Journal of cancer science and clinical therapeutics最新文献

{"title":"Individual-Level Factors that Contribute to Delayed Cervical Cancer Diagnosis among Patients in Kenya; A Hospital-Based Assessment.","authors":"Marthaclaire Zammit, Jackline Nyaberi, Susan Mambo, Careena Otieno, Bridget Kimani","doi":"10.26502/jcsct.5079237","DOIUrl":"https://doi.org/10.26502/jcsct.5079237","url":null,"abstract":"<p><p>Cervical cancer ranks 4th as the most prevalent cancer among women worldwide. In Kenya, it is the 2nd most frequently diagnosed cancer and the leading cause of cancer-related deaths among women. Globally, more than 50% of Cervical Cancer diagnoses are made late, with this proportion rising to over 80% in developing countries. This study aimed to determine the individual-level factors contributing to delayed cervical cancer diagnosis. A cross-sectional hospital-based study was adopted to collect data on; Socio-demographics, affordability and use of health insurance, Cervical cancer and Human Papillomavirus (HPV) screening awareness, Prior HPV screening, Diagnosis circumstances, Time taken to seek medical attention, Fears and social support experiences, from 139 cervical cancer patients systematically sampled at the Kenyatta National Hospital, using a semi-structured questionnaire. Additionally, 8 Key Informants were purposively selected, to provide in-depth information. Associations between stage at diagnosis and individual-level factors were tested using logistic regression at 95% Confidence Interval. The mean age was 51 years and all participants were African and Christians. Majority (63.31%) were married and educated up to primary level, and more than half (61.15%) were unemployed. The prevalence of delayed diagnosis was 86(61.9%). The Risk Factors for delayed diagnosis were; Older age; 50-59 (p-value=0.049) & 60-69 years (0.013), Lack of HPV screening awareness (P-value=0.017), and Seeking medical attention only due to a symptomatic trigger (P-value=0.030). In corroboration, qualitative information reported that, inability to afford diagnosis costs, lack of awareness and poor medical care seeking habits, contribute to delayed diagnosis. The study identified gaps in awareness of Cervical Cancer and HPV screening among women and affordability of diagnosis costs. More community-level awareness should be created and, increase of centers and resources for diagnosis and free screening. Women should also be encouraged to pay for the National Health Insurance Fund (NHIF), so as to lessen their financial burden of diagnosis.</p>","PeriodicalId":73634,"journal":{"name":"Journal of cancer science and clinical therapeutics","volume":"8 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7617629/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Web Application for Predicting Drug Combination Efficacy Using Monotherapy Data and IDACombo.","authors":"Yunong Xia, Alexander L Ling, Weijie Zhang, Adam Lee, Mei-Chi Su, Robert F Gruener, Sampreeti Jena, Yingbo Huang, Siddhika Pareek, Yuting Shan, R Stephanie Huang","doi":"10.26502/jcsct.5079218","DOIUrl":"10.26502/jcsct.5079218","url":null,"abstract":"<p><p>We recently reported a computational method (IDACombo) designed to predict the efficacy of cancer drug combinations using monotherapy response data and the assumptions of independent drug action. Given the strong agreement between IDACombo predictions and measured drug combination efficacy in vitro and in clinical trials, we believe IDACombo can be of immediate use to researchers who are working to develop novel drug combinations. While we previously released our method as an R package, we have now created an R Shiny application to allow researchers without programming experience to easily utilize this method. The app provides a graphical interface which enables users to easily generate efficacy predictions with IDACombo using provided data from several high-throughput cell line screens or using custom, user-provided data.</p>","PeriodicalId":73634,"journal":{"name":"Journal of cancer science and clinical therapeutics","volume":"7 4","pages":"253-258"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10852200/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139725201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biophysical and Biological Mechanisms of Tumor Treating Fields in Glioblastoma.","authors":"Jeremy Pan, Tony Eskandar, Zubair Ahmed, Devendra K Agrawal","doi":"10.26502/jcsct.5079249","DOIUrl":"10.26502/jcsct.5079249","url":null,"abstract":"<p><p>Glioblastoma (GBM) is one of the most aggressive forms of brain cancer that presents with a median survival rate of 14-30 months and along with a discouraging five-year survival rate of 4-5%. Standard treatment of newly diagnosed GBM, also known as the Stupp protocol, includes a maximally safe surgical resection followed by radiation and chemotherapy. Despite these treatment regimens, recurrence is almost inevitable, emphasizing the need for new therapies to combat the aggressive nature of GBMs. Tumor Treating Fields (TTFs) are a relatively new application to the treatment of GBMs, and results have been promising with both progression-free survival and overall survival when TTFs have been used in combination with temozolomide. This article critically reviews the biophysical and biological mechanisms of TTFs, their clinical efficacy, and discusses the results in clinical trials, including EF-11 and EF-14. Both trials have demonstrated that TTFs can enhance progression free survival and overall survival without compromising quality of life or causing severe adverse effects. Despite the high cost associated with TTFs and the need for further analysis to determine the most effective ways to integrate TTFs into GBM treatments, TTFs represent a significant advancement in GBM therapy and offer hope for improved patient prognosis.</p>","PeriodicalId":73634,"journal":{"name":"Journal of cancer science and clinical therapeutics","volume":"8 3","pages":"265-270"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11448370/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142373726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Small-Cell Lung Cancer in a Cancer Center in Colombia","authors":"C. Carvajal, D. Ballen, Natallie Jurado,, Rafael Beltrán, M. Alarcón, Camilo Vallejo-Yepes, Marcela Núñez, R. Parra, Ricardo Brugés-Maya","doi":"10.26502/jcsct.5079186","DOIUrl":"https://doi.org/10.26502/jcsct.5079186","url":null,"abstract":"","PeriodicalId":73634,"journal":{"name":"Journal of cancer science and clinical therapeutics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69348405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Different Coagulation Markers as Predictors of Severity in Cancer Patients with COVID-19 Infection","authors":"F. Alfraih, Mostafa F. Mohammed Saleh, A. Abdrabou, A. Haroon, K. AlSaleh, T. Owaidah","doi":"10.26502/jcsct.5079194","DOIUrl":"https://doi.org/10.26502/jcsct.5079194","url":null,"abstract":"","PeriodicalId":73634,"journal":{"name":"Journal of cancer science and clinical therapeutics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69348526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spinal Intramedullary Ewing Sarcoma with Meningeal Carcinomatosis: A Complete Response to Chemotherapy and Neuroaxis Irradiation. Case Report and Review of Literature","authors":"V. Albarrán, M. Villamayor, Ignacio Ruz, Jesús Chamorro, D. Rosero, J. Pozas, María San Román, P. A. Ballesteros, María Ángeles Vaz","doi":"10.26502/jcsct.5079195","DOIUrl":"https://doi.org/10.26502/jcsct.5079195","url":null,"abstract":"","PeriodicalId":73634,"journal":{"name":"Journal of cancer science and clinical therapeutics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69348532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Liquiritigenin Enhances the Inhibitory Effects of the Cholesterol Biosynthesis Inhibitor RO 48-8071 on Cell Viability in Ovarian-Cancer Cells in Vitro","authors":"Yayun Liang, Salman M Hyder","doi":"10.26502/jcsct.5079207","DOIUrl":"https://doi.org/10.26502/jcsct.5079207","url":null,"abstract":"Almost 25,000 new cases of epithelial ovarian cancer (EOC) are reported each year in the United States. Cancers of the ovary have poor prognosis due to drug resistance and metastasis, and have the highest mortality rate of all the known gynecological malignancies. Despite concerted efforts to develop new strategies for preventing and treating ovarian cancer, novel and more effective non-toxic therapies for ovarian cancer are urgently needed. Recent observations show that RO 48-8071 ([4’-[6-(Allylmethylamino)hexyloxy]-4-bromo-2’-fluorobenzophenone fumarate] [RO], a small-molecule inhibitor of the key cholesterol biosynthesis enzyme 2, 3-oxidosqualene cyclase, inhibits breast and prostate cancer cells. RO also induces the tumor-suppressor protein estrogen receptor (ER) β in both breast- and prostate-cancer cells, and also inhibits growth of ovarian-cancer cells both in vitro and in vivo. Extending upon these earlier studies, here we found that RO also induces ERβ expression in OVCAR-3 ovarian-cancer cells. Further, we demonstrated that treatment of two ovarian-cancer cell lines (OVCAR-3 and SK-OV-3) with liquiritigenin (LQ), a naturally occurring compound that is an ERβ agonist, reduced cell viability in vitro. When we treated OVCAR-3 and SK-OV-3 cells with RO, LQ, or RO + LQ, we observed that RO + LQ combination treatment synergistically reduced cell viability. Further in vivo studies examining the effects of RO + LQ combination treatment on EOC are warranted, as a means of exploring a potential new therapeutic approach to combat ovarian cancers with minimal toxicity.","PeriodicalId":73634,"journal":{"name":"Journal of cancer science and clinical therapeutics","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135838181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lung Hydatid Cysts in Children, Evaluation and Surgical Management","authors":"Burkan Nasr, Anwar Al_junaeed, Ghaleb Al Sady, Ahmad Al Shehari, A. Amri, M. Issa, Abdulhakim Al Tamimi, Saeed Al Bahlooli, Mohammed Al_Sormi, Abdulfattah Altam, Yasser A Obadiel, M. Al-Shehari, Ali Hiddan.","doi":"10.26502/jcsct.5079189","DOIUrl":"https://doi.org/10.26502/jcsct.5079189","url":null,"abstract":"","PeriodicalId":73634,"journal":{"name":"Journal of cancer science and clinical therapeutics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69348494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reviewing Stereotactic Body Radiation Therapy Boost after Neoadjuvant Chemoradiation as an Alternative to Brachytherapy Boost for Locally Advanced Cervical Cancer","authors":"","doi":"10.26502/jcsct.5079196","DOIUrl":"https://doi.org/10.26502/jcsct.5079196","url":null,"abstract":"","PeriodicalId":73634,"journal":{"name":"Journal of cancer science and clinical therapeutics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69348580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Experience of Palliative Care Patients Who Underwent Telemedicine in the State of Qatar during the COVID-19 Pandemic","authors":"A. Hassan, A. Allam, Saad Jobran Eziada, Hiba Elathir, Azar Saleeml, Sair Ibrahim, Zeinab Idris, Shaikhah Mohsen","doi":"10.26502/jcsct.5079201","DOIUrl":"https://doi.org/10.26502/jcsct.5079201","url":null,"abstract":"","PeriodicalId":73634,"journal":{"name":"Journal of cancer science and clinical therapeutics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69348640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}