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Journal of cancer science and clinical therapeutics最新文献

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Phosphatidylserine’s Exposure on Tumor Cells Determines a Tumor’s Microenvironment and Checkpoint Molecule Exposure, a Hypothesis 磷脂酰丝氨酸在肿瘤细胞上的暴露决定了肿瘤的微环境和检查点分子暴露，一个假设
Journal of cancer science and clinical therapeutics Pub Date : 2023-01-01 DOI: 10.26502/jcsct.5079190
James Randall Kennedy
{"title":"Phosphatidylserine’s Exposure on Tumor Cells Determines a Tumor’s Microenvironment and Checkpoint Molecule Exposure, a Hypothesis","authors":"James Randall Kennedy","doi":"10.26502/jcsct.5079190","DOIUrl":"https://doi.org/10.26502/jcsct.5079190","url":null,"abstract":"","PeriodicalId":73634,"journal":{"name":"Journal of cancer science and clinical therapeutics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69348497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Breast Lymphoma: A Report of 5 Cases and Literature Review 乳腺淋巴瘤5例报告并文献复习
Journal of cancer science and clinical therapeutics Pub Date : 2023-01-01 DOI: 10.26502/jcsct.5079200
Abidi Fethia, O. Chaibi, Riahi Nihed, Essghaier Sonia, Ksentini Feriel, A. Zidi
{"title":"Breast Lymphoma: A Report of 5 Cases and Literature Review","authors":"Abidi Fethia, O. Chaibi, Riahi Nihed, Essghaier Sonia, Ksentini Feriel, A. Zidi","doi":"10.26502/jcsct.5079200","DOIUrl":"https://doi.org/10.26502/jcsct.5079200","url":null,"abstract":"","PeriodicalId":73634,"journal":{"name":"Journal of cancer science and clinical therapeutics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69348635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Concurrent Versus Sequential Chemoradiotherapy in Stage III Non-Small Cell Lung Cancer-A Comparative Study 同步与序贯放化疗治疗III期非小细胞肺癌的比较研究
Journal of cancer science and clinical therapeutics Pub Date : 2023-01-01 DOI: 10.26502/jcsct.5079209
Aditi Paul Chowdhury, Md. Ruhul Amin Bhuiyan, Md. Ershadul Haque, Abdul Mannan, Abdullah Al Mamun
{"title":"Concurrent Versus Sequential Chemoradiotherapy in Stage III Non-Small Cell Lung Cancer-A Comparative Study","authors":"Aditi Paul Chowdhury, Md. Ruhul Amin Bhuiyan, Md. Ershadul Haque, Abdul Mannan, Abdullah Al Mamun","doi":"10.26502/jcsct.5079209","DOIUrl":"https://doi.org/10.26502/jcsct.5079209","url":null,"abstract":"Background: Non-small cell Lung carcinoma is the most common carcinoma in both worldwide and Bangladesh. Most of them presents with locally advanced disease. Though Concurrent Chemoradiation (CCRT) is the standard approach, Sequential chemoradiotherapy (SCRT) can also be considered in stage III NSCLC. This study’s aim is to compare the local control and toxicity of CCRT and SCRT in stage III NSCLC.","PeriodicalId":73634,"journal":{"name":"Journal of cancer science and clinical therapeutics","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136258916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Breast Cancer or even an Artistic Fantasy in the Paintings of Rembrandt and Rubens? 乳腺癌还是伦勃朗和鲁本斯画作中的艺术幻想?
Journal of cancer science and clinical therapeutics Pub Date : 2023-01-01 DOI: 10.26502/jcsct.5079193
P. Kosiorek, Dorota Elzbieta Kazberuk, Katarzyna Jarznbek, Magdalena Joanna Borkowska
{"title":"Breast Cancer or even an Artistic Fantasy in the Paintings of Rembrandt and Rubens?","authors":"P. Kosiorek, Dorota Elzbieta Kazberuk, Katarzyna Jarznbek, Magdalena Joanna Borkowska","doi":"10.26502/jcsct.5079193","DOIUrl":"https://doi.org/10.26502/jcsct.5079193","url":null,"abstract":"","PeriodicalId":73634,"journal":{"name":"Journal of cancer science and clinical therapeutics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69348522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mycobacterium Bovis-Related Abdominal Aortic Aneurysm after Intravesical Bacillus Calmette-Guérin Therapy for Non-Muscle Invasive Bladder Cancer 非肌肉浸润性膀胱癌膀胱内卡介苗-谷氨酰胺治疗后与牛分枝杆菌相关的腹主动脉瘤
Journal of cancer science and clinical therapeutics Pub Date : 2023-01-01 DOI: 10.26502/jcsct.5079188
A. Angeles, J. Faulds, E. Ni Mhurchu, G. Wang, Monty Martin, L. Nappi
{"title":"Mycobacterium Bovis-Related Abdominal Aortic Aneurysm after Intravesical Bacillus Calmette-Guérin Therapy for Non-Muscle Invasive Bladder Cancer","authors":"A. Angeles, J. Faulds, E. Ni Mhurchu, G. Wang, Monty Martin, L. Nappi","doi":"10.26502/jcsct.5079188","DOIUrl":"https://doi.org/10.26502/jcsct.5079188","url":null,"abstract":"","PeriodicalId":73634,"journal":{"name":"Journal of cancer science and clinical therapeutics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69348420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transitional Cell Carcinoma: Impact of Life Style on Grading of Tumor 移行细胞癌:生活方式对肿瘤分级的影响
Journal of cancer science and clinical therapeutics Pub Date : 2023-01-01 DOI: 10.26502/jcsct.5079205
M. Arefin, Homayra Tahseen Hossain
{"title":"Transitional Cell Carcinoma: Impact of Life Style on Grading of Tumor","authors":"M. Arefin, Homayra Tahseen Hossain","doi":"10.26502/jcsct.5079205","DOIUrl":"https://doi.org/10.26502/jcsct.5079205","url":null,"abstract":"","PeriodicalId":73634,"journal":{"name":"Journal of cancer science and clinical therapeutics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69348700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unveiling Brain Region Patterns in PET/CT scans for Lung Cancer Assessment: A Computational AI Framework 揭示肺癌评估的PET/CT扫描中的脑区域模式:一个计算AI框架
Journal of cancer science and clinical therapeutics Pub Date : 2023-01-01 DOI: 10.26502/jcsct.5079210
Hakan Sat Bozcuk, Ahmet Eren Sen, Mehmet Artac, Bugra Kaya
{"title":"Unveiling Brain Region Patterns in PET/CT scans for Lung Cancer Assessment: A Computational AI Framework","authors":"Hakan Sat Bozcuk, Ahmet Eren Sen, Mehmet Artac, Bugra Kaya","doi":"10.26502/jcsct.5079210","DOIUrl":"https://doi.org/10.26502/jcsct.5079210","url":null,"abstract":"This study aims to investigate potential differences in brain activity between lung cancer patients and healthy controls at the time of diagnosis, utilizing a computer vision artificial intelligence (AI) model. Participants undergoing evaluation for lung cancer (cases) and with benign pulmonary nodules (controls) underwent Positron Emission Tomography/ Computerized Tomography (PET/CT) scans. Specialized software reconstructed and labeled brain images. A computer vision AI model was developed using EfficientNet B0 through transfer learning, complemented by multivariate discriminant analysis. A total of 84 cases were recruited into the study. The constructed AI model exhibited robust accuracy (internal accuracy=1.0, external sensitivity=0.83) on a subset of cases (52 lung cancer patients, 22 controls). Notably, the right frontal lobe emerged as a crucial discriminator, displaying a 5% reduction in the ratio of frontal lobe to brainstem activity in lung cancer cases (Wilk’s Lambda=0.877, P=0.002). Based solely on PET/CT brain imaging data, our AI model accurately classified lung cancer patients. The distinct role of the right frontal lobe in this study underscores the broader significance, shedding light on brain function disparities at lung cancer diagnosis.","PeriodicalId":73634,"journal":{"name":"Journal of cancer science and clinical therapeutics","volume":"57 68 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135505501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Simplicity: Web-Based Visualization and Analysis of High-Throughput Cancer Cell Line Screens. 简单：基于网络的高通量癌症细胞系筛选可视化和分析。
Journal of cancer science and clinical therapeutics Pub Date : 2023-01-01 Epub Date: 2023-12-08 DOI: 10.26502/jcsct.5079217
Alexander L Ling, Weijie Zhang, Adam Lee, Yunong Xia, Mei-Chi Su, Robert F Gruener, Sampreeti Jena, Yingbo Huang, Siddhika Pareek, Yuting Shan, R Stephanie Huang
{"title":"Simplicity: Web-Based Visualization and Analysis of High-Throughput Cancer Cell Line Screens.","authors":"Alexander L Ling, Weijie Zhang, Adam Lee, Yunong Xia, Mei-Chi Su, Robert F Gruener, Sampreeti Jena, Yingbo Huang, Siddhika Pareek, Yuting Shan, R Stephanie Huang","doi":"10.26502/jcsct.5079217","DOIUrl":"10.26502/jcsct.5079217","url":null,"abstract":"<p><p>High-throughput drug screens are a powerful tool for cancer drug development. However, the results of such screens are often made available only as raw data, which is intractable for researchers without informatics skills, or as highly processed summary statistics, which can lack essential information for translating screening results into clinically meaningful discoveries. To improve the usability of these datasets, we developed Simplicity, a robust and user-friendly web interface for visualizing, exploring, and summarizing raw and processed data from high- throughput drug screens. Importantly, Simplicity allows for easy recalculation of summary statistics at user-defined drug concentrations. This allows Simplicity's outputs to be used with methods that rely on statistics being calculated at clinically relevant doses. Simplicity can be freely accessed at https://oncotherapyinformatics.org/simplicity/.</p>","PeriodicalId":73634,"journal":{"name":"Journal of cancer science and clinical therapeutics","volume":"7 4","pages":"249-252"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10906814/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140023550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of Complete Blood Count in the Breast Cancer Patients of Arsenic Exposed Population of Bihar. 比哈尔邦砷暴露人群乳腺癌患者全血计数分析
Journal of cancer science and clinical therapeutics Pub Date : 2023-01-01 DOI: 10.26502/jcsct.5079211
Yerravarapu Vamsi Krishna, Chandrajeet Kumar, Arun Kumar
{"title":"Assessment of Complete Blood Count in the Breast Cancer Patients of Arsenic Exposed Population of Bihar.","authors":"Yerravarapu Vamsi Krishna, Chandrajeet Kumar, Arun Kumar","doi":"10.26502/jcsct.5079211","DOIUrl":"https://doi.org/10.26502/jcsct.5079211","url":null,"abstract":"Arsenic contamination of groundwater has recently been recognized as a major threat to human health. They developed cancer after being exposed to arsenic for a long time. Among women, breast cancer is a rapidly expanding health problem in the modern era. Arsenic exposure leads to hormonal imbalance and breast cancer in the exposed population. Blood samples from n=203 breast cancer study participants and n=100 control female individuals were taken for analysis of complete blood count in this present research. The study reveals that there is significant elevation in the WBC counts and decrease in the RBC counts, platelets counts and haemoglobin percentage in the breast cancer patients. Out of n=203, female breast cancer patients, n=174 subject’s blood had significant changes in the haematological parameters in comparison to the control patient’s blood samples. Women who have been exposed to arsenic for an extended period of time in the state of Bihar have hormonal imbalances in their bodies as a result of the poisoning. In the present study, there was significant decrease (p<0.05) in the RBC counts in 92% of breast cancer patients in comparison to the control patients. Moreover, RBC indices were significantly fluctuated (p<0.05) in PCV%, MCV, MCH and MCHC levels in breast cancer patients in comparison to the control patients. The haemoglobin percentage in 94% in breast cancer patients had significant less levels (p<0.05) in comparison to the control patients. Finally, there was significant increase (p<0.05) in the WBC counts in 85% of the breast cancer patients in comparison to the control patients. This denotes that there haemotological parameters are highly affected. Moreover, these breast cancer patients were from the arsenic hotspot areas, where in the recent times the breast cancer disease burden has increased many folds. Hence, there is need to make strategies to control the disease burden in these arsenic hotspot regions.","PeriodicalId":73634,"journal":{"name":"Journal of cancer science and clinical therapeutics","volume":"141 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135101367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
BRCA2 Status Alters the Effect of the P53 Reactivator HO-3867 in Ovarian Cancer Cells BRCA2状态改变P53再激活物HO-3867在卵巢癌细胞中的作用
Journal of cancer science and clinical therapeutics Pub Date : 2023-01-01 DOI: 10.26502/jcsct.5079197
Eric J Devor, Ariane E Thomas, Brandon M Schickling
{"title":"BRCA2 Status Alters the Effect of the P53 Reactivator HO-3867 in Ovarian Cancer Cells","authors":"Eric J Devor, Ariane E Thomas, Brandon M Schickling","doi":"10.26502/jcsct.5079197","DOIUrl":"https://doi.org/10.26502/jcsct.5079197","url":null,"abstract":"","PeriodicalId":73634,"journal":{"name":"Journal of cancer science and clinical therapeutics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69348589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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