Journal of chemical health & safety最新文献

{"title":"Integrated HSE Protocols for High-Pressure CO2 Adsorption Experiments in Shale: A Laboratory Risk Management Case Study","authors":"Zaheer Hussain*,&nbsp;, ,&nbsp;Dzeti Farhah Mohshim,&nbsp;, ,&nbsp;Faizan Ali,&nbsp;, ,&nbsp;Qadir Mahmood Soomro,&nbsp;, ,&nbsp;Sarfraz Muin,&nbsp;, and ,&nbsp;Gulzar Ahmed,&nbsp;","doi":"10.1021/acs.chas.5c00178","DOIUrl":"https://doi.org/10.1021/acs.chas.5c00178","url":null,"abstract":"<p >CO₂ adsorption experiments on shale at higher pressures pose unique safety challenges. These challenges may be due to confined lab spaces, the presence of toxic gases and high-pressure systems, but Health, Safety and Environment (HSE) protocols still remain unreported at the laboratory level. This study presents a reproducible HSE framework for a dual cell adsorption system operated up to 120 bar and 70 °C. This multilayer HSE framework integrates engineering controls, structured safety related documentation and personal competency verification. It was observed that during the 24 runs there were no occurences of gas leakage, incidents or PPE violations. An emergency response time of 42 ± 5 s was observed during drills. The approach provides transferable guidelines for carbon capture and storage (CCS) laboratories, bridging a literature gap between industrial CCS risk analysis and early stage adsorption studies. Implementation of HSE protocols into experimental design enhanced operational safety and reproducibility within laboratory-scale adsorption experiments, while providing guidance that may inform safety planning for larger CCS experimental programs.</p>","PeriodicalId":73648,"journal":{"name":"Journal of chemical health & safety","volume":"33 3","pages":"371–381"},"PeriodicalIF":3.4,"publicationDate":"2026-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acs.chas.5c00178","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148010289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Suppression Mechanisms of Ferrocene on Methane–Hydrogen Explosion Propagation in Pipe: An Integrated Study of Experiments and Chemical Reaction Kinetics","authors":"Shuo Wang*,&nbsp;, ,&nbsp;Qin He,&nbsp;, ,&nbsp;Hongfu Mi*,&nbsp;, ,&nbsp;Yulong Duan,&nbsp;, ,&nbsp;Sen He,&nbsp;, ,&nbsp;Yanling Yang,&nbsp;, ,&nbsp;Peng Shao,&nbsp;, ,&nbsp;Guoqing Xiao,&nbsp;, and ,&nbsp;Jinjun Yang,&nbsp;","doi":"10.1021/acs.chas.6c00023","DOIUrl":"https://doi.org/10.1021/acs.chas.6c00023","url":null,"abstract":"<p >This study investigates the performance and mechanism of ferrocene in suppressing the propagation of methane–hydrogen explosions through experiments and chemical kinetic simulations. The experimental results demonstrate that ferrocene can decrease the flame speed and attenuate the explosion pressure by inhibiting the mutual excitation between the flame and the premixed zone. Specifically, the addition of ferrocene at concentrations of 0.1 g·L^–1, 0.2 g·L^–1, and 0.3 g·L^–1 increased the flame propagation time by 93.02%, 323.26%, and 597.67%, respectively, and decreased the maximum explosion pressure by 68.03%, 81.56%, and 95.49%. Kinetic modeling reveals that the decomposition products of ferrocene, FeC₅H₅, Fe, and FeO can consume key radicals, such as H, O, and OH in the explosion chain reactions, leading to a significant reduction in the concentrations of the active component and the effective combination. Moreover, the catalytic cyclic reactions of Fe-containing species continuously consume H and O, which diminish the promotional effect of various radical reactions on the temperature and flame speed of the explosion system. The findings provide theoretical support for protecting and suppressing methane–hydrogen explosions at the microscopic level.</p>","PeriodicalId":73648,"journal":{"name":"Journal of chemical health & safety","volume":"33 3","pages":"528–538"},"PeriodicalIF":3.4,"publicationDate":"2026-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acs.chas.6c00023","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148010178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improved Exhaust System for Laboratory Work with Fluorine","authors":"Clara Moedl,&nbsp; and ,&nbsp;Ralf Keding*,&nbsp;","doi":"10.1021/acs.chas.5c00122","DOIUrl":"https://doi.org/10.1021/acs.chas.5c00122","url":null,"abstract":"<p >Hydrofluoric acid (HF) is a widely used chemical in laboratories as well as in the glass and ceramics industries. It is valued for its high reactivity; however, it poses significant disadvantages, including high toxicity to humans and corrosive effects on equipment. To prevent damage to laboratory and surrounding equipment as well as to ensure operator safety, an appropriate exhaust ventilation system must be used. Exhaust systems for hydrofluoric acid applications must meet stringent technical standards. Depending on the frequency of use, they may incorporate wet scrubbers, which necessitate considerable energy input and consumption of alkaline neutralizing agents and cause a substantial pressure drop. We here present an easy-to-handle alternative system based on calcium hydroxide honeycomb monoliths (HMs). We calculated and simulated the HF precipitation on the HMs based on thermodynamic data and with finite elements. We considered a liquid HF concentration of up to 50% in use within a standard laboratory fume hood. The HF concentration in the exhaust air after HMs throughflow was measured as well as the pressure drop. Theoretically and experimentally, HF was completely bound to calcium hydroxide HMs. Moreover, we find that the pressure drop in the fume hood was low compared to that of wet scrubbers. Calcium hydroxide HMs are a promising option for adsorbing HF from exhaust gas flows. From the economic viewpoint and from technical and organizational requirements, HMs offer significant benefits over wet scrubbers. Our findings can be directly implemented within experimental laboratories handling HF containing exhaust air.</p>","PeriodicalId":73648,"journal":{"name":"Journal of chemical health & safety","volume":"33 3","pages":"389–394"},"PeriodicalIF":3.4,"publicationDate":"2026-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acs.chas.5c00122","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148010220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modeling Time-Dependent Chemical Concentrations in Confined Spaces for General Safety Applications","authors":"Diya Godavarti,&nbsp;, ,&nbsp;Waynell Simbafo,&nbsp;, ,&nbsp;John Pederson*,&nbsp;, ,&nbsp;Jenny Houlroyd,&nbsp;, and ,&nbsp;Pamela Pollet*,&nbsp;","doi":"10.1021/acs.chas.6c00021","DOIUrl":"https://doi.org/10.1021/acs.chas.6c00021","url":null,"abstract":"<p >Enclosed spaces with little to no ventilation present significant chemical exposure risks in many occupational environments. This study develops and verifies an open-source computational fluid dynamics (CFD)-based diffusion model to predict vapor-phase transient concentrations as a function of time and geometry-specific context. Our contribution is to make foundational diffusion-based exposure models accurate, reliable, and broadly accessible to nonspecialists. A combined mesh and time-step refinement study was performed to evaluate the convergence of observables (i.e., concentrations and time) for diffusion-based simulations. Simulations tracked vapor front progression of benzene, a carcinogen, and our selected model compound using its OSHA Short-Term Exposure Limit (STEL) of 5 ppm in the headspace of a truck tank. We compare our model with results from the analytical semi-infinite medium solution. The diffusion model aligned closely with the analytical solution at early times but diverged later due to transverse diffusion resulting from the space-specific geometry. Additionally, we report analyses that quantified deviations as well as posture-dependent exposure timelines. Sensitivity analyses of varying temperatures and liquid pool heights were also performed. These findings underscore the importance of transient, geometry-conscious modeling for risk assessment, complementing and informing physical sampling needs, and ventilation strategies. By relying on open-source software like OpenFOAM and shareable code, this work expands the CFD-based exposure modeling beyond specialized commercial environments, moving toward a more practical use in public and noncontrolled situations.</p>","PeriodicalId":73648,"journal":{"name":"Journal of chemical health & safety","volume":"33 3","pages":"516–527"},"PeriodicalIF":3.4,"publicationDate":"2026-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acs.chas.6c00021","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148010252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated HSE Protocols for High-Pressure CO2 Adsorption Experiments in Shale: A Laboratory Risk Management Case Study","authors":"Zaheer Hussain*,&nbsp;, ,&nbsp;Dzeti Farhah Mohshim,&nbsp;, ,&nbsp;Faizan Ali,&nbsp;, ,&nbsp;Qadir Mahmood Soomro,&nbsp;, ,&nbsp;Sarfraz Muin,&nbsp;, and ,&nbsp;Gulzar Ahmed,&nbsp;","doi":"10.1021/acs.chas.5c00178","DOIUrl":"https://doi.org/10.1021/acs.chas.5c00178","url":null,"abstract":"<p >CO₂ adsorption experiments on shale at higher pressures pose unique safety challenges. These challenges may be due to confined lab spaces, the presence of toxic gases and high-pressure systems, but Health, Safety and Environment (HSE) protocols still remain unreported at the laboratory level. This study presents a reproducible HSE framework for a dual cell adsorption system operated up to 120 bar and 70 °C. This multilayer HSE framework integrates engineering controls, structured safety related documentation and personal competency verification. It was observed that during the 24 runs there were no occurences of gas leakage, incidents or PPE violations. An emergency response time of 42 ± 5 s was observed during drills. The approach provides transferable guidelines for carbon capture and storage (CCS) laboratories, bridging a literature gap between industrial CCS risk analysis and early stage adsorption studies. Implementation of HSE protocols into experimental design enhanced operational safety and reproducibility within laboratory-scale adsorption experiments, while providing guidance that may inform safety planning for larger CCS experimental programs.</p>","PeriodicalId":73648,"journal":{"name":"Journal of chemical health & safety","volume":"33 3","pages":"371–381"},"PeriodicalIF":3.4,"publicationDate":"2026-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acs.chas.5c00178","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148010286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Practicalities of Studying Phosgene at a Neutron Source: Safety, Collaboration, and Lessons Learned","authors":"Sven Ringelband,&nbsp;, ,&nbsp;Frank Tambornino,&nbsp;, ,&nbsp;Ethan Baker,&nbsp;, ,&nbsp;Jason Chandler,&nbsp;, ,&nbsp;A. Dominic Fortes,&nbsp;, ,&nbsp;Chris Goodway,&nbsp;, ,&nbsp;Kimberley Greenough,&nbsp;, ,&nbsp;Ian Hickman,&nbsp;, ,&nbsp;Christopher M. Howard,&nbsp;, ,&nbsp;Stewart F. Parker*,&nbsp;, ,&nbsp;Maksim Schastny,&nbsp;, and ,&nbsp;James D. Taylor*,&nbsp;","doi":"10.1021/acs.chas.5c00220","DOIUrl":"https://doi.org/10.1021/acs.chas.5c00220","url":null,"abstract":"<p >Phosgene (carbonyl dichloride, COCl₂) has a well-deserved reputation as an extremely toxic gas. However, it is widely used in industry, principally for the production of isocyanates, key intermediates in polyurethane manufacture. Comparatively little is known about the solid state of phosgene. This article describes the processes that went into enabling <i>ca</i>. 10 g of phosgene to be safely produced, measured by neutron powder diffraction and neutron vibrational spectroscopy, and appropriately disposed of. The factors that allowed these operations to be carried out at the ISIS Neutron and Muon Source are discussed, and the lessons learned for future work with hazardous materials are described.</p>","PeriodicalId":73648,"journal":{"name":"Journal of chemical health & safety","volume":"33 3","pages":"442–449"},"PeriodicalIF":3.4,"publicationDate":"2026-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acs.chas.5c00220","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148010166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Smart Acrylic Coating, Incorporated with PAN/MOF/CNT Composite, for Real-Time and Noncontact Detection of Accidental Acid/Base Contamination","authors":"Jahyun Nam,&nbsp;, ,&nbsp;Jina Yang,&nbsp;, ,&nbsp;Kyung-Min Yeon*,&nbsp;, and ,&nbsp;Jungbae Kim*,&nbsp;","doi":"10.1021/acs.chas.5c00182","DOIUrl":"https://doi.org/10.1021/acs.chas.5c00182","url":null,"abstract":"<p >A smart acrylic coating, functionalized with a nanocomposite of polyaniline (PAN), a metal–organic framework (MOF), and carbon nanotubes (CNT), is developed as an intelligent engineering control for the real-time, noncontact detection of chemical hazards. The coating provides a dual-signal response to acid/base contamination, exhibiting a reversible, pH-dependent color shift, while simultaneously generating measurable surface-voltage fluctuations. Formulated for practical application in a commercial water-borne acrylic matrix, the coating is demonstrated to be safe and durable, with low volatile organic compound emissions (0.055 mg/m² h) and acceptable color stability (Δ<i>E</i> &lt; 4 after a month). The system shows electrical signals to chemical spills, with the surface voltage increasing from a 4.5 mV baseline to 184 mV upon acid contact and −50 mV upon ammonia exposure. The versatility of the core technology is further demonstrated in a passive near field communication tag, which functions as a chemi-responsive switch for nonline-of-sight detection within confined spaces. This work validates a multimodal sensing technology across multiple platforms, presenting a significant advancement in proactive engineering controls for chemical safety.</p>","PeriodicalId":73648,"journal":{"name":"Journal of chemical health & safety","volume":"33 3","pages":"395–406"},"PeriodicalIF":3.4,"publicationDate":"2026-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acs.chas.5c00182","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148010208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kinetic Stability and Safety Management Protocols for High-Reactivity Precursors (Zr, Hf, and Si) in Semiconductor Manufacturing: Focusing on Thermal Runaway and Hydrolysis Risks","authors":"Tae Hun Kwak,&nbsp;, ,&nbsp;Soyoung Ahn,&nbsp;, and ,&nbsp;Kyungjun Kang*,&nbsp;","doi":"10.1021/acs.chas.5c00219","DOIUrl":"https://doi.org/10.1021/acs.chas.5c00219","url":null,"abstract":"<p >The transition to sub-10 nm semiconductor nodes necessitates the use of highly reactive zirconium (Zr), hafnium (Hf), and silicon (Si) precursors, which introduce severe safety risks due to their low activation energies and high kinetic lability. This study investigates the critical degradation mechanisms of these precursors, specifically focusing on the self-accelerating thermal decomposition of organometallics and the rapid hydrolysis of chlorosilanes that generates explosive hydrogen gas. By analyzing representative accident scenarios─including canister rupture due to thermal runaway and hydrogen explosions in storage cabinets─we identify significant gaps in current safety guidelines that lack material-specific kinetic data. Consequently, we propose a comprehensive, kinetically based safety management protocol. Key measures include the implementation of a strict active cold chain to prevent thermal runaway, advanced multigas detection systems (H₂/HCl) for atmosphere control, and a dynamic shelf-life assessment based on thermal history. These strategies provide a scientific framework for mitigating catastrophic risks and ensuring process integrity in next-generation semiconductor fabrication.</p>","PeriodicalId":73648,"journal":{"name":"Journal of chemical health & safety","volume":"33 3","pages":"435–441"},"PeriodicalIF":3.4,"publicationDate":"2026-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acs.chas.5c00219","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148010222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polar and Organic Phase Modulation of Lipids in Lung and Systemic Tissues Following Silica Particle Pulmonary Exposure in Mice","authors":"Jenna N. Swihart,&nbsp;, ,&nbsp;Christina R. Ferreira,&nbsp;, ,&nbsp;Arjun Pitchai,&nbsp;, ,&nbsp;Akshada Shinde,&nbsp;, and ,&nbsp;Jonathan H. Shannahan*,&nbsp;","doi":"10.1021/acs.chas.5c00225","DOIUrl":"https://doi.org/10.1021/acs.chas.5c00225","url":null,"abstract":"<p >Inhaled exposures to particulate matter are increasingly recognized to perturb lipid metabolism both at the site of deposition and systemically. However, lipidomic assessments following particle inhalation often neglect the polar fraction, potentially omitting amphipathic species such as phospholipids, sphingolipids, and ceramides that may partition into the aqueous phase. This exclusion can obscure key lipidomic signatures relevant to inflammation and toxicity. Silica particles (SiO₂), generated from natural and industrial sources, elicit not only pulmonary toxicity but are also implicated in kidney, cardiovascular, and autoimmune diseases. We hypothesized that SiO₂ exposure disrupts lipidomic signatures in both organic and polar phases across multiple tissues, promoting inflammation and systemic toxicity. To evaluate this, mice were exposed to 1 mg of SiO₂ by oropharyngeal aspiration, with controls receiving water (n = 6/group). At 24 h postexposure, acute toxicity end points and lipidomic modifications were evaluated in the lung, liver, kidney, brain, and serum. Gene expression analyses revealed significant upregulation of inflammatory markers in the lung and lipid metabolism dysregulation, specifically an upregulation of <i>prostaglandin-endoperoxide synthase 2 (COX-2), across</i> all evaluated tissues following SiO₂ exposure. Lipidomic results revealed widespread remodeling in both organic and polar fractions due to SiO₂, with the lung showing the greatest magnitude of change. Polar-phase alterations were dominated by glycerophospholipids, whereas the organic fraction reflected shifts in triglycerides and diglycerides. Summed-phase analyses uncovered additional differences not apparent when either phase was assessed independently and revealed distinct lipidomic profiles between control and SiO₂-exposed mice. Moreover, numerous lipid species shared between groups exhibited significant abundance differences. Together, these findings indicate that acute SiO₂ inhalation induces coordinated lipid alterations across organ systems, linking pulmonary exposure to systemic responses. Incorporating both organic and aqueous fractions in lipidomic workflows provides a more complete picture of particle-induced dysregulation and may reveal mechanisms linking pulmonary exposure to systemic outcomes.</p>","PeriodicalId":73648,"journal":{"name":"Journal of chemical health & safety","volume":"33 3","pages":"450–465"},"PeriodicalIF":3.4,"publicationDate":"2026-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acs.chas.5c00225","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148010608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polar and Organic Phase Modulation of Lipids in Lung and Systemic Tissues Following Silica Particle Pulmonary Exposure in Mice","authors":"Jenna N. Swihart,&nbsp;, ,&nbsp;Christina R. Ferreira,&nbsp;, ,&nbsp;Arjun Pitchai,&nbsp;, ,&nbsp;Akshada Shinde,&nbsp;, and ,&nbsp;Jonathan H. Shannahan*,&nbsp;","doi":"10.1021/acs.chas.5c00225","DOIUrl":"https://doi.org/10.1021/acs.chas.5c00225","url":null,"abstract":"<p >Inhaled exposures to particulate matter are increasingly recognized to perturb lipid metabolism both at the site of deposition and systemically. However, lipidomic assessments following particle inhalation often neglect the polar fraction, potentially omitting amphipathic species such as phospholipids, sphingolipids, and ceramides that may partition into the aqueous phase. This exclusion can obscure key lipidomic signatures relevant to inflammation and toxicity. Silica particles (SiO₂), generated from natural and industrial sources, elicit not only pulmonary toxicity but are also implicated in kidney, cardiovascular, and autoimmune diseases. We hypothesized that SiO₂ exposure disrupts lipidomic signatures in both organic and polar phases across multiple tissues, promoting inflammation and systemic toxicity. To evaluate this, mice were exposed to 1 mg of SiO₂ by oropharyngeal aspiration, with controls receiving water (n = 6/group). At 24 h postexposure, acute toxicity end points and lipidomic modifications were evaluated in the lung, liver, kidney, brain, and serum. Gene expression analyses revealed significant upregulation of inflammatory markers in the lung and lipid metabolism dysregulation, specifically an upregulation of <i>prostaglandin-endoperoxide synthase 2 (COX-2), across</i> all evaluated tissues following SiO₂ exposure. Lipidomic results revealed widespread remodeling in both organic and polar fractions due to SiO₂, with the lung showing the greatest magnitude of change. Polar-phase alterations were dominated by glycerophospholipids, whereas the organic fraction reflected shifts in triglycerides and diglycerides. Summed-phase analyses uncovered additional differences not apparent when either phase was assessed independently and revealed distinct lipidomic profiles between control and SiO₂-exposed mice. Moreover, numerous lipid species shared between groups exhibited significant abundance differences. Together, these findings indicate that acute SiO₂ inhalation induces coordinated lipid alterations across organ systems, linking pulmonary exposure to systemic responses. Incorporating both organic and aqueous fractions in lipidomic workflows provides a more complete picture of particle-induced dysregulation and may reveal mechanisms linking pulmonary exposure to systemic outcomes.</p>","PeriodicalId":73648,"journal":{"name":"Journal of chemical health & safety","volume":"33 3","pages":"450–465"},"PeriodicalIF":3.4,"publicationDate":"2026-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acs.chas.5c00225","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148010702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}