Journal of advanced periodontology & implant dentistry最新文献

{"title":"Embracing the future: The evolution of systematic reviews and meta-analyses in periodontology.","authors":"Fatemeh Pournaghi Azar, Morteza Ghojazadeh","doi":"10.34172/japid.2023.025","DOIUrl":"10.34172/japid.2023.025","url":null,"abstract":"","PeriodicalId":73584,"journal":{"name":"Journal of advanced periodontology & implant dentistry","volume":"15 2","pages":"65-66"},"PeriodicalIF":0.0,"publicationDate":"2023-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10862048/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139736865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Susceptibility of periodontal pathogens to a novel target-specific drug delivery system containing self-nanoemulsifying curcumin: An in vitro study.","authors":"Veena Hr, Riya Achamma Daniel, Ashwin Prabhu, Shilpa P, Suman Basavaraju","doi":"10.34172/japid.2023.024","DOIUrl":"10.34172/japid.2023.024","url":null,"abstract":"<p><strong>Background: </strong>Long-term use of many classic chemotherapeutic agents as adjuncts in the management of periodontitis has adverse complications, leading to seeking out naturopathic remedies. Although curcumin has been investigated in managing periodontitis, its therapeutic benefits have not been fully explored due to its limited solubility in an aqueous medium. This study aimed to develop a novel target-specific drug delivery system containing 1% self-nanoemulsifying curcumin (SNEC) in a hydroxypropylmethylcellulose (HPMC) matrix and evaluate the susceptibility of periodontal pathogens to this system in vitro.</p><p><strong>Methods: </strong>Its antibacterial activity against Tannerella forsythia, Porphyromonas gingivalis, Prevotella intermedia, and Aggregatibacter actinomycetemcomitans was evaluated and compared to pure nano-curcumin and SNEC alone by estimating their minimum inhibitory concentrations (MIC).</p><p><strong>Results: </strong>The antibacterial activity of pure nano-curcumin, SNEC, and SNEC in HPMC against the four periodontal pathogens evaluated in terms of MIC was recorded in the range of 0.2‒0.4, 0.4‒0.8, and 0.2‒0.8 µg/mL, respectively. However, the MIC of all three curcumin formulations against the periodontal pathogens tested was higher than that of the standard moxifloxacin. While both pure nano-curcumin and SNEC showed increasing values of inhibition zones with increasing concentrations on disk diffusion assay, lower concentrations of SNEC in HPMC did not show a zone of inhibition against the tested pathogens.</p><p><strong>Conclusion: </strong>The novel delivery system containing SNEC in HPMC may be a potential adjunct in managing periodontitis due to its probable sustained antimicrobial activity against the tested periodontal pathogens.</p>","PeriodicalId":73584,"journal":{"name":"Journal of advanced periodontology & implant dentistry","volume":"15 2","pages":"67-73"},"PeriodicalIF":0.0,"publicationDate":"2023-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10862046/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139736807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical evaluation of chitosan/polycaprolactone nanofibrous scaffolds releasing tetracycline hydrochloride in periodontal pockets of patients with chronic periodontitis.","authors":"Janet Moradi Haghgoo, Parviz Torkzaban, Parisa Hashemi, Rana Sarvari, Sana Hashemi, Elahe Fakhri, Behnaz Alafchi","doi":"10.34172/japid.2023.023","DOIUrl":"10.34172/japid.2023.023","url":null,"abstract":"<p><strong>Background: </strong>The role of bacteria in the initiation and progression of periodontitis has led to a great interest in using antibiotics to suppress pathogenic microbiota. Considering the drawbacks of systemic antibiotics' application, local delivery systems directly in the periodontal pocket can be helpful. Therefore, the effect of an efficient tetracycline-loaded delivery system was investigated on the clinical parameters of periodontitis.</p><p><strong>Methods: </strong>In this clinical trial with a split-mouth design, 10 patients with periodontitis with pocket depths≥5 mm were included. After scaling and root planing (SRP) for all the patients, one side of the mouth was randomly considered as the control group, and on the other side, chitosan/polycaprolactone (PCL) nanofibrous films containing tetracycline (5%) were placed in pockets of 5 mm and deeper. Clinical measurements of pocket probing depth (PPD), clinical attachment loss (CAL), and bleeding on probing (BOP) indices were made at the beginning and after 8 weeks of intervention. PPD, CAL, and BOP parameters were compared between the control and test groups before and after the intervention with paired <i>t</i> tests using SPSS 24. The significance level of the tests was considered at <i>P</i><0.05.</p><p><strong>Results: </strong>The mean PPD, CAL, and BOP in both the control (SRP) and test (LDDs) groups decreased after 8 weeks. A significant difference was detected in reducing PPD, BOP, and CAL after 8 weeks in 5-mm pockets, and the mean values were higher in the test group than in the control (<i>P</i><0.05).</p><p><strong>Conclusion: </strong>The local drug delivery system using chitosan/PCL nanofibrous films containing tetracycline can effectively control periodontal diseases by reducing pocket depth and inflammation and improving CAL without offering side effects, although further evaluations are needed.</p>","PeriodicalId":73584,"journal":{"name":"Journal of advanced periodontology & implant dentistry","volume":"15 2","pages":"74-79"},"PeriodicalIF":0.0,"publicationDate":"2023-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10862042/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139736859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nasopalatine duct cyst as a delayed consequence of dental implant placement in the anterior maxilla: A case report.","authors":"Mohammadreza Talebi Ardakani, Behzad Houshmand, Aida Kheiri","doi":"10.34172/japid.2023.022","DOIUrl":"10.34172/japid.2023.022","url":null,"abstract":"<p><p>Dental implants are now the best treatment method to replace missing teeth. However, complications may necessitate further therapeutic interventions because of anatomic limitations and mistakes during surgical procedures. In this case report, a nasopalatine duct cyst (NPDC) due to implant placement was studied. After clinical and radiographic evaluation, unilocular radiolucency with disturbance to the nasopalatine canal was observed. Following that, flap elevation was performed. Subsequently, the cyst was enucleated, and the bone defect was filled with xenograft and further covered with a resorbable membrane. Histopathology results confirmed NPDC as the definite diagnosis. After six months, the defect was completely resolved.</p>","PeriodicalId":73584,"journal":{"name":"Journal of advanced periodontology & implant dentistry","volume":"15 2","pages":"134-137"},"PeriodicalIF":0.0,"publicationDate":"2023-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10862041/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139736805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Periodontitis as a risk factor for organic erectile dysfunction: A case-control study in a sub-Saharan population.","authors":"Abdoulaye Diouf, William Ndjidda Bakari, Marie Hélène Sounlin, Ahmad Moustapha Diallo, Daibel Thiam, Mouhamadou Lamine Guirassy, Adam Seck Diallo, Henri Michel Benoist","doi":"10.34172/japid.2023.021","DOIUrl":"10.34172/japid.2023.021","url":null,"abstract":"<p><strong>Background: </strong>This study investigated the association between periodontitis and organic erectile dysfunction (ED) in a sub-Saharan population.</p><p><strong>Methods: </strong>This multicenter analytical study lasted from April to September 2021. A total of 114 patients (38 cases and 76 controls) were recruited and matched on age, diabetes, and smoking status. Medical history and ED were recorded, as well as the plaque index, bleeding index, maximum interdental clinical attachment loss (CALmax), maximum probing depth, clinically detectable furcation involv ement, number of teeth in the mouth, number of teeth lost for periodontal reasons, and tooth mobility. The analysis was performed with SPSS 20.0 with a significance threshold set at 5%.</p><p><strong>Results: </strong>The two study groups were comparable regarding sociodemographic characteristics. Periodontitis was present in 76.31% of cases and 75% of controls without a significant difference (<i>P</i>=0.878). Logistic regression showed a significant association between high blood pressure and ED with an OR=4.78 (95% CI: 1.80‒12.70). Periodontitis was not associated with ED (OR=1.52, 95% CI: 0.55‒4.16); however, severe periodontitis was significantly associated with severe ED (OR=1.44, 95% CI: 1.11‒1.85, and OR=1.68, 95% CI: 1.15‒2.44, respectively for CALmax and tooth loss).</p><p><strong>Conclusion: </strong>Within the limits of this study, periodontitis was not associated with organic ED. However, the severity of periodontal disease significantly increased in patients with organic ED.</p>","PeriodicalId":73584,"journal":{"name":"Journal of advanced periodontology & implant dentistry","volume":"15 2","pages":"80-85"},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10862040/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139736806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of direct oral anticoagulant dabigatran on early bone healing: An experimental study in rats.","authors":"Ioanna Kyriakaki, Theodora Karanikola, Theodoros Lillis, Eleana Kontonasaki, Nikolaos Dabarakis","doi":"10.34172/japid.2023.020","DOIUrl":"10.34172/japid.2023.020","url":null,"abstract":"<p><strong>Background: </strong>Dabigatran belongs to the new generation of direct oral anticoagulants (DOACs). Its advantages are oral administration and no need for international normalized ratio (INR) monitoring. Although its use has increased, its potential side effects on bone healing and remodeling have not been fully investigated. The present study aimed to evaluate the possible effects of dabigatran on early bone healing.</p><p><strong>Methods: </strong>Sixteen male Wistar rats were divided into two groups; in group A, 20-mg/kg dabigatran dose was administered orally daily for 15 days, while group B served as a control. Two circular bone defects (d=6 mm) were created on either side of the parietal bones. Two weeks after surgery and euthanasia of the animals, tissue samples (parietal bones that contained the defects) were harvested for histological and histomorphometric analysis. Statistical analysis was performed with a significance level of α=0.5.</p><p><strong>Results: </strong>No statistically significant differences were found between the two groups regarding the regenerated bone (21.9% vs. 16.3%, <i>P</i>=0.172) or the percentage of bone bridging (63.3% vs. 53.5%, <i>P</i>=0.401).</p><p><strong>Conclusion: </strong>Dabigatran did not affect bone regeneration, suggesting that it might be a safer drug compared to older anticoagulants known to lead to bone healing delay.</p>","PeriodicalId":73584,"journal":{"name":"Journal of advanced periodontology & implant dentistry","volume":"15 2","pages":"86-92"},"PeriodicalIF":0.0,"publicationDate":"2023-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10862050/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139736863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of different surface treated implants after provisionalization: A 6-month prospective study.","authors":"Anshdha Shah, Amitabh Srivastava, Shivam Yadav, Charu Tandon","doi":"10.34172/japid.2023.019","DOIUrl":"10.34172/japid.2023.019","url":null,"abstract":"<p><strong>Background: </strong>Replacing missing teeth with dental implants has become the best treatment option; therefore, clinicians need to understand the predictability of the treatment. Surface treatment of implants is one of the methods to improve osseointegration, thus improving the quality of treatment. Increasing esthetic awareness among patients has led to the popularity of immediate provisionalization of dental implants. This study investigated the effect of surface treatment on implant stability when loaded with immediate non-functional temporary prostheses and compared the superiority of one surface treatment over the other in terms of osseointegration by evaluating implant stability quotient (ISQ).</p><p><strong>Methods: </strong>Twenty implants with different surface treatments were placed, i.e., resorbable blast media (RBM) surface and alumina blasted/acid-etched (AB/AE) surfaces. All the implants were non-functionally loaded, and ISQ was measured immediately after implant placement and 6 and 12 weeks after non-functional loading. Crestal bone levels, mPI, mSBI, and peri-implant probing depths were compared for both groups at 1, 3, and 6 months.</p><p><strong>Results: </strong>At 12 weeks, all the implants showed desirable ISQ, indicating successful osseointegration. The increase in ISQ at 12 weeks was significantly higher for RBM implants compared to baseline, indicating a more predictable course of osseointegration. Crestal bone levels recorded at 1, 3, and 6 months did not significantly differ between the groups. All other parameters showed comparable values for both groups at all intervals.</p><p><strong>Conclusion: </strong>Replacing missing teeth with dental implants with immediate non-functional restorations is a predictable treatment option.</p>","PeriodicalId":73584,"journal":{"name":"Journal of advanced periodontology & implant dentistry","volume":"15 2","pages":"93-99"},"PeriodicalIF":0.0,"publicationDate":"2023-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10862049/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139736866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative effect of anthocyanin on proliferation and migration of human gingival fibroblasts in the absence or presence of nicotine.","authors":"Sarina Azimian, Maryam Torshabi, Zeinab Rezaei Esfahrood","doi":"10.34172/japid.2023.018","DOIUrl":"10.34172/japid.2023.018","url":null,"abstract":"<p><strong>Background: </strong>Oral fibroblast malfunction can result in periodontal diseases. Nicotine can prolong the healing process as an irritant of oral tissues. Anthocyanins have been demonstrated to have potential benefits in preventing or treating smoking-related periodontal diseases. Cyanidin chloride's (CC's) potential in oral wound healing and the viability, proliferation, and migration of human gingival fibroblasts (HGFs) were examined in the presence and absence of nicotine by an in vitro study.</p><p><strong>Methods: </strong>The effects of different nicotine concentrations (1, 2, 3, 4, and 5 mM) on the viability and proliferation of HGF cells were evaluated in the presence and absence of different CC concentrations (5, 10, 25, and 50 μM) using the quantitative MTT assay. The scratch test was performed to evaluate the migration of CC-treated cells in the presence of 2.5-mM nicotine.</p><p><strong>Results: </strong>No cytotoxicity was observed at 1‒100 μM CC concentrations after 24, 48, and 72 hours of exposure to HGF cells. However, a concentration of 200 μM significantly reduced cell viability by about 20% at all the three-time intervals (<i>P</i><0.05). Also, 3‒5-mM concentrations of nicotine significantly reduced cell viability in a dose- and time-dependent manner. Moreover, the understudied CC concentrations decreased nicotine's adverse effects on cell migration to some extent.</p><p><strong>Conclusion: </strong>Although the understudied CC concentrations could not significantly reduce the adverse effects of understudied nicotine concentrations on the viability and proliferation of HGF cells, they were able to reduce the detrimental effects of nicotine on cell migration significantly.</p>","PeriodicalId":73584,"journal":{"name":"Journal of advanced periodontology & implant dentistry","volume":"15 2","pages":"100-107"},"PeriodicalIF":0.0,"publicationDate":"2023-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10862044/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139736860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of zinc supplementation as an adjuvant to corticosteroid treatment in patients with oral lichen planus: A systematic review.","authors":"Ayla Bahramian, Mona Rahbaran, Maria Bahramian, Sepideh Bohlouli, Katayoun Katebi","doi":"10.34172/japid.2023.017","DOIUrl":"10.34172/japid.2023.017","url":null,"abstract":"<p><strong>Background: </strong>Oral lichen planus (OLP) and one of its main presentations, desquamative gingivitis, are common diseases with no definite treatment. Zinc deficiency has a critical role in the pathogenesis of oral mucosal diseases. The current study systematically reviewed the effect of zinc in addition to topical corticosteroids in the treatment of OLP.</p><p><strong>Methods: </strong>English articles in PubMed, Web of Sciences, Embase, and Scopus were searched until August 2022. The differences in symptoms were analyzed, including pain, burning sensation, and lesion sizes in patients with lichen planus receiving zinc supplementation as an adjuvant to corticosteroid treatment.</p><p><strong>Results: </strong>A total of 148 articles related to the searched keywords were found. Eventually, two clinical trials were selected. The total population of studied individuals included 60 patients. Due to the high heterogeneity between the studies, meta-analysis was not possible. Administering zinc, in addition to corticosteroids, did not improve the symptoms compared to corticosteroid monotherapy.</p><p><strong>Conclusion: </strong>Considering the limited number of studies and lack of sufficient evidence, it is not currently possible to reach a definite conclusion regarding the effects of zinc on OLP.</p>","PeriodicalId":73584,"journal":{"name":"Journal of advanced periodontology & implant dentistry","volume":"15 2","pages":"128-133"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10862047/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139736864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of morbidity at the donor site and clinical efficacy at the recipient site between two different connective tissue graft harvesting techniques from the palate: A randomized clinical trial.","authors":"Amine Beymouri, Siamak Yaghobee, Afshin Khorsand, Yaser Safi","doi":"10.34172/japid.2023.016","DOIUrl":"10.34172/japid.2023.016","url":null,"abstract":"<p><strong>Background: </strong>This study was conducted to compare the pain levels in patients and the clinical efficacy of grafts obtained using two techniques, namely de-epithelialized gingival graft (DGG) and subepithelial connective tissue graft (SCTG), in combination with coronally advanced flap (CAF) for the treatment of multiple adjacent gingival recessions.</p><p><strong>Methods: </strong>Twelve patients were treated using DGG+CAF on one side and SCTG+CAF on the other. The patients' pain levels at the surgical site, the number of analgesics taken on days 3 and 7, the mean root coverage (MRC), the percentage of complete root coverage (CRC), color match, and gingival thickness (GT) at the graft recipient site were evaluated 6 months after surgery.</p><p><strong>Results: </strong>The total number of analgesics taken during the 7-day period after surgery and pain levels at the surgical site from day 3 to day 7 were significantly higher in the DGG+CAF group compared to the SCTG+CAF group (<i>P</i>=0.001). In the 6-month follow-up, color match and CRC were significantly higher in the SCTG+CAF group, while GT was significantly higher in the DGG+CAF group. There was no significant difference in MRC between the two groups.</p><p><strong>Conclusion: </strong>The pain and analgesic consumption levels were higher in the DGG+CAF group compared to the SCTG+CAF group, and the recipient site had a weaker color match. However, this technique can lead to a greater increase in the thickness of the grafted area.</p>","PeriodicalId":73584,"journal":{"name":"Journal of advanced periodontology & implant dentistry","volume":"15 2","pages":"108-116"},"PeriodicalIF":0.0,"publicationDate":"2023-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10862051/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139736862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}