JID innovations : skin science from molecules to population health最新文献

{"title":"Paraprotein-Negative IL-1–Mediated Inflammatory Dermatosis: An Update on Schnitzler-Like Syndrome in the Absence of a Gammopathy","authors":"Rizwan Ahmad ,&nbsp;Jean Dunne ,&nbsp;Katie Ridge ,&nbsp;Nicole Fagan ,&nbsp;Niall Conlon","doi":"10.1016/j.xjidi.2025.100405","DOIUrl":"10.1016/j.xjidi.2025.100405","url":null,"abstract":"<div><div>Schnitzler syndrome (SchS) is a rare autoinflammatory condition characterized by chronic urticaria and systemic inflammation. Obligate diagnostic criteria include the presence of a monoclonal IgM or IgG band, with nearly all cases demonstrating a prompt response to IL-1 blockade. Recently, \"Schnitzler-like\" cases without a paraprotein have been reported. Although the exact nature of their relation to the original eponymous syndrome remains unclear, these cases share similar clinical features and response to IL-1 inhibition. Diagnostic delay is common in autoinflammatory syndromes, and the need to recognize potentially emerging cases is important. We present the case of a male aged 47 years with refractory urticaria, joint pain, and systemic inflammation resembling SchS but without detectable paraprotein, consistent with recently proposed paraprotein-negative IL-1–mediated inflammatory dermatosis (PANID). After failing conventional therapies, the patient achieved rapid and sustained remission with IL-1 blockade. This case underscores the importance of recognizing autoinflammatory syndromes, including PANID, in patients with refractory urticaria with associated inflammatory features. It also highlights the importance of a therapeutic trial of IL-1 inhibition.</div></div>","PeriodicalId":73548,"journal":{"name":"JID innovations : skin science from molecules to population health","volume":"5 6","pages":"Article 100405"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145219073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Racial Differences in Work Relative Value Units for Outpatient Pediatric Dermatology Visits","authors":"Udeyvir S. Cheema ,&nbsp;Beiyu Liu ,&nbsp;Ethan Borre ,&nbsp;Cynthia L. Green ,&nbsp;Lauren A.V. Orenstein ,&nbsp;Suephy C. Chen","doi":"10.1016/j.xjidi.2025.100411","DOIUrl":"10.1016/j.xjidi.2025.100411","url":null,"abstract":"<div><div>Measures of clinical productivity may tilt financial incentives toward providing care to specific patient populations, reinforcing inequitable care. Race, sex, and age have been shown to influence differences in work relative value units (wRVUs) generated during adult dermatology encounters. We sought to identify the association of patient race and sex with wRVUs generated by outpatient pediatric dermatology encounters. A total of 22,434 encounters among 10,063 unique patients were included; most encounters were with female (12,639 [56.3%]) and White (13,036 [58.1%]) individuals. The mean (SD) wRVUs per encounter was 1.57 (0.76). Visits with Asian patients, Black patients, and patients of other races generated 0.21 (95% confidence interval [CI] = 0.16–0.25), 0.19 (95% CI = 0.16–0.22), and 0.14 (95% CI = 0.10–0.17) fewer wRVUs per encounter, respectively, than pediatric outpatient dermatology visits with White patients (<em>P</em> &lt; .001 for all). There was no significant association between sex and wRVUs per encounter. Laser treatment for vascular lesions was a mediator for the observed differences in wRVUs by race (60.5% [95% CI = 45.8–75.1%] for Asian race, 62.4% [95% CI = 52.9–71.9%] for Black race, and 53.3% [95% CI = 31.7–74.9%] for other races). Variations in wRVUs by patient race may create inadvertent incentives at the health systems level to prioritize certain groups.</div></div>","PeriodicalId":73548,"journal":{"name":"JID innovations : skin science from molecules to population health","volume":"5 6","pages":"Article 100411"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145265627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing Treatment Efficacy for Dermatologic Immune-Related Adverse Events: A Systematic Review","authors":"Christian L. Bailey-Burke ,&nbsp;Kristin A. Tissera ,&nbsp;Lauren Baughman ,&nbsp;Samantha A. Polly ,&nbsp;Meenal Kheterpal","doi":"10.1016/j.xjidi.2025.100410","DOIUrl":"10.1016/j.xjidi.2025.100410","url":null,"abstract":"<div><div>The management of dermatologic immune–related adverse events (D-irAEs) remains inconsistent owing to variability in treatment responses and a lack of standardized guidelines. Establishing evidence-based recommendations is critical to improving patient outcomes and minimizing interruptions in immune checkpoint inhibitor therapy. This review aims to systematically evaluate the level of evidence for reported D-irAE treatments and provide insights to guide clinical decision making. Of the D-irAEs identified, those that were commonly reported include maculopapular, lichenoid, psoriasiform, immunobullous (including bullous pemphigoid), granulomatous, vitiligo, and potentially life-threatening erosive mucocutaneous conditions (such as erythema multiforme, Steven–Johnson syndrome, and toxic epidermal necrosis). Treatments ranged from corticosteroids (topical, oral, intravenous) to biologics (eg, omalizumab, rituximab) and oral immunomodulators (eg, methotrexate, apremilast), with topical and oral corticosteroids, along with apremilast, receiving the strongest evidence rating (3B). Although the strongest evidence supports corticosteroids, most treatments for D-irAEs lack robust validation owing to limitations in study type (ie, randomized control trials and prospective cohort studies). This underscores the importance of multidisciplinary approaches to optimize D-irAE management and support continuity in cancer care. Future research should prioritize randomized control trials and prospective cohort studies to aid in standardizing D-irAE treatment protocols to solidify treatment consensus.</div></div>","PeriodicalId":73548,"journal":{"name":"JID innovations : skin science from molecules to population health","volume":"5 6","pages":"Article 100410"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145157849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating CLA+ Memory T Cells in Skin Diseases: A Translational Perspective","authors":"Tali Czarnowicki ,&nbsp;Lea Tordjman ,&nbsp;Irene García-Jiménez ,&nbsp;Luis F. Santamaria-Babí","doi":"10.1016/j.xjidi.2025.100403","DOIUrl":"10.1016/j.xjidi.2025.100403","url":null,"abstract":"<div><div>Circulating cutaneous lymphocyte-associated antigen–positive T cells constitute a subset of memory T cells with a unique phenotype, effector function, and therapeutic relevance because they reflect the regional functions of the cutaneous immune system. These cells are involved in the pathological mechanisms of diverse cutaneous diseases. This review brings updated translational insights into these cells and identifies key questions for future research in the field.</div></div>","PeriodicalId":73548,"journal":{"name":"JID innovations : skin science from molecules to population health","volume":"5 6","pages":"Article 100403"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144996263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunoregulatory Microenvironment in the Elderly Skin","authors":"Yuri Shimizu ,&nbsp;Hanako Koguchi-Yoshioka ,&nbsp;Toshiki Kubo ,&nbsp;Yutaka Matsumura ,&nbsp;Shoichi Matsuda ,&nbsp;Atsushi Tanemura ,&nbsp;Michiko Nomori ,&nbsp;Naoya Otani ,&nbsp;Mifue Taminato ,&nbsp;Koichi Tomita ,&nbsp;Tateki Kubo ,&nbsp;Manabu Fujimoto ,&nbsp;Rei Watanabe","doi":"10.1016/j.xjidi.2025.100401","DOIUrl":"10.1016/j.xjidi.2025.100401","url":null,"abstract":"<div><div>Previous studies have revealed that skin T cells accumulate and maintain immune responses in the elderly. However, we questioned why these functional T cells fail to recognize and eliminate malignant cells, making elderly skin more prone to developing malignant tumors. To address this question, we examined the overall skin microenvironment in aging using the Nanostring nCounter system and 10x Xenium digital spatial RNA sequencing. The digital RNA counts of <em>CIITA</em> and <em>HLA-DMA</em>, which are involved in antigen presentation, were negatively correlated with age, whereas the counts of <em>UBE2L3</em> and <em>SOCS1</em>, molecules that play roles in immune regulation, were positively correlated with aging. The upregulation of <em>SOCS1</em> was detected in the microenvironment of the skin malignant tumors. Spatial transcriptome analysis revealed that cells with high levels of <em>SOCS1</em> were distributed in upper dermis and periadnexal area, and some <em>SOCS1</em>-positive fibroblasts were closely lined with <em>CD163</em>-positive macrophages. Our study showed that the skin microenvironment in the elderly may shift to an immunoregulatory condition. Furthermore, modulating certain molecules that may be involved in shared immunoregulatory mechanisms between healthy elderly skin and malignant tumors could serve as a potential strategy for preventing malignancies in elderly skin.</div></div>","PeriodicalId":73548,"journal":{"name":"JID innovations : skin science from molecules to population health","volume":"5 6","pages":"Article 100401"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144911802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peptide Epitopes of NC16A BP180 in the Diagnostics of Bullous Pemphigoid","authors":"Simon D. Lytton ,&nbsp;Christine Wagger ,&nbsp;Damian Meyersburg ,&nbsp;Birgit Mussnig ,&nbsp;Roland Lang ,&nbsp;Roberto Maglie ,&nbsp;Florian Anzengruber ,&nbsp;Emiliano Antiga ,&nbsp;Russell P. Hall ,&nbsp;Johann W. Bauer","doi":"10.1016/j.xjidi.2025.100415","DOIUrl":"10.1016/j.xjidi.2025.100415","url":null,"abstract":"<div><div>Bullous pemphigoid is a severe autoimmune blistering skin disorder causing significant morbidity and mortality among the elderly. Improved diagnostic strategies rely on the identification of autoantigen epitopes recognized by pathogenic autoantibodies. Continuous (linear) peptide epitopes, unlike conformational epitopes in recombinant proteins, offer advantages such as chemical stability, reproducibility, and lower production costs, making them attractive for diagnostic assay development. To identify relevant linear epitopes, a microarray of overlapping peptides spanning the NC16A domain of BP180 and the C-terminus of BP230 autoantigens was screened with sera of 13 patients with bullous pemphigoid and 2 control sera. A 25-mer peptide of NC16A, termed Pep7-NC16A, was evaluated by ELISA in 2 independent patient cohorts (n = 35 and 26 bullous pemphigoid cases, n = 48 and 53 controls). Pep7-NC16A ELISA showed sensitivity of 71% and 62% and specificity of 92% and 98%, with area under the curve values of 0.92 and 0.754 (<em>P</em> &lt; .001). Reactivity strongly correlated with commercial BP180 NC16A ELISA (r = 0.72, <em>P</em> &lt; .0001). In this study, we demonstrate the diagnostic potential of synthetic peptide in bullous pemphigoid. The identified epitope could also serve as a potential biomarker for BP180-associated conditions or future peptide-based immunotherapies.</div></div>","PeriodicalId":73548,"journal":{"name":"JID innovations : skin science from molecules to population health","volume":"5 6","pages":"Article 100415"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145265626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to ‘Factors Associated with Adoption of Immune Checkpoint Inhibitor Treatment for Advanced Melanoma: A SEER-Medicare Cohort Study’ JID Innovations, Volume 4, Issue 4, July 2024, 100289","authors":"Cassandra Mohr ,&nbsp;Kaiping Liao ,&nbsp;Candice L. Hinkston ,&nbsp;Mackenzie R. Wehner ,&nbsp;Meng Li","doi":"10.1016/j.xjidi.2025.100407","DOIUrl":"10.1016/j.xjidi.2025.100407","url":null,"abstract":"","PeriodicalId":73548,"journal":{"name":"JID innovations : skin science from molecules to population health","volume":"5 6","pages":"Article 100407"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145219079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Divergence in Estimated Risks and Actual Rates of Atherosclerotic Cardiovascular Events and their Management in a Longitudinal Cohort of Patients with Dermatomyositis with Skin Involvement","authors":"Megan Zhao ,&nbsp;Caroline Stone ,&nbsp;Rui Feng ,&nbsp;Victoria P. Werth ,&nbsp;Kevin Jon Williams","doi":"10.1016/j.xjidi.2025.100399","DOIUrl":"10.1016/j.xjidi.2025.100399","url":null,"abstract":"<div><div>Patients with dermatomyositis (DM), an autoimmune disorder affecting the skin, muscle, and lung, have been reported to be at a heightened risk of clinical events, chiefly heart attacks and strokes, from atherosclerotic cardiovascular disease. In this study, we examined current cardiovascular management in a single-center study of all 388 patients who have DM with skin involvement, either with symptomatic muscle disease (“classic DM”) or with clinically amyopathic DM. By the new guidelines, the most recent low-density lipoprotein cholesterol levels were above goal for 290 of 388 (74.7%). Surprisingly, statin use was similar between this cohort and a longitudinal lupus cohort. Almost two thirds of the cohort had hypertension (249 of 388, 64.2%), which was undertreated or untreated in 199 of 249 (79.9%). One third of the cohort were former or current smokers. Prediabetes and diabetes were generally well-managed. Three published methods for estimating atherosclerotic cardiovascular disease event risk in primary prevention showed meaningful discordance for 196 of 305 (64.3%). The documented rate of atherosclerotic cardiovascular disease events in the first 10 years after enrollment was 12.8% for classic DM and 8.4% for clinically amyopathic DM, indicating at-risk populations. We conclude that patients with DM are undermanaged for conventional therapeutic targets to reduce atherosclerotic cardiovascular disease event risk, particularly hypercholesteremia and hypertension.</div></div>","PeriodicalId":73548,"journal":{"name":"JID innovations : skin science from molecules to population health","volume":"5 6","pages":"Article 100399"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144904143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating Transcriptional Age Acceleration in Inflammatory Skin Diseases","authors":"Richie Jeremian ,&nbsp;Melissa Galati ,&nbsp;Rayyan Fotovati ,&nbsp;Kaiyang Li ,&nbsp;Carolyn Jack ,&nbsp;David O. Croitoru ,&nbsp;Stephan Caucheteux ,&nbsp;Philippe Lefrançois ,&nbsp;Vincent Piguet","doi":"10.1016/j.xjidi.2025.100386","DOIUrl":"10.1016/j.xjidi.2025.100386","url":null,"abstract":"<div><div>Epigenetic age acceleration has previously been observed in inflammatory skin disease; however, less is known regarding recently described age-related gene expression patterns (“transcriptional clocks”). We investigated the role of transcriptional clocks in patients with hidradenitis suppurativa (n = 37), those with atopic dermatitis (n = 27), those with plaque psoriasis (n = 28), and healthy subjects (n = 38) using 7 clock algorithms, to improve the understanding of underlying pathophysiology and disease trajectory. Five of 7 transcriptional clocks demonstrated moderate-to-strong accuracy in predicting age across groups (patients with atopic dermatitis: <em>ρ</em> = 0.40–0.86, those with hidradenitis suppurativa: <em>ρ</em> = 0.46–0.74, those with plaque psoriasis: <em>ρ</em> = 0.50–0.80, healthy subjects: <em>ρ</em> = 0.32–0.60; <em>P</em> &lt; .05). Age acceleration was observed in lesional versus healthy (patients with atopic dermatitis: +3.9∼9.8y, <em>t =</em> 2.8∼5.9; those with hidradenitis suppurativa: +5.0∼6.1y, <em>t</em> = 2.5∼4.1; those with plaque psoriasis: +6.5∼12.5y, <em>t</em> = 5.1∼8.0; <em>P</em> &lt; .05) and in lesional versus nonlesional skin in all diseases and less frequently observed in nonlesional versus healthy skin. In atopic dermatitis, loss-of-function sequence variants in the FLG gene were associated with transcriptional age acceleration, including <em>FLGR244X/2282del4</em> dual carrier status (<em>t</em> = 2.3, <em>P</em> &lt; .05) and <em>FLGR501X</em> carrier status (<em>t</em> = 2.6, <em>P</em> &lt; .05). Pathway enrichment analyses revealed that clock genes are enriched in signatures related to aging, inflammation, and metabolism. Our study provides evidence for transcriptional age acceleration in inflammatory skin disease and sets a foundation for further investigation into the role of age-related transcriptional changes in the pathophysiology of these diseases.</div></div>","PeriodicalId":73548,"journal":{"name":"JID innovations : skin science from molecules to population health","volume":"5 5","pages":"Article 100386"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144653764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toward the Next Generation of In Silico Modeling of Dynamic Host-Microbiota Interactions in the Skin","authors":"Jamie Lee ,&nbsp;Hiu Lam Athena Wu ,&nbsp;Ahmad A. Mannan ,&nbsp;Yuumi Nakamura ,&nbsp;Masayuki Amagai ,&nbsp;Alan D. Irvine ,&nbsp;Reiko J. Tanaka","doi":"10.1016/j.xjidi.2025.100385","DOIUrl":"10.1016/j.xjidi.2025.100385","url":null,"abstract":"<div><div>Understanding how the skin microbiota contributes to skin health and disease requires knowledge of the dynamic interactions between the skin and its resident microbes. In silico modeling complements in vivo and in vitro experiments by enabling a systems-level understanding of dynamic skin-microbiota interactions. However, the number of published in silico skin microbiota models remains limited. This paper provides the first comprehensive exploration of in silico skin microbiota modeling. We identify current challenges, learn from leading experimental validation approaches adopted in in silico gut microbiota research, and propose ways to enhance the predictive power of in silico skin microbiota models.</div></div>","PeriodicalId":73548,"journal":{"name":"JID innovations : skin science from molecules to population health","volume":"5 5","pages":"Article 100385"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144321806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}