Stimulation of Skin Pigmentation with UVR Is a Risk Factor for Cholelithiasis

Stanislav Pavel , Patrick A. Riley
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Abstract

Long-term clinical experience suggested that skin fairness is one of the risk factors for developing cholelithiasis. However, it was unclear how to connect skin color with the development of gallstones. The discovery of reactive melanin precursors resulted in the hypothesis that some of these compounds could be excreted via bile and form the basis of gallstones. There are indications that the excretion of these compounds from melanocytes is higher in individuals with less pigmented skin who were irradiated by UV radiation. A clinical study revealed that people with fair skin who like sunbathing run a very high risk of developing cholelithiasis. We also present several studies that report a significant increase in cholelithiasis among psoriasis patients. Most gallstones remain asymptomatic. However, some patients may develop symptoms shortly after the gallstones are formed. We cite several investigations that found the highest frequency of cholecystectomies and cases of acute pancreatitis in the summer and the lowest in the winter. We propose that skin fairness should be considered a real risk factor for cholelithiasis, but only in combination with UV stimulation of cutaneous pigmentation. In this review, we discuss the laboratory and clinical work that can be connected to this hypothesis.
紫外线照射刺激皮肤色素沉着是胆石症的危险因素
长期临床经验提示,皮肤白皙度是发生胆石症的危险因素之一。然而,如何将肤色与胆结石的发展联系起来还不清楚。活性黑色素前体的发现导致了一种假设,即这些化合物中的一些可以通过胆汁排出并形成胆结石的基础。有迹象表明,在受到紫外线照射的皮肤色素较少的个体中,这些化合物从黑素细胞中排出的量更高。一项临床研究表明,喜欢日光浴的白皙皮肤的人患胆石症的风险非常高。我们还报告了几项研究,报告了银屑病患者胆石症的显著增加。大多数胆结石没有症状。然而,有些病人可能在胆结石形成后不久就出现症状。我们引用了几项调查,发现夏季胆囊切除术和急性胰腺炎的发生率最高,而冬季最低。我们建议,皮肤白皙应该被认为是胆石症的一个真正的危险因素,但只有在紫外线刺激皮肤色素沉着的情况下。在这篇综述中,我们讨论了与这一假设相关的实验室和临床工作。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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CiteScore
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