Journal of cancer science and clinical therapeutics最新文献_第3页

Breast Cancer or even an Artistic Fantasy in the Paintings of Rembrandt and Rubens? 乳腺癌还是伦勃朗和鲁本斯画作中的艺术幻想?

Journal of cancer science and clinical therapeutics Pub Date : 2023-01-01 DOI: 10.26502/jcsct.5079193

P. Kosiorek, Dorota Elzbieta Kazberuk, Katarzyna Jarznbek, Magdalena Joanna Borkowska

引用次数: 0

Mycobacterium Bovis-Related Abdominal Aortic Aneurysm after Intravesical Bacillus Calmette-Guérin Therapy for Non-Muscle Invasive Bladder Cancer 非肌肉浸润性膀胱癌膀胱内卡介苗-谷氨酰胺治疗后与牛分枝杆菌相关的腹主动脉瘤

Journal of cancer science and clinical therapeutics Pub Date : 2023-01-01 DOI: 10.26502/jcsct.5079188

A. Angeles, J. Faulds, E. Ni Mhurchu, G. Wang, Monty Martin, L. Nappi

引用次数: 0

Transitional Cell Carcinoma: Impact of Life Style on Grading of Tumor 移行细胞癌:生活方式对肿瘤分级的影响

Journal of cancer science and clinical therapeutics Pub Date : 2023-01-01 DOI: 10.26502/jcsct.5079205

M. Arefin, Homayra Tahseen Hossain

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Unveiling Brain Region Patterns in PET/CT scans for Lung Cancer Assessment: A Computational AI Framework 揭示肺癌评估的PET/CT扫描中的脑区域模式:一个计算AI框架

Journal of cancer science and clinical therapeutics Pub Date : 2023-01-01 DOI: 10.26502/jcsct.5079210

Hakan Sat Bozcuk, Ahmet Eren Sen, Mehmet Artac, Bugra Kaya

{"title":"Unveiling Brain Region Patterns in PET/CT scans for Lung Cancer Assessment: A Computational AI Framework","authors":"Hakan Sat Bozcuk, Ahmet Eren Sen, Mehmet Artac, Bugra Kaya","doi":"10.26502/jcsct.5079210","DOIUrl":"https://doi.org/10.26502/jcsct.5079210","url":null,"abstract":"This study aims to investigate potential differences in brain activity between lung cancer patients and healthy controls at the time of diagnosis, utilizing a computer vision artificial intelligence (AI) model. Participants undergoing evaluation for lung cancer (cases) and with benign pulmonary nodules (controls) underwent Positron Emission Tomography/ Computerized Tomography (PET/CT) scans. Specialized software reconstructed and labeled brain images. A computer vision AI model was developed using EfficientNet B0 through transfer learning, complemented by multivariate discriminant analysis. A total of 84 cases were recruited into the study. The constructed AI model exhibited robust accuracy (internal accuracy=1.0, external sensitivity=0.83) on a subset of cases (52 lung cancer patients, 22 controls). Notably, the right frontal lobe emerged as a crucial discriminator, displaying a 5% reduction in the ratio of frontal lobe to brainstem activity in lung cancer cases (Wilk’s Lambda=0.877, P=0.002). Based solely on PET/CT brain imaging data, our AI model accurately classified lung cancer patients. The distinct role of the right frontal lobe in this study underscores the broader significance, shedding light on brain function disparities at lung cancer diagnosis.","PeriodicalId":73634,"journal":{"name":"Journal of cancer science and clinical therapeutics","volume":"57 68 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135505501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of Complete Blood Count in the Breast Cancer Patients of Arsenic Exposed Population of Bihar. 比哈尔邦砷暴露人群乳腺癌患者全血计数分析

Journal of cancer science and clinical therapeutics Pub Date : 2023-01-01 DOI: 10.26502/jcsct.5079211

Yerravarapu Vamsi Krishna, Chandrajeet Kumar, Arun Kumar

{"title":"Assessment of Complete Blood Count in the Breast Cancer Patients of Arsenic Exposed Population of Bihar.","authors":"Yerravarapu Vamsi Krishna, Chandrajeet Kumar, Arun Kumar","doi":"10.26502/jcsct.5079211","DOIUrl":"https://doi.org/10.26502/jcsct.5079211","url":null,"abstract":"Arsenic contamination of groundwater has recently been recognized as a major threat to human health. They developed cancer after being exposed to arsenic for a long time. Among women, breast cancer is a rapidly expanding health problem in the modern era. Arsenic exposure leads to hormonal imbalance and breast cancer in the exposed population. Blood samples from n=203 breast cancer study participants and n=100 control female individuals were taken for analysis of complete blood count in this present research. The study reveals that there is significant elevation in the WBC counts and decrease in the RBC counts, platelets counts and haemoglobin percentage in the breast cancer patients. Out of n=203, female breast cancer patients, n=174 subject’s blood had significant changes in the haematological parameters in comparison to the control patient’s blood samples. Women who have been exposed to arsenic for an extended period of time in the state of Bihar have hormonal imbalances in their bodies as a result of the poisoning. In the present study, there was significant decrease (p<0.05) in the RBC counts in 92% of breast cancer patients in comparison to the control patients. Moreover, RBC indices were significantly fluctuated (p<0.05) in PCV%, MCV, MCH and MCHC levels in breast cancer patients in comparison to the control patients. The haemoglobin percentage in 94% in breast cancer patients had significant less levels (p<0.05) in comparison to the control patients. Finally, there was significant increase (p<0.05) in the WBC counts in 85% of the breast cancer patients in comparison to the control patients. This denotes that there haemotological parameters are highly affected. Moreover, these breast cancer patients were from the arsenic hotspot areas, where in the recent times the breast cancer disease burden has increased many folds. Hence, there is need to make strategies to control the disease burden in these arsenic hotspot regions.","PeriodicalId":73634,"journal":{"name":"Journal of cancer science and clinical therapeutics","volume":"141 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135101367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Simplicity: Web-Based Visualization and Analysis of High-Throughput Cancer Cell Line Screens. 简单：基于网络的高通量癌症细胞系筛选可视化和分析。

Journal of cancer science and clinical therapeutics Pub Date : 2023-01-01 Epub Date: 2023-12-08 DOI: 10.26502/jcsct.5079217

Alexander L Ling, Weijie Zhang, Adam Lee, Yunong Xia, Mei-Chi Su, Robert F Gruener, Sampreeti Jena, Yingbo Huang, Siddhika Pareek, Yuting Shan, R Stephanie Huang

引用次数: 0

Apalutamide Induced Neutropenia: An Unusual Side Effect and a Literature Review 阿帕鲁胺诱导中性粒细胞减少症:一种不寻常的副作用和文献综述

Journal of cancer science and clinical therapeutics Pub Date : 2023-01-01 DOI: 10.26502/jcsct.5079204

Feras A Moria, Changsu L Park, Ramy R Saleh

引用次数: 0

BRCA2 Status Alters the Effect of the P53 Reactivator HO-3867 in Ovarian Cancer Cells. BRCA2状态改变P53再激活物HO-3867在卵巢癌细胞中的作用

Journal of cancer science and clinical therapeutics Pub Date : 2023-01-01 Epub Date: 2023-04-27 DOI: 10.26502/jcsct.5079197

Eric J Devor, Ariane E Thomas, Brandon M Schickling

{"title":"BRCA2 Status Alters the Effect of the P53 Reactivator HO-3867 in Ovarian Cancer Cells.","authors":"Eric J Devor, Ariane E Thomas, Brandon M Schickling","doi":"10.26502/jcsct.5079197","DOIUrl":"10.26502/jcsct.5079197","url":null,"abstract":"<p><p>The vast majority of ovarian cancers have a TP53 mutation. Among these, a substantial proportion also have a BRCA1 and/or a BRCA2 mutation. Given a rising interest in the therapeutic use of p53 reactivating agents, we assessed the effect that such BRCA mutants would have on the action of a p53 reactivator. As an initial tool to examine the effect of a BRCA mutation on the action of a p53 reactivator we chose to utilize a naturally occurring experimental model. The high grade serous ovarian cancer cell lines PEO1 and PEO4 were established from the same patient. Both cell lines have a missense TP53 mutation, G244D. However, PEO1 cells also have a nonsense BRCA2 mutation, Y1655ter, which is cancelled out by a second mutation, Y1655Y, that renders PEO4 cells BRCA2 wild-type. This makes these cell lines an ideal experimental platform to begin to assess the effect of a BRCA mutation on the action of a p53 reactivator. Both PEO1 and PEO4 cells were treated with a p53 reactivator, the synthetic curcumin analog HO-3867. The effect of treatment was assessed through quantitative PCR (qPCR) assays of fourteen known p53 target loci, including p53 itself. In all cases there was a definite difference between treated and untreated cells relative to their BRCA2 status. While these results are preliminary, the fact that BRCA2 status influences the effect of a p53 reactivator on numerous target loci suggests that this relationship should be further investigated and that, in future, the BRCA status of ovarian tumors containing missense TP53 mutations should be considered when opting for the therapeutic use of a p53 reactivator.</p>","PeriodicalId":73634,"journal":{"name":"Journal of cancer science and clinical therapeutics","volume":"1 1","pages":"86-92"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11905286/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69348589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Real World Experience with Osteosarcoma from a Tertiary Cancer Centre in India 来自印度三级癌症中心骨肉瘤的真实世界经验

Journal of cancer science and clinical therapeutics Pub Date : 2023-01-01 DOI: 10.26502/jcsct.5079198

P. Goyal, S. Joga, R. Tripathi, Arpit Jain, M. Sharma, Varun Goel, V. Talwar, U. Batra, S. Pasricha, Dinesh Chandra Doval

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The PERK/Akt Pathway Mediates Apoptosis Resistance to ER Ca2+ Stress in LNCaP Prostate Cancer Cells PERK/Akt通路介导LNCaP前列腺癌细胞对ER Ca2+应激的凋亡抵抗

Journal of cancer science and clinical therapeutics Pub Date : 2023-01-01 DOI: 10.26502/jcsct.5079199

Charlotte Dubois, Dheeraj Kannancheri Puthooru, F. Vanden Abeele

引用次数: 0