JMA journalPub Date : 2025-04-28Epub Date: 2025-02-14DOI: 10.31662/jmaj.2024-0281
Masakazu Kohda, Akira Okada, Hideo Yasunaga
{"title":"Difference in Age- and Sex-adjusted Prevalence of Diseases between Employees and Nonemployees with Health Insurance in Japan.","authors":"Masakazu Kohda, Akira Okada, Hideo Yasunaga","doi":"10.31662/jmaj.2024-0281","DOIUrl":"10.31662/jmaj.2024-0281","url":null,"abstract":"<p><strong>Introduction: </strong>Administrative claims data are used in clinical studies. However, individuals insured by different insurance systems have different backgrounds, ages, and disease prevalences. This study aimed to examine the crude and adjusted prevalence of diseases between employee and nonemployee health insurance in Japan.</p><p><strong>Methods: </strong>We conducted a cross-sectional study using the DeSC database, an administrative claims database covering multiple insurers. We calculated the prevalence of 10 disease categories and 6 specific cancers with and without adjustments for age and sex and compared them between the employee (Kempo) and nonemployee (Kokuho) insurance systems.</p><p><strong>Results: </strong>We identified 740,217 and 3,312,042 individuals covered by Kempo and Kokuho, respectively. The Kokuho group showed a higher crude prevalence of malignancies, endocrinological diseases, mental disorders, neurological diseases, cardiovascular diseases, and kidney or genitourinary diseases. The adjusted prevalence differed in mental disorders (7.2% vs. 10.6%), neurological diseases (10.5% vs. 14.0%), and gastrointestinal diseases (50.1% vs. 34.1%) between the Kempo and Kokuho groups.</p><p><strong>Conclusions: </strong>While using administrative claims data, researchers should consider differences in patient backgrounds and disease prevalence among insurance providers.</p>","PeriodicalId":73550,"journal":{"name":"JMA journal","volume":"8 2","pages":"411-416"},"PeriodicalIF":1.5,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12095125/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144144718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
JMA journalPub Date : 2025-04-28Epub Date: 2025-01-31DOI: 10.31662/jmaj.2024-0360
Akiko Morimoto, Nao Sonoda
{"title":"Dissemination of Information to Foreigners in Preparation for Natural Disasters: Response to a Letter to the Editor.","authors":"Akiko Morimoto, Nao Sonoda","doi":"10.31662/jmaj.2024-0360","DOIUrl":"10.31662/jmaj.2024-0360","url":null,"abstract":"","PeriodicalId":73550,"journal":{"name":"JMA journal","volume":"8 2","pages":"660-661"},"PeriodicalIF":1.5,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12095827/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144144769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clinical Information and Prognosis of High-risk Luminal Breast Cancer Subjects Eligible for the MonarhE Study.","authors":"Mio Adachi, Toshiyuki Ishiba, Sakiko Maruya, Kumiko Hayashi, Yuichi Kumaki, Goshi Oda, Tomoyuki Aruga","doi":"10.31662/jmaj.2024-0243","DOIUrl":"10.31662/jmaj.2024-0243","url":null,"abstract":"<p><strong>Introduction: </strong>Luminal breast cancer is the most common breast cancer subtype. Although its prognosis can be good, this type of breast cancer is characterized by a high incidence of late recurrence. However, to the best of our knowledge, there are no publications showing prognostic value regarding the invasive-disease-free survival (IDFS) and distant relapse-free survival in this group in clinical practice. Therefore, this study examined the clinical data and prognosis of patients participating in the MonarchE trial.</p><p><strong>Methods: </strong>This study included patients who underwent surgery at Tokyo Metropolitan Komagome Hospital and whose corresponding prognosis to the Monarch E trial could be followed up.</p><p><strong>Results: </strong>The total number of participants was 152, of whom 104 (68%) were treated with chemotherapy. Seventy-five patients (49%) were postmenopausal. The IDFS after 5 years was 85.0%. Although IDFS did not differ in terms of the menstrual status, premenopausal patients tended to receive a higher proportion of tamoxifen, and there was a greater number of patients treated with chemotherapy. However, neither chemotherapy nor menstrual statuses were found to affect the IDFS incidence.</p><p><strong>Conclusions: </strong>Real clinical data applicable to the MonarchE study were examined. Our univariate analysis revealed that there were no factors affecting IDFS.</p>","PeriodicalId":73550,"journal":{"name":"JMA journal","volume":"8 2","pages":"486-497"},"PeriodicalIF":1.5,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12095113/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144144609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
JMA journalPub Date : 2025-04-28Epub Date: 2025-02-21DOI: 10.31662/jmaj.2024-0249
Yusuke Sasahara, Yasufumi Gon, Eisuke Hida
{"title":"Association between Acute Care Accessibility and in-Hospital Mortality among Patients with Acute Ischemic Stroke.","authors":"Yusuke Sasahara, Yasufumi Gon, Eisuke Hida","doi":"10.31662/jmaj.2024-0249","DOIUrl":"10.31662/jmaj.2024-0249","url":null,"abstract":"<p><strong>Introduction: </strong>Acute ischemic stroke (AIS) can lead to sequelae or death if not treated promptly. Patients residing in areas with limited acute care access may not receive prompt treatment; however, the association between accessibility to acute care and discharge outcomes in patients with AIS remains controversial. This study aimed to clarify the association between acute care density index (ACDI) and home-to-hospital distance and in-hospital mortality in patients with AIS.</p><p><strong>Methods: </strong>Using the Japanese registry of all cardiac and vascular diseases-diagnosis procedure combination database, we examined 525,689 patients (from April 2015 to March 2020). Hospital accessibility was assessed using ACDI and home-to-hospital distance. The patient residences were classified as urban, rural, or depopulated.</p><p><strong>Results: </strong>In urban areas, ACDI was associated with in-hospital mortality, with adjusted odds ratios for Q2, Q3, and Q4 compared with Q1 of 1.16 (95% confidence interval: 1.02-1.31), 1.23 (1.10-1.39), and 1.35 (1.19-1.53), respectively. Similar trends were observed in rural areas. In depopulated areas, home-to-hospital distance exceeding the median was associated with a reduction in in-hospital mortality, with adjusted odds ratios for Q3 and Q4 compared with Q1 of 0.84 (0.74-0.95) and 0.78 (0.68-0.89), respectively.</p><p><strong>Conclusions: </strong>A lower ACDI was associated with higher in-hospital mortality in both urban and rural areas, whereas longer home-to-hospital distance was not necessarily associated with higher in-hospital mortality.</p>","PeriodicalId":73550,"journal":{"name":"JMA journal","volume":"8 2","pages":"417-429"},"PeriodicalIF":1.5,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12095654/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144144753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
JMA journalPub Date : 2025-04-28Epub Date: 2025-02-07DOI: 10.31662/jmaj.2024-0189
Yoshiaki Takamura
{"title":"Symptomatic Expanding Porencephalic Cyst after Evacuation of Intracerebral Hematoma in an Adult: A Case Report.","authors":"Yoshiaki Takamura","doi":"10.31662/jmaj.2024-0189","DOIUrl":"10.31662/jmaj.2024-0189","url":null,"abstract":"<p><p>Porencephalic cysts are very rare in adults. Herein, we present a case of an 88-year-old man with a symptomatic expanding porencephalic cyst after intracerebral hematoma evacuation. He was admitted because of disturbed consciousness and right hemiparesis. A computed tomography (CT) showed a large subcortical hematoma in the left parietal lobe. Hematoma evacuation was performed, his consciousness level improved but gradually deteriorated. Follow-up CT revealed a new cystic lesion with perifocal edema at the hematoma site, with progressive expansion of the cyst. Cyst drainage and -peritoneal shunt placement were performed on postoperative day 14; consequently, his symptoms improved. Considerably, a porencephalic cyst have developed because the cerebrospinal fluid flowed into the closed hematoma cavity from the ventricle owing to the osmotic pressure difference between the ventricle and the hematoma cavity.</p>","PeriodicalId":73550,"journal":{"name":"JMA journal","volume":"8 2","pages":"637-640"},"PeriodicalIF":1.5,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12095862/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144144836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
JMA journalPub Date : 2025-04-28Epub Date: 2025-03-28DOI: 10.31662/jmaj.2025-0038
Soichiro Saeki
{"title":"Letters and Opinions by Early-career Writers.","authors":"Soichiro Saeki","doi":"10.31662/jmaj.2025-0038","DOIUrl":"10.31662/jmaj.2025-0038","url":null,"abstract":"","PeriodicalId":73550,"journal":{"name":"JMA journal","volume":"8 2","pages":"669-670"},"PeriodicalIF":1.5,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12095843/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144144853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
JMA journalPub Date : 2025-04-28Epub Date: 2025-03-28DOI: 10.31662/jmaj.2024-0182
Yu Michimuko-Nagahara, Yu Nakagama, Marvin Stanley Rodriguez, Natsuko Kaku, Yuko Nitahara, Katherine Candray, Evariste Tshibangu-Kabamba, Shinjiro Hamano, Kenji Hirayama, Akira Kaneko, Junko Nakajima-Shimada, Yoko Onizuka, José Eduardo Romero, José Ricardo Palacios, Carmen Elena Arias, William Mejía, Ricardo Cardona Alvarenga, Yasutoshi Kido
{"title":"Natural Reservoir of <i>Trypanosoma cruzi</i> Found in Triatomines Targeting Humans: Results from Nation-wide Vector Surveillance in El Salvador.","authors":"Yu Michimuko-Nagahara, Yu Nakagama, Marvin Stanley Rodriguez, Natsuko Kaku, Yuko Nitahara, Katherine Candray, Evariste Tshibangu-Kabamba, Shinjiro Hamano, Kenji Hirayama, Akira Kaneko, Junko Nakajima-Shimada, Yoko Onizuka, José Eduardo Romero, José Ricardo Palacios, Carmen Elena Arias, William Mejía, Ricardo Cardona Alvarenga, Yasutoshi Kido","doi":"10.31662/jmaj.2024-0182","DOIUrl":"10.31662/jmaj.2024-0182","url":null,"abstract":"<p><strong>Introduction: </strong>Chagas disease is one of the most critical of the neglected tropical diseases in Latin America where it poses a serious public health issue. However, the current burden of vectorial transmission from natural reservoirs to humans is unclear. This study aimed to clarify the active mode of transmission to humans disentangled from the feeding pattern of <i>Triatoma dimidiata</i> (<i>T. dimidiata</i>) infected by <i>Trypanosoma cruzi</i> (<i>T. cruzi</i>).</p><p><strong>Methods: </strong>A total of 1,376 <i>T. dimidiata</i> specimens were collected across the 14 departments of El Salvador. From these specimens, 135 midgut samples from 37 households in eight departments were positive for <i>T. cruzi</i> (n = 135/1,376; 9.8% [95% confidential interval (CI): 8.35%-11.5%]). Using a universal vertebrate primer, vertebrate blood sources were positively identified by next-generation sequence analysis of deoxyribonucleic acid (DNA) extracted from the midgut contents of <i>T. dimidiata.</i></p><p><strong>Results: </strong>A total of 13 vertebrates were detected as blood sources; humans, and five domestic, three synanthropic, and four sylvatic species. Triatomines identified as having fed on human blood accounted for approximately 67% (n = 90/135 [95% CI: 58.3%-74.1%]) of the samples analyzed.</p><p><strong>Conclusions: </strong>In this study, a holistic understanding of the feeding patterns of <i>T. cruzi</i>-positive <i>T. dimidiata</i> in El Salvador is dated. The detection of human DNA in the midgut contents of <i>T. dimidiata</i> indicated the possibility of active vectorial transmission to humans.</p>","PeriodicalId":73550,"journal":{"name":"JMA journal","volume":"8 2","pages":"432-443"},"PeriodicalIF":1.5,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12095551/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144144857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}