Journal of advanced periodontology & implant dentistry最新文献

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Comparison of osseodensification and standard drilling methods on implant stability quotient and insertion torque values of implants. 骨化与标准钻孔方法对种植体稳定商及植入扭矩值的影响。
Journal of advanced periodontology & implant dentistry Pub Date : 2025-04-23 eCollection Date: 2025-06-01 DOI: 10.34172/japid.025.3475
Omid Moghaddas, Vanda Banazadeh
{"title":"Comparison of osseodensification and standard drilling methods on implant stability quotient and insertion torque values of implants.","authors":"Omid Moghaddas, Vanda Banazadeh","doi":"10.34172/japid.025.3475","DOIUrl":"10.34172/japid.025.3475","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to compare insertion torque (IT) and implant stability quotient (ISQ) values immediately and three months after surgery with standard drilling (SD) and osseodensification (OD) drilling methods.</p><p><strong>Methods: </strong>In this prospective study, 39 implants with the same diameter and length were placed in 21 patients using SD (23 implants) and OD (16 implants) methods in the posterior maxilla. The amounts of IT after surgery and ISQ after surgery and three months later were evaluated. The data were extracted and statistically analyzed with PASS2 software. The difference between IT and ISQ was determined by the two-way repeated-measures ANOVA at a significance level of 0.001.</p><p><strong>Results: </strong>Immediately after surgery, the amount of IT using the OD drilling method was 37% higher than the SD drilling (<i>P</i><0.001). ISQ values after surgery did not show a significant difference between SD and OD (<i>P</i>1<0.176). Three months after surgery, the ISQ values in both groups were not significantly different. ISQ values for all OD and SD group experimental parameters remained above the threshold value of 68. IT values showed a positive correlation with ISQ values at baseline.</p><p><strong>Conclusion: </strong>In the present study, the OD technique provided a higher IT rate after surgery compared to the SD method; however, no difference was seen between the two groups regarding ISQ value either after surgery or three months later.</p>","PeriodicalId":73584,"journal":{"name":"Journal of advanced periodontology & implant dentistry","volume":"17 2","pages":"59-64"},"PeriodicalIF":0.0,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261070/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144651346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Slim V-shaped frenectomy: Description of a minimally invasive surgical technique. 纤细v型系带切除术:一种微创手术技术的描述。
Journal of advanced periodontology & implant dentistry Pub Date : 2025-04-22 eCollection Date: 2025-06-01 DOI: 10.34172/japid.025.3524
Abdusalam E Alrmali, Paolo Nava, Jacob Martin Zimmer, Syed Hanan Rufai, Andreas Onisiforou, Hom-Lay Wang
{"title":"Slim V-shaped frenectomy: Description of a minimally invasive surgical technique.","authors":"Abdusalam E Alrmali, Paolo Nava, Jacob Martin Zimmer, Syed Hanan Rufai, Andreas Onisiforou, Hom-Lay Wang","doi":"10.34172/japid.025.3524","DOIUrl":"10.34172/japid.025.3524","url":null,"abstract":"<p><p>This article introduces a minimally invasive slim V-shaped surgical technique for labial frenectomy, specifically targeting high labial frenulum attachment. Proper frenulum management is critical in dental specialties, influencing aesthetics, phonetics, and prosthetic rehabilitation outcomes. The described technique is adaptable to various types of labial frenulum, including mucosal, gingival, papillary, and papilla penetrating. It involves a slim V-shaped incision, consecutive frenulum detachment, and repositioning within the vestibule, effectively addressing potential recurrence growth. Its minimally invasive nature reduces wound expansion into neighboring structures, ensuring optimal healing and minimizing postoperative discomfort. In conclusion, the slim V-shaped surgical technique offers a promising solution, minimizing complications and maximizing treatment success for high labial frenulum attachment.</p>","PeriodicalId":73584,"journal":{"name":"Journal of advanced periodontology & implant dentistry","volume":"17 2","pages":"119-122"},"PeriodicalIF":0.0,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261069/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144651350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of emergence profile and space gap size on excess cement in cement-retained implant reconstructions. 骨水泥保留种植体重建中涌现轮廓和间隙大小对过量骨水泥的影响。
Journal of advanced periodontology & implant dentistry Pub Date : 2025-04-21 eCollection Date: 2025-06-01 DOI: 10.34172/japid.025.2292
Fariborz Vafaee, Saeed Nikanjam, Arash Farahnaki, Meysam Mahabadi, Sajjad Farashi, Sara Khazaei, Shiva Shahabi
{"title":"Effect of emergence profile and space gap size on excess cement in cement-retained implant reconstructions.","authors":"Fariborz Vafaee, Saeed Nikanjam, Arash Farahnaki, Meysam Mahabadi, Sajjad Farashi, Sara Khazaei, Shiva Shahabi","doi":"10.34172/japid.025.2292","DOIUrl":"10.34172/japid.025.2292","url":null,"abstract":"<p><strong>Background: </strong>Excess cement is one of the most prevalent problems with cement-retained implant-supported prostheses. The excess cement may be considered an important source of inflammation during implant application. Optimizing the design procedure for reducing excess cement is necessary for successful and safe implant applications.</p><p><strong>Methods: </strong>This study assessed the effect of two confounding factors, i.e., emergence profile and space gap size, on the level of excess cement. Three types of emergence profiles (concave, convex, and straight) and three different gap sizes (30, 60, and 90 µm) were considered for implant design, and the level of excess cement was measured for each design.</p><p><strong>Results: </strong>Statistical analyses using one-way ANOVA followed by post hoc <i>P</i> value correction revealed that the best emergence profile with the lowest excess cement was the straight profile, with statistically lower excess cement compared with concave and convex profiles (<i>P</i><0.05) and no significant difference between concave and convex profiles. Furthermore, analyses showed that lower gap size was associated with lower excess cement, even though increasing the gap size from a threshold (>60 µm) made the difference significant. Interaction analysis using two-way ANOVA also indicated the interaction between the emergence profile and space gap size.</p><p><strong>Conclusion: </strong>The results emphasized that a straight profile with a smaller gap size should be considered to reduce the excess cement. However, due to the small sample size of the study, further analyses with different types of materials, angles of deformation, and gap sizes are required to reveal the exact relationship between excess cement and the design specifications.</p>","PeriodicalId":73584,"journal":{"name":"Journal of advanced periodontology & implant dentistry","volume":"17 2","pages":"65-70"},"PeriodicalIF":0.0,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261064/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144651347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CBCT data relevant in treatment planning for immediate mandibular molar implant placement. CBCT数据与即刻下颌磨牙种植种植治疗计划的相关性。
Journal of advanced periodontology & implant dentistry Pub Date : 2025-04-14 eCollection Date: 2025-06-01 DOI: 10.34172/japid.025.3722
Maziar Ebrahimi Dastgurdi, Douglas Deporter, Max Xia, Mohammad Ketabi
{"title":"CBCT data relevant in treatment planning for immediate mandibular molar implant placement.","authors":"Maziar Ebrahimi Dastgurdi, Douglas Deporter, Max Xia, Mohammad Ketabi","doi":"10.34172/japid.025.3722","DOIUrl":"10.34172/japid.025.3722","url":null,"abstract":"<p><strong>Background: </strong>Immediate molar implants (IMIs) have been shown to provide an effective treatment, but their placement comes with potential anatomically related risks.</p><p><strong>Methods: </strong>CBCTs of>400 dental sites were analyzed for key anatomical features at mandibular molar sites that can impact the placement of IMIs. Features measured included distances from each molar furcation to points risking lingual plate perforation or inferior alveolar nerve (IAC) damage, distances from molar root apices to IAC, mesiodistal and buccolingual widths of molar inter-septal bone (ISB), and thicknesses of buccal and lingual cortical plates at first and second mandibular molar sites.</p><p><strong>Results: </strong>Distances from molar furcations to contact with lingual cortical plates and to IAC decreased significantly from mesial to distal, as did distances from root apices to the mandibular canal. Both buccolingual and mesiodistal ISB widths and thicknesses of buccal and lingual cortical plates increased mesiodistally. Buccolingual ISB widths were largest coronally for both molar sites and decreased apically. The reverse was found with mesiodistal septal ISB widths, which increased coronoapically.</p><p><strong>Conclusion: </strong>Risks of lingual perforations or IAC damage were significantly greater at second molars vs. first molars. The ability to place IMIs in ISB at first molars was estimated to be>twice as often as at second molars. Maximal implant lengths for IMIs placed in the furcal bone should not exceed 10 mm.</p>","PeriodicalId":73584,"journal":{"name":"Journal of advanced periodontology & implant dentistry","volume":"17 2","pages":"71-76"},"PeriodicalIF":0.0,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261068/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144651345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Oral manifestations of sickle cell disease and its effects on dental and periodontal health: A systematic review. 镰状细胞病的口腔表现及其对牙齿和牙周健康的影响:一项系统综述。
Journal of advanced periodontology & implant dentistry Pub Date : 2025-04-13 eCollection Date: 2025-06-01 DOI: 10.34172/japid.025.3467
Mouhamadou Lamine Guirassy, Folly Emmanuel Baglo, Ahmad Moustapha Diallo, Ndeye Lira Mbow, Diabel Thiam, Adam Seck-Diallo, Henri Michel Benoist
{"title":"Oral manifestations of sickle cell disease and its effects on dental and periodontal health: A systematic review.","authors":"Mouhamadou Lamine Guirassy, Folly Emmanuel Baglo, Ahmad Moustapha Diallo, Ndeye Lira Mbow, Diabel Thiam, Adam Seck-Diallo, Henri Michel Benoist","doi":"10.34172/japid.025.3467","DOIUrl":"10.34172/japid.025.3467","url":null,"abstract":"<p><strong>Background: </strong>Sickle cell disease is a genetic disorder that manifests itself in several organs. There is little consensus in the literature on oral manifestations, particularly dental and periodontal. This study aimed to identify the oral manifestations of sickle cell disease, focusing on dental and periodontal manifestations.</p><p><strong>Methods: </strong>An electronic search was performed in PubMed, Embase, and African Index Medicus. Quality and risk of bias were assessed using the Newcastle-Ottawa Scale, the modified Newcastle-Ottawa Scale, and the 2013 Guideline CARE. This systematic review covered research published between 2000 and 2022.</p><p><strong>Results: </strong>A total of 962 articles were identified, 26 of which were selected, including 13 case-control studies, 4 cohort studies, 7 cross-sectional studies, and 2 case reports. The risk of bias was high for 3.84% of the studies, medium for 38.46%, and low for 57.60%. Oral manifestations were reported in 24 studies, with a predominance of periodontal ones in 10 studies. An association between sickle cell disease and dental caries, pulpal necrosis, and delayed tooth eruption has been reported.</p><p><strong>Conclusion: </strong>Several oral manifestations, particularly periodontal, of sickle cell disease have been reported. However, current data do not provide evidence of a possible association between sickle cell disease and oral symptoms, particularly periodontal manifestations.</p>","PeriodicalId":73584,"journal":{"name":"Journal of advanced periodontology & implant dentistry","volume":"17 2","pages":"103-110"},"PeriodicalIF":0.0,"publicationDate":"2025-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261066/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144651349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A novel technique for computer-assisted dental autotransplantation: A case report with 42 months of follow-up. 计算机辅助自体牙移植新技术:42个月随访1例。
Journal of advanced periodontology & implant dentistry Pub Date : 2025-04-13 eCollection Date: 2025-06-01 DOI: 10.34172/japid.025.3760
Ehsan Chegeni, José Marques, Rui Figueiredo, Eduard Valmaseda-Castellón, Mahdi Kadkhodazadeh
{"title":"A novel technique for computer-assisted dental autotransplantation: A case report with 42 months of follow-up.","authors":"Ehsan Chegeni, José Marques, Rui Figueiredo, Eduard Valmaseda-Castellón, Mahdi Kadkhodazadeh","doi":"10.34172/japid.025.3760","DOIUrl":"10.34172/japid.025.3760","url":null,"abstract":"<p><p>Dental autotransplantation (DAT) is an effective technique for replacing missing teeth. This case report presents a novel computer-assisted approach using cone-beam computed tomography (CBCT) for 3D planning. A 15-year-old female with a hopeless molar due to failed endodontic treatment underwent DAT. Following 3D planning, the donor tooth was surgically extracted and transplanted into the prepared socket, followed by semi-rigid splinting. A meticulous 42-month clinical and radiographic follow-up demonstrated the success and stability of the procedure. This innovative method emphasizes the role of advanced computer technology and 3D imaging in enhancing surgical precision and treatment outcomes. Within the limitations of this case report, DAT, combined with computer-assisted planning, proved a reliable and predictable treatment option for replacing hopeless teeth, particularly in young patients. This approach showed the potential of DAT to transform tooth replacement strategies with better accuracy and decision-making.</p>","PeriodicalId":73584,"journal":{"name":"Journal of advanced periodontology & implant dentistry","volume":"17 2","pages":"111-118"},"PeriodicalIF":0.0,"publicationDate":"2025-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261065/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144651344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Treatment of an endodontic-periodontal lesion using peripheral blood mesenchymal stem cells (PBMSCs) and platelet-rich fibrin matrix (PRFM): A case report. 使用外周血间充质干细胞(PBMSCs)和富血小板纤维蛋白基质(PRFM)治疗牙髓-牙周病变1例报告。
Journal of advanced periodontology & implant dentistry Pub Date : 2025-03-08 eCollection Date: 2025-03-01 DOI: 10.34172/japid.025.3502
Sphoorthi Anup Belludi, Sharaz Shaik, Neha Pradhan, Sreeparvathy Rema
{"title":"Treatment of an endodontic-periodontal lesion using peripheral blood mesenchymal stem cells (PBMSCs) and platelet-rich fibrin matrix (PRFM): A case report.","authors":"Sphoorthi Anup Belludi, Sharaz Shaik, Neha Pradhan, Sreeparvathy Rema","doi":"10.34172/japid.025.3502","DOIUrl":"https://doi.org/10.34172/japid.025.3502","url":null,"abstract":"<p><p>In the current report, we discuss the available treatment options and present a successfully treated periodontal-endodontic lesion using autogenous peripheral blood mesenchymal stem cells (PBMSCs) and platelet-rich fibrin matrix (PRFM). A patient presented with a complaint of food impaction and bad breath. Clinically, the lower right first molar was non-vital and had a deep periodontal pocket and attachment loss. Radiographically, the distal root had an angular bone loss extending to the apex. The endodontic condition was treated with chemomechanical debridement, calcium hydroxide dressing, and obturation. Later, we reflected a full-thickness mucoperiosteal flap and thoroughly debrided the granulation tissue. We filled the defect with a gel containing PBMSCs and PRFM, prepared from the patient's peripheral blood, and sutured the flap. After nine months, we noticed significant osseous fill and 5 mm of gain in the clinical attachment level. The outcomes of the case show the periodontal regenerative potential of the novel combination.</p>","PeriodicalId":73584,"journal":{"name":"Journal of advanced periodontology & implant dentistry","volume":"17 1","pages":"54-58"},"PeriodicalIF":0.0,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12010481/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144061440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correlation between concentrations of salivary and gingival crevicular fluid inflammatory cytokines in patients with gingivitis and periodontitis and healthy individuals. 牙龈炎和牙周炎患者与健康人群唾液和龈沟液炎症细胞因子浓度的相关性
Journal of advanced periodontology & implant dentistry Pub Date : 2025-03-04 eCollection Date: 2025-03-01 DOI: 10.34172/japid.025.2244
Ferya Azami, Vahid Esfahanian, Mahsa Ahmadi Shadmehri, Sami Rafiei
{"title":"Correlation between concentrations of salivary and gingival crevicular fluid inflammatory cytokines in patients with gingivitis and periodontitis and healthy individuals.","authors":"Ferya Azami, Vahid Esfahanian, Mahsa Ahmadi Shadmehri, Sami Rafiei","doi":"10.34172/japid.025.2244","DOIUrl":"https://doi.org/10.34172/japid.025.2244","url":null,"abstract":"<p><strong>Background: </strong>This study compared tumor necrosis factor-α (TNF-α) and interlukin-1β (IL-1β) concentrations in the saliva and gingival crevicular fluid (GCF) of patients with gingivitis and periodontitis and healthy individuals.</p><p><strong>Methods: </strong>In this study, 45 patients (n=15 in each group) were selected, and the concentrations of inflammatory cytokines TNF-α and IL-1β in their salivary and GCF samples were measured using the ELISA method. Shapiro-Wilk test, one-way analysis of variance, post hoc Bonferroni test, and Pearson's correlation coefficient were used to analyze the data.</p><p><strong>Results: </strong>According to the results of the post hoc Bonferroni test, the mean salivary and GCF levels of TNF-α and IL-1β in healthy individuals were significantly lower than those with periodontitis (<i>P</i><0.05) and gingivitis (<i>P</i><0.05). Also, the mean levels of TNF-α and IL-1β in the saliva and GCF of patients with periodontitis were significantly higher than patients with gingivitis (<i>P</i><0.05).</p><p><strong>Conclusion: </strong>Based on the findings of the study, saliva, like GCF, can be considered a source for monitoring the markers related to periodontal disease. However, more uniformity was observed in GCF than in saliva in terms of alignment of markers secretion.</p>","PeriodicalId":73584,"journal":{"name":"Journal of advanced periodontology & implant dentistry","volume":"17 1","pages":"31-35"},"PeriodicalIF":0.0,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12010477/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stem cell therapy for regenerating periodontal bony defects: A narrative review. 干细胞治疗牙周骨缺损再生:综述。
Journal of advanced periodontology & implant dentistry Pub Date : 2025-03-03 eCollection Date: 2025-03-01 DOI: 10.34172/japid.025.3749
Samira Mohammad Mirzapour, Fatemeh Jalali
{"title":"Stem cell therapy for regenerating periodontal bony defects: A narrative review.","authors":"Samira Mohammad Mirzapour, Fatemeh Jalali","doi":"10.34172/japid.025.3749","DOIUrl":"https://doi.org/10.34172/japid.025.3749","url":null,"abstract":"<p><p>Periodontal bony defects pose a significant challenge in periodontology, necessitating advanced regenerative approaches to restore the lost structures. Stem cell-based therapies have emerged as a promising solution due to their ability to differentiate into various cells, modulating the regenerative microenvironment. This narrative review explores the potential of stem cells derived from multiple sources in treating periodontal bony defects. Additionally, we examine evidence from both animal and human studies, highlighting advancements, clinical outcomes, and limitations. By investigating these findings, this article provides a comprehensive overview of the advantages of stem cell-based therapies compared to other regenerative techniques in addressing periodontal bony defects and discusses the limitations of their translation into routine clinical practice.</p>","PeriodicalId":73584,"journal":{"name":"Journal of advanced periodontology & implant dentistry","volume":"17 1","pages":"1-14"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12010474/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144013889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antimicrobial efficacy and cytotoxicity of ethanolic extracts of Salvia officinalis and Juglans regia against oral pathogens. 鼠尾草和核桃乙醇提取物对口腔病原菌的抑菌效果及细胞毒性研究。
Journal of advanced periodontology & implant dentistry Pub Date : 2025-02-16 eCollection Date: 2025-03-01 DOI: 10.34172/japid.025.3710
Sara Ghadaksaz, Safar Farajnia, Fatemeh Pournaghiazar, Hamed Ebrahimzadeh Leylabadlo, Reza Salahlou, Abbas Delazar, Amir Zandesh
{"title":"Antimicrobial efficacy and cytotoxicity of ethanolic extracts of <i>Salvia officinalis</i> and <i>Juglans regia</i> against oral pathogens.","authors":"Sara Ghadaksaz, Safar Farajnia, Fatemeh Pournaghiazar, Hamed Ebrahimzadeh Leylabadlo, Reza Salahlou, Abbas Delazar, Amir Zandesh","doi":"10.34172/japid.025.3710","DOIUrl":"https://doi.org/10.34172/japid.025.3710","url":null,"abstract":"<p><strong>Background: </strong>Herbal extracts have gained attention for their potential benefits in promoting oral health and preventing dental caries and periodontal diseases. This study evaluated the antimicrobial effects and cytotoxicity of ethanolic extracts of <i>Salvia officinalis</i> and <i>Juglans regia</i>, both individually and in combination, against <i>Streptococcus mutans, Lactobacillus casei,</i> and <i>Candida albicans</i>, microorganisms associated with oral diseases.</p><p><strong>Methods: </strong>In this <i>in vitro</i> study, the hydroalcoholic (ethanolic) extracts of <i>J. regia</i> and <i>S. officinalis</i> were prepared using the maceration method. To determine the antimicrobial effectiveness, the zone of inhibition in the disk agar diffusion, minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were assessed for each extract, separately and in combination. The extracts' cytotoxicity was investigated at their effective doses using the MTT (methyl thiazole tetrazolium) assay.</p><p><strong>Results: </strong>Compared to the negative control, ethanolic extracts of <i>S. officinalis</i> and <i>J. regia</i> exhibited a significant inhibitory effect (<i>P</i><0.001) on <i>S. mutans</i> and <i>L. casei. Salvia officinalis</i> extract exhibited antimicrobial activities, as evidenced by the MIC values of 237.5 µg/mL for <i>S. mutans</i>, 118.7 µg/mL for <i>Lactobacillus casei</i>, and 31.25 mg/mL for <i>C. albicans</i>. The ethanolic extract of <i>Juglans regia</i> exhibited MIC values of 29.6 µg/mL for <i>S. mutans</i>, 475 µg/mL for <i>L. casei</i>, and 15.62 mg/mL for <i>C. albicans</i>, respectively. MTT assay results showed that the extracts had no cytotoxic effects at the MIC on the L929 cell line; however, pure chlorhexidine was toxic at 0.2% concentration.</p><p><strong>Conclusion: </strong>The study results revealed that the ethanolic extracts of <i>S. officinalis</i> and <i>J. regia</i> and their combined application showed antimicrobial activity against pathogenic microorganisms pertinent to oral health. In addition, cytotoxicity evaluations indicated that these extracts are non-toxic to the L929 cell line at effective concentrations.</p>","PeriodicalId":73584,"journal":{"name":"Journal of advanced periodontology & implant dentistry","volume":"17 1","pages":"46-53"},"PeriodicalIF":0.0,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12010476/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144036280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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