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Journal of 3D printing in medicine最新文献

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3D bioprinting as a designer organoid to assess pathological processes in translational medicine 3D生物打印作为一种设计类器官来评估转化医学中的病理过程
Journal of 3D printing in medicine Pub Date : 2022-01-20 DOI: 10.2217/3dp-2021-0006
P. Rameshwar, V. H. Savanur, J. Etchegaray, M. Guvendiren
{"title":"3D bioprinting as a designer organoid to assess pathological processes in translational medicine","authors":"P. Rameshwar, V. H. Savanur, J. Etchegaray, M. Guvendiren","doi":"10.2217/3dp-2021-0006","DOIUrl":"https://doi.org/10.2217/3dp-2021-0006","url":null,"abstract":"3D bioprinting is an additive manufacturing method, formulated with cells printed in bioinks of basic matrix such as hydrogels. Bioinks are relevant to precision medicine mainly due to recapitulation of tissue organoids with broad application. 3D bioprinting can address the issue of increased cost in drug development with overall benefit in healthcare. Despite research, solid and hematological cancer remain a clinical problem. Existing models such as patient-derived xenografts and organoids, although beneficial, have limitations. This perspective discusses 3D bioprinting in key clinical issues to hasten treatment to patients. The diseases addressed are aging, cancer metastasis, cancer dormancy and drug screening. The perspective also discusses the application for other diseases and the future for 3D bioprinting in medicine.","PeriodicalId":73578,"journal":{"name":"Journal of 3D printing in medicine","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85615567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
3D bioprinting for meniscus tissue engineering: a review of key components, recent developments and future opportunities 半月板组织工程的3D生物打印:关键部件，最新发展和未来机会的回顾
Journal of 3D printing in medicine Pub Date : 2021-12-01 DOI: 10.2217/3dp-2021-0017
X. Barceló, S. Scheurer, Rajesh Lakshmanan, C. Moran, Fiona E. Freeman, D. Kelly
{"title":"3D bioprinting for meniscus tissue engineering: a review of key components, recent developments and future opportunities","authors":"X. Barceló, S. Scheurer, Rajesh Lakshmanan, C. Moran, Fiona E. Freeman, D. Kelly","doi":"10.2217/3dp-2021-0017","DOIUrl":"https://doi.org/10.2217/3dp-2021-0017","url":null,"abstract":"3D bioprinting has the potential to transform the field of regenerative medicine as it enables the precise spatial patterning of biomaterials, cells and biomolecules to produce engineered tissues. Although numerous tissue engineering strategies have been developed for meniscal repair, the field has yet to realize an implant capable of completely regenerating the tissue. This paper first summarized existing meniscal repair strategies, highlighting the importance of engineering biomimetic implants for successful meniscal regeneration. Next, we reviewed how developments in 3D (bio)printing are accelerating the engineering of functional meniscal tissues and the development of implants targeting damaged or diseased menisci. Some of the opportunities and challenges associated with use of 3D bioprinting for meniscal tissue engineering are identified. Finally, we discussed key emerging research areas with the capacity to enhance the bioprinting of meniscal grafts.","PeriodicalId":73578,"journal":{"name":"Journal of 3D printing in medicine","volume":"74 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88950985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Biomimetic design considerations for 3D-printed joints 3d打印关节的仿生设计考虑
Journal of 3D printing in medicine Pub Date : 2021-11-26 DOI: 10.2217/3dp-2021-0016
Alessandro Luna
{"title":"Biomimetic design considerations for 3D-printed joints","authors":"Alessandro Luna","doi":"10.2217/3dp-2021-0016","DOIUrl":"https://doi.org/10.2217/3dp-2021-0016","url":null,"abstract":"3D-printing innovations are being explored as a uniting framework for the future of individualized joint replacement. The ability to convert 2D medical images to adjustable 3D models means a patient’s own anatomy can serve as the foundation for implant design. There are three biomimetic design considerations to understand the research on these new implants. First, optimizing the unit cell of 3D models can give researchers the essential building block necessary to 3D-print reliable artificial joints. Second, adequate porosity when designing a 3D-printed biomimetic joint is a balance between strength and the need for osseointegration. Third, functionally graded material as a design principle connects unit cell and porosity to create a 3D-printed product with complex properties along different spacial axes. 3D printing offers the opportunity to incorporate biomimetic design principles that were previously unobtainable with traditional manufacturing methods.","PeriodicalId":73578,"journal":{"name":"Journal of 3D printing in medicine","volume":"119 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86183756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Deep learning in bioengineering and biofabrication: a powerful technology boosting translation from research to clinics 生物工程和生物制造中的深度学习:一项促进从研究到临床转化的强大技术
Journal of 3D printing in medicine Pub Date : 2021-11-19 DOI: 10.2217/3dp-2021-0007
João B Costa, J. Silva-Correia, R. Reis, J. Oliveira
{"title":"Deep learning in bioengineering and biofabrication: a powerful technology boosting translation from research to clinics","authors":"João B Costa, J. Silva-Correia, R. Reis, J. Oliveira","doi":"10.2217/3dp-2021-0007","DOIUrl":"https://doi.org/10.2217/3dp-2021-0007","url":null,"abstract":"Bioengineering has been revolutionizing the production of biofunctional tissues for tackling unmet clinical needs. Bioengineers have been focusing their research in biofabrication, especially 3D bioprinting, providing cutting-edge approaches and biomimetic solutions with more reliability and cost–effectiveness. However, these emerging technologies are still far from the clinical setting and deep learning, as a subset of artificial intelligence, can be widely explored to close this gap. Thus, deep-learning technology is capable to autonomously deal with massive datasets and produce valuable outputs. The application of deep learning in bioengineering and how the synergy of this technology with biofabrication can help (more efficiently) bring 3D bioprinting to clinics, are overviewed herein.","PeriodicalId":73578,"journal":{"name":"Journal of 3D printing in medicine","volume":"50 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72550121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Is it time to get ‘on-track’ with 3D printing for recurrent shoulder instability? 是时候让3D打印“走上正轨”治疗复发性肩膀不稳了吗?
Journal of 3D printing in medicine Pub Date : 2021-09-22 DOI: 10.2217/3dp-2021-0020
Zachary S Aman, T. Dekker, F. Familiari, R. LaPrade, Nicholas N. DePhillipo
{"title":"Is it time to get ‘on-track’ with 3D printing for recurrent shoulder instability?","authors":"Zachary S Aman, T. Dekker, F. Familiari, R. LaPrade, Nicholas N. DePhillipo","doi":"10.2217/3dp-2021-0020","DOIUrl":"https://doi.org/10.2217/3dp-2021-0020","url":null,"abstract":"","PeriodicalId":73578,"journal":{"name":"Journal of 3D printing in medicine","volume":"63 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78294344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
3D printing in spine surgery: current and future applications 3D打印在脊柱外科:当前和未来的应用
Journal of 3D printing in medicine Pub Date : 2021-09-01 DOI: 10.2217/3dp-2021-0008
Umar F Samdani, Steven W. Hwang
{"title":"3D printing in spine surgery: current and future applications","authors":"Umar F Samdani, Steven W. Hwang","doi":"10.2217/3dp-2021-0008","DOIUrl":"https://doi.org/10.2217/3dp-2021-0008","url":null,"abstract":"The revolutionary technology of 3D printing has gained traction in the medical field in recent years; spine surgery has in particular seen major advances in 3D printing. The applications of this technology have grown from utilizing 3D models to enhance patient education to patient specific, highly detailed intraoperative anatomical molds. However, obstacles remain that prevent the widespread utilization of 3D printing in spine surgery such as cost, time consumption, lack of long-term data, and regulation by the US FDA. Despite these obstacles, it is evident that 3D printing will be utilized to optimize preoperative, intraoperative, and postoperative care of patients with spine deformity. The purpose of this review is to establish the applications of 3D printing for spine surgery.","PeriodicalId":73578,"journal":{"name":"Journal of 3D printing in medicine","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82430699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
3D-printed dynamic heart models allow accurate prediction of cardiac complications by simulating hemodynamics 3d打印的动态心脏模型可以通过模拟血液动力学来准确预测心脏并发症
Journal of 3D printing in medicine Pub Date : 2021-09-01 DOI: 10.2217/3dp-2021-0026
Zhonghua Sun
{"title":"3D-printed dynamic heart models allow accurate prediction of cardiac complications by simulating hemodynamics","authors":"Zhonghua Sun","doi":"10.2217/3dp-2021-0026","DOIUrl":"https://doi.org/10.2217/3dp-2021-0026","url":null,"abstract":"","PeriodicalId":73578,"journal":{"name":"Journal of 3D printing in medicine","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73655606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bespoke regulation for bespoke medicine? A comparative analysis of bioprinting regulation in Europe, the USA and Australia 定制药物的定制监管?欧洲、美国和澳大利亚生物打印法规的比较分析
Journal of 3D printing in medicine Pub Date : 2021-09-01 DOI: 10.2217/3dp-2021-0011
Jane Nielsen, J. Kaldor, Adam Irwin, C. Stewart, D. Nicol
{"title":"Bespoke regulation for bespoke medicine? A comparative analysis of bioprinting regulation in Europe, the USA and Australia","authors":"Jane Nielsen, J. Kaldor, Adam Irwin, C. Stewart, D. Nicol","doi":"10.2217/3dp-2021-0011","DOIUrl":"https://doi.org/10.2217/3dp-2021-0011","url":null,"abstract":"Like most health-technology innovators, bioprinters are required to traverse a complex landscape featuring varied forms of regulation. This article focuses on one of the most complex aspects: the requirement imposed by regulatory authorities to satisfy them of the safety, efficacy and clinical utility of resultant healthcare products. Satisfaction of such requirements can result in a significant lag between ‘breakthrough’ and clinical delivery. This article examines this aspect of regulation in the USA, Europe and Australia, three leading bioprinting research jurisdictions. In particular, it examines medical devices and medicines categories of regulation, questioning whether a new approach to regulation is required or whether existing product-based regimes are sufficiently adaptive.","PeriodicalId":73578,"journal":{"name":"Journal of 3D printing in medicine","volume":"49 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74285404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Automated fabrication of human skin substitutes: inherent advantages and fundamental challenges 人类皮肤替代品的自动化制造:固有优势和基本挑战
Journal of 3D printing in medicine Pub Date : 2021-08-20 DOI: 10.2217/3dp-2021-0019
S. Boyce
{"title":"Automated fabrication of human skin substitutes: inherent advantages and fundamental challenges","authors":"S. Boyce","doi":"10.2217/3dp-2021-0019","DOIUrl":"https://doi.org/10.2217/3dp-2021-0019","url":null,"abstract":"","PeriodicalId":73578,"journal":{"name":"Journal of 3D printing in medicine","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86783177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of 3D-printer settings for producing personal protective equipment. 评估用于生产个人防护装备的3d打印机设置。
Journal of 3D printing in medicine Pub Date : 2021-07-01 Epub Date: 2021-08-20 DOI: 10.2217/3dp-2021-0005
Carson Studders, Ian Fraser, Joshua W Giles, Stephanie M Willerth
{"title":"Evaluation of 3D-printer settings for producing personal protective equipment.","authors":"Carson Studders,&nbsp;Ian Fraser,&nbsp;Joshua W Giles,&nbsp;Stephanie M Willerth","doi":"10.2217/3dp-2021-0005","DOIUrl":"https://doi.org/10.2217/3dp-2021-0005","url":null,"abstract":"<p><p><b>Aim:</b> COVID-19 resulted in a shortage of personal protective equipment. Community members united to 3D-print face shield headbands to support local healthcare workers. This study examined factors altering print time and strength. <b>Materials & methods:</b> Combinations of infill density (50%, 100%), shell thickness (0.8, 1.2 mm), line width (0.2 mm, 0.4 mm), and layer height (0.1 mm, 0.2 mm) were evaluated through tensile testing, finite element analysis, and printing time. <b>Results:</b> Strength increased with increased infill (p < 0.001) and shell thickness (p < 0.001). Layer height had no effect on strength. Increasing line width increased strength (p < 0.001). <b>Discussion:</b> Increasing layer height and line width decreased print time by 50 and 39%, respectively. Increased shell thickness did not alter print time. These changes are recommended for printing.</p>","PeriodicalId":73578,"journal":{"name":"Journal of 3D printing in medicine","volume":"5 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8384239/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39368228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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