JID innovations : skin science from molecules to population health最新文献

{"title":"Toward the Next Generation of In Silico Modeling of Dynamic Host-Microbiota Interactions in the Skin","authors":"Jamie Lee ,&nbsp;Hiu Lam Athena Wu ,&nbsp;Ahmad A. Mannan ,&nbsp;Yuumi Nakamura ,&nbsp;Masayuki Amagai ,&nbsp;Alan D. Irvine ,&nbsp;Reiko J. Tanaka","doi":"10.1016/j.xjidi.2025.100385","DOIUrl":"10.1016/j.xjidi.2025.100385","url":null,"abstract":"<div><div>Understanding how the skin microbiota contributes to skin health and disease requires knowledge of the dynamic interactions between the skin and its resident microbes. In silico modeling complements in vivo and in vitro experiments by enabling a systems-level understanding of dynamic skin-microbiota interactions. However, the number of published in silico skin microbiota models remains limited. This paper provides the first comprehensive exploration of in silico skin microbiota modeling. We identify current challenges, learn from leading experimental validation approaches adopted in in silico gut microbiota research, and propose ways to enhance the predictive power of in silico skin microbiota models.</div></div>","PeriodicalId":73548,"journal":{"name":"JID innovations : skin science from molecules to population health","volume":"5 5","pages":"Article 100385"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144321806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating Transcriptional Age Acceleration in Inflammatory Skin Diseases","authors":"Richie Jeremian ,&nbsp;Melissa Galati ,&nbsp;Rayyan Fotovati ,&nbsp;Kaiyang Li ,&nbsp;Carolyn Jack ,&nbsp;David O. Croitoru ,&nbsp;Stephan Caucheteux ,&nbsp;Philippe Lefrançois ,&nbsp;Vincent Piguet","doi":"10.1016/j.xjidi.2025.100386","DOIUrl":"10.1016/j.xjidi.2025.100386","url":null,"abstract":"<div><div>Epigenetic age acceleration has previously been observed in inflammatory skin disease; however, less is known regarding recently described age-related gene expression patterns (“transcriptional clocks”). We investigated the role of transcriptional clocks in patients with hidradenitis suppurativa (n = 37), those with atopic dermatitis (n = 27), those with plaque psoriasis (n = 28), and healthy subjects (n = 38) using 7 clock algorithms, to improve the understanding of underlying pathophysiology and disease trajectory. Five of 7 transcriptional clocks demonstrated moderate-to-strong accuracy in predicting age across groups (patients with atopic dermatitis: <em>ρ</em> = 0.40–0.86, those with hidradenitis suppurativa: <em>ρ</em> = 0.46–0.74, those with plaque psoriasis: <em>ρ</em> = 0.50–0.80, healthy subjects: <em>ρ</em> = 0.32–0.60; <em>P</em> &lt; .05). Age acceleration was observed in lesional versus healthy (patients with atopic dermatitis: +3.9∼9.8y, <em>t =</em> 2.8∼5.9; those with hidradenitis suppurativa: +5.0∼6.1y, <em>t</em> = 2.5∼4.1; those with plaque psoriasis: +6.5∼12.5y, <em>t</em> = 5.1∼8.0; <em>P</em> &lt; .05) and in lesional versus nonlesional skin in all diseases and less frequently observed in nonlesional versus healthy skin. In atopic dermatitis, loss-of-function sequence variants in the FLG gene were associated with transcriptional age acceleration, including <em>FLGR244X/2282del4</em> dual carrier status (<em>t</em> = 2.3, <em>P</em> &lt; .05) and <em>FLGR501X</em> carrier status (<em>t</em> = 2.6, <em>P</em> &lt; .05). Pathway enrichment analyses revealed that clock genes are enriched in signatures related to aging, inflammation, and metabolism. Our study provides evidence for transcriptional age acceleration in inflammatory skin disease and sets a foundation for further investigation into the role of age-related transcriptional changes in the pathophysiology of these diseases.</div></div>","PeriodicalId":73548,"journal":{"name":"JID innovations : skin science from molecules to population health","volume":"5 5","pages":"Article 100386"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144653764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Translational Dermatology Initiative: Aiming at a New Disease Classification of Inflammatory Skin Diseases","authors":"Pontus Jonsson ,&nbsp;Anna Caroline Pilz ,&nbsp;Heydar Maboudi ,&nbsp;David Ranzinger ,&nbsp;Paul Wagner ,&nbsp;Larissa-Nele Schaffert-Stone ,&nbsp;Caecilia Burg ,&nbsp;Mahsa Shahidi Dadras ,&nbsp;Maria Bradley ,&nbsp;Franziska Schauer ,&nbsp;Christoph Mathis Schempp ,&nbsp;Natalie Garzorz-Stark ,&nbsp;Stefanie Eyerich ,&nbsp;Kilian Eyerich","doi":"10.1016/j.xjidi.2025.100381","DOIUrl":"10.1016/j.xjidi.2025.100381","url":null,"abstract":"<div><div>Although precision medicine is at least partially realized in dermato-oncology, the field of dermatoimmunology comprising inflammatory skin diseases is only at the step from traditional toward stratified medicine. This lack of innovation leaves clinically relevant questions unanswered, including predicting the personal likelihood of therapeutic success as well as the risk of drug-related adverse events or the development of comorbidities. The translational dermatology initiative hypothesizes that these shortcomings are due to the subjective nature of the current disease ontology, which does not address the heterogeneity and dynamics of diseases. By integrating deep clinical phenotyping and repetitive multiomics analyses of tissue and circulation of patients covering the whole spectrum of chronic skin inflammation independent of the traditional disease nomenclature, the translational dermatology initiative creates a high-quality dataset optimized for machine learning. The aim of the translational dermatology initiative is to reclassify inflammatory skin diseases on the basis of objective molecular events that enable prediction of clinically meaningful outcome variables. The translational dermatology initiative is currently recruiting at 2 centers (Freiburg and Stockholm), with the aim to expand this into a global initiative.</div></div>","PeriodicalId":73548,"journal":{"name":"JID innovations : skin science from molecules to population health","volume":"5 5","pages":"Article 100381"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144223296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accounting for Biological Sex and Gender Identity in the Pathogenesis, Artistic Depictions, and Quality of Life in Neurofibromatosis Type 1","authors":"Nidhi Kuchimanchi ,&nbsp;Renee M. McKay ,&nbsp;Lu Q. Le","doi":"10.1016/j.xjidi.2025.100393","DOIUrl":"10.1016/j.xjidi.2025.100393","url":null,"abstract":"<div><div>Neurofibromatosis type 1 (NF1) is an autosomal dominant neurocutaneous syndrome caused by pathogenic alterations in the tumor suppressor protein neurofibromin. NF1 is characterized clinically by café-au-lait macules, skinfold freckling, iris hamartomas, benign and malignant nerve sheath tumors, optic pathway tumors, skeletal abnormalities, breast malignancies, and neurocognitive challenges. Although progress has been made in understanding biological sex- and gender identity–based differences in a variety of dermatologic conditions, the role of these factors on NF1 and vice versa is not well-defined. In this narrative review, we examine the reciprocal influences of biological sex and gender identity on various NF1 clinical features, discuss the psychosocial and sociocultural factors that may contribute to these observed effects, and highlight historical artistic depictions of NF1. We also identify gaps in our current knowledge in this area that warrant additional research. A comprehensive understanding of NF1 clinical presentations through the lens of biological sex and gender identity can lead to a patient-centered approach of treatment, thereby improving long-term outcomes for affected patients.</div></div>","PeriodicalId":73548,"journal":{"name":"JID innovations : skin science from molecules to population health","volume":"5 5","pages":"Article 100393"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144680208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myeloid and Mast Cell Progenitors Are Elevated in Atopic Dermatitis","authors":"Katie Ridge ,&nbsp;Barry Moran ,&nbsp;Mark A. Little ,&nbsp;Cliona O’Farrelly ,&nbsp;Jean Dunne ,&nbsp;Julianne Clowry ,&nbsp;Clodagh Loftus ,&nbsp;Conor M. Finlay ,&nbsp;Alan D. Irvine ,&nbsp;Niall Conlon","doi":"10.1016/j.xjidi.2025.100390","DOIUrl":"10.1016/j.xjidi.2025.100390","url":null,"abstract":"<div><div>Chronic spontaneous urticaria and atopic dermatitis (AD) are chronic skin disorders characterized by itch. Although mast cells play an integral role in the pathogenesis of chronic spontaneous urticaria, their role in AD is unclear, having a contributory role in a disease largely driven by T helper 2 polarization. Despite this, the role of mast cells in AD is important, given their release of proinflammatory mediators. Recently, myeloid and mast cell progenitors were identified as potential biomarkers for treatment response in chronic spontaneous urticaria. These Lin⁻CD117⁺CD34⁺FceRI⁺ cells appear to have increased egress from the bone marrow in atopy. We measured Lin⁻CD117⁺CD34⁺FceRI⁺ cells in the peripheral blood of 10 individuals with AD and 10 healthy controls. Flow cytometry revealed a significant increase in myeloid progenitors in participants with AD (<em>P</em> = .0067). Total serum IgE levels did not correlate with myeloid progenitors. To our knowledge, examination of this cell type in AD is previously unreported. Our findings suggest increased progenitor egress from the bone marrow in these patients and a possible role for myeloid progenitors in disease pathogenesis.</div></div>","PeriodicalId":73548,"journal":{"name":"JID innovations : skin science from molecules to population health","volume":"5 5","pages":"Article 100390"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144623413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cover","authors":"","doi":"10.1016/S2667-0267(25)00068-2","DOIUrl":"10.1016/S2667-0267(25)00068-2","url":null,"abstract":"","PeriodicalId":73548,"journal":{"name":"JID innovations : skin science from molecules to population health","volume":"5 5","pages":"Article 100412"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145104567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of Keratin 5-Expressing Fibroblasts for Regenerating Keratinocytes in the Necrotic Skin Graft","authors":"Yoshikazu Hirose ,&nbsp;Asaka Miura ,&nbsp;Yuki Kobayashi ,&nbsp;Takashi Shimbo ,&nbsp;Yuya Ouchi ,&nbsp;Tomomi Kitayama ,&nbsp;Tomoya Mori ,&nbsp;Akio Tanaka ,&nbsp;Manabu Fujimoto ,&nbsp;Kotaro Saga ,&nbsp;Katsuto Tamai","doi":"10.1016/j.xjidi.2025.100394","DOIUrl":"10.1016/j.xjidi.2025.100394","url":null,"abstract":"<div><div>Skin transplantation is commonly used to compensate for normal cutaneous tissues in full-thickness wounds or surgically excised skin. Despite complete termination of initial blood flow, transplanted skin usually maintains its dermal and epidermal structures without scar formation. However, the precise role of engrafted cells in maintaining epidermal and dermal homeostasis remains unclear. In this study, we investigated the chronological changes in neonatal full-thickness skin grafts on mice at the histological and single-cell transcriptomic levels. We found devastating necrotic changes in the dermal and epidermal tissues on postoperative day 3, followed by significant regeneration of follicular and interfollicular tissues after postoperative day 6. We identified a unique mesenchymal subpopulation that expressed keratinocyte-specific genes (keratin 5 gene <em>K</em><em>rt</em><em>5</em>, <em>Epcam</em>, and <em>Irf6</em>) involved in mesenchymal–epithelial transition. Mesenchymal cells transitioning to epithelial cells showed keratinocyte differentiation activity both in vitro and in vivo. These results highlight the contribution of unique mesenchymal cell populations to epithelial regeneration after severe necrosis of a skin graft.</div></div>","PeriodicalId":73548,"journal":{"name":"JID innovations : skin science from molecules to population health","volume":"5 5","pages":"Article 100394"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144723446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the Associations between Dietary Vitamin Intake and Atopic Dermatitis: A Regional Cross-Sequential Study among Singapore and Malaysia Young Chinese Adults","authors":"Jun Jie Lim ,&nbsp;Kavita Reginald ,&nbsp;Yee-How Say ,&nbsp;Mei Hui Liu ,&nbsp;Fook Tim Chew","doi":"10.1016/j.xjidi.2025.100387","DOIUrl":"10.1016/j.xjidi.2025.100387","url":null,"abstract":"<div><div>This study demonstrates that naturally derived vitamins, estimated from whole foods in the diets of young Chinese adults from Singapore and Malaysia, are associated with atopic dermatitis (AD). Higher intake of vitamins E, K1, C, B2, and D was associated with lower odds of AD. The protective effect of vitamin C was not confounded by smoking and enhanced by higher fruit intake. These findings underscore the potential role of dietary vitamins in mitigating AD risk and support further research into whole-food-based dietary strategies for AD management.</div></div>","PeriodicalId":73548,"journal":{"name":"JID innovations : skin science from molecules to population health","volume":"5 5","pages":"Article 100387"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144471185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex Bias in Autoimmunity: New Findings and New Opportunities","authors":"Vincent van Drongelen ,&nbsp;Joanna Rew ,&nbsp;Allison C. Billi","doi":"10.1016/j.xjidi.2025.100391","DOIUrl":"10.1016/j.xjidi.2025.100391","url":null,"abstract":"<div><div>Autoimmune diseases result from the immune system’s inability to discriminate between self and foreign antigens, leading to development of self-reactive immune cells and autoantibodies that can cause organ damage and failure. It has long been known that many autoimmune diseases are more common in females. Although much progress has been made over the years, the exact mechanisms for this sex bias are not yet fully understood. In this review, we provide an overview and update on how chromosomes, genes, sex hormones (including gender-affirming hormone therapy), immunometabolism, and the skin can play a role in sex-biased autoimmunity. We also identify gaps in our understanding that require additional research. In an era of increased development of personalized medicine, a thorough understanding of sex bias in autoimmunity may facilitate the development of much-needed targeted therapeutics, thereby reducing the risks of broader immunosuppression and adverse effects that lead to premature termination of treatment by patients.</div></div>","PeriodicalId":73548,"journal":{"name":"JID innovations : skin science from molecules to population health","volume":"5 5","pages":"Article 100391"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144680232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Topical Corticosteroid Treatment on microRNA Expression in Infants with Atopic Dermatitis","authors":"Janna Nousbeck ,&nbsp;Maeve A. McAleer ,&nbsp;Elaine M. Kenny ,&nbsp;Alan D. Irvine","doi":"10.1016/j.xjidi.2025.100388","DOIUrl":"10.1016/j.xjidi.2025.100388","url":null,"abstract":"<div><div>MicroRNAs (miRNAs) have been implicated in a variety of disorders. Although studies have examined miRNA in pediatric atopic dermatitis (AD), the impact of topical corticosteroid (TCS) therapy on miRNA expression in pediatric AD has not been investigated. We sought to investigate the effects of 6 weeks of TCS therapy on miRNA expression in infants with AD. Small RNA sequencing and real-time RT-qPCR were performed to identify differentially expressed miRNAs in PBMCs of infants with AD after TCS treatment; HTG EdgeSeq was used to identify differentially expressed miRNAs in plasma. Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis was conducted using a list of experimentally verified miRNA targets sourced from the DIANA-TarBase and miRTarBase databases. Five miRNAs were differentially expressed in circulating PBMCs after TCS treatment (miR-143-3p, miR-27a-5p, miR-126-3p, miR-451a, and miR-223-3p); 12 miRNAs were differentially expressed in plasma. These miRNAs have regulatory functions crucial for regulating cell growth and survival, vascular adhesion, angiogenesis, skin barrier integrity, stress and nervous system processes, immune responses, inflammation, and T helper 17 cell differentiation. TCS treatment led to a distinct miRNA expression profile in peripheral blood, providing insights into how this treatment impacts disease mechanisms in childhood AD.</div></div>","PeriodicalId":73548,"journal":{"name":"JID innovations : skin science from molecules to population health","volume":"5 5","pages":"Article 100388"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144535414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}