Advances in Orthopedics最新文献

{"title":"Is Umbilical Cord-Derived Platelet-Rich Plasma a Valid Alternative to Conventional Orthobiologics Post-Knee Arthroscopy?","authors":"Simone Giusti, Simona Cerulli, Elisabetta Giacinto, Ezio Adriani","doi":"10.1155/aort/8026214","DOIUrl":"10.1155/aort/8026214","url":null,"abstract":"<p><strong>Background: </strong>Orthobiologic treatments such as autologous platelet-rich plasma (A-PRP) and mesenchymal stem cells (MSCs) are widely used for knee osteoarthritis (OA). Umbilical cord-derived PRP (UCD-PRP), with its standardized composition and high growth factor content, has emerged as a promising allogeneic alternative, though comparative data are limited.</p><p><strong>Purpose: </strong>To compare the short-term clinical outcomes of UCD-PRP versus adipose tissue-derived MSCs (ADT-MSCs) following debridement and lavage arthroscopy in patients with early-stage knee OA.</p><p><strong>Study design: </strong>Cohort study; Level of evidence, 3.</p><p><strong>Methods: </strong>This retrospective study included 225 patients with Kellgren-Lawrence grade I-II knee OA treated with either UCD-PRP (<i>n</i> = 75) or ADT-MSCs (<i>n</i> = 150) after arthroscopy. Outcomes assessed at baseline, 6, and 12 months included the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Knee Injury and Osteoarthritis Outcome Score (KOOS), International Knee Documentation Committee (IKDC) score, and Visual Analog Scale (VAS) for pain. Multivariate analysis assessed predictors of outcome.</p><p><strong>Results: </strong>Both groups showed significant functional and pain improvements from baseline at all follow-up points. The UCD-PRP group demonstrated superior pain reduction on VAS at 3 and 6 months compared with ADT-MSCs (ΔVAS at 3 months, <i>p</i> = 0.042; at 6 months, <i>p</i> = 0.0065). Functional scores (WOMAC, KOOS, and IKDC) showed no significant between-group differences at 12 months. Higher BMI was independently associated with poorer clinical outcomes (<i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>UCD-PRP provides superior short-term pain relief compared with ADT-MSCs following knee arthroscopy for early OA, with comparable functional outcomes at 12 months. Its standardized, allogeneic preparation and minimal donor-site morbidity make UCD-PRP a promising orthobiologic option for knee OA management.</p><p><strong>Level of evidence: </strong>Level III.</p>","PeriodicalId":7358,"journal":{"name":"Advances in Orthopedics","volume":"2025 ","pages":"8026214"},"PeriodicalIF":1.5,"publicationDate":"2025-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12611710/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145538522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of Intramedullary Nailing Versus Plate Fixation of Humerus Shaft Fractures: A Single-Center Retrospective Study.","authors":"Asma Al Rasbi, Ayman Al Amri, Ahmed Al Hadeethi, Issam Al Aghbari, Osama Al Senani","doi":"10.1155/aort/8821939","DOIUrl":"10.1155/aort/8821939","url":null,"abstract":"<p><p>The optimal fixation method for humeral shaft fractures remains a topic of debate. Intramedullary nailing (IM nailing) and plate fixation are the most common surgical options, each with distinct advantages and complications. This study aimed to compare the functional outcomes and complications associated with IM nailing and plating fixation for humeral shaft fractures at Sultan Qaboos University Hospital. This retrospective cohort study included adults who underwent humeral shaft fracture fixation from January 2012 to December 2022. Patients were treated with either IM nailing or plate fixation. Outcomes that were measured included time to union, operative time, complications rate, and the abbreviated form of the Disabilities of the Arm, Shoulder, and Hand (DASH) score. About 73 patients were included in the study, 37 of whom underwent IM nailing, and 36 patients had plate fixation. There were no statistically significant differences in any of the measured outcomes: surgical site infection (<i>p</i> = 0.475), operative time (<i>p</i> = 0.365), time to union (<i>p</i> = 0.055), delayed union (<i>p</i> = 0.325), nonunion (<i>p</i> = 0.491), revision procedures (<i>p</i> = 0.254), and postoperative radial nerve injury (<i>p</i> = 1.000). The Quick DASH scores were similar between the two groups (<i>p</i> = 0.443). In conclusion, both IM nailing and plating fixation are effective methods for treatment of humerus shaft fractures with no statistically significant differences. The Nail group showed not only a trend of slightly shorter time to union but also a higher rate of complications. The Plate group had a higher incidence of delayed union but fewer cases of postoperative complications. Surgical choice should be individualized based on patient and fracture characteristics.</p>","PeriodicalId":7358,"journal":{"name":"Advances in Orthopedics","volume":"2025 ","pages":"8821939"},"PeriodicalIF":1.5,"publicationDate":"2025-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12592684/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145480567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tranexamic Acid Reduces Transfusion Rates After Modular Hemiarthroplasty for Pathological Femoral Fractures: A Retrospective Study.","authors":"Piotr Biega, Grzegorz Guzik","doi":"10.1155/aort/3173784","DOIUrl":"10.1155/aort/3173784","url":null,"abstract":"<p><strong>Background: </strong>Fractures of the femur are one of the major complications of solid tumor metastasis to bone. Tumor resection with reconstruction using modular prostheses achieves optimal local tumor control, pain reduction, and improved patient function and quality of life. Unfortunately, the surgical treatment of femoral fractures with prostheses is associated with high blood loss, requiring the transfusion of blood products. Blood transfusion carries several risks, including immune suppression and a higher risk of postoperative infection, deterioration of functional outcomes, and prolonged hospital stays. An inexpensive and effective way to reduce blood loss and the number of transfusions is tranexamic acid (TXA).</p><p><strong>Methodology: </strong>In our study, we analyzed 82 cases of patients treated with resectional prostheses for pathological fractures between 2017 and 2021. The operations of 42 patients were performed between 2017 and 2019 without the use of TXA. Another 38 patients were operated on in 2020-2021 with the use of TXA prophylaxis. Total blood loss (TBL), hemoglobin drop, number of transfusions, and adverse thromboembolic events were evaluated.</p><p><strong>Results: </strong>After surgery, patients who received TXA had higher hemoglobin levels on the first day than those in the control group (0.99 g/dL <i>p</i> = 0.03), and the blood loss was reduced by 217 mL in the TXA group (<i>p</i> = 0.09). Transfusion rate was reduced from 43% to 17% (<i>p</i> = 0.04). No differences were seen in the number of complications.</p><p><strong>Conclusion: </strong>TXA significantly reduced transfusion rates and hemoglobin drop, without increasing complications.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov identifier: NCT06244498.</p>","PeriodicalId":7358,"journal":{"name":"Advances in Orthopedics","volume":"2025 ","pages":"3173784"},"PeriodicalIF":1.5,"publicationDate":"2025-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12572632/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145429908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Female Radiological Metatarsal Morphometry and Diameter Suitability of Intramedullary Implants Used for Midfoot Charcot.","authors":"Kaissar Yammine, Youssef Jamaleddine, Anthony ElAlam, Joseph Mouawad, Ahmad Haj Hussein, Taha Khaled, George Sayegh, Chahine Assi","doi":"10.1155/aort/7497747","DOIUrl":"10.1155/aort/7497747","url":null,"abstract":"<p><strong>Objective: </strong>Radiological biometrics of the metatarsal have been reported in few studies but mostly with no relevance to clinical settings. The smaller female metatarsal diameter could be an impediment for intramedullary implants. This study investigates female radiological metatarsal morphometry for diameter suitability of intramedullary implants used for midfoot Charcot fusion.</p><p><strong>Methods: </strong>Standing foot roentgenograms of 143 female patients were collected for radiological measurements. Cortical thickness at the metatarsal neck level was calculated by subtracting inner width from outer width values. After hypothetical reaming, inner width, outer width, and cortical thickness mean values were considered for suitability estimation. Implant suitability was deemed acceptable when (a) inner width values more than the cut-off value of 6 mm and/or (b) cortical thickness more than the cut-off value of 2 mm (1 mm on each cortex side).</p><p><strong>Results: </strong>The results were (a) inner width: M5 had a higher mean value when compared to M2, M3, and M4 (<i>p</i> < 0.00001) with no difference between central metatarsals and (b) outer width: M2 showed a significantly higher outer width than M3 and M4 (<i>p</i> < 0.00001) with no difference with M5. Based on the cut-off values, the simulated reaming width values to accept implant diameter were found unsuitable for M2, M3, and M4 and the estimated cortical thickness values were found unsuitable for M3, M4, and M5.</p><p><strong>Conclusion: </strong>Our study indicates for the first time a mismatch between the inner width of the lateral metatarsals at the neck level with the commercially available Charcot-specific IM implants for female patients.</p>","PeriodicalId":7358,"journal":{"name":"Advances in Orthopedics","volume":"2025 ","pages":"7497747"},"PeriodicalIF":1.5,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12539660/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145375840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in Augmented Reality in Sports Surgery: A Systematic Review.","authors":"Negarsadat Namazi, Yashar Khani, Amirhossein Salmannezhad, Mohammad Behdadfard, Ehsan Safaee, Sanam Mohammadzadeh, Mohammad Nouroozi, Amir Mehrvar","doi":"10.1155/aort/6707884","DOIUrl":"10.1155/aort/6707884","url":null,"abstract":"<p><p><b>Purpose:</b> Augmented reality (AR) blends computer-generated information with the real environment to support surgical visualization, guidance, and training. In sports surgery, where arthroscopic views constrain depth perception and hand-eye coordination, AR may enhance intraoperative accuracy and efficiency and enable engaging rehabilitation. Novelty: To our knowledge, this is the first systematic review focused specifically on AR across the sports surgery continuum (operative and rehabilitative), synthesizing visualization modalities, use cases, and measured outcomes to identify translational gaps. <b>Methods:</b> We searched MEDLINE (PubMed), Embase, Scopus, and Web of Science (January 2024), registered the protocol on PROSPERO (CRD42024543974), and reported according to PRISMA 2020. Eligibility included preclinical and clinical studies using AR/MR in sports-orthopedic contexts. Risk of bias was assessed using RoB 2 (RCTs), ROBINS-I (nonrandomized studies), and NIH tools for other designs. Qualitative synthesis was structured by AR type, surgical indication/use case, and outcome domain. <b>Results and Findings:</b> Twenty-one articles met the criteria. Sixteen assessed intraoperative applications and four rehabilitation, with knee arthroscopy being the most common. Comparative human studies reported more accurate femoral tunnel placement in ACL reconstruction and shorter operative time in selected workflows, while several studies showed feasibility in simulators/cadavers. Video see-through (VST) and optical see-through (OST) (e.g., HoloLens) were most frequently used. <b>Conclusions:</b> AR shows early promise for guidance, training/telementoring, and postoperative rehabilitation in sports surgery, but current evidence is heterogeneous and often feasibility-focused. Larger, controlled clinical trials with standardized outcome definitions and reporting are needed to confirm benefits, evaluate learning curves and ergonomics, and support integration into operating room workflows.</p>","PeriodicalId":7358,"journal":{"name":"Advances in Orthopedics","volume":"2025 ","pages":"6707884"},"PeriodicalIF":1.6,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12443500/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145085018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multivariate Quantitative Outcomes of Periacetabular Osteotomy Using Discrete Element Analysis.","authors":"Victor Grenier, Catherine Ruel, Jean Ruel, Quentin Sercia, Myriam Rioux, Philippe Corbeil, Etienne L Belzile","doi":"10.1155/aort/1479343","DOIUrl":"10.1155/aort/1479343","url":null,"abstract":"<p><p><b>Introduction:</b> Multiple biomechanical models have been suggested to quantify lower limb joint contact stress distributions, with varying results. Among others, the choice of cartilage morphology and gait loading patterns can significantly affect simulation results. Moreover, there is currently no consensus on simulating the input and output data needed to obtain reliable results and enable a comprehensive analysis. <b>Objectives:</b> The aim of this study was to compare the reliability and clinical relevance of joint contact metrics by calculating pre- and postoperative hip joint contact stress distributions of a dysplastic cohort under various simulation scenarios. <b>Methods:</b> A cohort of 22 dysplastic patients has been treated using periacetabular osteotomy (6-month follow-up). Five radiographic measurements of the acetabular cup were taken from imagery pre- and postoperatively. Eight osteoarthritis-predictive joint stress metrics were computed using discrete element analysis in 6 unique simulation scenarios (2 cartilage models; 3 hip gait loading profiles) pre- and postoperatively. <b>Results:</b> A multivariate analysis of variance confirmed the significant effects of treatment, cartilage model, and loading profile on the computed stress metrics (<i>p</i> < 0.01). Also, average- and threshold-based metrics, such as average contact area, average stress, and Maxian overdose, were shown as more reliable indicators of successful surgical treatment than the maximum-based metrics. Finally, correlations between radiographic measurements and stress metrics revealed greater influence of the acetabular index and anterior center-edge angle than the lateral center-edge angle. <b>Conclusions:</b> Average and threshold-based metrics, as well as the acetabular index and anterior center-edge angle, should be of greater interest in future studies regarding hip dysplasia. <b>Clinical Significance:</b> Level 2 (Prospective Study: Therapeutic).</p>","PeriodicalId":7358,"journal":{"name":"Advances in Orthopedics","volume":"2025 ","pages":"1479343"},"PeriodicalIF":1.6,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12396905/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Novel Approach by Integrating CT-Based Imaging Data and Machine Learning to Predict Patient-Specific Young's Modulus Values.","authors":"Resmi S L, Hashim V, Jesna Mohammed, Dileep P N","doi":"10.1155/aort/6257188","DOIUrl":"10.1155/aort/6257188","url":null,"abstract":"<p><p>Finite element analysis (FEA) stands as a cornerstone in preclinical investigations for implant therapy, particularly in orthopaedics and biomechanics. Accurate modelling of bone properties is crucial for meaningful FEA outcomes, considering the complex nature of bone tissue. This study proposes a novel approach by integrating CT-based imaging data and machine learning to predict patient-specific Young's modulus values. A back propagation neural network (BPNN), incorporating texture properties extracted from CT images, demonstrates robustness in predicting Young's modulus. Validation against three-point bending experiments on rabbit femur bones shows promising results, with stress values within 13% of those from FEA. The proposed methodology holds the potential for enhancing preclinical evaluations of implant therapy and fostering the development of patient-specific implants for improved clinical outcomes.</p>","PeriodicalId":7358,"journal":{"name":"Advances in Orthopedics","volume":"2025 ","pages":"6257188"},"PeriodicalIF":1.5,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12370390/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the Association Between Educational Status and Carpal Tunnel Syndrome Presentations and Severity.","authors":"Moh'd S Dawod, Mohammad N Alswerki, Ahmad F Alelaumi, Taghleb Al-Awad, Abdualmajid Alameri, Abdulrahman Abu-Humdan, Nedal Alsabatin, Ala'a Altaher, Khaled Al-Amer, Aws Khanfar","doi":"10.1155/aort/9975946","DOIUrl":"10.1155/aort/9975946","url":null,"abstract":"<p><p><b>Introduction:</b> Carpal tunnel syndrome (CTS), a painful prevalent orthopedic hand condition causing pain and paresthesia, is typically diagnosed clinically. Initial management involves analgesia trials, steroid injections, and night splints, with surgery as an option for failed conservative treatment. While prior research has explored the relationship between patients' educational status and various orthopedic conditions, no studies have investigated its association with clinical presentation and symptom severity in CTS. Therefore, our study aims to investigate this important link. <b>Methods:</b> Our study utilized a retrospective study design, which included 681 patients undergoing carpal tunnel release surgery at a prominent teaching hospital. The aim was to investigate the association between four distinct educational levels and the clinical presentation and severity of the disease. Disease severity was evaluated using the Boston Carpal Tunnel Questionnaire (BCTQ). <b>Results:</b> The study included individuals with a mean age of 52.0 years and diverse educational backgrounds: 20.0% high school, 34.9% diploma, 28.5% bachelor's degree, and 6.6% higher education qualifications. Subjective grip strength decline was more pronounced in high school and diploma categories (83.1% and 82.4%, respectively) compared to bachelor's and higher education categories (71.0% and 68.8%, respectively; <i>p</i>=0.005). Additionally, high school patients had higher Gabapentin usage for analgesia (32.4%) compared to other groups (<i>p</i>=0.014). <b>Conclusion:</b> In patients with CTS, there is a correlation between lower education and symptoms of subjective weakened grip strength, increased analgesic use, and higher Gabapentin utilization. Conversely, higher education is associated with greater utilization of night splints. Moreover, postoperative improvements were observed across all educational groups with no significant differences. <b>Level of Evidence:</b> Level III, Retrospective Study.</p>","PeriodicalId":7358,"journal":{"name":"Advances in Orthopedics","volume":"2025 ","pages":"9975946"},"PeriodicalIF":1.6,"publicationDate":"2025-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12358232/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144881820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of Percutaneous Versus Open Lumbopelvic Fixation of Spinopelvic Dissociation.","authors":"Sean Taylor, Saurabh Rawall, Asa Peterson, Gerald McGwin, Sakthivel Rajaram","doi":"10.1155/aort/9946662","DOIUrl":"10.1155/aort/9946662","url":null,"abstract":"<p><p><b>Introduction:</b> Spinopelvic dissociation is a devastating injury that remains difficult to manage due to its complexity and low incidence. Lumbopelvic fixation is a treatment option traditionally performed with an open approach. However, open fixation is associated with substantial blood loss and infection risk in critical polytrauma patients. Technological advancements have enabled this procedure to be performed percutaneously. Thus, we evaluate outcomes between patients receiving open lumbopelvic fixation and those receiving percutaneous lumbopelvic fixation. <b>Methods:</b> A retrospective review was conducted of patients undergoing either open or percutaneous lumbopelvic fixation for spinopelvic dissociation from 2012 to 2024. The AOSpine classification system was used to classify all fractures. Patient demographic, clinical, and operative outcomes were analyzed. <b>Results:</b> 48 patients with spinopelvic dissociation were included in the final analysis, with 21 receiving open lumbopelvic fixation and 27 receiving percutaneous lumbopelvic fixation. Preoperative characteristics and demographics were similar between the two groups. The percutaneous group demonstrated significantly reduced blood loss (82 vs. 679 mL; <i>p</i> < 0.01), shorter operative time (168 vs. 284 min; <i>p</i> < 0.01), fewer surgical site infections (0 vs. 4; <i>p</i>=0.03), and reduced OR cost ($35,097 vs. $23,743; <i>p</i>=0.01) but had a higher rate of anterior pelvic ring injuries (63% vs. 19%; <i>p</i>=0.003). There was no significant difference in length of stay (<i>p</i>=0.63) or length of follow-up (<i>p</i>=0.64). <b>Conclusion:</b> Our findings suggest that percutaneous lumbopelvic fixation offers an attractive less invasive and shorter procedure to treat spinopelvic dissociation without added morbidity.</p>","PeriodicalId":7358,"journal":{"name":"Advances in Orthopedics","volume":"2025 ","pages":"9946662"},"PeriodicalIF":1.2,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12283201/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144688606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preliminary Report on the Time-Related Effect of a Single Autologous Adipose-Derived Mesenchymal Stem Cells Injection in Hip Osteoarthritis: A Retrospective Observational Study.","authors":"Adriano Braile, Annalisa De Cicco, Sara Liguori, Vincenzo De Matteo, Gianluca Conza, Michele Vasso, Maria Consiglia Trotta, Giuseppe Toro, Umberto Tarantino","doi":"10.1155/aort/3424035","DOIUrl":"10.1155/aort/3424035","url":null,"abstract":"<p><p><b>Background:</b> Recently, intra-articular injection of mesenchymal stem cells (MSCs) had been proposed as a conservative treatment for hip osteoarthritis (HOA). Adipose tissue was demonstrated as a viable source of MSCs because of the high concentration of cells and the easy access to the donor site. The purpose of this study was to evaluate the time-related results of a single intra-articular injection of autologous adipose-derived stem cells (aASCs) in a series of patients with HOA. <b>Methods:</b> A retrospective study was conducted on 30 patients with HOA, who underwent an intra-articular injection of aASCs between September 2018 and January 2021. Inclusion criteria for the procedure were as follows: onset of symptoms of the affected hip in the prior six or more months ago, failure of the conservative treatment (NSAIDs and/or physiotherapy) and age > 18 years. Exclusion criteria were trauma in the affected hip occurred in the previous 3 months, recent arthroscopic treatment, infectious joint disease, chondromatosis of the hip or any other secondary HOA, malignancy, hyaluronic acid or other injections in the previous 6 months and incomplete follow-up. Because a low BMI makes extremely difficult to harvest enough adipose tissue, patients with a BMI < 18 were also excluded. The Oxford Hip Score, the 12-item Short Form Survey and Visual Analogue Scale were used to evaluate the results of the proposed treatment at regular intervals. <b>Results:</b> In 27/30 patients, a constant improvement in pain relief, hip function and quality of life was observed during the entire follow-up period of 12 months. Two patients underwent a subsequent total hip arthroplasty. <b>Conclusion:</b> The single injection of aAMSCs seems to be a valuable treatment for HOA. A constant amelioration of pain and function could be observed in most patients at 12 months of follow-up.</p>","PeriodicalId":7358,"journal":{"name":"Advances in Orthopedics","volume":"2025 ","pages":"3424035"},"PeriodicalIF":1.2,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12185193/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144473738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}