Journal of cancer science and clinical therapeutics最新文献_第4页

Liver Endothelium Microenvironment Promotes HER3-mediated Cell Growth in Pancreatic Ductal Adenocarcinoma. 肝脏内皮微环境促进 HER3 介导的胰腺导管腺癌细胞生长

Journal of cancer science and clinical therapeutics Pub Date : 2022-01-01 Epub Date: 2022-12-15 DOI: 10.26502/jcsct.5079182

Moeez Rathore, Wei Zhang, Michel'le Wright, Mehrdad Zarei, Ali Vaziri-Gohar, Omid Hajihassani, Ata Abbas, Hao Feng, Jonathan Brody, Sanford D Markowitz, Jordan Winter, Rui Wang

{"title":"Liver Endothelium Microenvironment Promotes HER3-mediated Cell Growth in Pancreatic Ductal Adenocarcinoma.","authors":"Moeez Rathore, Wei Zhang, Michel'le Wright, Mehrdad Zarei, Ali Vaziri-Gohar, Omid Hajihassani, Ata Abbas, Hao Feng, Jonathan Brody, Sanford D Markowitz, Jordan Winter, Rui Wang","doi":"10.26502/jcsct.5079182","DOIUrl":"10.26502/jcsct.5079182","url":null,"abstract":"~90% metastatic pancreatic ductal adenocarcinoma (mPDAC) occurs in the liver, and the 5-year survival rate for patients with mPDAC is only at 3%. The liver has a unique endothelial cell (EC)-rich microenvironment, and preclinical studies showed that ECs promote cancer cell survival pathways by secreting soluble factors in a paracrine fashion in other types of cancer. However, the effects of liver ECs on mPDAC have not been elucidated. In this study, we used primary liver ECs and determined that liver EC-secreted factors containing conditioned medium (CM) increased PDAC cell growth, compared to control CM from PDAC cells. Using an unbiased receptor tyrosine kinase array, we identified human epidermal growth factor receptor 3 (HER3, also known as ErbB3) as a key mediator of liver EC-induced growth in PDAC cells with HER3 expression (HER3 +ve). We found that EC-secreted neuregulins activated the HER3-AKT signaling axis, and that depleting neuregulins from EC CM or blocking HER3 with an antibody, seribantumab, attenuated EC-induced functions in HER3 +ve PDAC cells, but not in cells without HER3 expression. Furthermore, we determined that EC CM increased PDAC xenograft growth in vivo, and that seribantumab blocked EC-induced growth in xenografts with HER3 expression. These findings elucidated a paracrine role of liver ECs in promoting PDAC cell growth, and identified the HER3-AKT axis as a key mediator in EC-induced functions in HER3 +ve PDAC cells. As over 70% mPDAC express HER3, this study highlights the potential of using HER3-targeted therapies for treating patients with HER3 +ve mPDAC.","PeriodicalId":73634,"journal":{"name":"Journal of cancer science and clinical therapeutics","volume":"6 4","pages":"431-445"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9838560/pdf/nihms-1860370.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10595197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A new era: tumor microenvironment in chemoresistance of pancreatic cancer. 新时代:胰腺癌化疗耐药的肿瘤微环境。

Journal of cancer science and clinical therapeutics Pub Date : 2022-01-01 Epub Date: 2022-02-15 DOI: 10.26502/jcsct.5079146

Xueping Zhao, Zongze Li, Zongting Gu

引用次数: 2

When Midazolam Fails and the Professional Twitches: Propofol for Palliative Sedation 当咪达唑仑失效和专业抽搐:异丙酚姑息镇静

Journal of cancer science and clinical therapeutics Pub Date : 2022-01-01 DOI: 10.26502/jcsct.5079177

A. Vilalta-Lacarra, M. Palacios-Berraquero, C. Centeno Cortés

引用次数: 0

Headway of miR200 Family as a Novel Biomarker in Head and Neck Cancers miR200家族作为头颈部肿瘤新生物标志物的进展

Journal of cancer science and clinical therapeutics Pub Date : 2022-01-01 DOI: 10.26502/jcsct.5079179

Shivani Kadarla, Rajesh Kumar Galimudi, S. Hanumanth

引用次数: 0

Rapidly Progressive Paraneoplastic Neuropathy Associated with Renal Cell Carcinoma: A Case Report. 快速进展的副肿瘤神经病变伴肾细胞癌1例报告。

Journal of cancer science and clinical therapeutics Pub Date : 2022-01-01 DOI: 10.26502/jcsct.5079171

Divya Shah, Jaya Trivedi, Steven Vernino, Shaida Khan

{"title":"Rapidly Progressive Paraneoplastic Neuropathy Associated with Renal Cell Carcinoma: A Case Report.","authors":"Divya Shah, Jaya Trivedi, Steven Vernino, Shaida Khan","doi":"10.26502/jcsct.5079171","DOIUrl":"https://doi.org/10.26502/jcsct.5079171","url":null,"abstract":"Background: Paraneoplastic neurological disorders are rare syndromes that occur with various malignancies including renal cell carcinoma. Symptoms of paraneoplastic neurological disorders are diverse and involve either the central nervous system, peripheral nervous system, or both.Case presentation: We present a patient with diffuse limb pain, rapidly progressive asymmetric motor and sensory symptoms and distal upper limb atrophy. Electrodiagnostic testing was suggestive of mononeuritis multiplex. Initial empiric treatment with corticosteroids did not lead to improvement. Further diagnostic studies revealed bilateral clear cell renal carcinoma. Treatment with plasmapheresis led to significant and rapid improvement in pain and limb strength.Conclusions: This case highlights the rare occurrence of paraneoplastic neuropathy in renal cancer and emphasizes the importance of screening for malignancy in patients presenting with rapidly progressive multifocal neuropathy.","PeriodicalId":73634,"journal":{"name":"Journal of cancer science and clinical therapeutics","volume":"6 3","pages":"333-335"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9851384/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10627591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Forward Variable Selection Improves the Power of Random Forest for High-Dimensional Micro Biome Data 前向变量选择提高了随机森林对高维微生物群数据的处理能力

Journal of cancer science and clinical therapeutics Pub Date : 2022-01-01 DOI: 10.26502/jcsct.5079147

Tung Dang, H. Kishino

{"title":"Forward Variable Selection Improves the Power of Random Forest for High-Dimensional Micro Biome Data","authors":"Tung Dang, H. Kishino","doi":"10.26502/jcsct.5079147","DOIUrl":"https://doi.org/10.26502/jcsct.5079147","url":null,"abstract":"Random forest (RF) captures complex feature patterns that differentiate groups of samples and is rapidly being adopted in microbiome studies. However, a major challenge is the high dimensionality of microbiome datasets. They include thousands of species or molecular functions of particular biological interest. This high dimensionality significantly reduces the power of random forest approaches for identifying true differences and functional characterization. The widely used Boruta algorithm iteratively removes features that are proved by a statistical test to be less relevant than random probes. We developed a massively parallel forward variable selection algorithm and coupled it with the RF classifier to maximize the predictive performance. The forward variable selection algorithm adds new variable to a set of selected variables as far as the prespecified criterion of predictive power is improved. At each step, the parameters of random forest are optimized. We demonstrated the performance of the proposed approach, which we named RF-FVS, by analyzing two published datasets from large-scale case-control studies: (i) 16S rRNA gene amplicon data for Clostridioides Difficile Infection (CDI) and (ii) shotgun metagenomics data for human colorectal cancer (CRC). The RF-FVS approach further screened the variables that the Boruta algorithm left J Cancer Sci Clin Ther 2022; 6 (1): 87-105 DOI: 10.26502/jcsct.5079147 Journal of Cancer Science and Clinical Therapeutics 88 and improved the accuracy of the random forest classifier from 81% to 99.01% for CDI and from 75.14% to 90.17% for CRC. Valid variable selection is essential for the analysis of high-dimensional microbiota data. By adopting the Boruta algorithm for pre-screening of the variables, our proposed RF-FVS approach improves the accuracy of random forest significantly with minimum increase of computational burden. The procedure can be used to identify the functional profiles that differentiate samples between different conditions.","PeriodicalId":73634,"journal":{"name":"Journal of cancer science and clinical therapeutics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69348233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Chronic Myelomonocytic Leukemia (CMML): A systematic Review of Literature and Update 慢性髓单细胞白血病(CMML):文献综述和最新进展

Journal of cancer science and clinical therapeutics Pub Date : 2022-01-01 DOI: 10.26502/jcsct.5079150

A. Blackmon, I. Amanam, Monzr M. Al Malki, H. Ali, S. Otoukesh

引用次数: 0

Respiratory Viral Infections in Cancer Patients: Epidemiological, Clinical and Cost-Effectiveness study from a Developing Country 癌症患者的呼吸道病毒感染:来自一个发展中国家的流行病学、临床和成本效益研究

Journal of cancer science and clinical therapeutics Pub Date : 2022-01-01 DOI: 10.26502/jcsct.5079166

N. Bansal, N. Sachdeva, D. Bhurani, G. Kapoor, Pinky Yadav, S. Goyal, V. Talwar, U. Batra

{"title":"Respiratory Viral Infections in Cancer Patients: Epidemiological, Clinical and Cost-Effectiveness study from a Developing Country","authors":"N. Bansal, N. Sachdeva, D. Bhurani, G. Kapoor, Pinky Yadav, S. Goyal, V. Talwar, U. Batra","doi":"10.26502/jcsct.5079166","DOIUrl":"https://doi.org/10.26502/jcsct.5079166","url":null,"abstract":"Background: Diagnosis of respiratory viral pathogens can lead to therapeutic changes, improvement in infection control practices and reduction in use of antibiotics. Methods: This is a retrospective study which looked into the case records of patients (June 2020-Dec 2021) who were diagnosed with a respiratory viral infection. Demographic, clinical and antibiotic prescription patterns of these patients were studied. Inter-group analysis was done between antibiotic de-escalation cohort and non-descalation cohort. Results: Total of 57 patients were identified with median age of 40 years (range: 3-68). Hematological malignancies were present in 45 (78.9%) of patients, whereas 14 (24.5%) patients were stem cell transplant recipients. Severe neutropenia was seen in 32 (56.1%) patients with median duration of neutropenia of 7 (range 5-20) days. RSV (36.8%) was the most common virus detected. Antibiotic de-escalation was done in 33 (57.8%) of patients and in 13 (22.8%) bacterial co-infection was diagnosed. More than 3/4 th patients were shifted to isolation and nearly 9000 INR per patient were saved by de-escalation of antibiotics. On inter-group analysis, non-de-escalation cohort had longer length of stay (10 vs 3 days; p =0.005), no antibiotic cost reduction (0 vs 9620; p=0.0003), higher mortality (16.6% vs 0%; p =0.01) & higher rhinovirus detection rates (41.6% vs 3%; p=0.0002). Conclusion: Diagnosis of respiratory viral infection helped in improving antibiotic stewardship and infection control practices.","PeriodicalId":73634,"journal":{"name":"Journal of cancer science and clinical therapeutics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69348666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HPV16-Positive Skin Metastasis at the Nose 5 Years Following Treatment of an HPV16-Positive Squamous Cell Carcinoma of the Tonsil – A Case Report and Review of Literature hpv16阳性扁桃体鳞状细胞癌治疗5年后鼻部皮肤转移1例报告及文献复习

Journal of cancer science and clinical therapeutics Pub Date : 2022-01-01 DOI: 10.26502/jcsct.5079173

Christiane Stuhlmann-Leisz, A. Fazel, Lukas Lükewille, C. Röcken, M. Laudien, Elgar Susanne Quabius, M. Hoffmann

{"title":"HPV16-Positive Skin Metastasis at the Nose 5 Years Following Treatment of an HPV16-Positive Squamous Cell Carcinoma of the Tonsil – A Case Report and Review of Literature","authors":"Christiane Stuhlmann-Leisz, A. Fazel, Lukas Lükewille, C. Röcken, M. Laudien, Elgar Susanne Quabius, M. Hoffmann","doi":"10.26502/jcsct.5079173","DOIUrl":"https://doi.org/10.26502/jcsct.5079173","url":null,"abstract":"This case report presents the disease course of a patient who developed HPV16-positive skin metastasis to the nose of HPV16-positive tonsillar carcinoma treated 5 years previously. The report critically reviews the available literature, particularly the comparable case reports available to date. In light of conflicting findings, it now appears unclear whether the occurrence of skin metastases reflecting an unusual pattern of metastasis is more typical of the course of HPV-positive HN/OSCC. There are reports suggesting this association, including our case report. On the other hand, there are retrospective study results that rather do not point to an association of skin metastases explicitly with (HPV-positive) OSCC. Rather, it must be critically questioned whether there is indeed a significant association between a specific metastatic pattern including unusual metastatic sites such as the skin, or whether merely increased attention to HPV-positive cancers leads to a higher publication rate of these cases. Extensive epidemiologic evidence should be obtained on a retrospective and prospective basis before recommendations for surveillance of corresponding patients are derived from the assumption of an atypical or different metastatic pattern in HPV-positive HNSCC.","PeriodicalId":73634,"journal":{"name":"Journal of cancer science and clinical therapeutics","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69348786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effective Prevention and Effective Treatment Oncological Diseases with Methods Resonance Destruction and Resonance of Creation 共振破坏和共振创造方法有效预防和治疗肿瘤疾病

Journal of cancer science and clinical therapeutics Pub Date : 2022-01-01 DOI: 10.26502/jcsct.5079152

Praznikov Viktor

{"title":"Effective Prevention and Effective Treatment Oncological Diseases with Methods Resonance Destruction and Resonance of Creation","authors":"Praznikov Viktor","doi":"10.26502/jcsct.5079152","DOIUrl":"https://doi.org/10.26502/jcsct.5079152","url":null,"abstract":"1. Literature Review In our previous work (Praznikov V. \"Resonant Medicine\" \"International Journal of Medical Science and Clinical Invention\". 9 (2), p. 5962-5973, 2022 [1] and in monographs [2-7] considered two options for using resonance in medicine the resonance of destruction and the resonance of creation. Resonance has been used for many years in the treatment of various diseases [1-7, 11]. In this paper, we will consider the possibilities of effective treatment and effective prevention of oncological diseases using the methods of resonance of destruction and resonance of creation. For the diagnosis and treatment of diseases, bioresonance therapy is used, which arose thanks to the German researchers R. Fol, F. Werner [12], Shimmel H.W. [13]. In the diagnosis and treatment of bioresonance therapy, the so-called \"nosodes\" are used wave copies of various diseases, including oncological ones, and \"organ preparations\" wave copies of normally functioning organs. A feature of the use of nosodes and organ preparations in our work was that we used not only low potencies of nosodes and organ preparations, but also high ones [1-7], while in previous works we used only low potencies of nosodes and organ preparations [8-11].","PeriodicalId":73634,"journal":{"name":"Journal of cancer science and clinical therapeutics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69348288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6