JMA journal最新文献

{"title":"Physical Function Changes in Older Adults Living in Temporary Housing after the Great East Japan Earthquake.","authors":"Toshiki Abe, Hiroaki Saito, Nobuaki Moriyama, Michio Murakami, Naomi Ito, Yoshitaka Nishikawa, Morihito Takita, Isamu Amir, Yoshitaka Shiba, Takeaki Ishii, Sae Ochi, Chika Yamamoto, Tianchen Zhao, Makoto Kosaka, Masaharu Tsubokura","doi":"10.31662/jmaj.2025-0121","DOIUrl":"10.31662/jmaj.2025-0121","url":null,"abstract":"<p><strong>Introduction: </strong>The aging of the global population presents significant challenges in extending healthy life expectancy, particularly among older adults. The prevalence of musculoskeletal disorders and the growing demand for nursing care are expected to reduce healthy life expectancy. These outcomes are particularly influenced by disasters that cause major environmental changes. This study aimed to clarify the long-term effects on physical function resulting from temporary changes in the living environment of older adults who relocated to temporary housing (TH) following the Great East Japan Earthquake.</p><p><strong>Methods: </strong>This retrospective cohort study included 4,680 residents of Soma City, Fukushima Prefecture, aged ≥64 years, who underwent locomotor function examinations between 2013 and 2022. Participants were categorized into two groups: TH (n = 440) and control (n = 4,240). The primary outcomes were grip strength and one-leg standing time. A growth curve model was used to estimate the longitudinal associations.</p><p><strong>Results: </strong>The mean age- and sex-adjusted one-leg standing time was lower in the TH group than in the control group in 2013 (35.5 seconds vs. 39.3 seconds) and remained lower thereafter. The results showed an association between one-leg standing time and TH experience (intercept estimate: -4.32, 95% confidence interval: -7.49 to -1.16). No differences in grip strength were observed between the groups.</p><p><strong>Conclusions: </strong>These results suggest that long-term support is necessary for evacuees, and it is essential to develop and implement support measures that effectively address muscle weakness and other aspects of physical function.</p>","PeriodicalId":73550,"journal":{"name":"JMA journal","volume":"8 3","pages":"779-788"},"PeriodicalIF":1.8,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12328901/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144818482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reliability of Gait Analysis Using ORPHE ANALYTICS in Patients with Type 2 Diabetes: A Single-center Observational Study.","authors":"Takaaki Matsuda, Yoshinori Osaki, Hirofumi Takahashi, Erika Matsuda, Yasuhiro Suzuki, Kosuke Kojo, Yuki Murayama, Yoko Sugano, Hitoshi Iwasaki, Bryan J Mathis, Hiroaki Suzuki, Motohiro Sekiya, Hitoshi Shimano","doi":"10.31662/jmaj.2024-0422","DOIUrl":"10.31662/jmaj.2024-0422","url":null,"abstract":"<p><strong>Introduction: </strong>People with diabetes tend to show abnormalities in gait parameters, including walking speed and stride length, relative to those without diabetes. While inertial measurement units (IMUs) provide a portable alternative to optical motion capture systems, the reliability of gait analysis is influenced by factors such as walking distance, timing, and examiner differences. However, the impact of these parameters on gait analysis in patients with type 2 diabetes (T2D) remains unclear. This study aimed to evaluate the reliability of ORPHE ANALYTICS, an IMU-based gait analysis system, under varying measurement conditions in patients with T2D.</p><p><strong>Methods: </strong>We conducted a single-center observational study (n = 9) to clarify the reliability of ORPHE ANALYTICS, a gait analysis motion sensor system developed by ORPHE Inc., which evaluates more than 15 gait parameters, in patients with T2D. The relative reliability was assessed using intraclass correlation coefficients (ICC): ICC_(1,1) or ICC_(1,3) for intra-rater reliability and ICC_(2,1) for inter-rater reliability based on the differences in distance (10 vs. 30 m), examiners, and timing (morning vs. afternoon).</p><p><strong>Results: </strong>Intra-rater reliability was excellent (ICC_(1,1) and ICC_(1,3) ≥0.9) for all gait parameters except coefficient of variation of stride duration and lateral displacement. Measurements taken under different conditions of distance and timing exhibited almost good inter-rater reliability (ICC_(2,1) ≥0.75), while measurements by different examiners exhibited moderate to good reliability (ICC_(2,1) ≥0.50). Significant novel differences were observed in lateral sway during the swing phase, medial sway during the stance phase, and foot angle, with random errors (expressed as percentage of minimal detectable change) exceeding 40% under various measurement conditions.</p><p><strong>Conclusions: </strong>ORPHE ANALYTICS exhibited good to excellent intra-rater and inter-rater reliability based on differences in distance and timing. However, persistent inter-rater reliability challenges in patients with T2D warrant analysis by a single examiner.</p>","PeriodicalId":73550,"journal":{"name":"JMA journal","volume":"8 3","pages":"853-870"},"PeriodicalIF":1.8,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12328463/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144818492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seasonality and Trend of Cellulitis, Herpes Zoster, and Varicella: A Nationwide Population-based Study.","authors":"Hideaki Miyachi, Daisuke Sato, Sayuri Shimizu, Yaei Togawa, Kentaro Sakamaki, Kensuke Yoshimura","doi":"10.31662/jmaj.2025-0010","DOIUrl":"10.31662/jmaj.2025-0010","url":null,"abstract":"<p><strong>Introduction: </strong>Cellulitis, herpes zoster, and varicella are common infectious skin diseases with significant public health implications. While these conditions have been studied in some countries, comprehensive nationwide data on their seasonality and trends in Japan remain limited. Understanding these patterns is essential for effective public health planning and disease management.</p><p><strong>Methods: </strong>This study analyzed monthly outpatient data for cellulitis, herpes zoster, and varicella using aggregated summary tables from the National Database of Health Insurance Claims of Japan for fiscal years 2014 to 2019. Seasonal patterns and trends were examined using seasonal decomposition of time series by locally estimated scatterplot smoothing.</p><p><strong>Results: </strong>Distinct seasonal patterns were observed for the three diseases. Both cellulitis and herpes zoster peaked during the summer months, while varicella exhibited a winter predominance. Trend analysis revealed a 13.5% increase in cellulitis cases over the study period. Herpes zoster cases also increased, whereas varicella cases showed a significant decline between fiscal years 2014 and 2015, coinciding with the introduction of universal varicella vaccination. The seasonal patterns were consistent with findings from previous studies in other countries.</p><p><strong>Conclusions: </strong>This nationwide study confirmed distinct seasonal patterns and trends for cellulitis, herpes zoster, and varicella in Japan. The findings enhance the understanding of the epidemiology of these infectious skin diseases at a nationwide population level and provide valuable insights for public health planning.</p>","PeriodicalId":73550,"journal":{"name":"JMA journal","volume":"8 3","pages":"903-910"},"PeriodicalIF":1.8,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12328888/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144818498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delayed Perforation after Colorectal Cold Snare Polypectomy with Simultaneously Performed Endoscopic Submucosal Dissection: A Case Report and Literature Review.","authors":"Hironao Matsumoto, Takeshi Yamashina, Masaaki Shimatani","doi":"10.31662/jmaj.2024-0414","DOIUrl":"10.31662/jmaj.2024-0414","url":null,"abstract":"","PeriodicalId":73550,"journal":{"name":"JMA journal","volume":"8 3","pages":"974-978"},"PeriodicalIF":1.8,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12328887/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144818459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Full-endoscopic Removal of a Lumbar Synovial Cyst after Laminectomy for Lumbar Spinal Canal Stenosis.","authors":"Tatsuya Maegawa, Eitaro Okumura, Kotaro Kohara, Ryo Hashimoto, Motoo Kubota","doi":"10.31662/jmaj.2024-0394","DOIUrl":"10.31662/jmaj.2024-0394","url":null,"abstract":"","PeriodicalId":73550,"journal":{"name":"JMA journal","volume":"8 3","pages":"992-995"},"PeriodicalIF":1.8,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12329005/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144818469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurosarcoidosis Limited to the Central Nervous System and Spleen, Presenting with Episodic Nonfluent Aphasia.","authors":"Satoka Yano, Takashi Matsukawa, Kensho Sumi, Reo Yoshioka, Yusuke Baba, Hirotaka Maekawa, Masashi Hamada, Wataru Satake, Masako Ikemura, Tatsushi Toda","doi":"10.31662/jmaj.2025-0067","DOIUrl":"10.31662/jmaj.2025-0067","url":null,"abstract":"","PeriodicalId":73550,"journal":{"name":"JMA journal","volume":"8 3","pages":"996-997"},"PeriodicalIF":1.8,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12331416/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144818480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial Intelligence in Nursing Support for Families: A Rapid Review.","authors":"Michihiro Tsubaki, Kohei Kajiwara, Jun Kako, Masamitsu Kobayashi, Yoshiyasu Ito, Makoto Yamanaka, Hideaki Sakuramoto, Takahiro Kakeda","doi":"10.31662/jmaj.2024-0434","DOIUrl":"10.31662/jmaj.2024-0434","url":null,"abstract":"","PeriodicalId":73550,"journal":{"name":"JMA journal","volume":"8 3","pages":"961-964"},"PeriodicalIF":1.8,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12329141/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144818455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Mediating Effect of Smoking on the Association between Income and Dementia among Japanese Older People.","authors":"Satomi Shimada, Yusuke Matsuyama, Katsunori Kondo, Jun Aida","doi":"10.31662/jmaj.2025-0018","DOIUrl":"10.31662/jmaj.2025-0018","url":null,"abstract":"<p><strong>Introduction: </strong>Health inequalities in dementia have been reported. Smoking is a risk factor for dementia and is disproportionately distributed in marginalized populations. This study examined the mediating effect of smoking on the association between income and dementia among older Japanese people.</p><p><strong>Methods: </strong>This longitudinal study was based on the Japan Gerontological Evaluation Study from 2010 (response rate = 64.3%) to 2019 (follow-up rate = 98.5%). A total of 44,083 participants independent in daily life were analyzed (mean age: 73.7; women 53.2%). The outcome variable was the incidence of dementia between 2010 and 2019, and the explanatory variable was equivalent income measured in 2010. Causal mediation analyses with a Cox proportional hazard model were performed to evaluate the mediating effect of smoking status in 2010. Multiple imputation was performed for the missing data.</p><p><strong>Results: </strong>Among the participants, the incidence rates of dementia were 16.2% for men and 18.2% for women. Low income was associated with the incidence of dementia (total effect in excess relative risk, ERR [95% confidence interval (CI)]: 0.095 [0.032-0.157] in overall participants, 0.102 [0.011-0.192] for men, 0.082 [-0.003 to 0.168] for women). Causal mediation analyses showed that smoking mediated the association between income and dementia (natural indirect effect in ERR [95% CI]: 0.007 [0.004-0.011] for overall participants, 0.007 [0.002-0.013] for men, and 0.005 [0.001-0.009] for women). The proportions of the mediating effect were 7.7% for all participants, 7.3% for men, and 6.4% for women.</p><p><strong>Conclusions: </strong>Our results showed that smoking partially explained the association between income and dementia. There is a possibility that smoking cessation may contribute to reducing health inequalities in dementia.</p>","PeriodicalId":73550,"journal":{"name":"JMA journal","volume":"8 3","pages":"766-776"},"PeriodicalIF":1.8,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12329067/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144818502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of the World's First In Vitro Cancer Epigenome Diagnostic through Biomarker Research for Personalized Cancer Treatment of RAS-wild-type Colorectal Cancer -Secondary Publication - Secondary Publication.","authors":"Chikashi Ishioka","doi":"10.31662/jmaj.2025-0074","DOIUrl":"10.31662/jmaj.2025-0074","url":null,"abstract":"<p><p>Epigenetic regulation mechanisms such as deoxy ribonucleic acid (DNA) methylation are important for controlling various biological phenomena by regulating gene expression at the genome level. Epigenetic abnormalities are associated with the onset of diseases including cancers. Aberrant DNA methylation is an important epigenetic change in the development and progression of colorectal cancer. DNA methylation in tumor tissues occurs mainly in CpG islands in the promoter regions of genes and inactivates gene functions by negatively suppressing transcription. The CpG island methylator phenotype (CIMP) is an important carcinogenic mechanism in colorectal cancer related to DNA methylation and is involved in approximately 20% of all colorectal cancers. However, CIMP does not always represent the genome-wide DNA methylation status in colorectal cancer. We developed a new method to assess genome-wide DNA methylation status and showed that it is a predictor of the efficacy of anti-estimated glomerular filtration rate (EGFR) antibody drugs and a prognostic factor. This new method has received regulatory approval as a new in vitro diagnostic for predicting sensitivity to anti-EGFR antibody drugs in colorectal cancer.</p>","PeriodicalId":73550,"journal":{"name":"JMA journal","volume":"8 3","pages":"703-707"},"PeriodicalIF":1.8,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12328270/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144818461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Intradialytic Exercise on Activities of Daily Living and Physical Function in Hospitalized Hemodialysis Patients: A Study of Efficacy and Safety.","authors":"Ren Takahashi, Hiroki Yabe, Hideaki Ishikawa, Takashi Hibino, Akio Suzumura, Tetsuya Yamada","doi":"10.31662/jmaj.2024-0349","DOIUrl":"10.31662/jmaj.2024-0349","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to examine the effects of intradialytic exercise (IDE) on improving activities of daily living (ADL) and physical function in hospitalized hemodialysis (HD) patients. The research question focused on improving outcomes in ADL and physical function.</p><p><strong>Methods: </strong>This study is a single-center, historical cohort study. Subjects were hospitalized HD patients undergoing rehabilitation between April 2017 and February 2023. Patients were divided into two groups: the IDE group, which received IDE, and the non-IDE group, which did not. The outcomes measured were Barthel Index (BI), grip strength, isometric knee extension strength (IKES), 10-meter walking speed (10MWS), and Short Physical Performance Battery (SPPB). Outcome measures were taken at admission and discharge, and changes were analyzed using a linear mixed model.</p><p><strong>Results: </strong>The study included 76 participants (IDE group: 13, non-IDE group: 63). The IDE group showed significant improvements in ΔBI (13.7 [0.96-26.38] points) and Δ10MWS (0.25 [0.05-0.45] m/sec) (p < 0.05). No significant differences were observed between the two groups in ΔGrip strength (2.10 [-0.40 to 4.60] kg), ΔIKES (7.40 [-2.20 to 17.02] %), or ΔSPPB (1.23 [-0.48 to 2.94] points) (p > 0.05). However, the IDE group showed significant pre-post improvements in grip strength (1.55 [1.46-1.65] kg) and SPPB (2.44 [1.34-3.55] points) (p < 0.05).</p><p><strong>Conclusions: </strong>IDE contributed to greater improvements in BI and 10MWS in HD patients. These findings suggest that adding IDE to inpatient rehabilitation may enhance functional recovery in this population.</p>","PeriodicalId":73550,"journal":{"name":"JMA journal","volume":"8 3","pages":"834-845"},"PeriodicalIF":1.8,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12328902/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144818501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}