Edward Vitkin , Julia Wise , Ariel Berl , Ofir Shir-az , Batel Gabay , Amrita Singh , Vladimir Kravtsov , Zohar Yakhini , Avshalom Shalom , Alexander Golberg
{"title":"Differential Expression Analysis of Cutaneous Squamous Cell Carcinoma and Basal Cell Carcinoma Proteomic Profiles Sampled with Electroporation-Based Biopsy","authors":"Edward Vitkin , Julia Wise , Ariel Berl , Ofir Shir-az , Batel Gabay , Amrita Singh , Vladimir Kravtsov , Zohar Yakhini , Avshalom Shalom , Alexander Golberg","doi":"10.1016/j.xjidi.2024.100304","DOIUrl":"10.1016/j.xjidi.2024.100304","url":null,"abstract":"<div><div>Clinical misdiagnosis between cutaneous squamous cell carcinoma (cSCC) and basal cell carcinoma (BCC) affects treatment plans. We report a tissue sampling approach with molecular biopsy using electroporation. This method, coined electroporation-based biopsy (e-biopsy), enables nondestructive nonthermal permeabilization of cells in the skin for vacuum-assisted extraction of biomolecules. We used e-biopsy for ex vivo proteome extraction from 3 locations per patient in 21 cSCC, 20 BCC, and 7 actinic keratosis human skin samples. Using liquid chromatography with tandem mass spectrometry, we identified 5966 proteins observed with nonzero intensity in at least 1 sample. The intrapatient Pearson correlation of 0.888 ± 0.065 for patients with BCC, 0.858 ± 0.077 for patients with cSCC, and 0.876 ± 0.116 for those with solar actinic keratosis indicates high consistency of the e-biopsy sampling. The mass spectra presented significantly different proteome profiles for cSCC, BCC, and solar actinic keratosis, with several hundreds of proteins differentially expressed. Notably, our study showed that proteomes sampled with e-biopsy from cSCC and BCC lesions are different and that proteins of <em>CRNN</em>, <em>SULT1E1</em>, and <em>ITPK1</em> genes are significantly overexpressed in BCC in comparison with those in cSCC. Our results provide evidence that the e-biopsy approach could potentially be used as a tool to support cutaneous lesions classification with molecular pathology.</div></div>","PeriodicalId":73548,"journal":{"name":"JID innovations : skin science from molecules to population health","volume":"4 6","pages":"Article 100304"},"PeriodicalIF":0.0,"publicationDate":"2024-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142446133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
David I. Latoni , Danica C. McDaniel , Hensin Tsao , Sandy S. Tsao
{"title":"Update on the Pathogenesis of Keloid Formation","authors":"David I. Latoni , Danica C. McDaniel , Hensin Tsao , Sandy S. Tsao","doi":"10.1016/j.xjidi.2024.100299","DOIUrl":"10.1016/j.xjidi.2024.100299","url":null,"abstract":"<div><p>Keloids are abnormal skin growths occurring in a significant portion of the global population. Despite their pervasiveness, the underlying pathophysiology of this scarring process is yet to be fully understood. In this review article, we delve into the current literature on the pathophysiological mechanisms of keloids. We take a top-down approach, first looking at host factors such as genetics and endocrine factors and then taking a more granular approach describing specific control factors such as germline keloid predisposition variants, epigenetics and transcriptomics, inflammatory and immune dysregulation, and the role of profibrotic and angiogenic cell signaling pathways. We then discuss current knowledge gaps, propose further research avenues, and explore potential future treatment options considering our increased understanding of keloid pathogenesis.</p></div>","PeriodicalId":73548,"journal":{"name":"JID innovations : skin science from molecules to population health","volume":"4 6","pages":"Article 100299"},"PeriodicalIF":0.0,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667026724000468/pdfft?md5=d8dbe4af64f3a3426966133bf7f489bb&pid=1-s2.0-S2667026724000468-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141848383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Matt Spick , Jan Higgins , Cynthia L. Green , Roland Matsouaka , Daniel B. Shin , Russell P. Hall III , Nophar Geifman
{"title":"Observations from Statistical Review Editors: A Commentary","authors":"Matt Spick , Jan Higgins , Cynthia L. Green , Roland Matsouaka , Daniel B. Shin , Russell P. Hall III , Nophar Geifman","doi":"10.1016/j.xjidi.2024.100302","DOIUrl":"10.1016/j.xjidi.2024.100302","url":null,"abstract":"","PeriodicalId":73548,"journal":{"name":"JID innovations : skin science from molecules to population health","volume":"4 6","pages":"Article 100302"},"PeriodicalIF":0.0,"publicationDate":"2024-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667026724000493/pdfft?md5=97c3630d4e746cb820f0b1b9e037f9df&pid=1-s2.0-S2667026724000493-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141839868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Carina Nogueira Garcia , Christoph Wies , Katja Hauser , Titus J. Brinker
{"title":"Noninvasive Technologies for the Diagnosis of Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis","authors":"Carina Nogueira Garcia , Christoph Wies , Katja Hauser , Titus J. Brinker","doi":"10.1016/j.xjidi.2024.100303","DOIUrl":"10.1016/j.xjidi.2024.100303","url":null,"abstract":"<div><p>Early cutaneous squamous cell carcinoma (cSCC) diagnosis is essential to initiate adequate targeted treatment. Noninvasive diagnostic technologies could overcome the need of multiple biopsies and reduce tumor recurrence. To assess performance of noninvasive technologies for cSCC diagnostics, 947 relevant records were identified through a systematic literature search. Among the 15 selected studies within this systematic review, 7 were included in the meta-analysis, comprising of 1144 patients, 224 cSCC lesions, and 1729 clinical diagnoses. Overall, the sensitivity values are 92% (95% confidence interval [CI] = 86.6–96.4%) for high-frequency ultrasound, 75% (95% CI = 65.7–86.2%) for optical coherence tomography, and 63% (95% CI = 51.3–69.1%) for reflectance confocal microscopy. The overall specificity values are 88% (95% CI = 82.7–92.5%), 95% (95% CI = 92.7–97.3%), and 96% (95% CI = 94.8–97.4%), respectively. Physician’s expertise is key for high diagnostic performance of investigated devices. This can be justified by the provision of additional tissue information, which requires physician interpretation, despite insufficient standardized diagnostic criteria. Furthermore, few deep learning studies were identified. Thus, integration of deep learning into the investigated devices is a potential investigating field in cSCC diagnosis.</p></div>","PeriodicalId":73548,"journal":{"name":"JID innovations : skin science from molecules to population health","volume":"4 6","pages":"Article 100303"},"PeriodicalIF":0.0,"publicationDate":"2024-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266702672400050X/pdfft?md5=e2d200dbc371629064d1b3b62bc3f822&pid=1-s2.0-S266702672400050X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141843941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maxime Sintès , Petra Kovjenic , Liasmine Haine (Hablal) , Kevin Serror , Mohamed Beladjine , Véronique Parietti (Montcuquet) , Marine Delagrange , Bertrand Ducos , Jean-David Bouaziz , David Boccara , Maurice Mimoun , Armand Bensussan , Martine Bagot , Nicolas Huang , Laurence Michel
{"title":"Coencapsulation of Immunosuppressive Drug with Anti-Inflammatory Molecule in Pickering Emulsions as an Innovative Therapeutic Approach for Inflammatory Dermatoses","authors":"Maxime Sintès , Petra Kovjenic , Liasmine Haine (Hablal) , Kevin Serror , Mohamed Beladjine , Véronique Parietti (Montcuquet) , Marine Delagrange , Bertrand Ducos , Jean-David Bouaziz , David Boccara , Maurice Mimoun , Armand Bensussan , Martine Bagot , Nicolas Huang , Laurence Michel","doi":"10.1016/j.xjidi.2024.100273","DOIUrl":"10.1016/j.xjidi.2024.100273","url":null,"abstract":"<div><p>Psoriasis is an inflammatory skin disease characterized by epidermal and immune dysfunctions. Although efficient, current topical treatments display adverse effects, including skin atrophy and burning sensation, leading to poor patient adherence. To overcome these downsides, pickering emulsions were formulated in which the calcitriol-containing dispersed phase was stabilized with either cyclosporin A– or tacrolimus-loaded poly(lactic-co-glycolic) acid nanoparticles. This study aimed to investigate their biological effects on lymphocytes and epidermal cells and their effectiveness in an imiquimod-induced psoriasis-like mouse model. Results showed that both emulsions significantly inhibited nuclear factor of activated T cell translocation in T lymphocytes as well as their IL-2 production, cell activation, and proliferation. In keratinocytes, inhibition of nuclear factor of activated T cell translocation decreased the production of IL-8 and TNF-α. Topical application of emulsions over skin biopsies ex vivo showed accumulation of rhodamin B–coupled poly(lactic-co-glycolic) acid nanoparticles throughout the epidermis by immunofluorescence and significantly decreased the antigen-presenting capacity of Langerhans cells in relation to a reduced expression of activation markers CD40, CD86, and HLA-DR. Using an imiquimod-induced psoriasis model in vivo, pickering emulsions significantly alleviated psoriasiform lesions potentially attributed to the decreased cutaneous expression of T-cell markers, proinflammatory cytokines, chemokines, and specific epidermal cell genes. Altogether, pickering emulsion might be a very efficient formulation for treating inflammatory dermatoses.</p></div>","PeriodicalId":73548,"journal":{"name":"JID innovations : skin science from molecules to population health","volume":"4 4","pages":"Article 100273"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667026724000201/pdfft?md5=5840a5e889e492fcc62f06d177b01f94&pid=1-s2.0-S2667026724000201-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140403255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hyeon Ki Jeong , Christine Park , Simon W. Jiang , Matilda Nicholas , Suephy Chen , Ricardo Henao , Meenal Kheterpal
{"title":"Image Quality Assessment Using Convolutional Neural Network in Clinical Skin Images","authors":"Hyeon Ki Jeong , Christine Park , Simon W. Jiang , Matilda Nicholas , Suephy Chen , Ricardo Henao , Meenal Kheterpal","doi":"10.1016/j.xjidi.2024.100285","DOIUrl":"https://doi.org/10.1016/j.xjidi.2024.100285","url":null,"abstract":"<div><p>The image quality received for clinical evaluation is often suboptimal. The goal is to develop an image quality analysis tool to assess patient- and primary care physician–derived images using deep learning model. Dataset included patient- and primary care physician–derived images from August 21, 2018 to June 30, 2022 with 4 unique quality labels. VGG16 model was fine tuned with input data, and optimal threshold was determined by Youden’s index. Ordinal labels were transformed to binary labels using a majority vote because model distinguishes between 2 categories (good vs bad). At a threshold of 0.587, area under the curve for the test set was 0.885 (95% confidence interval = 0.838–0.933); sensitivity, specificity, positive predictive value, and negative predictive value were 0.829, 0.784, 0.906, and 0.645, respectively. Independent validation of 300 additional images (from patients and primary care physicians) demonstrated area under the curve of 0.864 (95% confidence interval = 0.818–0.909) and area under the curve of 0.902 (95% confidence interval = 0.85–0.95), respectively. The sensitivity, specificity, positive predictive value, and negative predictive value for the 300 images were 0.827, 0.800, 0.959, and 0.450, respectively. We demonstrate a practical approach improving the image quality for clinical workflow. Although users may have to capture additional images, this is offset by the improved workload and efficiency for clinical teams.</p></div>","PeriodicalId":73548,"journal":{"name":"JID innovations : skin science from molecules to population health","volume":"4 4","pages":"Article 100285"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667026724000328/pdfft?md5=3096c45a51c4538d05749966b424a85b&pid=1-s2.0-S2667026724000328-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141486565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Julia Bajsert , Valérie De Glas , Emilie Faway , Catherine Lambert de Rouvroit , Miguel Pérez-Aso , Paul W. Cook , Yves Poumay
{"title":"Characterization of Reconstructed Human Epidermis in a Chemically-Defined, Animal Origin-Free Cell Culture","authors":"Julia Bajsert , Valérie De Glas , Emilie Faway , Catherine Lambert de Rouvroit , Miguel Pérez-Aso , Paul W. Cook , Yves Poumay","doi":"10.1016/j.xjidi.2024.100298","DOIUrl":"10.1016/j.xjidi.2024.100298","url":null,"abstract":"<div><p>The Reconstructed Human Epidermis (RHE) model derived from epidermal keratinocytes offers an ethical and scientific alternative to animal experimentation, particularly in cutaneous toxicology and dermatological research, where the elimination of animal cruelty is of paramount importance. Thus, we compared commercially available chemically defined animal origin-free (cdAOF) supplements, designed for regenerative medicine, to the widely utilized supplement (human keratinocyte growth supplement), which contains growth factors and bovine pituitary extract. Herein we present the extended characterization of RHE derived from newborn, adult, and immortalized N/telomerase reverse transcriptase keratinocytes under cdAOF conditions. Culture of RHE in the cdAOF media produced histological features that were similar to that produced using human keratinocyte growth supplement, with the exception that the basal keratinocytes were less cylindrical. Additionally, immunolocalization of involucrin in the basal layer and increased mRNA expression of several inflammatory-proliferative markers were observed under cdAOF conditions. In RHEs cultured in cdAOF media, expression and immunolocalization of other expected markers of keratinization were similar, while monitoring of barrier function (transepithelial electrical resistance) revealed results that were statistically equal to, or lower than those observed in RHE cultured in human keratinocyte growth supplement. Our study indicates that reconstruction of RHE was accomplished under cdAOF culture conditions and that further refinement could promote an expanded use beyond regenerative medicine, for in vitro toxicology applications.</p></div>","PeriodicalId":73548,"journal":{"name":"JID innovations : skin science from molecules to population health","volume":"4 5","pages":"Article 100298"},"PeriodicalIF":0.0,"publicationDate":"2024-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667026724000456/pdfft?md5=727f6880ad1ae8364d70328a593b5c15&pid=1-s2.0-S2667026724000456-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141951884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alysia N. Hughes , Xing Li , Julia S. Lehman , Steven A. Nelson , David J. DiCaudo , Rekha Mudappathi , Angelina Hwang , Jacob Kechter , Mark R. Pittelkow , Aaron R. Mangold , Aleksandar Sekulic
{"title":"Drug Repurposing Using Molecular Network Analysis Identifies Jak as Targetable Driver in Necrobiosis Lipoidica","authors":"Alysia N. Hughes , Xing Li , Julia S. Lehman , Steven A. Nelson , David J. DiCaudo , Rekha Mudappathi , Angelina Hwang , Jacob Kechter , Mark R. Pittelkow , Aaron R. Mangold , Aleksandar Sekulic","doi":"10.1016/j.xjidi.2024.100296","DOIUrl":"10.1016/j.xjidi.2024.100296","url":null,"abstract":"<div><div>Drug repurposing is an attractive strategy for therapy development, particularly in rare diseases where traditional drug development approaches may be challenging owing to high cost and small numbers of patients. In this study, we used a drug identification and repurposing pipeline to identify candidate targetable drivers of disease and corresponding therapies through application of causal reasoning using a combination of open-access resources and transcriptomics data. We optimized our approach on psoriasis as a disease model, demonstrating the ability to identify known and, to date, unrecognized molecular drivers of psoriasis and link them to current and emerging therapies. Application of our approach to a cohort of tissue samples of necrobiosis lipoidica (an unrelated; rare; and, to date, molecularly poorly characterized cutaneous inflammatory disorder) identified a unique set of upstream regulators, particularly highlighting the role of IFNG and the Jak–signal transducer and activator of transcription pathway as a likely driver of disease pathogenesis and linked it to Jak inhibitors as potential therapy. Analysis of an independent cohort of necrobiosis lipoidica samples validated these findings, with the overall agreement of drug-matched upstream regulators above 96%. These data highlight the utility of our approach in rare diseases and offer an opportunity for drug discovery in other rare diseases in dermatology and beyond.</div></div>","PeriodicalId":73548,"journal":{"name":"JID innovations : skin science from molecules to population health","volume":"4 6","pages":"Article 100296"},"PeriodicalIF":0.0,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142359550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Andrew Blauvelt , Yanqing Chen , Patrick J. Branigan , Xuejun Liu , Samuel DePrimo , Brice E. Keyes , Monica Leung , Steven Fakharzadeh , Ya-Wen Yang , Ernesto J. Muñoz-Elías , James G. Krueger , Richard G. Langley
{"title":"Differential Pharmacodynamic Effects on Psoriatic Biomarkers by Guselkumab Versus Secukinumab Correlate with Long-Term Efficacy: An ECLIPSE Substudy","authors":"Andrew Blauvelt , Yanqing Chen , Patrick J. Branigan , Xuejun Liu , Samuel DePrimo , Brice E. Keyes , Monica Leung , Steven Fakharzadeh , Ya-Wen Yang , Ernesto J. Muñoz-Elías , James G. Krueger , Richard G. Langley","doi":"10.1016/j.xjidi.2024.100297","DOIUrl":"10.1016/j.xjidi.2024.100297","url":null,"abstract":"<div><p>IL-23 is a cytokine produced by myeloid cells that drives the T helper 17 pathway and plays an essential role in the pathophysiology of plaque psoriasis. IL-23 activation initiates a cascade of cytokines subsequently inducing the expression of many psoriasis-related proteins. This study aimed to better understand the underlying mechanisms driving the differences between IL-23 and IL-17A blockade in patients with psoriasis and their implications for durability of clinical responses. Serum and/or skin biopsies were isolated from patients treated with guselkumab or secukinumab for evaluation of potential biomarkers of pharmacodynamic response to treatment. Guselkumab treatment led to significantly greater reductions of IL-17F and IL-22 serum levels than treatment with secukinumab at weeks 24 and 48, demonstrating sustained regulation of the IL-23/T helper 17 pathway. Analyses of proteomic and transcriptomic profiles of patient sera and skin biopsies demonstrated differential regulation of proteins involved in chemokine, TNF, and relevant immune signaling pathways to a greater degree with guselkumab than with secukinumab treatment. These data provide insights into the differences between the mechanisms and impact of IL-23 and IL-17A blockade in psoriasis, with implications for efficacy observations and treatment paradigms. Trial Registration: The original study was registered at <span><span>ClinicalTrials.gov</span><svg><path></path></svg></span> (NCT03090100).</p></div>","PeriodicalId":73548,"journal":{"name":"JID innovations : skin science from molecules to population health","volume":"4 5","pages":"Article 100297"},"PeriodicalIF":0.0,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667026724000444/pdfft?md5=01db74f44a90f4fcecc903affcff3cfb&pid=1-s2.0-S2667026724000444-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141979729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Prevalence and Impact of Unacceptable Symptom State among Patients with Psoriatic Arthritis: Results from the National Psoriasis Foundation’s 2019 Annual Survey","authors":"","doi":"10.1016/j.xjidi.2024.100292","DOIUrl":"10.1016/j.xjidi.2024.100292","url":null,"abstract":"<div><p>The National Psoriasis Foundation surveyed a random, stratified sample of individuals with psoriatic disease in the United States to determine the prevalence of an unacceptable psoriatic arthritis (PsA) symptom state and its effect on depression and social participation. Acceptable and unacceptable levels of PsA were defined using established cutoff points (acceptable ≤4 vs unacceptable >4) on the Psoriatic Arthritis Impact of Disease 9. Psoriasis severity was defined by body surface area: mild < 3%, moderate–severe ≥ 3%. Depression was assessed utilizing the Patient Health Questionnaire 2. Social participation was assessed by the Patient Reported Outcome Information Measurement System Ability to Participate in Social Role and Activities-SF4a. The analysis cohort comprised 801 patients with PsA. Unacceptable disease activity level (Psoriatic Arthritis Impact of Disease >4) was reported by 59.6% of participants. After adjusting for age, sex, and psoriasis severity, individuals with likely depression (OR = 0.014, <em>P</em> < .001) and those with limited ability to participate in social roles and activities (OR = 0.05, <em>P</em> < .001) were less likely to experience acceptable levels of PsA activity. Ultimately, the results demonstrated that most United States patients with PsA have unacceptable levels of disease activity, which is associated with increased prevalence of depression and limitations in social participation.</p></div>","PeriodicalId":73548,"journal":{"name":"JID innovations : skin science from molecules to population health","volume":"4 5","pages":"Article 100292"},"PeriodicalIF":0.0,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667026724000390/pdfft?md5=848c12c7c5d789c8a2cbee55d431a42a&pid=1-s2.0-S2667026724000390-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141400361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}