Journal of advanced periodontology & implant dentistry最新文献

{"title":"Efficacy of different suturing techniques on gingival grafts: A scoping review.","authors":"Mina Shekarian, Shiva Shekarian, Mahboobe Heydari, Zohreh Afshari, Romina Meshkinnejad","doi":"10.34172/japid.025.3805","DOIUrl":"10.34172/japid.025.3805","url":null,"abstract":"<p><strong>Background: </strong>This review evaluated the efficacy of various suturing techniques in gingival graft stabilization to optimize clinical outcomes and minimize the need for revision surgeries.</p><p><strong>Methods: </strong>This scoping review was conducted across Scopus, PubMed, Cochrane, Web of Science, and ProQuest (through April 2025) using PICO criteria: Population (gingival grafts around teeth), Intervention (different suturing techniques), Comparison (efficacy of various suturing techniques in gingival graft stabilization), and Outcomes (keratinized tissue width [KTW], keratinized tissue height [KTH], and root coverage [RC]). From 838 initial records, 73 studies met the inclusion criteria after dual-reviewer screening with arbitration by a third reviewer. Study quality was assessed using the Joanna Briggs Institute tools.</p><p><strong>Results: </strong>For free gingival grafts (FGGs), primary stabilization methods included interrupted sutures (with/without periosteal fixation), sling sutures, and cyanoacrylate. Connective tissue grafts (CTGs) predominantly use sling sutures, often combined with cross-mattress or interrupted sutures, vertical/double-cross mattress techniques, or continuous sutures with coronally advanced/tunnel flaps. While 72% of FGG studies (23/32) reported significant KTW improvement with interrupted sutures (a mean gain of 2.1±0.8 mm), CTG studies demonstrated 96% RC success (43/45) with sling-based techniques. However, outcomes showed substantial heterogeneity due to variability in the Miller classification (33/67 studies focused on Class I only) and inconsistent reporting of suture material (only 5/67 specified size/type).</p><p><strong>Conclusion: </strong>No single suturing technique demonstrated clear superiority in graft stabilization, likely due to study heterogeneity. While sling/mattress combinations showed optimal RC for CTGs and interrupted sutures/cyanoacrylate performed well for FGGs, standardized RCTs controlling for confounding variables are required to establish definitive protocols.</p>","PeriodicalId":73584,"journal":{"name":"Journal of advanced periodontology & implant dentistry","volume":"18 1","pages":"55-69"},"PeriodicalIF":0.0,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12913211/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146230040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of antimicrobial activity of sutures soaked in injectable platelet rich fibrin or platelet rich fibrin lysate against common oral pathogens: A pilot study.","authors":"Megha Hulumanderi Ravikumar, Raison Thomas, Rucha Shah, Chandan Shivamallu, Chandan Dharmashekhar, Triveni Mavinakote Gowda","doi":"10.34172/japid.025.2240","DOIUrl":"10.34172/japid.025.2240","url":null,"abstract":"<p><strong>Background: </strong>Suture materials in the oral cavity can promote bacterial adhesion and contamination. While antimicrobial-coated sutures are effective, their use is limited by cost, availability, and toxicity. Platelet-rich fibrin (PRF) derivatives have shown antimicrobial activity against periodontal pathogens. This study compared the antimicrobial efficacy of sutures soaked in saline, i-PRF, and PRF lysate.</p><p><strong>Methods: </strong>An in vitro study was used to determine the minimum inhibitory concentration (MIC) of sutures soaked in saline, i-PRF, and PRF lysate. The sutures were tested against <i>Streptococcus mutans</i>, <i>Prevotella intermedia</i>, and <i>Porphyromonas gingivalis</i> by measuring inhibition zones. Non-absorbable 3-0 black silk sutures were cut and soaked for 10 minutes in saline (group A), i-PRF (group B), or PRF lysate (group C), then incubated anaerobically at 37 °C for 24 hours. Additionally, samples from all three groups were incubated at 37 °C in 5 mL of saliva from patients with chronic periodontitis, and colony-forming units (CFUs) were assessed on days 1, 3, 5, and 7.</p><p><strong>Results: </strong>Sutures soaked in i-PRF and PRF lysate demonstrated a statistically significant increase in the zone of inhibition and a reduction in CFU against <i>S. mutans</i>, <i>P. intermedia</i>, and <i>P. gingivalis</i>. Scanning electron microscopy analyses showed a fibrin network on sutures soaked in i-PRF and PRF lysate.</p><p><strong>Conclusion: </strong>The antimicrobial efficacy of i-PRF- and PRF lysate-treated sutures against oral pathogens appears promising. These biologically enhanced sutures may serve as effective alternatives to conventional antimicrobial sutures.</p>","PeriodicalId":73584,"journal":{"name":"Journal of advanced periodontology & implant dentistry","volume":"17 4","pages":"182-187"},"PeriodicalIF":0.0,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12702087/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145764222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical evaluation of two techniques of soft tissue graft removal (free gingival graft/de-epithelialized and linear/subepithelial technique) from the palate: A prospective cohort study.","authors":"Eduardo Moreira Lessa, Gustavo Vicentis Oliveira Fernandes, Juliana Campos Hasse Fernandes, Júlio César Joly","doi":"10.34172/japid.025.3548","DOIUrl":"10.34172/japid.025.3548","url":null,"abstract":"<p><strong>Background: </strong>Periodontal and peri-implant soft tissue management in oral rehabilitation is often necessary to achieve more esthetic and stable clinical results. This involves harvesting connective tissue from the palate. There is no consensus about the technique that will cause less postoperative pain in the donor area. Thus, this prospective cohort study compared the postoperative morbidity of two surgical techniques from the palate donor site: the free gingival graft (FGG)/de-epithelialized technique and the linear technique/subepithelial technique.</p><p><strong>Methods: </strong>Sixteen patients were randomly assigned to the FGG/de-epithelialized removal group (G1) and the removal of the connective tissue graft (CTG) with the linear/subepithelial technique group (G2). The morbidity analysis consisted of measuring the number of anti-inflammatory agents taken in the postoperative period, pain analysis through a visual analog scale, and visual analysis of healing of palatal soft tissues 1, 2, and 3 weeks after surgery.</p><p><strong>Results: </strong>The results showed that the G1 patients took more anti-inflammatory drugs (mean=9.88) than the G2 (mean=3.63) and experienced more postoperative pain (mean=6.38) than G2 (mean=3) (<i>P</i><0.05 for both parameters). In the visual analysis of healing, the results were better for G1 on days 7 and 21; however, on day 14, the results were better for G2, with no significant differences (<i>P</i>>0.05) between the groups at any of the experimental times.</p><p><strong>Conclusion: </strong>Both techniques promoted effective healing of the palatal area; however, the removal by the linear graft technique caused less postoperative pain.</p>","PeriodicalId":73584,"journal":{"name":"Journal of advanced periodontology & implant dentistry","volume":"17 4","pages":"196-204"},"PeriodicalIF":0.0,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12702088/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145764216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Miniscrew placement on mandibular buccal shelf and infra-zygomatic crest area: A finite element analysis.","authors":"Setareh Khosravi, Hosein Jahanshad, Mahsa Moafi, Mohamadreza Shahmohamadi, Mojgan Kachoei","doi":"10.34172/japid.025.3687","DOIUrl":"10.34172/japid.025.3687","url":null,"abstract":"<p><strong>Background: </strong>This study investigated the optimal placement of mini-implants in the mandibular buccal shelf and infra-zygomatic crest regions using finite element analysis.</p><p><strong>Methods: </strong>Three-dimensional finite element method (FEM) models of bone and mini-implants were created. In the mandibular buccal shelf (MBS) region, mini-screws were positioned at three sites: between the first molar roots, between the second molar roots, and distal to the second molar, tested at two depths (4 mm and 8 mm) and two angles to the occlusal plane (60° and 90°). In the infra-zygomatioc crest (IZC) region, mini-screws were placed between the first and second maxillary molars and adjacent to the mesiobuccal root of the second molar, at depths of 7 mm and 11 mm, and angles of 40° and 75° relative to the occlusal surface. The force of 200 g was applied as immediate loading and in a vertical direction to the center of the miniscrew.</p><p><strong>Results: </strong>In the MBS region, the distal second molar site at 8 mm depth and 60° angle exhibited the lowest von Mises stress, while the lowest strain occurred between the first molar roots at the same depth and angle. In the IZC region, the best biomechanical response was found at 7-mm depth between the first and second molars at a 75° angle, with the highest stress occurring near the mesiobuccal root of the second molar at 11-mm depth and 40° angle.</p><p><strong>Conclusion: </strong>These findings suggest that for optimal biomechanical performance, MBS mini-screws should be placed distal to the second molar at 4-8-mm depth and 60° angle, and IZC mini-screws between the first and second molars at 7-mm depth and 75° angle.</p>","PeriodicalId":73584,"journal":{"name":"Journal of advanced periodontology & implant dentistry","volume":"17 4","pages":"205-215"},"PeriodicalIF":0.0,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12702082/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145764358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The rising potential of tooth germ-derived stem cells and the future of oral rehabilitation.","authors":"Adileh Shirmohammadi, Sina Ghertasi Oskouei","doi":"10.34172/japid.025.3960","DOIUrl":"10.34172/japid.025.3960","url":null,"abstract":"","PeriodicalId":73584,"journal":{"name":"Journal of advanced periodontology & implant dentistry","volume":"17 3","pages":"123-125"},"PeriodicalIF":0.0,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12501481/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145253621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of nonsurgical periodontal therapy on the eradication of gastric <i>Helicobacter pylori</i> infection: A randomized clinical trial.","authors":"Parichehr Behfarnia, Reza Birang, Shirin Rostami, Vahid Sebghatollahi","doi":"10.34172/japid.025.3895","DOIUrl":"10.34172/japid.025.3895","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to assess the effectiveness of \"a combined systemic and nonsurgical periodontal treatment\" in eradicating gastric <i>Helicobacter pylori</i> in patients having the bacterium within their subgingival biofilm.</p><p><strong>Methods: </strong>This randomized clinical trial (RCT) investigated 102 patients diagnosed with peptic ulcer or dyspepsia and a positive stomach test for <i>H. pylori</i> infection (G+). Participants with a negative test for oral infection received only triple therapy (G3, n=38), and those positive for oral infection were randomly allocated to one of the two treatment regimens: a 14-day course of triple therapy (comprising antibiotics, antimicrobials, and proton pump inhibitors) alongside periodontal therapy (G1, n=32) or triple therapy alone (G2, n=32). The effectiveness of <i>H. pylori</i> eradication was assessed four weeks after treatment using the <i>H. pylori</i> stool antigen (stool Ag) test. Data analysis was performed using SPSS 22.</p><p><strong>Results: </strong>In the G2 and G3 groups, triple therapy achieved success rates of 52% and 84%, respectively. When periodontal therapy was integrated with triple therapy in the G1 group, the success rate was 80%. Significant differences were observed between the G1 and G2 groups (<i>P</i>=0.037) and also between the G3 and G2 groups (<i>P</i>=0.015). Conversely, no significant difference was found between the G1 and G3 groups (<i>P</i>>0.05).</p><p><strong>Conclusion: </strong>Periodontal therapy has the potential to substantially increase the efficacy of <i>H. pylori</i> eradication regimens for gastric infections.</p>","PeriodicalId":73584,"journal":{"name":"Journal of advanced periodontology & implant dentistry","volume":"17 3","pages":"145-151"},"PeriodicalIF":0.0,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12501473/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145254034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Buccal window approach: A favorable technique for preserving periodontium in impacted third molar surgery.","authors":"Fatemeh Latifi, Azadeh Esmaeilnejad, Seyed Mohamad Mahdi Bahaodini, Shakila Peymani, Ardeshir Khorsand, Milad Baseri","doi":"10.34172/japid.025.3652","DOIUrl":"10.34172/japid.025.3652","url":null,"abstract":"<p><strong>Background: </strong>The present study assessed the probing depth of the second molar distal aspect after the surgical removal of adjacent mandibular impacted third molars using osteotomy by a buccal window and routine crestal flaps.</p><p><strong>Methods: </strong>In this double-blind, randomized clinical trial, 16 candidates for the surgical removal of bilateral mandibular third molars were selected, and each side's tooth was assigned to a different osteotomy group. The surgery was performed using a sulcular flap and a distal extension for one group, while the osteotomy was performed using the buccal window technique. The pocket probing depth of the adjacent second molars was calculated before and three months after the surgical removal. The data of both groups were statistically analyzed using normality and t-tests in the SPSS software. Statistical significance was set at <i>P</i><0.05.</p><p><strong>Results: </strong>At three months postoperatively, significant differences were found between the two groups regarding pocket probing depth at mesiobuccal (5.23±1.12 mm in the crestal osteotomy and 4.03±1.16 mm in the buccal window osteotomy; <i>P</i><0.006), mid-distal (5.77±1.08 mm in the crestal osteotomy and 4.25±1.35 mm in the buccal window osteotomy; <i>P</i><0.002), and distolingual aspects (5.46±1.34 mm in the crestal osteotomy and 3.96±1.11 mm in the crestal osteotomy; <i>P</i><0.002) of the adjacent second molars. The mean pocket probing depth of the mid-distal area was significantly lower in the buccal window osteotomy.</p><p><strong>Conclusion: </strong>According to the results, this technique can be used as an alternative to crestal osteotomy in level C impactions and Cl I and Cl II impactions regarding position towards the anterior edges of the mandibular ramus.</p>","PeriodicalId":73584,"journal":{"name":"Journal of advanced periodontology & implant dentistry","volume":"17 3","pages":"152-156"},"PeriodicalIF":0.0,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12501471/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145254022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of photobiomodulation on wound healing and pain after crown lengthening surgery: A randomized clinical trial.","authors":"Parichehr Behfarnia, Reza Birang, Amineh Ghaznavi, Seyed Amir Mirghaderi","doi":"10.34172/japid.025.3658","DOIUrl":"10.34172/japid.025.3658","url":null,"abstract":"<p><strong>Background: </strong>The present study evaluated the synergistic effect of 808 nm and 660 nm diode lasers on the processes of healing and pain management following crown lengthening surgery.</p><p><strong>Methods: </strong>This randomized clinical trial involved 20 patients who underwent surgical crown lengthening on both sides of their jaw. Following the surgery, one tooth from each patient was randomly assigned to either the case group (irradiated with 808 nm and 660 nm diode lasers as photobiomodulation [PBM] therapy) or the control group (laser device remained switched off). The early healing index (EHI), comprising clinical signs of inflammation (CSI), clinical signs of homeostasis (CSH), and clinical signs of re-epithelialization (CSR), was assessed on days 3 and 7. Pain severity was quantified on the day of surgery and 1, 3, and 7 days after surgery using a visual analog scale. The data were analyzed using the Wilcoxon test.</p><p><strong>Results: </strong>No significant differences were observed in CSR on days 3 (<i>P</i>=0.18) and 7 (<i>P</i>=1.0), nor in CSI on day 3 (<i>P</i>=0.477) after surgery. However, a significant difference was identified in CSI on day 7 and in CSH on both days 3 and 7 (<i>P</i><0.05) after surgery. Furthermore, the level of postoperative pain demonstrated a significant difference (<i>P</i>≤0.005).</p><p><strong>Conclusion: </strong>PBM demonstrably enhanced CSI by day 7 and improved CSH by days 3 and 7, in addition to decreasing postoperative pain.</p>","PeriodicalId":73584,"journal":{"name":"Journal of advanced periodontology & implant dentistry","volume":"17 3","pages":"172-178"},"PeriodicalIF":0.0,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12501482/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145254048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A pilot study and histological examination of xenograft and autogenous bone combinations with i-PRF in guided bone regeneration.","authors":"Saurabh Kamat, Senthil Murugan M, Edlyn Rodrigues, Jochima Eudora Cota, Vikas Dhupar, Francis Akkara","doi":"10.34172/japid.025.3543","DOIUrl":"10.34172/japid.025.3543","url":null,"abstract":"<p><strong>Background: </strong>This study evaluated the impact of different regenerative biomaterial combinations on bone quality and implant stability in guided bone regeneration (GBR).</p><p><strong>Methods: </strong>A pilot study was conducted from September 2020 to October 2023 to compare the quality of bone regeneration and implant stability following GBR using three composite graft combinations. Forty-seven patients participated in the study in three experimental groups: group A (deproteinized cancellous bovine bone [xenograft] with injectable platelet-rich fibrin [i-PRF]), group B (xenograft with autogenous bone graft in a 2:1 ratio with i-PRF), and group C (xenograft with autogenous bone graft in a 1:1 ratio with i-PRF). The implant stability quotient (ISQ) was measured at the time of implant placement. Crestal bone biopsy procedures were performed.</p><p><strong>Results: </strong>The study found that group C, using a 1:1 ratio of xenograft and autogenous graft with i-PRF, achieved the highest new bone formation (65.83%) and demonstrated moderately high vascularization and osteoclastic activity, indicative of good remodeling potential. ISQ measurements for all groups indicated good primary stability of implants, ranging from 55 to 65 at the time of placement.</p><p><strong>Conclusion: </strong>Combining xenograft with autogenous graft in a 1:1 ratio, along with i-PRF, yielded optimal outcomes for new bone formation in GBR procedures. However, further research is needed to address the limitations associated with i-PRF, such as lack of rigidity and faster degradation, to enhance its application in GBR procedures.</p>","PeriodicalId":73584,"journal":{"name":"Journal of advanced periodontology & implant dentistry","volume":"17 3","pages":"132-139"},"PeriodicalIF":0.0,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12504848/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145260170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histologic evaluation of topical simvastatin effects on extraction sockets: A randomized controlled clinical trial.","authors":"Nasrin Faal Rastegar, Farzane Vaziri, Seyed Mostafa Mahmoudi","doi":"10.34172/japid.025.3478","DOIUrl":"10.34172/japid.025.3478","url":null,"abstract":"<p><strong>Background: </strong>The reduction of alveolar ridge volume after tooth extraction can be decreased through ridge preservation. According to previous studies, statin drugs induce osteogenesis. Therefore, this study aimed to evaluate the effect of simvastatin on the preservation and ossification of the alveolar ridge after tooth extraction.</p><p><strong>Methods: </strong>In this single-center randomized clinical trial, 40 dental sockets in 40 patients were randomly divided into the treatment group (collagen with simvastatin) and the control group (collagen only). Histologic bone examination was performed under a light microscope two months after socket preservation at the time of dental implants. The predictable variable was using simvastatin in dental sockets. In the treatment group, collagen was used with simvastatin; in the control group, only collagen was used. The percentage of bone formation was the primary outcome, which was measured as the area of newly formed bone. In this study, inflammatory reaction, the amount of remaining bone substitute, and foreign body reaction were compared between the two groups. Covariates included age, sex, and tooth location. T-test was used for normally distributed data, while the Mann-Whitney test was used for non-normal data. <i>P</i><0.05 was considered significant.</p><p><strong>Results: </strong>The results showed that following eight weeks of simvastatin use in the treatment group, the percentage of new bone formation was significantly higher compared to the control group (treatment group vs. control group: 69.28±3.93 vs. 52.76±2.01; <i>P</i>=0.0001). No foreign body reaction and residual graft materials were observed in the treatment and control groups. Furthermore, the study showed an inflammatory reaction in only 23.5% of the samples in the control group (<i>P</i>=0.045).</p><p><strong>Conclusion: </strong>Simvastatin significantly increased the formation of new bone in the dental socket in the treatment group.</p>","PeriodicalId":73584,"journal":{"name":"Journal of advanced periodontology & implant dentistry","volume":"17 3","pages":"140-144"},"PeriodicalIF":0.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12501483/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145254027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}