JID innovations : skin science from molecules to population health最新文献

Development of Human Skin Equivalents with Inducible Ceramide Depletion for In Vitro Modeling of Lipid Impairment 诱导神经酰胺耗竭的人体皮肤等效物的开发用于脂质损伤的体外模型

JID innovations : skin science from molecules to population health Pub Date : 2025-05-14 DOI: 10.1016/j.xjidi.2025.100383

Durotimi O. Dina , Miriam Maiellaro , Emanuela Camera , John T. Connelly

{"title":"Development of Human Skin Equivalents with Inducible Ceramide Depletion for In Vitro Modeling of Lipid Impairment","authors":"Durotimi O. Dina , Miriam Maiellaro , Emanuela Camera , John T. Connelly","doi":"10.1016/j.xjidi.2025.100383","DOIUrl":"10.1016/j.xjidi.2025.100383","url":null,"abstract":"<div><div>The lipid composition of the epidermis plays a critical role in the skin’s barrier function, and defects in lipid synthesis or assembly can cause a spectrum of skin diseases, ranging from dry skin to severe ichthyoses. The aim of this study was to develop an in vitro model of human skin with tunable inhibition of lipid synthesis. Human N/TERT keratinocytes were engineered to express doxycycline-inducible short hairpin RNAs targeting ceramide synthase 3, which is essential for synthesis of ultralong-chain ceramides and skin barrier function. We show that 3-dimensional human skin equivalents with induced knockdown of ceramide synthase 3 display normal stratification and terminal differentiation but have reduced Nile red staining for polar lipids. Further analysis of the lipidome by mass spectrometry confirmed a significant reduction in specific classes of ceramides and ceramide chain length in the ceramide synthase 3–depleted human skin equivalents. We also show that ceramide synthase 3 knockdown is reversible upon removal of doxycycline and can be used to study recovery and repair of epidermal lipids. Together, these findings provide an overall strategy for genetically regulating the lipid composition within human skin models and establish a tunable in vitro model of ceramide deficiency.</div></div>","PeriodicalId":73548,"journal":{"name":"JID innovations : skin science from molecules to population health","volume":"5 4","pages":"Article 100383"},"PeriodicalIF":0.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144190202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Weak Sensitizers May Be Associated with CD80 Polymorphisms: Implications for Systemic Contact Dermatitis 弱致敏剂可能与CD80多态性有关：对系统性接触性皮炎的影响

JID innovations : skin science from molecules to population health Pub Date : 2025-05-09 DOI: 10.1016/j.xjidi.2025.100382

Susan Nedorost , Ge Zhang , Desta Fekedulegn , Kara Fluharty , Wei Wang , Bonnie Frye , Elma Baron , Kathryn Zug , Berran Yucesoy

{"title":"Weak Sensitizers May Be Associated with CD80 Polymorphisms: Implications for Systemic Contact Dermatitis","authors":"Susan Nedorost , Ge Zhang , Desta Fekedulegn , Kara Fluharty , Wei Wang , Bonnie Frye , Elma Baron , Kathryn Zug , Berran Yucesoy","doi":"10.1016/j.xjidi.2025.100382","DOIUrl":"10.1016/j.xjidi.2025.100382","url":null,"abstract":"<div><div>Chronic irritant dermatitis predisposes to Th2 skewed allergic contact dermatitis. Chronic hand dermatitis due to wet work or childhood- onset irritant flexural dermatitis (AD) is associated with sensitization to weak or non-sensitizing antigens as defined by the local lymph node (LLN) assay. In about 15% of these patients, ingestion of allergens results in systemic contact dermatitis, defined as recall dermatitis at previous sites. In this large exploratory study, not even known associations (e.g. IL4R and AD) survived correction for tests of multiple associations. As such, we analyzed for associations using p<0.005 combined with OR >1.8 or <0.5. We found that positive patch tests to weak allergens were common with 3 polymorphisms of CD80. CD80 is a co-stimulatory molecule on several cell types including innate lymphoid group 2 cells (ILC2). ILC2 presentation may bypass education in the local lymph node, explaining the association of antigens classified as non-sensitizers in LLN assay with CD80, and the absence of symptoms of immediate type hypersensitivity in many of these patients. Food handlers with hand dermatitis and patients with atopic dermatitis should be patch tested to allergens in foods (e.g. propylene glycol, vanillin, nickel, cobalt, and chromates) and instructed on dietary restriction of these allergens.</div></div>","PeriodicalId":73548,"journal":{"name":"JID innovations : skin science from molecules to population health","volume":"5 4","pages":"Article 100382"},"PeriodicalIF":0.0,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144190201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tape Strip Profiling of Checkpoint Inhibitor–Associated Dermatitis Highlights Pan-T-Cell Activation: A Pilot Study 检查点抑制剂相关皮炎的条带分析强调泛t细胞激活：一项试点研究

JID innovations : skin science from molecules to population health Pub Date : 2025-05-05 DOI: 10.1016/j.xjidi.2025.100375

Camille M. Powers , Madeline Kim , Annie Chang , Benjamin D. Hu , Brandon R. Block , Austin J. Piontkowski , Jeremy Orloff , Jade N. Young , Yeriel D. Estrada , Digpal S. Gour , Emma Guttman-Yassky , Nicholas Gulati

{"title":"Tape Strip Profiling of Checkpoint Inhibitor–Associated Dermatitis Highlights Pan-T-Cell Activation: A Pilot Study","authors":"Camille M. Powers , Madeline Kim , Annie Chang , Benjamin D. Hu , Brandon R. Block , Austin J. Piontkowski , Jeremy Orloff , Jade N. Young , Yeriel D. Estrada , Digpal S. Gour , Emma Guttman-Yassky , Nicholas Gulati","doi":"10.1016/j.xjidi.2025.100375","DOIUrl":"10.1016/j.xjidi.2025.100375","url":null,"abstract":"<div><div>Immune checkpoint inhibitors (ICIs) have become mainstay therapy in the treatment of certain cancers. However, they are frequently associated with adverse effects in nontumor tissues. Cutaneous immune-related adverse events are the most prevalent toxicities, yet their underlying mechanisms remain poorly understood. This pilot study investigated the molecular phenotype of ICI-associated eczematous dermatitis and ICI–associated lichen planus using minimally invasive tape strip sampling to compare these conditions with patients with atopic dermatitis and healthy controls. Transcriptomic analysis revealed significant T helper 1 upregulation in lesional ICI-associated eczematous dermatitis and ICI–associated lichen planus, surpassing the dysregulation seen in atopic dermatitis. T helper 2–related markers, including <em>IL4R</em>, were elevated in both ICI subtypes, aligning with prior clinical reports of dupilumab efficacy for cutaneous immune-related adverse events. Notably, <em>J</em><em>AK</em><em>3</em> modulation was uniquely observed in lesional ICI-associated eczematous dermatitis. Lesional and nonlesional ICI–associated lichen planus demonstrated broad immune dysregulation, suggesting possible early inflammatory activity in seemingly unaffected skin. These findings highlight distinct immune pathway alterations in cutaneous immune-related adverse events compared with their ICI-independent counterparts, shedding light on potential therapeutic targets to manage these conditions without compromising ICI efficacy. Future studies in larger cohorts are warranted to validate these observations and evaluate targeted interventions for cutaneous immune-related adverse events.</div></div>","PeriodicalId":73548,"journal":{"name":"JID innovations : skin science from molecules to population health","volume":"5 4","pages":"Article 100375"},"PeriodicalIF":0.0,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144166580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of Skin Dysbiosis and Quorum Sensing in Atopic Dermatitis 皮肤生态失调和群体感应在特应性皮炎中的作用

JID innovations : skin science from molecules to population health Pub Date : 2025-05-04 DOI: 10.1016/j.xjidi.2025.100377

Hiroki Okamoto , Shuo Li , Yuumi Nakamura

引用次数: 0

Insights into Keratinocyte and Immunologic Landscape in Cutaneous Graft-Versus-Host Disease through Single-Cell Transcriptomics 通过单细胞转录组学研究皮肤移植物抗宿主病的角化细胞和免疫景观

JID innovations : skin science from molecules to population health Pub Date : 2025-04-25 DOI: 10.1016/j.xjidi.2025.100373

Amy J. Petty , Adela Rambi Cardones , Yingai Jane Jin , Vaibhav Jain , Emily Hocke , Harsh B. Pathak , Amrita Mitra , Simon G. Gregory , M. Angelica Selim , Jennifer Y. Zhang

{"title":"Insights into Keratinocyte and Immunologic Landscape in Cutaneous Graft-Versus-Host Disease through Single-Cell Transcriptomics","authors":"Amy J. Petty , Adela Rambi Cardones , Yingai Jane Jin , Vaibhav Jain , Emily Hocke , Harsh B. Pathak , Amrita Mitra , Simon G. Gregory , M. Angelica Selim , Jennifer Y. Zhang","doi":"10.1016/j.xjidi.2025.100373","DOIUrl":"10.1016/j.xjidi.2025.100373","url":null,"abstract":"<div><div>Cutaneous manifestations are the most common presenting sign of chronic graft-versus-host disease (GVHD), and the extent of cutaneous involvement is also highly correlated with prognosis. Very little is understood about the underlying pathogenesis underpinning injury at this location, especially the contribution of keratinocytes and other structural skin cells. We performed single-cell RNA sequencing to compare the transcriptome of epidermal and dermal chronic GVHD samples with that of healthy control samples. Our findings reveal unique nonimmunologic and immunologic changes in epidermal keratinocytes and dermal immune cells. Specifically, we observed upregulation of alarmins and inflammatory cytokines and downregulation of anti-reduction–oxidation and activator protein-1 pathway genes in the keratinocyte compartments. In dermal immune cell subsets, we showed increased CD8<sup>+</sup> T, CD4<sup>+</sup> T, CD4<sup>+</sup>Foxp3<sup>+</sup> regulatory T, and NK cells in chronic GVHD, accompanied by increased signals of leukocyte functions, inflammatory responses, cytolysis, and macrophage M1 polarization. Finally, we also delineated the donor versus recipient cellular origin of nonimmune and immune cell populations in sex-mismatched chronic GVHD. Taken together, these data reveal complex keratinocyte and immune responses in cutaneous chronic GVHD, supporting future studies of skin cell contributions to pathogenesis and potential local treatment strategies.</div></div>","PeriodicalId":73548,"journal":{"name":"JID innovations : skin science from molecules to population health","volume":"5 4","pages":"Article 100373"},"PeriodicalIF":0.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144083942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Actinic Keratosis as a Risk Factor for Subsequent Nonskin Cancer Risk 光化性角化病作为继发非皮肤癌危险因素的评价

JID innovations : skin science from molecules to population health Pub Date : 2025-04-22 DOI: 10.1016/j.xjidi.2025.100374

Alexander R. Gomez-Lara , Christopher D. George , Chen Jiang , Jie Yin , Yuhree Kim , Charles P. Quesenberry , Eric Jorgenson , Shabnam Madani , Maryam M. Asgari , Hélène Choquet

{"title":"Evaluation of Actinic Keratosis as a Risk Factor for Subsequent Nonskin Cancer Risk","authors":"Alexander R. Gomez-Lara , Christopher D. George , Chen Jiang , Jie Yin , Yuhree Kim , Charles P. Quesenberry , Eric Jorgenson , Shabnam Madani , Maryam M. Asgari , Hélène Choquet","doi":"10.1016/j.xjidi.2025.100374","DOIUrl":"10.1016/j.xjidi.2025.100374","url":null,"abstract":"<div><div>Actinic keratosis (AK) is a precancerous lesion that develops on chronically sun-exposed skin. Immunosuppression is known to increase the risk of both AK and other cancers, highlighting the need to evaluate potential associations between AK and subsequent nonskin cancers. To determine whether a diagnosis of AK is associated with an increased subsequent incident of nonskin cancers, we conducted a retrospective case-control study within a large integrated healthcare delivery system. The study included 53,778 patients with AK and 152,896 controls without prior cancer diagnoses at enrollment. AK was more prevalent in males (30.7 vs 23.5% in females). AK was not associated with increased risk of overall nonskin cancers after adjusting for demographic (age, sex), clinical (body mass index, immunosuppression history), behavioral (smoking, alcohol use), and healthcare utilization factors (adjusted hazard ratio = 0.99, 95% confidence interval = 0.95–1.02). However, significant associations were observed between AK and breast (adjusted hazard ratio = 1.11, 95% confidence interval = 1.03–1.19) and prostate (adjusted hazard ratio =1.14, 95% confidence interval = 1.03–1.26) cancers. This large study reveals that AK may be a predictor of risk for subsequent cancers, notably breast and prostate cancers. These findings emphasize the need for increased surveillance for these cancer types in individuals with AK.</div></div>","PeriodicalId":73548,"journal":{"name":"JID innovations : skin science from molecules to population health","volume":"5 4","pages":"Article 100374"},"PeriodicalIF":0.0,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143923032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SUB6 Subtilisin is Involved During the Initial Adhesion of Trichophyton benhamiae and T. mentagrophytes onto Reconstructed Human Epidermis SUB6枯草菌素参与了benhami毛藻和T. mentagrophytes在重建的人表皮上的初始粘附

JID innovations : skin science from molecules to population health Pub Date : 2025-04-11 DOI: 10.1016/j.xjidi.2025.100370

Émilie Faway , Wilfried Poirier , Tsuyoshi Yamada , Kiyotaka Ozawa , Michel Monod , Bernard Mignon , Yves Poumay

{"title":"SUB6 Subtilisin is Involved During the Initial Adhesion of Trichophyton benhamiae and T. mentagrophytes onto Reconstructed Human Epidermis","authors":"Émilie Faway , Wilfried Poirier , Tsuyoshi Yamada , Kiyotaka Ozawa , Michel Monod , Bernard Mignon , Yves Poumay","doi":"10.1016/j.xjidi.2025.100370","DOIUrl":"10.1016/j.xjidi.2025.100370","url":null,"abstract":"<div><div>The growing incidence of dermatophytoses and the emergence of strains resistant to available antifungal agents raise the need for a better understanding of the virulence mechanisms of dermatophytes to identify new therapeutic targets. The proteases of the subtilisin family have previously been highlighted as potential virulence factors for dermatophytes, in particular the protease SUB6, which was first discovered to be an allergen capable of inducing immediate and delayed hypersensitivity skin reactions. Moreover, <em>SUB6</em> expression and SUB6 protein production were detected during experimental and natural skin infections with several dermatophyte species. In this study, we specifically investigated the importance of SUB6 during <em>Trichophyton benhamiae</em> and <em>T</em><em>.</em> <em>mentagrophytes</em> dermatophytosis in a reconstructed human epidermis model by comparing parental strains with genetically engineered ones deleted (Δ<em>SUB6</em>) or complemented for the SUB6-encoding gene. Thereby, a role for SUB6 has been identified in the initial steps of adhesion to the host epidermal surface. However, the Δ<em>SUB6</em> strains were able to finally invade the reconstructed human epidermis, suggesting that SUB6 is a robust fungal marker of infection but not an essential virulence factor.</div></div>","PeriodicalId":73548,"journal":{"name":"JID innovations : skin science from molecules to population health","volume":"5 4","pages":"Article 100370"},"PeriodicalIF":0.0,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143902561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Wnt Signaling in Male Genital Lichen Sclerosus, Differentiated Penile Intraepithelial Neoplasia, and Penile Squamous Cell Carcinoma Wnt信号在男性生殖器硬化地衣、分化性阴茎上皮内瘤变和阴茎鳞状细胞癌中的作用

JID innovations : skin science from molecules to population health Pub Date : 2025-04-11 DOI: 10.1016/j.xjidi.2025.100372

Georgios Kravvas , Boyu Xie , Michael Millar , Alex Freeman , Aiman Haider , Hussain M. Alnajjar , Asif Muneer , Aamir Ahmed , Christopher Barry Bunker

{"title":"Wnt Signaling in Male Genital Lichen Sclerosus, Differentiated Penile Intraepithelial Neoplasia, and Penile Squamous Cell Carcinoma","authors":"Georgios Kravvas , Boyu Xie , Michael Millar , Alex Freeman , Aiman Haider , Hussain M. Alnajjar , Asif Muneer , Aamir Ahmed , Christopher Barry Bunker","doi":"10.1016/j.xjidi.2025.100372","DOIUrl":"10.1016/j.xjidi.2025.100372","url":null,"abstract":"<div><h3>Introduction</h3><div>Male genital lichen sclerosus (MGLSc) is a chronic inflammatory disease causing scarring and significant morbidity, and predisposing individuals to differentiated penile intraepithelial neoplasia (dPeIN) and penile squamous cell carcinoma (PeSCC). Penile carcinogenesis follows two pathways: HPV-related and non-HPV-related. While HPV drives undifferentiated PeIN and warty/basaloid PeSCC, MGLSc is implicated in non-HPV-related dPeIN and \"usual\" PeSCC. Wnt signalling, pivotal in carcinogenesis, remains underexplored in MGLSc and PeIN.</div></div><div><h3>Methods</h3><div>Tissue arrays from 114 archival samples of MGLSc, dPeIN, and PeSCC were analyzed using multi-label fluorescence staining and confocal microscopy for Wnt4, cyclin D1, c-MYC, and MMP7 expression.</div></div><div><h3>Results</h3><div>Wnt signalling proteins were upregulated in PeSCC: cyclin D1 (2.3-fold), Wnt4 (2-fold), c-MYC (2.5-fold), and MMP7 (1.8-fold). Wnt4 expression increased in MGLSc (p=0.02), while dPeIN showed minimal changes. Altered co-localization of Wnt4/MMP7 (p=0.04) was observed in MGLSc and significant co-localization alterations of several protein pairs were also identified in PeSCC.</div></div><div><h3>Conclusion</h3><div>Wnt signalling plays a role in progression from MGLSc to PeSCC through protein dysregulation. Overexpression and altered interactions in PeSCC highlight its potential as a diagnostic, prognostic, and therapeutic target.</div></div>","PeriodicalId":73548,"journal":{"name":"JID innovations : skin science from molecules to population health","volume":"5 4","pages":"Article 100372"},"PeriodicalIF":0.0,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143942202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Skin & Digital: The 2024 Startups Skin & Digital: 2024年创业公司

JID innovations : skin science from molecules to population health Pub Date : 2025-04-10 DOI: 10.1016/j.xjidi.2025.100371

Dominique du Crest , Annelies Avermaete , Estella Benz , Olga Afanasiev , Hassan Galadari , Alfonso Medela , Eleanor Jones , Dina Sidani , Alexander Zink , Merete Hædersdal , Lilit Garibyan

引用次数: 0

Outcome Measures in Dystrophic Calcinosis Cutis: A Systematic Review 营养不良性皮肤钙质沉着症的疗效评价：系统综述

JID innovations : skin science from molecules to population health Pub Date : 2025-04-03 DOI: 10.1016/j.xjidi.2025.100368

Jennifer Foster , Leslie Guerrero , Benjamin F. Chong

{"title":"Outcome Measures in Dystrophic Calcinosis Cutis: A Systematic Review","authors":"Jennifer Foster , Leslie Guerrero , Benjamin F. Chong","doi":"10.1016/j.xjidi.2025.100368","DOIUrl":"10.1016/j.xjidi.2025.100368","url":null,"abstract":"<div><h3>Background</h3><div>Calcinosis cutis is a skin condition characterized by calcium salt deposition in the skin and subcutaneous tissues, significantly affecting patients' QOL. Owing to its rarity and lack of standardized outcome measures, there are no approved medications.</div></div><div><h3>Objective</h3><div>This systematic review aims to summarize clinically relevant outcome measures used to assess dystrophic calcinosis cutis.</div></div><div><h3>Methods</h3><div>A systematic literature search was conducted in Medline, Embase, and Web of Science. Studies were included if they reported clinical outcomes assessing dystrophic calcinosis cutis. Data extraction and risk of bias assessment were performed independently by 2 researchers using standardized tools.</div></div><div><h3>Results</h3><div>Twenty-six studies met inclusion criteria, with the majority being retrospective observational studies. Commonly used outcome measures included clinician-reported measures (73.1%), imaging (50.0%), and patient-reported outcomes (42.3%). Radiographs were the most frequently used imaging modality. No consistent outcome measures were identified across studies.</div></div><div><h3>Conclusion</h3><div>There is a lack of standardized outcome measures for dystrophic calcinosis cutis, impeding treatment development. Incorporating patient-reported outcomes is crucial for assessing treatment impact on QOL in this refractory condition. To promote new therapeutics for calcinosis cutis, objective outcome measures, such as imaging, need to be developed and prospectively validated in patients with calcinosis cutis.</div></div>","PeriodicalId":73548,"journal":{"name":"JID innovations : skin science from molecules to population health","volume":"5 4","pages":"Article 100368"},"PeriodicalIF":0.0,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143907749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0