratories: A Focused Review 降低化学实验室的潜在风险：重点回顾

Journal of chemical health & safety Pub Date : 2024-01-24 DOI: 10.1021/acs.chas.3c00097

Hossein Abedsoltan*, and , Mark B. Shiflett*,

引用次数: 0

ACS Chemical Health & Safety: The Next Phase of Development ACS 化学健康与安全：下一阶段的发展

Journal of chemical health & safety Pub Date : 2024-01-22 DOI: 10.1021/acs.chas.3c00120

Mary Beth Mulcahy*,

引用次数: 0