{"title":"Remote anchorage implants as an emerging treatment modality for the severely atrophic maxilla.","authors":"Mohammadreza Talebi Ardakani, Aida Kheiri","doi":"10.34172/japid.026.4247","DOIUrl":"10.34172/japid.026.4247","url":null,"abstract":"","PeriodicalId":73584,"journal":{"name":"Journal of advanced periodontology & implant dentistry","volume":"18 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12935377/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147313277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Investigation of attachment and proliferation of MG-63 osteoblast-like cells to titanium disks in the presence of iPRF (injectable platelet-rich fibrin) or CGF (Concentrated Growth Factor): A laboratory study.","authors":"Maryam Torshabi, Zeinab Rezaei Esfahrood, Behzad Houshmand, Seyed Hosein Tabatabaee","doi":"10.34172/japid.026.3383","DOIUrl":"https://doi.org/10.34172/japid.026.3383","url":null,"abstract":"<p><strong>Background: </strong>The attachment of the dental implant to the host bone (osteointegration) is considered a critical factor in the success of implant treatment. Osteoblasts are the primary cells in the osteointegration process. Today, compounds containing growth factors are used to shorten osteointegration time and increase the treatment success rate. This study evaluated the effects of iPRF (injectable platelet-rich fibrin) and CGF (concentrated growth factor) platelet extracts on the attachment and proliferation of MG-63 osteoblast-like cells over titanium disk surfaces.</p><p><strong>Methods: </strong>Titanium pieces with a length of 12.1 mm and a width of 3.8 mm were prepared. The MG-63 cell viability, attachment, and proliferation on titanium disks were evaluated in the presence of prepared extracts from iPRF and CGF using methyl thiazolyl tetrazolium (MTT) assay and scanning electron microscopy (SEM).</p><p><strong>Results: </strong>The results of the direct exposure of different concentrations of extracts on MG-63 cells cultured on the polystyrene surface of cell culture plates in the absence of fetal bovine serum (FBS) showed no significant difference between different concentrations of iPRF and CGF extracts in the first 24 hours after exposure (<i>P</i>>0.05). However, 48 hours after exposure, CGF extracts showed better effects (<i>P</i><0.05). In the first 24 hours, MG-63 cell attachment to the titanium disks was significantly higher after exposure to CGF compared to iPRF and the control group (<i>P</i><0.05). Nevertheless, 48 hours after culturing, no significant differences were observed in MG-63 survival, proliferation, and attachment between iPRF, CGF, and the control group (absence of iPRF and CGF) (<i>P</i>>0.05).</p><p><strong>Conclusion: </strong>The results showed a better short-term (first 24 hours after exposure) effect of CGF on primary cell survival, attachment, and proliferation compared to iPRF; however, this superiority disappeared over time.</p>","PeriodicalId":73584,"journal":{"name":"Journal of advanced periodontology & implant dentistry","volume":"18 1","pages":"3-10"},"PeriodicalIF":0.0,"publicationDate":"2025-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12913209/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146230101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Farhan Musaie, Setareh Garousi, Mehregan Shahrokhi, Mahsa Babareshani, Danial Zamani, Zahra Ashrafi, Ala Shadbin, Ali Rezvanimehr, Zahra Sanei, Mehran Mottahedi, Nima Rahimipetrudi, Nozhan Azimi, Niloofar Deravi, Fatemeh Arabpour, Hamed Taheri
{"title":"Effects of periodontitis on micro and macro vascular complications of diabetes: A systematic review.","authors":"Farhan Musaie, Setareh Garousi, Mehregan Shahrokhi, Mahsa Babareshani, Danial Zamani, Zahra Ashrafi, Ala Shadbin, Ali Rezvanimehr, Zahra Sanei, Mehran Mottahedi, Nima Rahimipetrudi, Nozhan Azimi, Niloofar Deravi, Fatemeh Arabpour, Hamed Taheri","doi":"10.34172/japid.026.3353","DOIUrl":"https://doi.org/10.34172/japid.026.3353","url":null,"abstract":"<p><strong>Background: </strong>Periodontitis (PD) is a chronic inflammatory disease of the oral cavity. PD can adversely affect glycemic control and cause macro- and micro-vascular diseases in diabetic patients. This article aims to systematically review the association between periodontitis and micro- and macro-vascular complications of diabetes.</p><p><strong>Methods: </strong>This review was conducted under the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA). A thorough search of the Scopus and PubMed databases was performed up to 2022. English articles were included.</p><p><strong>Results: </strong>In this study, seven studies with 29,679 participants investigated the relationship between periodontitis and micro- and macro-vascular complications. There were two cohort studies, six cross-sectional studies, and one case‒control study. Follow-up durations ranged from 6 months to 11.64 years. The reports were published between 2002 and 2022. There was a relationship between periodontitis and the microvascular complications of diabetes in four studies. One study found no significant association between periodontitis and the microvascular complications of diabetes. The correlation between coronary heart disease (CHD) and periodontal disease was confirmed by one study. Furthermore, another study found that periodontitis increased the risk of cerebral and myocardial infarctions.</p><p><strong>Conclusion: </strong>The present study demonstrated that diabetes mellitus (DM) patients with periodontitis are at an increased risk of macro- and micro-vascular complications, particularly myocardial and cerebral infarctions.</p>","PeriodicalId":73584,"journal":{"name":"Journal of advanced periodontology & implant dentistry","volume":"18 1","pages":"48-54"},"PeriodicalIF":0.0,"publicationDate":"2025-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12913210/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146230029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effect of autogenous tooth vs. autogenous bone grafts on periodontal phenotype around immediate implants: A randomized clinical trial.","authors":"Adileh Shirmohammadi, Elnaz Ziaei-Rad, Leila Roshangar, Samira Mohammad Mirzapour, Fatemeh Aghaziarati","doi":"10.34172/japid.026.4099","DOIUrl":"https://doi.org/10.34172/japid.026.4099","url":null,"abstract":"<p><strong>Background: </strong>Immediate implant placement can result in a horizontal defect between the implant and alveolar bone, potentially affecting osseointegration and esthetic outcomes. Grafting this space supports bone regeneration. This study compared the effectiveness of autogenous tooth-derived and autogenous bone grafts for horizontal gap augmentation in the maxillary anterior region.</p><p><strong>Methods: </strong>This parallel-arm randomized, single-masked clinical trial enrolled patients attending the Tabriz University of Medical Sciences School of Dentistry, who were candidates for immediate implant placement in the maxillary anterior region. After implant placement, the control sites (n=11) received autogenous bone grafts. In contrast, the intervention sites (n=11) received autogenous dentin grafts to fill the horizontal gap between the implant and the buccal wall (jumping gap). A connective tissue graft was subsequently placed in both groups to enhance buccal soft tissue. Buccal bone thickness (measured 2 mm and 5 mm below the marginal crest) and soft tissue thickness were measured at two points at the time of surgery and again six months postoperatively. Data were analyzed using paired t-tests to assess changes within each group and independent t-tests to compare differences between the two groups.</p><p><strong>Results: </strong>Both groups showed significant increases in buccal bone and soft tissue thickness compared with baseline. At 2 mm below the marginal crest, buccal bone thickness did not differ significantly between the two groups (<i>P</i>=0.401). At 5 mm below the marginal crest, the autogenous bone graft group showed significantly greater bone thickness (2.15±0.21 mm) than the dentin graft group (1.50±0.53 mm, <i>P</i>=0.001). There was no significant difference in buccal soft tissue thickness changes between the bone graft (1.15±0.18 mm) and dentin graft (1.1±0.17 mm) groups.</p><p><strong>Conclusion: </strong>Both autogenous dentin and bone grafts effectively enhanced buccal bone and soft tissue thickness around immediate implants. Autogenous bone grafts produced significantly greater increases in buccal bone at 5 mm below the marginal crest. <b>Trial Registration.</b> Iranian Registry of Clinical Trials (IRCT), IRCT20110726007128N11, Trial ID 86072.</p>","PeriodicalId":73584,"journal":{"name":"Journal of advanced periodontology & implant dentistry","volume":"18 1","pages":"32-40"},"PeriodicalIF":0.0,"publicationDate":"2025-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12913200/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146230020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Assessment of gingival characteristics by professional versus smartphone imaging.","authors":"Mohan Kumar Pasupuleti, Gurramkonda Sirisha, Gabu Pujitha, Gautami Subhadra Penmetsa, Supraja Salwaji, Nissi Gurindapalli","doi":"10.34172/japid.026.3806","DOIUrl":"https://doi.org/10.34172/japid.026.3806","url":null,"abstract":"<p><strong>Background: </strong>Accurate evaluation of gingival health requires understanding inflammation as a sign of disease activity or healing. Only a few studies have examined the gingiva in depth using non-invasive imaging techniques. Therefore, this study assessed the accuracy of evaluating gingival parameters using professional (Canon EOS 1300D, Canon Inc., Japan) and smartphone (iPhone 15 Pro, Apple Inc., USA) cameras, with pre- and post-treatment photographs.</p><p><strong>Methods: </strong>Thirty-four patients with gingivitis were selected, and photographs were captured using professional and smartphone cameras. Gingival parameters were examined using pictures of the maxillary anterior region taken at distances of 24, 28, and 32 cm from the examination site. All the images were evaluated using the free ImageJ software (US National Institutes of Health, Bethesda, Maryland, USA) with an accuracy of 0.01 mm. The paired t-test was used to compare gingival color values and clinical measurements. A P value of<0.05 was considered statistically significant.</p><p><strong>Results: </strong>There were no significant differences in gingival parameters between images taken using either professional or smartphone photography. The results showed no significant differences in gingival color assessment at 24-, 28-, and 32-cm distances between the two images.</p><p><strong>Conclusion: </strong>Digital images obtained with DSLR and smartphone cameras showed comparable accuracy for gingival parameter measurements at the tested distances.</p>","PeriodicalId":73584,"journal":{"name":"Journal of advanced periodontology & implant dentistry","volume":"18 1","pages":"11-19"},"PeriodicalIF":0.0,"publicationDate":"2025-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12913202/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146230111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Beyond probes and charts: The AI revolution reshaping diagnosis, prognosis, and treatment decision-making in periodontology.","authors":"Mohammadreza Talebi Ardakani, Sajad Jahantigh","doi":"10.34172/japid.025.4144","DOIUrl":"10.34172/japid.025.4144","url":null,"abstract":"","PeriodicalId":73584,"journal":{"name":"Journal of advanced periodontology & implant dentistry","volume":"17 4","pages":"179-181"},"PeriodicalIF":0.0,"publicationDate":"2025-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12702081/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145764114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Omid Moghaddas, Nima Naddafpour, Sareh Farhadi, Zahra Mosalmani, Sephora Khandan
{"title":"Histopathological evaluation of bone formation using hydroxyapatite/β-tricalcium phosphate following tooth extraction: A comparative study of two time intervals.","authors":"Omid Moghaddas, Nima Naddafpour, Sareh Farhadi, Zahra Mosalmani, Sephora Khandan","doi":"10.34172/japid.025.3476","DOIUrl":"https://doi.org/10.34172/japid.025.3476","url":null,"abstract":"<p><strong>Background: </strong>Ridge resorption following tooth extraction can be managed with bone graft substitutes. The present study histologically evaluated the amount of new bone formation 3 and 4 months after tooth extraction and ridge preservation using the hydroxyapatite/β-tricalcium phosphate (HA/βTCP) graft material (OSTEON II).</p><p><strong>Methods: </strong>Forty patients requiring tooth extraction and subsequent implant placement were enrolled in this randomized controlled clinical trial. Ridge preservation using HA/βTCP alloplast (OSTEON II) in extraction sockets was divided into three months (group A) and four months (group B). Bone samples were collected from each grafted socket at the implant placement site. Histomorphometric analyses were performed to determine the amount of new bone formation and the residual graft material. In addition, we evaluated changes in histological indices, i.e., inflammation rate, percentage of ossification, and the amount of remaining biomaterial.</p><p><strong>Results: </strong>There were no significant differences in the amount of newly formed bone and the residual graft material between the two groups. In the 3-month group, an average of 20.11% of newly formed bone and 6.82% of the remaining graft were seen. In contrast, they were 20.67% and 7.38% in the 4-month group.</p><p><strong>Conclusion: </strong>The findings suggest that the HA/βCP bone graft material (OSTEON II) may enhance bone regeneration within a shorter healing time.</p>","PeriodicalId":73584,"journal":{"name":"Journal of advanced periodontology & implant dentistry","volume":"18 1","pages":"20-25"},"PeriodicalIF":0.0,"publicationDate":"2025-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12913207/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146230072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A critical review of existing peri-implantitis classification systems and a novel three-dimensional framework.","authors":"Mohammad Mohammadi, Shahin Shahbazpey","doi":"10.34172/japid.025.3948","DOIUrl":"10.34172/japid.025.3948","url":null,"abstract":"<p><strong>Background: </strong>Peri-implantitis remains a clinically relevant complication characterized by soft tissue inflammation and progressive bone loss. Existing classification systems vary in their emphasis on clinical severity or defect morphology and seldom provide operational, treatment-linked guidance-particularly for apical disease.</p><p><strong>Methods: </strong>We conducted a structured critical review of PubMed, Scopus, and Web of Science for studies published in English from January 1990 to December 2023 (last search: December 31, 2023). Full search strategies are reported in Supplementary file 1. Grey literature and conference abstracts were excluded a priori. Two reviewers independently screened records in consensus; a PRISMA-style flow diagram summarizes the selection process. Using a predefined rubric (domains covered, anchors, required inputs, treatment linkage, validation/reliability), we synthesized ten published classification systems (2004-2019) and complemented them with one proposed framework.</p><p><strong>Results: </strong>Across systems, recurrent gaps included limited integration of clinical parameters with radiographic morphology, inconsistent coverage of implant apical lesions (IALs), and sparse, non-graded treatment guidance. We therefore introduce a three-dimensional framework that classifies lesions as crestal, apical (IAL), or lateral, each with severity strata and operational thresholds (radiographic bone loss relative to functional implant length:<25%, 25-50%,>50%). A standardized measurement protocol is specified (paralleling periapical radiographs as default; selective cone beam computed tomography (CBCT) for suspected buccal/facial dehiscence or equivocal lateral defects), with rules for cases lacking baseline radiographs. A one-page decision algorithm links categories to management options whose strength of recommendation follows the EFP 2023 S3 guideline; laser use is presented as an adjunct where evidence is mixed. Three clinical vignettes illustrate how the framework informs treatment planning. Plans for inter-rater reliability testing are outlined.</p><p><strong>Conclusion: </strong>This review consolidates and contrasts existing systems and offers an implementable, consensus-aligned framework that unifies morphology, severity, and apical disease with transparent, evidence-graded treatment pathways. Prospective validation and reliability studies are warranted.</p>","PeriodicalId":73584,"journal":{"name":"Journal of advanced periodontology & implant dentistry","volume":"17 4","pages":"227-233"},"PeriodicalIF":0.0,"publicationDate":"2025-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12702084/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145764643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Does orthodontic space opening in patients with congenitally missing maxillary lateral incisors also reduce the need for bone grafting during implant placement? A retrospective study.","authors":"Maryam Omidkhoda, Seyed Hosein Hoseini Zarch, Arezoo Jahanbin, Parisa Hatami, Alireza Ghasemzadeh","doi":"10.34172/japid.025.3765","DOIUrl":"https://doi.org/10.34172/japid.025.3765","url":null,"abstract":"<p><strong>Background: </strong>Different studies have provided inconsistent results regarding the effectiveness of orthodontic tooth movement in establishing an adequate width and height of the edentulous ridge in patients with missing maxillary lateral incisors. This study aimed to compare the dimensions and density of the alveolar ridge after canine distalization for the preparation of implant placement and after no significant canine movement along the ridge.</p><p><strong>Methods: </strong>Sixteen patients (30 sites) with congenitally missing teeth were included in this retrospective study. The patients were divided into two groups: group 1: patients with erupted canines adjacent to the central incisor treated for canine distalization; group 2: patients with erupted canine almost in the correct position, treated with canine alignment. The alveolar ridge width, height, buccal undercut, and density were measured by cone-beam computed tomography (CBCT). The data were analyzed according to sex, age, and type of orthodontic treatment. Chi-square test, t-test, and Pearson's correlation were used. The significance level was 0.05.</p><p><strong>Results: </strong>No significant differences were found between the two groups in alveolar ridge width at 3 mm and 6 mm apical to the alveolar crest, height, buccal undercut depth, and density in the position of the missing lateral incisors (<i>P</i>>0.05).</p><p><strong>Conclusion: </strong>Movement of the canine along the alveolar ridge in patients with congenitally missing maxillary lateral incisors did not significantly affect alveolar ridge width, height, buccal undercut, and density. Therefore, the effectiveness of canine distalization treatment in reducing the need for bone grafting is questionable.</p>","PeriodicalId":73584,"journal":{"name":"Journal of advanced periodontology & implant dentistry","volume":"18 1","pages":"26-31"},"PeriodicalIF":0.0,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12913198/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146230116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Melika Sadrejamali, Saba Mohammadi, Nasrin Esfahanizadeh
{"title":"Evaluation of salivary cortisol levels in peri-implant diseases: An analytical observational study.","authors":"Melika Sadrejamali, Saba Mohammadi, Nasrin Esfahanizadeh","doi":"10.34172/japid.025.3817","DOIUrl":"10.34172/japid.025.3817","url":null,"abstract":"<p><strong>Background: </strong>A well-documented positive correlation exists between salivary cortisol levels (SCLs) and periodontal disease. Given the clinical and pathophysiological similarities between peri-implant diseases and periodontal conditions, this study aimed to explore the association between SCLs and peri-implant mucositis and peri-implantitis.</p><p><strong>Methods: </strong>An analytical observational study was conducted involving 86 patients who had been using dental prostheses for a minimum of one year. Unstimulated salivary samples were collected from all the participants. Clinical assessments included periodontal probing depth (PPD), papilla bleeding index (PBI), Mombelli modified plaque index (mPI), and radiographic evaluation of bone loss. Based on clinical and radiographic findings, the subjects were categorized into three groups: (1) individuals with healthy peri-implant tissues, (2) patients with peri-implant mucositis, and (3) patients with peri-implantitis. Salivary cortisol concentrations were quantified using an enzyme-linked immunosorbent assay (ELISA). Statistical analysis was conducted using one-way analysis of variance (ANOVA), followed by independent t-tests and post hoc Tukey comparisons.</p><p><strong>Results: </strong>Significant differences were observed in mean PPD values between the three groups (<i>P</i><0.05), with the peri-implantitis group exhibiting the highest values. Likewise, mPI scores varied significantly across the groups (<i>P</i><0.05). However, no significant differences were detected in SCLs between the three groups.</p><p><strong>Conclusion: </strong>Within the limitations of this study, no significant association was identified between SCLs and peri-implant disease. Further studies with larger sample sizes and longitudinal designs are recommended to validate these findings.</p>","PeriodicalId":73584,"journal":{"name":"Journal of advanced periodontology & implant dentistry","volume":"17 4","pages":"188-195"},"PeriodicalIF":0.0,"publicationDate":"2025-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12702085/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145764233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}