Journal of advanced periodontology & implant dentistry最新文献

{"title":"Treatment of an endodontic-periodontal lesion using peripheral blood mesenchymal stem cells (PBMSCs) and platelet-rich fibrin matrix (PRFM): A case report.","authors":"Sphoorthi Anup Belludi, Sharaz Shaik, Neha Pradhan, Sreeparvathy Rema","doi":"10.34172/japid.025.3502","DOIUrl":"https://doi.org/10.34172/japid.025.3502","url":null,"abstract":"<p><p>In the current report, we discuss the available treatment options and present a successfully treated periodontal-endodontic lesion using autogenous peripheral blood mesenchymal stem cells (PBMSCs) and platelet-rich fibrin matrix (PRFM). A patient presented with a complaint of food impaction and bad breath. Clinically, the lower right first molar was non-vital and had a deep periodontal pocket and attachment loss. Radiographically, the distal root had an angular bone loss extending to the apex. The endodontic condition was treated with chemomechanical debridement, calcium hydroxide dressing, and obturation. Later, we reflected a full-thickness mucoperiosteal flap and thoroughly debrided the granulation tissue. We filled the defect with a gel containing PBMSCs and PRFM, prepared from the patient's peripheral blood, and sutured the flap. After nine months, we noticed significant osseous fill and 5 mm of gain in the clinical attachment level. The outcomes of the case show the periodontal regenerative potential of the novel combination.</p>","PeriodicalId":73584,"journal":{"name":"Journal of advanced periodontology & implant dentistry","volume":"17 1","pages":"54-58"},"PeriodicalIF":0.0,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12010481/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144061440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between concentrations of salivary and gingival crevicular fluid inflammatory cytokines in patients with gingivitis and periodontitis and healthy individuals.","authors":"Ferya Azami, Vahid Esfahanian, Mahsa Ahmadi Shadmehri, Sami Rafiei","doi":"10.34172/japid.025.2244","DOIUrl":"https://doi.org/10.34172/japid.025.2244","url":null,"abstract":"<p><strong>Background: </strong>This study compared tumor necrosis factor-α (TNF-α) and interlukin-1β (IL-1β) concentrations in the saliva and gingival crevicular fluid (GCF) of patients with gingivitis and periodontitis and healthy individuals.</p><p><strong>Methods: </strong>In this study, 45 patients (n=15 in each group) were selected, and the concentrations of inflammatory cytokines TNF-α and IL-1β in their salivary and GCF samples were measured using the ELISA method. Shapiro-Wilk test, one-way analysis of variance, post hoc Bonferroni test, and Pearson's correlation coefficient were used to analyze the data.</p><p><strong>Results: </strong>According to the results of the post hoc Bonferroni test, the mean salivary and GCF levels of TNF-α and IL-1β in healthy individuals were significantly lower than those with periodontitis (<i>P</i><0.05) and gingivitis (<i>P</i><0.05). Also, the mean levels of TNF-α and IL-1β in the saliva and GCF of patients with periodontitis were significantly higher than patients with gingivitis (<i>P</i><0.05).</p><p><strong>Conclusion: </strong>Based on the findings of the study, saliva, like GCF, can be considered a source for monitoring the markers related to periodontal disease. However, more uniformity was observed in GCF than in saliva in terms of alignment of markers secretion.</p>","PeriodicalId":73584,"journal":{"name":"Journal of advanced periodontology & implant dentistry","volume":"17 1","pages":"31-35"},"PeriodicalIF":0.0,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12010477/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stem cell therapy for regenerating periodontal bony defects: A narrative review.","authors":"Samira Mohammad Mirzapour, Fatemeh Jalali","doi":"10.34172/japid.025.3749","DOIUrl":"https://doi.org/10.34172/japid.025.3749","url":null,"abstract":"<p><p>Periodontal bony defects pose a significant challenge in periodontology, necessitating advanced regenerative approaches to restore the lost structures. Stem cell-based therapies have emerged as a promising solution due to their ability to differentiate into various cells, modulating the regenerative microenvironment. This narrative review explores the potential of stem cells derived from multiple sources in treating periodontal bony defects. Additionally, we examine evidence from both animal and human studies, highlighting advancements, clinical outcomes, and limitations. By investigating these findings, this article provides a comprehensive overview of the advantages of stem cell-based therapies compared to other regenerative techniques in addressing periodontal bony defects and discusses the limitations of their translation into routine clinical practice.</p>","PeriodicalId":73584,"journal":{"name":"Journal of advanced periodontology & implant dentistry","volume":"17 1","pages":"1-14"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12010474/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144013889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial efficacy and cytotoxicity of ethanolic extracts of <i>Salvia officinalis</i> and <i>Juglans regia</i> against oral pathogens.","authors":"Sara Ghadaksaz, Safar Farajnia, Fatemeh Pournaghiazar, Hamed Ebrahimzadeh Leylabadlo, Reza Salahlou, Abbas Delazar, Amir Zandesh","doi":"10.34172/japid.025.3710","DOIUrl":"https://doi.org/10.34172/japid.025.3710","url":null,"abstract":"<p><strong>Background: </strong>Herbal extracts have gained attention for their potential benefits in promoting oral health and preventing dental caries and periodontal diseases. This study evaluated the antimicrobial effects and cytotoxicity of ethanolic extracts of <i>Salvia officinalis</i> and <i>Juglans regia</i>, both individually and in combination, against <i>Streptococcus mutans, Lactobacillus casei,</i> and <i>Candida albicans</i>, microorganisms associated with oral diseases.</p><p><strong>Methods: </strong>In this <i>in vitro</i> study, the hydroalcoholic (ethanolic) extracts of <i>J. regia</i> and <i>S. officinalis</i> were prepared using the maceration method. To determine the antimicrobial effectiveness, the zone of inhibition in the disk agar diffusion, minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were assessed for each extract, separately and in combination. The extracts' cytotoxicity was investigated at their effective doses using the MTT (methyl thiazole tetrazolium) assay.</p><p><strong>Results: </strong>Compared to the negative control, ethanolic extracts of <i>S. officinalis</i> and <i>J. regia</i> exhibited a significant inhibitory effect (<i>P</i><0.001) on <i>S. mutans</i> and <i>L. casei. Salvia officinalis</i> extract exhibited antimicrobial activities, as evidenced by the MIC values of 237.5 µg/mL for <i>S. mutans</i>, 118.7 µg/mL for <i>Lactobacillus casei</i>, and 31.25 mg/mL for <i>C. albicans</i>. The ethanolic extract of <i>Juglans regia</i> exhibited MIC values of 29.6 µg/mL for <i>S. mutans</i>, 475 µg/mL for <i>L. casei</i>, and 15.62 mg/mL for <i>C. albicans</i>, respectively. MTT assay results showed that the extracts had no cytotoxic effects at the MIC on the L929 cell line; however, pure chlorhexidine was toxic at 0.2% concentration.</p><p><strong>Conclusion: </strong>The study results revealed that the ethanolic extracts of <i>S. officinalis</i> and <i>J. regia</i> and their combined application showed antimicrobial activity against pathogenic microorganisms pertinent to oral health. In addition, cytotoxicity evaluations indicated that these extracts are non-toxic to the L929 cell line at effective concentrations.</p>","PeriodicalId":73584,"journal":{"name":"Journal of advanced periodontology & implant dentistry","volume":"17 1","pages":"46-53"},"PeriodicalIF":0.0,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12010476/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144036280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Salivary alkaline phosphatase levels and alveolar bone crest changes in immediate vs. delayed implant placement.","authors":"Bahareh Hekmat, Masoumeh Amani, Farhad Aghmasheh, Zahra Mohammad Hasani","doi":"10.34172/japid.2025.006","DOIUrl":"https://doi.org/10.34172/japid.2025.006","url":null,"abstract":"<p><strong>Background: </strong>Dental implant therapy is a top option for replacing lost or unsalvageable teeth. The most common placement protocols are immediate and delayed. A key factor for successful treatment is the stability of the marginal bone, which can be evaluated through radiography and salivary biomarkers. This study evaluated the relationship between salivary alkaline phosphatase levels and the alveolar crest bone height in immediate and delayed implants.</p><p><strong>Methods: </strong>This study involved 62 patients: 31 for immediate and 31 for delayed implant placement in posterior jaw regions. Unstimulated saliva (5 mL) was collected from all the patients before surgery and at 14- and 4-month postoperative intervals to assess salivary alkaline phosphatase activity using spectrophotometry. Intraoral periapical digital radiographs were taken immediately after surgery and 2 and 4 months postoperatively to evaluate alveolar crest bone height. Measurements at the mesial and distal implant sites were analyzed using Scanora software.</p><p><strong>Results: </strong>No significant differences were found in salivary alkaline phosphatase activity or alveolar crest bone resorption based on gender, implant timing, or jaw region (<i>P</i>>0.05). However, patient age significantly correlated with alkaline phosphatase activity and bone resorption (<i>P</i><0.05). There was no correlation between alkaline phosphatase levels and alveolar crest bone height.</p><p><strong>Conclusion: </strong>Salivary alkaline phosphatase cannot be considered a reliable diagnostic biomarker for evaluating the condition of the alveolar crest bone around dental implants.</p>","PeriodicalId":73584,"journal":{"name":"Journal of advanced periodontology & implant dentistry","volume":"17 1","pages":"40-45"},"PeriodicalIF":0.0,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12010478/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144058790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical effectiveness of aloe vera gel as an adjunct to mechanical debridement in patients with periodontitis: A systematic review and meta-analysis.","authors":"Nisha Ashifa, Krishnan Viswanathan, Sivapragasam Srinivasan, Varsha K Pavithran, Shiva Shankar, Rajasekar Sundaram, Senthil Kumar, Divvi Anusha","doi":"10.34172/japid.2025.002","DOIUrl":"https://doi.org/10.34172/japid.2025.002","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to evaluate the clinical effect of aloe vera gel as an adjunct to scaling and root planing (SRP) on plaque index (PI), gingival index (GI), and probing pocket depth (PPD) in periodontitis treatment.</p><p><strong>Methods: </strong>Randomized controlled trials (RCTs) were included, focusing on aloe vera gel as an adjunct to SRP in periodontitis patients. An extensive literature search was conducted across PubMed, PubMed Central, Scopus, OVID, Google Scholar, and Cochrane Library databases up to October 2024. The risk of bias was assessed using the Revised Cochrane Risk of Bias tool (ROB 2.0), and statistical analysis was performed using Review Manager 5.4.1.</p><p><strong>Results: </strong>Fifteen RCTs were included in this systematic review, and separate meta-analyses were conducted for each outcome. For PI, the random effects model showed a mean difference (MD) of -0.23 (95% CI: -0.69, 0.23), favoring the experimental group (<i>P</i>=0.33). The fixed effects model for PI favored the control group (MD=0.12; <i>P</i>=0.20). For GI, the random effects model favored the experimental group (MD=-0.28, <i>P</i>=0.01), while the fixed effects model favored the control group (MD=0.17; <i>P</i><0.001). For PPD, the random effects model favored the experimental group (MD=-0.45, <i>P</i>=0.009).</p><p><strong>Conclusion: </strong>As an adjunct to SRP, aloe vera gel significantly improved PI, GI, and PPD in periodontitis patients.</p><p><strong>Trial registration: </strong>PROSPERO ID: CRD42020201315.</p>","PeriodicalId":73584,"journal":{"name":"Journal of advanced periodontology & implant dentistry","volume":"17 1","pages":"15-25"},"PeriodicalIF":0.0,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12010479/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of Lamin A gene in periodontitis: A cross-sectional study.","authors":"Naser Sargolzaie, Jalil Tavakkol-Afshari, Raziyeh Mohebati, Faeze Basiri, Arsalan Shahri, Mahdiye Fasihi Ramandi","doi":"10.34172/japid.2025.003","DOIUrl":"https://doi.org/10.34172/japid.2025.003","url":null,"abstract":"<p><strong>Background: </strong>The host defense process against invading bacteria leads to the destruction of the periodontium. Lamin A is an important protein for protecting DNA and preventing premature cell aging. This study investigated the expression of the Lamin A gene in periodontitis patients.</p><p><strong>Methods: </strong>Using an analytical cross-sectional design, Lamin A gene expression was evaluated in 23 periodontitis patients and 24 healthy individuals referred to the Periodontology Department of Mashhad Dental School and Hekmat Clinic, Mashhad, Iran. Gingival samples were collected, followed by RNA extraction, cDNA synthesis, and real-time PCR. Statistical analyses were conducted using SPSS.</p><p><strong>Results: </strong>While the age distribution did not show significant differences between the groups, gender distribution was statistically different. Therefore, the study focuses on comparing Lamin A gene expression levels between the patient and healthy groups, separated by gender. Considering the analysis of 47 gingival tissue samples, the Lamin A gene expression level was higher in healthy participants, with the difference being statistically significant only in female participants (198.45±54.00 in healthy females vs. 143.52±29.29 in periodontitis females).</p><p><strong>Conclusion: </strong>These findings suggest that the expression of the Lamin A gene was higher in healthy individuals than in periodontitis patients. More studies are needed to draw more accurate conclusions. If confirmed in larger studies, this protein group might serve as potential biomarkers, enhancing periodontitis assessment strategies.</p>","PeriodicalId":73584,"journal":{"name":"Journal of advanced periodontology & implant dentistry","volume":"17 1","pages":"36-39"},"PeriodicalIF":0.0,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12010475/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Salivary carcinoembryonic antigen in desquamative gingivitis: A comparative study in oral lichenoid reactions before and after topical corticosteroid therapy.","authors":"Ayla Bahramian, Farzaneh Pakdel, Solmaz Pourzare Mehrbani, Ehsan Golchin, Ensiyeh Maljaei, Maryam Hosseinpour Sarmadi, Tara Deljavanghodrati, Katayoun Katebi","doi":"10.34172/japid.2025.004","DOIUrl":"https://doi.org/10.34172/japid.2025.004","url":null,"abstract":"<p><strong>Background: </strong>Desquamative gingivitis is an immunological chronic disease that is considered precancerous and has the potential to develop into squamous cell carcinoma. Carcinoembryonic antigen (CEA), a common tumor marker, increases in many cancers. The present study compared salivary CEA levels in desquamative gingivitis before and after topical corticosteroid therapy.</p><p><strong>Methods: </strong>This case‒control study was conducted in the Department of Oral and Maxillofacial Medicine, Tabriz Faculty of Dentistry. Twenty patients with desquamative gingivitis in oral lichen planus (OLP) background were selected as the case group, with 20 healthy individuals as the control group. Desquamative gingivitis lesions were confirmed with biopsies. Salivary samples were obtained from both groups. Second, salivary samples were collected from the case group after a course of topical corticosteroid therapy. Salivary CEA levels were measured by a monobind kit using the ELISA method. Independent and paired t-tests were used to analyze the data in SPSS 17. <i>P</i><0.05 was considered statistically significant.</p><p><strong>Results: </strong>Before treatment, CEA levels were significantly higher in the case group (174.06±95.55) than in the control group (55.66±41.26 ng/mL) (<i>P</i><0.001). Salivary CEA levels in the case group decreased significantly after the treatment (96.77±66.25 ng/mL) compared to before treatment (174.06±95.55 ng/mL) (<i>P</i><0.001).</p><p><strong>Conclusion: </strong>This study demonstrated that CEA levels significantly decreased in patients with desquamative gingivitis associated with oral lichenoid reaction after receiving topical corticosteroid therapy.</p>","PeriodicalId":73584,"journal":{"name":"Journal of advanced periodontology & implant dentistry","volume":"17 1","pages":"26-30"},"PeriodicalIF":0.0,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12010480/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144047771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep margin elevation; Indications and periodontal considerations.","authors":"Parnian Alizadeh Oskoee, Sana Dibazar","doi":"10.34172/japid.2024.024","DOIUrl":"https://doi.org/10.34172/japid.2024.024","url":null,"abstract":"","PeriodicalId":73584,"journal":{"name":"Journal of advanced periodontology & implant dentistry","volume":"16 2","pages":"91-93"},"PeriodicalIF":0.0,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11699262/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142933884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of orthodontic forced eruption for implant site development in the maxillary esthetic zone: A systematic review of clinical data.","authors":"Mohammadreza Talebi Ardakani, Aida Kheiri, Majid Torabzadeh, Amirhosein Mahmoudian, Mohammad Hossien Talebi, Amir Talebi","doi":"10.34172/japid.2024.022","DOIUrl":"https://doi.org/10.34172/japid.2024.022","url":null,"abstract":"<p><p>Dental implant placement in the esthetic zone is associated with challenges for clinicians. The best esthetic outcome of this procedure can be obtained through precise management of hard and soft tissue. Orthodontic forced eruption (OFE) has presented an alternative approach to augment hard and soft tissues, which can be applied rapidly or slowly. OFE of hopeless teeth with its periodontal attachment results in a favorable implant preparation site. Therefore, the present systematic review evaluated the effect of implant site preparation using OFE in hopeless teeth. A complete electronic search was performed in PubMed/MEDLINE, Scopus, and Google Scholar from June 2020 to November 2023. The search was limited to clinical English language studies. Studies were excluded if OFE was performed without implant placement. Finally, 15 studies with a total of 21 teeth, all located in the maxillary anterior region, were included in this study. In eight studies, bone grafting procedures were performed before implant placement. Using OFE could rapidly prepare the implant site by enhancing hard and soft tissues. However, additional interventions like guided bone regeneration should be considered case-dependent.</p>","PeriodicalId":73584,"journal":{"name":"Journal of advanced periodontology & implant dentistry","volume":"16 2","pages":"173-178"},"PeriodicalIF":0.0,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11699265/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142933891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}