JID innovations : skin science from molecules to population health最新文献

ZNF750 Loss of Function Drives Spontaneous Psoriasiform Skin Inflammation ZNF750功能丧失驱动自发性牛皮癣样皮肤炎症

JID innovations : skin science from molecules to population health Pub Date : 2025-09-17 DOI: 10.1016/j.xjidi.2025.100416

Hilla Levi , Topaz Alfer , Roi Gazit , Idan Cohen

{"title":"ZNF750 Loss of Function Drives Spontaneous Psoriasiform Skin Inflammation","authors":"Hilla Levi , Topaz Alfer , Roi Gazit , Idan Cohen","doi":"10.1016/j.xjidi.2025.100416","DOIUrl":"10.1016/j.xjidi.2025.100416","url":null,"abstract":"<div><div>Epidermal keratinocytes are not only crucial for maintaining skin barrier physical functions but also play various roles in the initiation, progression, and maintenance phases of skin inflammation. ZNF750 is an epithelial-specific transcription factor expressed in differentiating keratinocytes, whose activity is required for keratinocyte terminal differentiation. In humans, <em>ZNF750</em> sequence variant causes psoriasis-like skin disease. In this study, using a genetic mouse model to study the role played by ZNF750 in epidermal homeostasis, we reveal that ZNF750 activity is essential for preventing skin inflammation. We show that a loss of ZNF750 activity results in the rapid development of psoriasiform skin lesions. Molecular dissection further demonstrated an impaired balance between epidermal cell proliferation and differentiation, induction of proinflammatory factors by <em>Znf750</em>-deficient keratinocytes, and a massive immune cell infiltration. Altogether, our study highlights the importance of keratinocytes in inflammatory skin disease pathogenesis, demonstrating ZNF750 loss-of-function sufficiency in driving severe psoriasiform skin inflammation, which resembles the diseased human condition in patients with pathogenic <em>ZNF750</em> sequence variants.</div></div>","PeriodicalId":73548,"journal":{"name":"JID innovations : skin science from molecules to population health","volume":"6 1","pages":"Article 100416"},"PeriodicalIF":0.0,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145242407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Translesion Synthesis DNA Polymerase Gene Expression Is Impacted by Age and IGF-1 in Epidermal Human Skin 翻译合成DNA聚合酶基因表达受年龄和IGF-1的影响

JID innovations : skin science from molecules to population health Pub Date : 2025-09-02 DOI: 10.1016/j.xjidi.2025.100409

Stanley D. Rider Jr. , Madison S. Owens , Craig A. Rohan , Jeffrey B. Travers , Michael G. Kemp

{"title":"Translesion Synthesis DNA Polymerase Gene Expression Is Impacted by Age and IGF-1 in Epidermal Human Skin","authors":"Stanley D. Rider Jr. , Madison S. Owens , Craig A. Rohan , Jeffrey B. Travers , Michael G. Kemp","doi":"10.1016/j.xjidi.2025.100409","DOIUrl":"10.1016/j.xjidi.2025.100409","url":null,"abstract":"<div><div>Regions of sun-exposed skin are prone to carcinogenesis in geriatric individuals and exhibit a reduced ability to remove mutagenic UV photoproducts from DNA. To determine whether geriatric skin may be more reliant on translesion synthesis (TLS) DNA polymerases to replicate unrepaired UV photoproducts, we examined the expression of TLS polymerases in the epidermis of young and geriatric individuals. Although significant differences were not observed between these 2 age groups, the expression of the TLS polymerase genes <em>POLH</em>, <em>POLI</em>, <em>POLK</em>, <em>REV1</em>, and <em>REV7</em> were found to be inversely correlated with the skin aging biomarker gene <em>COL1A1</em> but not with <em>S100A7</em> among geriatric individuals. We further examined the effect of UVB exposure on TLS polymerase expression and found that mRNA levels of <em>POLI</em>, <em>POLK</em>, and <em>REV1</em> were elevated in UVB-irradiated geriatric skin relative to those in young adult skin. Consistent with prior studies linking reduced insulin-like growth factor-1 production and signaling with altered UVB responses, studies with cultured keratinocytes and geriatric skin indicated that deficient insulin-like growth factor-1 signaling is associated with a stronger UVB-dependent induction of <em>REV1</em>. In summary, this work suggests that alterations to TLS polymerase gene expression in UVB-irradiated geriatric skin should be considered in future studies of skin cancer in human subjects.</div></div>","PeriodicalId":73548,"journal":{"name":"JID innovations : skin science from molecules to population health","volume":"5 6","pages":"Article 100409"},"PeriodicalIF":0.0,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145157758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing Treatment Efficacy for Dermatologic Immune-Related Adverse Events: A Systematic Review 评估皮肤免疫相关不良事件的治疗效果：一项系统综述

JID innovations : skin science from molecules to population health Pub Date : 2025-09-02 DOI: 10.1016/j.xjidi.2025.100410

Christian L. Bailey-Burke , Kristin A. Tissera , Lauren Baughman , Samantha A. Polly , Meenal Kheterpal

{"title":"Assessing Treatment Efficacy for Dermatologic Immune-Related Adverse Events: A Systematic Review","authors":"Christian L. Bailey-Burke , Kristin A. Tissera , Lauren Baughman , Samantha A. Polly , Meenal Kheterpal","doi":"10.1016/j.xjidi.2025.100410","DOIUrl":"10.1016/j.xjidi.2025.100410","url":null,"abstract":"<div><div>The management of dermatologic immune–related adverse events (D-irAEs) remains inconsistent owing to variability in treatment responses and a lack of standardized guidelines. Establishing evidence-based recommendations is critical to improving patient outcomes and minimizing interruptions in immune checkpoint inhibitor therapy. This review aims to systematically evaluate the level of evidence for reported D-irAE treatments and provide insights to guide clinical decision making. Of the D-irAEs identified, those that were commonly reported include maculopapular, lichenoid, psoriasiform, immunobullous (including bullous pemphigoid), granulomatous, vitiligo, and potentially life-threatening erosive mucocutaneous conditions (such as erythema multiforme, Steven–Johnson syndrome, and toxic epidermal necrosis). Treatments ranged from corticosteroids (topical, oral, intravenous) to biologics (eg, omalizumab, rituximab) and oral immunomodulators (eg, methotrexate, apremilast), with topical and oral corticosteroids, along with apremilast, receiving the strongest evidence rating (3B). Although the strongest evidence supports corticosteroids, most treatments for D-irAEs lack robust validation owing to limitations in study type (ie, randomized control trials and prospective cohort studies). This underscores the importance of multidisciplinary approaches to optimize D-irAE management and support continuity in cancer care. Future research should prioritize randomized control trials and prospective cohort studies to aid in standardizing D-irAE treatment protocols to solidify treatment consensus.</div></div>","PeriodicalId":73548,"journal":{"name":"JID innovations : skin science from molecules to population health","volume":"5 6","pages":"Article 100410"},"PeriodicalIF":0.0,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145157849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cover 封面

JID innovations : skin science from molecules to population health Pub Date : 2025-09-01 DOI: 10.1016/S2667-0267(25)00068-2

引用次数: 0

Stimulation of Skin Pigmentation with UVR Is a Risk Factor for Cholelithiasis 紫外线照射刺激皮肤色素沉着是胆石症的危险因素

JID innovations : skin science from molecules to population health Pub Date : 2025-08-25 DOI: 10.1016/j.xjidi.2025.100408

Stanislav Pavel , Patrick A. Riley

{"title":"Stimulation of Skin Pigmentation with UVR Is a Risk Factor for Cholelithiasis","authors":"Stanislav Pavel , Patrick A. Riley","doi":"10.1016/j.xjidi.2025.100408","DOIUrl":"10.1016/j.xjidi.2025.100408","url":null,"abstract":"<div><div>Long-term clinical experience suggested that skin fairness is one of the risk factors for developing cholelithiasis. However, it was unclear how to connect skin color with the development of gallstones. The discovery of reactive melanin precursors resulted in the hypothesis that some of these compounds could be excreted via bile and form the basis of gallstones. There are indications that the excretion of these compounds from melanocytes is higher in individuals with less pigmented skin who were irradiated by UV radiation. A clinical study revealed that people with fair skin who like sunbathing run a very high risk of developing cholelithiasis. We also present several studies that report a significant increase in cholelithiasis among psoriasis patients. Most gallstones remain asymptomatic. However, some patients may develop symptoms shortly after the gallstones are formed. We cite several investigations that found the highest frequency of cholecystectomies and cases of acute pancreatitis in the summer and the lowest in the winter. We propose that skin fairness should be considered a real risk factor for cholelithiasis, but only in combination with UV stimulation of cutaneous pigmentation. In this review, we discuss the laboratory and clinical work that can be connected to this hypothesis.</div></div>","PeriodicalId":73548,"journal":{"name":"JID innovations : skin science from molecules to population health","volume":"5 6","pages":"Article 100408"},"PeriodicalIF":0.0,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145094984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Paraprotein-Negative IL-1–Mediated Inflammatory Dermatosis: An Update on Schnitzler-Like Syndrome in the Absence of a Gammopathy 副蛋白阴性il -1介导的炎症性皮肤病：无Gammopathy的schnitzler样综合征的最新进展

JID innovations : skin science from molecules to population health Pub Date : 2025-08-20 DOI: 10.1016/j.xjidi.2025.100405

Rizwan Ahmad , Jean Dunne , Katie Ridge , Nicole Fagan , Niall Conlon

{"title":"Paraprotein-Negative IL-1–Mediated Inflammatory Dermatosis: An Update on Schnitzler-Like Syndrome in the Absence of a Gammopathy","authors":"Rizwan Ahmad , Jean Dunne , Katie Ridge , Nicole Fagan , Niall Conlon","doi":"10.1016/j.xjidi.2025.100405","DOIUrl":"10.1016/j.xjidi.2025.100405","url":null,"abstract":"<div><div>Schnitzler syndrome (SchS) is a rare autoinflammatory condition characterized by chronic urticaria and systemic inflammation. Obligate diagnostic criteria include the presence of a monoclonal IgM or IgG band, with nearly all cases demonstrating a prompt response to IL-1 blockade. Recently, \"Schnitzler-like\" cases without a paraprotein have been reported. Although the exact nature of their relation to the original eponymous syndrome remains unclear, these cases share similar clinical features and response to IL-1 inhibition. Diagnostic delay is common in autoinflammatory syndromes, and the need to recognize potentially emerging cases is important. We present the case of a male aged 47 years with refractory urticaria, joint pain, and systemic inflammation resembling SchS but without detectable paraprotein, consistent with recently proposed paraprotein-negative IL-1–mediated inflammatory dermatosis (PANID). After failing conventional therapies, the patient achieved rapid and sustained remission with IL-1 blockade. This case underscores the importance of recognizing autoinflammatory syndromes, including PANID, in patients with refractory urticaria with associated inflammatory features. It also highlights the importance of a therapeutic trial of IL-1 inhibition.</div></div>","PeriodicalId":73548,"journal":{"name":"JID innovations : skin science from molecules to population health","volume":"5 6","pages":"Article 100405"},"PeriodicalIF":0.0,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145219073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to ‘Factors Associated with Adoption of Immune Checkpoint Inhibitor Treatment for Advanced Melanoma: A SEER-Medicare Cohort Study’ JID Innovations, Volume 4, Issue 4, July 2024, 100289 《采用免疫检查点抑制剂治疗晚期黑色素瘤的相关因素：一项SEER-Medicare队列研究》的勘误表《JID创新》，第4卷，第4期，2024年7月，100289

JID innovations : skin science from molecules to population health Pub Date : 2025-08-18 DOI: 10.1016/j.xjidi.2025.100407

Cassandra Mohr , Kaiping Liao , Candice L. Hinkston , Mackenzie R. Wehner , Meng Li

引用次数: 0

Automated Detection of Benign and Malignant Skin Lesions from Reflectance Confocal Microscopy Images Using Deep Learning 利用深度学习从反射共聚焦显微镜图像中自动检测良性和恶性皮肤病变

JID innovations : skin science from molecules to population health Pub Date : 2025-08-08 DOI: 10.1016/j.xjidi.2025.100404

Jesutofunmi A. Omiye , Babar K. Rao , Shazli Razi , Nadiya Chuchvara , Fred M. Baik , Roxana Daneshjou , Lisa C. Zaba

{"title":"Automated Detection of Benign and Malignant Skin Lesions from Reflectance Confocal Microscopy Images Using Deep Learning","authors":"Jesutofunmi A. Omiye , Babar K. Rao , Shazli Razi , Nadiya Chuchvara , Fred M. Baik , Roxana Daneshjou , Lisa C. Zaba","doi":"10.1016/j.xjidi.2025.100404","DOIUrl":"10.1016/j.xjidi.2025.100404","url":null,"abstract":"<div><div>Reflectance confocal microscopy offers a noninvasive approach for diagnosing skin lesions at the point of care, but it remains underutilized owing to the specialized skill required for interpretation. Artificial intelligence provides an opportunity to automate this process. We developed deep learning models to automate the analysis of reflectance confocal microscopy block images. Reflectance confocal microscopy images acquired from 3rd and 4th generation VivaScope 1500 devices were preprocessed and split for training and testing. Two models were developed: a modified convolutional neural network ResNet-18, for skin layer detection, and a ResNet-34 integrated with a gated recurrent unit for lesion classification. The models were pretrained on 3rd generation images and fine tuned on 4th generation data, utilizing 5-fold cross-validation. Our cohort included 845 patients, 1147 lesions, and 4391 VivaBlock images. The layer detection model identified the dermis, epidermis, and dermoepidermal junction, achieving an area under the curve of 0.70, 0.71, and 0.57, respectively. The lesion classification model distinguished malignant from benign lesions with an area under the curve of 0.80 and specificity of 0.91. Our convolutional neural network gated recurrent unit approach effectively distinguished benign from malignant lesions, showing impressive diagnostic accuracy mimicking expert dermatological assessments. This highlights artificial intelligence's potential in improving reflectance confocal microscopy image interpretation, reducing unnecessary biopsies, and paves the way for future research.</div></div>","PeriodicalId":73548,"journal":{"name":"JID innovations : skin science from molecules to population health","volume":"5 6","pages":"Article 100404"},"PeriodicalIF":0.0,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145219078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Circulating CLA+ Memory T Cells in Skin Diseases: A Translational Perspective 循环CLA+记忆T细胞在皮肤病中的作用

JID innovations : skin science from molecules to population health Pub Date : 2025-08-05 DOI: 10.1016/j.xjidi.2025.100403

Tali Czarnowicki , Lea Tordjman , Irene García-Jiménez , Luis F. Santamaria-Babí

引用次数: 0

Superior Antiproliferative and Enhanced Synergistic Effects of a ROCK Inhibitor in Multiple Models for Keloid Disease 一种ROCK抑制剂在多种瘢痕疙瘩疾病模型中具有卓越的抗增殖和增强的协同作用

JID innovations : skin science from molecules to population health Pub Date : 2025-07-30 DOI: 10.1016/j.xjidi.2025.100402

Zeinab Ghasemishahrestani , Traci A. Wilgus , Nonhlanhla P. Khumalo , Ardeshir Bayat

{"title":"Superior Antiproliferative and Enhanced Synergistic Effects of a ROCK Inhibitor in Multiple Models for Keloid Disease","authors":"Zeinab Ghasemishahrestani , Traci A. Wilgus , Nonhlanhla P. Khumalo , Ardeshir Bayat","doi":"10.1016/j.xjidi.2025.100402","DOIUrl":"10.1016/j.xjidi.2025.100402","url":null,"abstract":"<div><div>Keloid disease is a common fibroproliferative skin disorder characterized by excessive scar tissue formation and frequent recurrence. Limited therapies and study models hinder progress in addressing this unmet clinical need. AMA0825, a ROCK (Rho-associated protein kinase) inhibitor, has shown promising antifibrotic and antiproliferative effects in other fibrotic conditions. This study investigated the therapeutic potential of AMA0825 using in vitro, ex vivo, and a 3-dimensional spheroid model of keloid disease, which partially reflects features of the keloid microenvironment. AMA0825 demonstrated potent antiproliferative activity against keloid fibroblasts, with a half-maximal growth inhibitory concentration of 28.19 ± 1.6 nM, significantly outperforming dexamethasone (half-maximal growth inhibitory concentration = 35.35 ± 2.6 μM) and triamcinolone (half-maximal growth inhibitory concentration = 37.84 ± 3 μM). This effect was confirmed by decreased Ki-67 expression and cell cycle arrest at the G1 phase. In the 3-dimensional spheroid model, AMA0825 effectively inhibited cell proliferation at nanomolar concentrations, exceeding the efficacy of dexamethasone. Although AMA0825 did not demonstrate significant antifibrotic activity at lower concentrations, it exhibited antifibrotic effects at higher concentrations. In addition, synergistic effects were observed when combined with dexamethasone. This study highlights the potential of ROCK inhibitors, particularly AMA0825, as an antiproliferative agent for keloid disease and underscores the value of 3-dimensional spheroid models for evaluating alternative therapeutic strategies.</div></div>","PeriodicalId":73548,"journal":{"name":"JID innovations : skin science from molecules to population health","volume":"5 6","pages":"Article 100402"},"PeriodicalIF":0.0,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144925543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0