JID innovations : skin science from molecules to population health最新文献

{"title":"Temporal outcomes and biomarkers of rituximab treatment response in pemphigus: Validation of a historical control dataset","authors":"Chuda Rujitharanawong, Sasima Tongsai, Aimee S. Payne","doi":"10.1016/j.xjidi.2026.100510","DOIUrl":"10.1016/j.xjidi.2026.100510","url":null,"abstract":"<div><div>Rituximab and corticosteroids remain the only clinically approved therapies for pemphigus vulgaris, although novel therapeutics are entering clinical development. A historical control dataset previously described clinical and serologic outcomes after rituximab therapy in pemphigus vulgaris, but whether these data are representative of other patient cohorts is currently unclear. A contemporary pemphigus vulgaris cohort (n = 97) was compared with the historical cohort (n = 107) to assess clinical outcomes as well as desmoglein 3 ELISA predictive performance for achieving complete remission off oral immunosuppressive therapy. A total of 41.2% of patients achieved complete remission off oral immunosuppressive therapy after the first rituximab cycle, with a maximum complete remission off oral immunosuppressive therapy prevalence of 52.8% at month 36, including multiple rituximab cycles. Despite differences in baseline characteristics and treatments (particularly rituximab dosing), the temporal patterns of remission, relapse, and retreatment were broadly similar across cohorts. A desmoglein 3 ELISA index value ≤ 130 RU/ml and > 90.7% titer reduction between months 3 and 9 demonstrated 90% specificity and 88% sensitivity for future achievement of complete remission off oral immunosuppressive therapy, with negative predictive values of 85% and 92%, respectively, suggesting that low and/or rapid large drops in autoantibody titers after rituximab may predict an absence of disease activity. These data describe the temporal outcomes of rituximab therapy in pemphigus vulgaris and validate the historical control dataset for future comparative effectiveness research and biomarker-driven management.</div></div><div>Rituximab and corticosteroids remain the only clinically approved therapies for pemphigus vulgaris, although novel therapeutics are entering clinical development. A historical control dataset previously described clinical and serologic outcomes after rituximab therapy in pemphigus vulgaris, but whether these data are representative of other patient cohorts is currently unclear. A contemporary pemphigus vulgaris cohort (n = 97) was compared with the historical cohort (n = 107) to assess clinical outcomes as well as desmoglein 3 ELISA predictive performance for achieving complete remission off oral immunosuppressive therapy. A total of 41.2% of patients achieved complete remission off oral immunosuppressive therapy after the first rituximab cycle, with a maximum complete remission off oral immunosuppressive therapy prevalence of 52.8% at month 36, including multiple rituximab cycles. Despite differences in baseline characteristics and treatments (particularly rituximab dosing), the temporal patterns of remission, relapse, and retreatment were broadly similar across cohorts. A desmoglein 3 ELISA index value ≤ 130 RU/ml and > 90.7% titer reduction between months 3 and 9 demonstrated 90% specificity and 88% sensitivity for future achievemen","PeriodicalId":73548,"journal":{"name":"JID innovations : skin science from molecules to population health","volume":"6 5","pages":"Article 100510"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149051164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cover","authors":"","doi":"10.1016/S2667-0267(26)00092-5","DOIUrl":"10.1016/S2667-0267(26)00092-5","url":null,"abstract":"","PeriodicalId":73548,"journal":{"name":"JID innovations : skin science from molecules to population health","volume":"6 5","pages":"Article 100537"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149051162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complete remission after rituximab therapy of pemphigus: Real-world evidence on dosing regimens and retreatment strategies","authors":"Chuda Rujitharanawong,&nbsp;Sasima Tongsai,&nbsp;Aimee S. Payne","doi":"10.1016/j.xjidi.2026.100508","DOIUrl":"10.1016/j.xjidi.2026.100508","url":null,"abstract":"<div><div>Although rituximab is clinically approved for pemphigus, real-world data on predictors of treatment success and optimal dosing remain limited. We conducted a retrospective cohort study of patients with pemphigus treated with rituximab with ≥1 year of follow-up at NewYork-Presbyterian Hospital. Patients initially received two 1000 mg doses 2 weeks apart or 4 weekly weight-adjusted (375 mg/m²) infusions. Factors associated with complete remission (CR) off oral immunosuppressive therapy were analyzed using Kaplan–Meier and Cox proportional hazards analyses. Among 105 patients, 44.7% achieved CR off therapy after the first rituximab cycle, increasing to 74.3% after multiple cycles, with a median time to remission of 7.4 months. Weight-adjusted rituximab dosing was associated with a higher likelihood of achieving CR off oral immunosuppressive therapy after the first rituximab cycle than the fixed-dose regimen (hazard ratio = 2.49, <em>P</em> = .01). For subsequent treatment, maintenance rituximab infusions every 6 months were associated with a shorter time to initial achievement of CR off therapy and a longer time to relapse than an on-demand approach; however, both achieved similar overall rates of CR off therapy. These findings support the benefit of weight-adjusted dosing for the first rituximab cycle and provide real-world data on outcomes of maintenance versus on-demand rituximab infusions for pemphigus therapy.</div></div><div>Although rituximab is clinically approved for pemphigus, real-world data on predictors of treatment success and optimal dosing remain limited. We conducted a retrospective cohort study of patients with pemphigus treated with rituximab with ≥1 year of follow-up at NewYork-Presbyterian Hospital. Patients initially received two 1000 mg doses 2 weeks apart or 4 weekly weight-adjusted (375 mg/m²) infusions. Factors associated with complete remission (CR) off oral immunosuppressive therapy were analyzed using Kaplan–Meier and Cox proportional hazards analyses. Among 105 patients, 44.7% achieved CR off therapy after the first rituximab cycle, increasing to 74.3% after multiple cycles, with a median time to remission of 7.4 months. Weight-adjusted rituximab dosing was associated with a higher likelihood of achieving CR off oral immunosuppressive therapy after the first rituximab cycle than the fixed-dose regimen (hazard ratio = 2.49, <em>P</em> = .01). For subsequent treatment, maintenance rituximab infusions every 6 months were associated with a shorter time to initial achievement of CR off therapy and a longer time to relapse than an on-demand approach; however, both achieved similar overall rates of CR off therapy. These findings support the benefit of weight-adjusted dosing for the first rituximab cycle and provide real-world data on outcomes of maintenance versus on-demand rituximab infusions for pemphigus therapy.</div>","PeriodicalId":73548,"journal":{"name":"JID innovations : skin science from molecules to population health","volume":"6 5","pages":"Article 100508"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149051163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Imaging transcriptomics in basal cell carcinoma: Coupling in vivo tumor morphology with gene expression","authors":"Kevin Jacobsen,&nbsp;Olivia Luxford Meyer,&nbsp;Stine Bøttcher Jacobsen,&nbsp;Vinzent Kevin Ortner,&nbsp;Silje Haukali Omland,&nbsp;Katrine Elisabeth Karmisholt,&nbsp;Martin Glud,&nbsp;Stine Regin Wiegell,&nbsp;Aditi Sahu,&nbsp;Cyril Maliakal,&nbsp;Niels Morling,&nbsp;Peter Alshede Philipsen,&nbsp;Jeppe Dyrberg Andersen,&nbsp;Merete Haedersdal","doi":"10.1016/j.xjidi.2026.100519","DOIUrl":"10.1016/j.xjidi.2026.100519","url":null,"abstract":"&lt;div&gt;&lt;div&gt;Combining spatial and molecular information enhances understanding of skin cancer biology. In this exploratory study, we investigated such associations in basal cell carcinoma (BCC) using 2 non-invasive approaches: line-field confocal optical coherence tomography (LC-OCT) to assess tumor morphology and tape stripping for gene expression profiling. With development, this combined image-transcriptomic approach could contribute to understanding of BCC pathogenesis in vivo. Histology-confirmed BCCs (n = 53) and control skin were scanned with LC-OCT for 44 morphological features and sampled via tape stripping for mRNA analysis. Differentially expressed genes were identified and examined through pathway-enrichment to uncover mechanisms. Seven LC-OCT image-features were associated with BCC compared with control skin (&lt;em&gt;P&lt;/em&gt; ≤ .004). Seventy-two differentially expressed genes were identified in BCC (false discovery rate &lt;0.001). A subset of 27 differentially expressed genes correlated with 2 LC-OCT features—the millefeuille pattern and collagen alterations—showing a 3.9 - to 11.8-fold increase in gene expression levels. Pathway-enrichment analysis highlighted BCL2A1, linked to tumorigenesis, in association with the millefeuille pattern, and FMO2, involved in collagen synthesis, with collagen alterations. This imaging–transcriptomic approach confirms the feasibility of tape stripping for detecting BCC-specific gene expression and introduces LC-OCT-based imaging transcriptomics, for investigating BCC pathobiology in vivo.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;Combining spatial and molecular information enhances understanding of skin cancer biology. In this exploratory study, we investigated such associations in basal cell carcinoma (BCC) using 2 non-invasive approaches: line-field confocal optical coherence tomography (LC-OCT) to assess tumor morphology and tape stripping for gene expression profiling. With development, this combined image-transcriptomic approach could contribute to understanding of BCC pathogenesis in vivo. Histology-confirmed BCCs (n = 53) and control skin were scanned with LC-OCT for 44 morphological features and sampled via tape stripping for mRNA analysis. Differentially expressed genes were identified and examined through pathway-enrichment to uncover mechanisms. Seven LC-OCT image-features were associated with BCC compared with control skin (&lt;em&gt;P&lt;/em&gt; ≤ .004). Seventy-two differentially expressed genes were identified in BCC (false discovery rate &lt;0.001). A subset of 27 differentially expressed genes correlated with 2 LC-OCT features—the millefeuille pattern and collagen alterations—showing a 3.9 - to 11.8-fold increase in gene expression levels. Pathway-enrichment analysis highlighted BCL2A1, linked to tumorigenesis, in association with the millefeuille pattern, and FMO2, involved in collagen synthesis, with collagen alterations. This imaging–transcriptomic approach confirms the feasibility of tape stripping for detecting BCC-specif","PeriodicalId":73548,"journal":{"name":"JID innovations : skin science from molecules to population health","volume":"6 5","pages":"Article 100519"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148951064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Demographic factors associated with skin barrier function in a large population-based study","authors":"Katrina Abuabara,&nbsp;Benjamin Stroebel,&nbsp;Shreya Sreekantaswamy,&nbsp;Richard W. Kim,&nbsp;Linda Zukley,&nbsp;Noreen Karim,&nbsp;Robert H. Rice,&nbsp;Blythe P. Durbin-Johnson,&nbsp;David M. Rocke,&nbsp;Theodora Mauro","doi":"10.1016/j.xjidi.2026.100480","DOIUrl":"10.1016/j.xjidi.2026.100480","url":null,"abstract":"<div><div>The skin plays a vital role in homeostasis, but there are conflicting data on skin barrier function–associated factors. We evaluated the relationship between participant characteristics and barrier function measures (baseline transepidermal water loss, barrier integrity [number of tape strips required to increase transepidermal water loss by 4 times baseline], dynamic barrier function [area under the curve of number of tape strips plotted against repeated transepidermal water loss measurements], and barrier recovery [percentage recovery in transepidermal water loss 24 hours after tape stripping]) in 286 participants aged 32–97 years in the Baltimore Longitudinal Study of Aging cohort. Multivariable analysis indicated that older age, female sex, Black race, and higher body mass index were associated with at least 1 measure of better barrier function: older age was associated with better dynamic barrier function (beta = −0.071, <em>P</em> = .035) and baseline barrier permeability (beta = −0.045, <em>P</em> = .018), female participants had better dynamic barrier function (beta = −2.028, <em>P</em> = .010) and barrier recovery (beta = 13.216, <em>P</em> = .001), Black participants also had better dynamic barrier function (beta = −2.956, <em>P</em> = .006) and barrier integrity (beta = 6.794, <em>P</em> &lt; .001), and higher body mass index was associated with better barrier integrity (beta = 0.289, <em>P</em> = .033). Subanalysis of protein expression from tape strips among 20 participants showed that protein families linked to barrier composition and insult response were higher among participants with above-median barrier function and below-median C-reactive protein (<em>P</em> &lt; .01).</div></div>","PeriodicalId":73548,"journal":{"name":"JID innovations : skin science from molecules to population health","volume":"6 4","pages":"Article 100480"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148565612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-throughput, multiplex immunofluorescence for the computer-automated immunophenotyping of Mycosis Fungoides","authors":"Patrick McMullan,&nbsp;Marc R. Benoit,&nbsp;Nathan Gasek,&nbsp;Sydney Riddick,&nbsp;Joseph Masison,&nbsp;Katalin Ferenczi,&nbsp;David Rowe,&nbsp;Gillian Weston","doi":"10.1016/j.xjidi.2026.100494","DOIUrl":"10.1016/j.xjidi.2026.100494","url":null,"abstract":"<div><div>The diagnosis of mycosis fungoides is difficult and often delayed, exacerbated by the limitation of conventional immunohistochemistry to analyze only 1 antigen per tissue section, often necessitating repeat biopsies and extensive workups. We sought to validate a high-throughput multiplex immunofluorescence method, coupled with computer-automated image analysis, to generate comprehensive immunophenotyping data from a single formalin-fixed, paraffin-embedded biopsy. We applied an 11-biomarker multiplex immunofluorescence panel across 18 archived skin specimens (9 mycosis fungoides/TCR clonality positive and 9 control/TCR clonality negative). Initial validation confirmed that multiplex immunofluorescence antigen expression and spatial localization were concordant with those of sequential immunohistochemistry-stained sections. Whole-slide image stacks were analyzed using both computer-assisted and computer-automated pipelines. Both methods successfully delineated immunophenotypic differences. Mycosis fungoides specimens showed a significant expansion of hematopoietic cells, atypical T-lymphocytes, and proliferative T-lymphocytes when compared with controls. Our results validate the potential of multiplex immunofluorescence to obtain comprehensive, high-dimensional diagnostic information from a single tissue section. Integration with computer-automated analysis offers a scalable, high-throughput platform that can significantly aid in the timely and accurate diagnosis of cutaneous lymphomas.</div></div>","PeriodicalId":73548,"journal":{"name":"JID innovations : skin science from molecules to population health","volume":"6 4","pages":"Article 100494"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13330524/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148392664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cover","authors":"","doi":"10.1016/S2667-0267(26)00069-X","DOIUrl":"10.1016/S2667-0267(26)00069-X","url":null,"abstract":"","PeriodicalId":73548,"journal":{"name":"JID innovations : skin science from molecules to population health","volume":"6 4","pages":"Article 100515"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148634711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occupational epidemiology of acral lentiginous melanoma","authors":"Lily Guo,&nbsp;Robin Kikuchi,&nbsp;April W. Armstrong,&nbsp;Suephy C. Chen","doi":"10.1016/j.xjidi.2026.100473","DOIUrl":"10.1016/j.xjidi.2026.100473","url":null,"abstract":"<div><div>Acral lentiginous melanoma (ALM) classically presents in glabrous skin. Some studies suggest an association between mechanical stress and ALM development. People working jobs with long periods of standing/walking may be exposed to near-daily mechanical stress. To investigate the relationship between occupation type and ALM development<em>,</em> we performed a retrospective cohort study using Optum’s Clinformatics Database (2007–2023). We compared the risk of ALM in adults with occupational data (n = 9,270,935). Retired patients had the highest prevalence (0.081) and incidence per 1,000,000 person-years (0.514, 95% confidence interval = 0.487–0.542) of ALM. We performed multivariate logistic regression, adjusted for demographics and insurance, and stratified by age. In patient aged &lt;65 years, homemaker patients had 55.2% increased risk of ALM (<em>P</em> &lt; .001). In patients aged ≥65 years, retired patients had 17% increased risk of ALM (<em>P</em> &lt; .001). Our findings suggest that homemaker and retired patients are at highest risk of ALM, possibly owing to increased mechanical stress on the palmoplantar surfaces associated with work around the home in homemakers. Occupation-related mechanical stress may play a role in the retired population as well, although the previous occupation of retired patients is unreported. Future directions include exploring prior occupations in the retired population.</div></div>","PeriodicalId":73548,"journal":{"name":"JID innovations : skin science from molecules to population health","volume":"6 4","pages":"Article 100473"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13316556/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148364245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From pixels to pimples","authors":"Maurice van Steensel","doi":"10.1016/j.xjidi.2026.100503","DOIUrl":"10.1016/j.xjidi.2026.100503","url":null,"abstract":"","PeriodicalId":73548,"journal":{"name":"JID innovations : skin science from molecules to population health","volume":"6 4","pages":"Article 100503"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148565611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Activation of MyD88/IRAK1 axis and downstream proinflammatory signaling in healthy adult and neonatal African American skin","authors":"Dimitri Trubetskoy,&nbsp;Patrick K. Grudzien,&nbsp;Anna Klopot,&nbsp;Lam C. Tsoi,&nbsp;Roopal V. Kundu,&nbsp;Bethany E. Perez White,&nbsp;Irina Budunova","doi":"10.1016/j.xjidi.2026.100488","DOIUrl":"10.1016/j.xjidi.2026.100488","url":null,"abstract":"<div><div>The increased prevalence of inflammatory skin diseases such as atopic dermatitis, hidradenitis suppurativa, acne, lupus erythematosus in African American (AA) compared to White Non-Hispanic population is well recognized. However, the underlying mechanisms are largely unknown. Here we analyzed proteome in healthy skin biopsies from AA and White Non-Hispanic volunteers using Olink Explore 384 Inflammation biomarker panel. Among proteins with higher expression in AA skin were IRAK1, IL1A, IL4, IL22RA1. It is known that IL1A binding to IL1R1 receptor results in recruitment of signaling adapter MyD88 and IL1R1-associated kinases including IRAK1, a key signal transducer involved in activation of downstream NF-κB and MAPK signaling cascades. We confirmed the increased IRAK1 expression as well as activation of NF-κB and extracellular signal–regulated kinase1/2 signaling in both AA adult and neonatal skin by western blot analysis of relevant proteins (p65/RelA, IKKs, IκBα, extracellular signal–regulated kinase1/2) phosphorylation at specific activating sites. We also confirmed the overexpression of previously reported differentially expressed in AA skin pro-inflammatory genes such as IL1A, TNFα, fold change ER1G in our sets of AA healthy adult and neonatal skin using qRT-PCR. Overall, our study suggests the importance of further analysis of molecular landscape of healthy AA skin to assess how it may contribute to the increased risk of certain inflammatory diseases within the AA population.</div></div>","PeriodicalId":73548,"journal":{"name":"JID innovations : skin science from molecules to population health","volume":"6 4","pages":"Article 100488"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13285840/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148310762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}