Journal of advanced periodontology & implant dentistry最新文献

{"title":"Effect of allogenic demineralized dentin matrix vs. xenograft in maxillary sinus floor augmentation: A randomized split-mouth study.","authors":"Fatemeh Aghaziarati, Mohammad-Taghi Chitsazi, Leila Roshangar, Amirreza Babaloo, Elnaz Ziaei-Rad","doi":"10.34172/japid.026.3985","DOIUrl":"10.34172/japid.026.3985","url":null,"abstract":"<p><strong>Introduction: </strong>Maxillary sinus floor augmentation (MSFA) is commonly required in posterior maxillary atrophy. This study compared allogenic demineralized dentin matrix (ADDM) with a xenograft in MSFA.</p><p><strong>Methods: </strong>In this randomized split-mouth trial, nine patients underwent bilateral MSFA with ADDM on one side and a xenograft on the other. Cone-beam computed tomography (CBCT) was used to assess bone height and density at baseline and at six months. Core biopsies were obtained for histologic analysis.</p><p><strong>Results: </strong>Both groups showed significant increases in bone height and density (<i>P</i><0.001). Mean bone density gain was 618.65±232.20 HU (ADDM) vs. 540.87±238.02 HU (xenograft, <i>P</i>=0.49). Mean bone height gain was 9.34±1.38 mm (ADDM) vs. 9.12±1.13 mm (xenograft, <i>P</i>=0.724). Histology showed viable new bone, with ADDM exhibiting higher collagen fiber density and vascularization.</p><p><strong>Conclusion: </strong>ADDM showed clinical, radiographic, and histological outcomes comparable to xenograft in MSFA, suggesting its potential as a viable alternative.</p>","PeriodicalId":73584,"journal":{"name":"Journal of advanced periodontology & implant dentistry","volume":"18 3","pages":"132-138"},"PeriodicalIF":0.0,"publicationDate":"2026-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13437221/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148681081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytocompatibility assessment of an anaerobic adhesive for use in implant dentistry: An in vitro study.","authors":"Barbara Magalhães Figueiredo Dias, Clara Almeida Mares, Beatriz Gomes de Lucardians, Talyta Couto de Freitas, Ana Flor Sá, Danilo Rocha Dias, Ivana Márcia Alves Diniz, Frederico Santos Lages","doi":"10.34172/japid.026.4208","DOIUrl":"10.34172/japid.026.4208","url":null,"abstract":"<p><strong>Introduction: </strong>This study evaluated the cytotoxic effects of anaerobic adhesive and its impact on cell viability and migration of epithelial and mesenchymal cells.</p><p><strong>Methods: </strong>The assays were conducted on commercially obtained eukaryotic cells: human keratinocytes (HaCaT) and mouse fibroblasts (L929). For cytotoxicity assessment, HaCaT cells were exposed to the adhesive extravasation after screwing the abutment‒implant assembly, and L929 cells were placed in contact with medium conditioned with the adhesive at concentrations of 0.5% and 1.0%. Cell viability was measured using the MTT reduction test, and migration was assessed with the scratch assay in L929 cells. Relative cytotoxic potential was determined with a negative control set at 100% viability. ANOVA followed by post hoc Tukey analysis was performed.</p><p><strong>Results: </strong>The evaluated anaerobic adhesive exhibited cytotoxic potential, especially in L929 fibroblasts. Cell migration was significantly reduced in mouse fibroblasts.</p><p><strong>Conclusion: </strong>This study indicated that although the application of anaerobic adhesive is limited to the threads of abutment screws and is handled responsibly, further studies are needed before recommending its use in implantology due to its cytotoxicity.</p>","PeriodicalId":73584,"journal":{"name":"Journal of advanced periodontology & implant dentistry","volume":"18 3","pages":"139-145"},"PeriodicalIF":0.0,"publicationDate":"2026-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13437219/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148681073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Submental abscess following anterior mandibular implantation: A case report and comprehensive literature review.","authors":"Elif Betul Yıldırım, Gulenay Colak","doi":"10.34172/japid.026.3991","DOIUrl":"10.34172/japid.026.3991","url":null,"abstract":"<p><p>Dental implants are a predictable treatment for tooth loss; however, infections extending into deep fascial spaces are rare and potentially life-threatening. This case highlights the importance of early diagnosis and multidisciplinary management of an implant-related submental abscess in a diabetic patient. A 33-year-old female with type 2 diabetes mellitus (HbA1c: 8.1%) presented with submental swelling five months after anterior mandibular implant placement. Clinical examination revealed erythema, tenderness, and purulent discharge around implant #41. Cone-beam computed tomography (CBCT) showed complete resorption of the lingual cortical plate and a radiolucent tract extending into the submental space, indicating abscess formation. The implant system used was Megagen AnyOne® (4.0×10 mm). The patient was treated with amoxicillin-clavulanic acid 1 g every 12 hours for 5 days, and nonsteroidal anti-inflammatory drugs (NSAIDs) for pain control, followed by extraoral drainage with Penrose drain placement. The infected implant was removed surgically under local anesthesia, followed by thorough debridement of the cavity and local irrigation with rifamycin SV solution (250 mg/3 mL). The postoperative course was uneventful, and CBCT at the 3-month follow-up confirmed complete bone healing without recurrence. This case suggests that implant-related submental infections may result from a combination of surgical errors, anatomical factors such as lingual plate perforation, and systemic risk factors, including diabetes mellitus. CBCT plays a vital role in detecting cortical perforation and deep-space extension. Careful preoperative imaging, proper implant angulation, and timely combined medical-surgical management are critical for preventing serious complications and achieving favorable outcomes.</p>","PeriodicalId":73584,"journal":{"name":"Journal of advanced periodontology & implant dentistry","volume":"18 3","pages":"174-182"},"PeriodicalIF":0.0,"publicationDate":"2026-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13437518/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148681316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiographic evaluation of malpositioning in immediate and early dental implant placement: A cross-sectional study.","authors":"Fatima Waleed Khalid, Zeinab Kadkhoda, Amir Raee, Farzaneh Mosavat, Shima Younespour","doi":"10.34172/japid.026.4041","DOIUrl":"10.34172/japid.026.4041","url":null,"abstract":"<p><strong>Introduction: </strong>Dental implants are commonly used to replace missing teeth. Immediate implant placement (IIP) has now become an increasingly common strategy to reduce treatment time. Dental implant malposition occurs when an implant is placed at an inappropriate dimension through the bone, which leads to a variety of aesthetic and functional complications. Therefore, this study aimed to compare immediate implant placement (IIP) and early implant placement (EIP) with respect to malposition.</p><p><strong>Methods: </strong>This cross-sectional study analyzed existing clinical records and accompanying periapical (PA) radiographs of 67 immediate implant placements (IIP) and 152 early implant placements (EIP). All the implants had originally been placed by senior periodontics residents. Postoperative PA radiographs obtained at the time of surgery were reviewed to assess implant malpositioning. Dental implant malposition was defined as mesiodistal angulation≥15° or inadequate proximity (<1.5 mm to adjacent teeth or<3 mm to adjacent implants). The associations between variables and malpositioning were assessed using both univariate and multivariable logistic regression.</p><p><strong>Results: </strong>A total of 219 implants were included from 85 individuals, comprising 31 males (36.47%) and 54 females (63.53%), with a mean age of 49.88±14.06 (range: 20‒80). Multivariable logistic regression analysis indicated that both the timing of implant placement and the implant position (maxilla vs. mandible) significantly influenced the risk of malpositioning. IIP was associated with a lower probability of malpositioning than EIP (adjusted OR=0.38; 95% CI: 0.16-0.90; <i>P</i>=0.03; Nagelkerke R²=0.10).</p><p><strong>Conclusion: </strong>Within the limitations of this cross-sectional study, multivariable regression analysis indicated that both the timing and position of implant placement are predictors of malpositioning. IIP demonstrated a lower risk of malpositioning compared with EIP, while maxillary placement remained a significant risk factor.</p>","PeriodicalId":73584,"journal":{"name":"Journal of advanced periodontology & implant dentistry","volume":"18 3","pages":"146-152"},"PeriodicalIF":0.0,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13437220/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148681289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of oxidative stress-related gst gene polymorphisms with periodontitis susceptibility: A systematic review and meta-analysis.","authors":"Paria Motahari, Negin Neshanifard","doi":"10.34172/japid.026.3866","DOIUrl":"10.34172/japid.026.3866","url":null,"abstract":"<p><strong>Introduction: </strong>Periodontitis is a prevalent inflammatory disease influenced by both genetic and environmental factors. Among genetic determinants, polymorphisms in oxidative stress-related g e n e s - p a r t i c u l a r l y <i>GSTM1</i>, <i>GSTT1</i>, and <i>GSTP1</i> (rs1695)-have been suggested as contributors to disease susceptibility. This systematic review and meta-analysis aimed to evaluate the association between <i>GSTM1</i>, <i>GSTT1</i>, and <i>GSTP1</i> (rs1695) gene polymorphisms and the risk of periodontitis.</p><p><strong>Methods: </strong>Following PRISMA 2020 guidelines, a comprehensive literature search was conducted in four databases (PubMed, Scopus, Web of Science, and Google Scholar) from inception to October 2025 for eligible case‒control studies. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. Heterogeneity was assessed using I² and Q tests (with P-values), and publication bias was evaluated using Egger's test and funnel plots. Evidence certainty was assessed with GRADE.</p><p><strong>Results: </strong>Seven studies with 1,525 participants were included. The GSTM1-null polymorphism was significantly associated with periodontitis (OR=2.94, 95% CI: 1.13-7.63, I2=93.5%) in subgroup analyses, particularly among Asians, in larger studies, and among heavy smokers. GSTT1-null polymorphism showed no significant effect (OR=0.64, 95% CI: 0.38-1.09, I²=69.7%). Initial pooled analyses indicated significant associations across all <i>GSTP1</i> (rs1695) genetic models; however, these associations were not robust and lost statistical significance after exclusion of a study that deviated from Hardy-Weinberg equilibrium. No publication bias was detected.</p><p><strong>Conclusion: </strong>This meta-analysis supports a potential role for the <i>GSTM1</i>-null polymorphism in increasing susceptibility to periodontitis. Associations for <i>GSTP1</i> (rs1695) were less consistent and sensitive to study quality, while the <i>GSTT1</i>-null polymorphism showed no clear effect. According to GRADE, the certainty of evidence was moderate for <i>GSTM1</i> and low for <i>GSTT1</i> and <i>GSTP1</i>; the results are therefore suggestive and require confirmation in larger multi-ethnic studies.</p>","PeriodicalId":73584,"journal":{"name":"Journal of advanced periodontology & implant dentistry","volume":"18 3","pages":"153-162"},"PeriodicalIF":0.0,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13437218/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148681061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Salivary antibody responses to <i>Fusobacterium nucleatum</i> and <i>Candida albicans</i> as indicators of periodontitis severity.","authors":"Muhammad Ihsan Rizal, Endang Winiati Bachtiar, Boy Muchlis Bachtiar, Yuniarti Soeroso, Fatimah Maria Tadjoedin, Retno Damajanti Soejoedono, Ferry Pergamus Gultom, Natalina Haerani, Melanie Sadono Djamil, Boedi Oetomo Roeslan","doi":"10.34172/japid.026.3982","DOIUrl":"10.34172/japid.026.3982","url":null,"abstract":"<p><strong>Introduction: </strong>Periodontitis is a chronic inflammatory disease that leads to the destruction of tooth-supporting tissues and remains a major cause of tooth loss worldwide. Its pathogenesis involves complex interactions between microbial pathogens and host immune responses, where salivary immunoglobulins serve as a first line of defense at mucosal surfaces. Identifying pathogen-specific salivary antibody responses that correlate with disease severity may provide noninvasive biomarkers for diagnosis and monitoring. The present work sought to explore how selected microbial pathogens and salivary antibody responses are connected with the severity of periodontitis and clinical periodontal status.</p><p><strong>Methods: </strong>A cross-sectional approach was applied. Saliva was obtained from 39 participants, including 31 patients diagnosed with periodontitis and 8 individuals with healthy periodontal tissues. Western blotting and enzyme-linked immunoassays were used to detect both microorganisms and immunoglobulins.</p><p><strong>Results: </strong>Patients classified as Stage IV periodontitis showed the highest occurrence of <i>Aggregatibacter actinomycetemcomitans</i>. Elevated IgA antibodies against <i>Fusobacterium nucleatum</i> (<i>P</i>=0.014) and <i>Candida albicans</i> (<i>P</i>=0.009) demonstrated significant associations with disease severity. Further associations were observed: plaque index with IgG to <i>C. albicans</i>; oral hygiene index with IgA to <i>A. actinomycetemcomitans</i> (<i>P</i>=0.008) and <i>C. albicans</i> (<i>P</i>=0.031), and papillary bleeding index with IgA to <i>A. actinomycetemcomitans</i> (<i>P</i>=0.003), <i>F. nucleatum</i> (<i>P</i>=0.002), and <i>C. albicans</i> (<i>P</i>=0.008).</p><p><strong>Conclusion: </strong>Salivary IgA and IgG responses to <i>Fusobacterium nucleatum</i> and <i>Candida albicans</i> exhibited significant stage-related associations with periodontitis severity, supporting their potential role as complementary immunological indicators.</p>","PeriodicalId":73584,"journal":{"name":"Journal of advanced periodontology & implant dentistry","volume":"18 3","pages":"122-131"},"PeriodicalIF":0.0,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13437217/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148681250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Navigating the ethical and legal landscape of artificial intelligence in dentistry.","authors":"Abdolhassan Kazemi, Adileh Shirmohammadi, Sana Kazemi, Sina Ghertasi Oskouei","doi":"10.34172/japid.026.4323","DOIUrl":"10.34172/japid.026.4323","url":null,"abstract":"","PeriodicalId":73584,"journal":{"name":"Journal of advanced periodontology & implant dentistry","volume":"18 2","pages":"70-71"},"PeriodicalIF":0.0,"publicationDate":"2026-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13243440/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148213749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of isolated gingival recession by tunneled coronally advanced flap and orthodontics: A case report.","authors":"Alejandro Guillen, Francisco Wilker Mustafa Gomes Muniz, Andrea Vergara-Buenaventura","doi":"10.34172/japid.026.3900","DOIUrl":"10.34172/japid.026.3900","url":null,"abstract":"<p><p>Gingival recession (GR) in malpositioned teeth with a thin periodontal phenotype poses a high risk during orthodontic movement. Phenotype modification before orthodontic treatment may reduce complications and improve clinical outcomes. A 27-year-old woman presented with a 3-mm RT2 gingival recession and<1 mm of keratinized tissue (KT) in tooth 31, which was labially displaced. Cone-beam computed tomography (CBCT) revealed the absence of the vestibular bone, and clinical evaluation confirmed a thin periodontal phenotype. To prevent GR progression during orthodontic movement, a tunneled coronally advanced flap (TCAF) combined with a subepithelial connective tissue graft (SCTG) was performed. Three months later, orthodontic treatment was initiated to lingualize the incisor. At 3-, 6-, and 10-month follow-ups, clinical improvements included an increase in KT width from<1 mm to 5 mm and greater gingival thickness. Complete root coverage was achieved and remained stable after orthodontic therapy. Esthetic results were rated as excellent using the root coverage esthetic score (RES=10/10). The patient reported minimal postoperative discomfort and no complications. This case highlights the successful use of TCAF with SCTG to modify the phenotype before orthodontic treatment in a high-risk GR case. The interdisciplinary approach led to favorable soft tissue augmentation, complete root coverage, and esthetic stability, supporting its use in similar clinical scenarios.</p>","PeriodicalId":73584,"journal":{"name":"Journal of advanced periodontology & implant dentistry","volume":"18 2","pages":"114-119"},"PeriodicalIF":0.0,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13241589/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148201183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of auto-adaptive metal artifact reduction (aMAR) program in cone-beam computed tomography on assessing pre-implant bone levels: Correspondence.","authors":"Hinpetch Daungsupawong, Viroj Wiwanitkit","doi":"10.34172/japid.026.3671","DOIUrl":"10.34172/japid.026.3671","url":null,"abstract":"","PeriodicalId":73584,"journal":{"name":"Journal of advanced periodontology & implant dentistry","volume":"18 2","pages":"120-121"},"PeriodicalIF":0.0,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13243438/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148213708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between HLA molecules and stage III/IV grade C periodontitis in a Moroccan population: A case-control study.","authors":"Khadija Amine, Wafa El Kholti, Siham Bennani, Jamila Kissa","doi":"10.34172/japid.026.3839","DOIUrl":"10.34172/japid.026.3839","url":null,"abstract":"<p><strong>Background: </strong>Literature data support the important role played by HLA molecules in predisposing to periodontitis. The present study evaluated possible associations between HLA class I and II phenotypes and stage III/IV grade C periodontitis in a Moroccan population.</p><p><strong>Methods: </strong>The sample comprised 26 patients aged 15‒30 years, diagnosed with stage III/IV grade C periodontitis (case group) and 202 patients ethnically similar to the case group (control group). The patients underwent phenotyping for HLA class I molecules using the BIOTEST microlymphocytic plate technique and genotyping for HLA DR molecules. Bivariate analysis was performed using the chi-squared test at a significance level of <i>P</i><0.05.</p><p><strong>Results: </strong>The results showed a variable distribution of A alleles, without any specificity, predominantly in periodontitis cases compared with the controls. B21 allele was found with a lower phenotypic frequency (10.34%) in periodontitis cases compared with controls (31.18%) (χ²=5.40 and <i>P</i>=0.02). The phenotypic frequency of the DR6 allele was significantly lower in periodontitis cases (11.52%) compared with the controls (33.16%) (χ²=5.07 and <i>P</i>=0.024).</p><p><strong>Conclusion: </strong>The present case‒control study reported a negative association between B21 and DR6 alleles and stage III/IV grade C Moroccan periodontitis cases compared with the controls with verified healthy periodontal status. This may help explain the particular profile of stage III/IV grade C periodontitis in Moroccan patients.</p>","PeriodicalId":73584,"journal":{"name":"Journal of advanced periodontology & implant dentistry","volume":"18 2","pages":"98-102"},"PeriodicalIF":0.0,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13243439/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148213586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}