JID innovations : skin science from molecules to population health最新文献_第2页

Immunoregulatory Microenvironment in the Elderly Skin 老年皮肤的免疫调节微环境

JID innovations : skin science from molecules to population health Pub Date : 2025-07-22 DOI: 10.1016/j.xjidi.2025.100401

Yuri Shimizu , Hanako Koguchi-Yoshioka , Toshiki Kubo , Yutaka Matsumura , Shoichi Matsuda , Atsushi Tanemura , Michiko Nomori , Naoya Otani , Mifue Taminato , Koichi Tomita , Tateki Kubo , Manabu Fujimoto , Rei Watanabe

{"title":"Immunoregulatory Microenvironment in the Elderly Skin","authors":"Yuri Shimizu , Hanako Koguchi-Yoshioka , Toshiki Kubo , Yutaka Matsumura , Shoichi Matsuda , Atsushi Tanemura , Michiko Nomori , Naoya Otani , Mifue Taminato , Koichi Tomita , Tateki Kubo , Manabu Fujimoto , Rei Watanabe","doi":"10.1016/j.xjidi.2025.100401","DOIUrl":"10.1016/j.xjidi.2025.100401","url":null,"abstract":"<div><div>Previous studies have revealed that skin T cells accumulate and maintain immune responses in the elderly. However, we questioned why these functional T cells fail to recognize and eliminate malignant cells, making elderly skin more prone to developing malignant tumors. To address this question, we examined the overall skin microenvironment in aging using the Nanostring nCounter system and 10x Xenium digital spatial RNA sequencing. The digital RNA counts of <em>CIITA</em> and <em>HLA-DMA</em>, which are involved in antigen presentation, were negatively correlated with age, whereas the counts of <em>UBE2L3</em> and <em>SOCS1</em>, molecules that play roles in immune regulation, were positively correlated with aging. The upregulation of <em>SOCS1</em> was detected in the microenvironment of the skin malignant tumors. Spatial transcriptome analysis revealed that cells with high levels of <em>SOCS1</em> were distributed in upper dermis and periadnexal area, and some <em>SOCS1</em>-positive fibroblasts were closely lined with <em>CD163</em>-positive macrophages. Our study showed that the skin microenvironment in the elderly may shift to an immunoregulatory condition. Furthermore, modulating certain molecules that may be involved in shared immunoregulatory mechanisms between healthy elderly skin and malignant tumors could serve as a potential strategy for preventing malignancies in elderly skin.</div></div>","PeriodicalId":73548,"journal":{"name":"JID innovations : skin science from molecules to population health","volume":"5 6","pages":"Article 100401"},"PeriodicalIF":0.0,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144911802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterization of Malignant Adnexal Tumors of the Head and Neck by Targeted Analysis of Cancer Genes and Human Papillomavirus 42 肿瘤基因和人乳头瘤病毒靶向分析头颈部附件恶性肿瘤的特征

JID innovations : skin science from molecules to population health Pub Date : 2025-07-07 DOI: 10.1016/j.xjidi.2025.100398

Eleanor Dowell , Ruchika Mahapatra , Justin Bishop , Andrew Matsumoto , Alexandra Callan , Travis W. Vandergriff , Aya Alame , Greg Hosler , Jeffrey Gagan , Rajiv I. Nijhawan , Richard C. Wang

{"title":"Characterization of Malignant Adnexal Tumors of the Head and Neck by Targeted Analysis of Cancer Genes and Human Papillomavirus 42","authors":"Eleanor Dowell , Ruchika Mahapatra , Justin Bishop , Andrew Matsumoto , Alexandra Callan , Travis W. Vandergriff , Aya Alame , Greg Hosler , Jeffrey Gagan , Rajiv I. Nijhawan , Richard C. Wang","doi":"10.1016/j.xjidi.2025.100398","DOIUrl":"10.1016/j.xjidi.2025.100398","url":null,"abstract":"<div><div>Malignant adnexal tumors of the head and neck, including syringoid eccrine carcinoma and microcystic adnexal carcinoma, are rare tumors that are thought to arise in adnexal epithelium. The etiopathogenesis of these tumors is poorly understood, and the precise classification of these tumors can be challenging. Human papillomavirus 42 (HPV42) promotes the development of digital papillary adenocarcinoma, a rare adnexal tumor of the extremities and genital skin. Malignant adnexal tumors of the head and neck were assessed through targeted RNA sequencing of the cancer exome and specific RT-PCR for HPV42. Of the 9 cases identified, 7 yielded RNA of sufficient quality for RNA sequencing. Unexpectedly, these analyses revealed a <em>MYB:</em><em>:</em><em>NFIB</em> fusion in 1 case, suggesting a molecular diagnosis of adenoid cystic carcinoma. Mutations in <em>TP53</em> were identified in 2 cases, and a missense mutation in <em>Jak1</em> (p.Ser914Asn) was identified in 1 case. For the 6 cases with sufficient RNA, transcripts for the early region of HPV42 could not be identified by RT-PCR. In situ hybridization and RT-PCR confirmed the presence of HPV42 in digital papillary adenocarcinoma. Our study confirms the presence of mutations in <em>TP53</em> and <em>Jak1</em> and suggests that HPV42 does not contribute to malignant adnexal tumors of the head and neck.</div></div>","PeriodicalId":73548,"journal":{"name":"JID innovations : skin science from molecules to population health","volume":"5 6","pages":"Article 100398"},"PeriodicalIF":0.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145026687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Divergence in Estimated Risks and Actual Rates of Atherosclerotic Cardiovascular Events and their Management in a Longitudinal Cohort of Patients with Dermatomyositis with Skin Involvement 一项累及皮肤的皮肌炎患者纵向队列中动脉粥样硬化性心血管事件的估计风险和实际发生率及其管理的差异

JID innovations : skin science from molecules to population health Pub Date : 2025-07-07 DOI: 10.1016/j.xjidi.2025.100399

Megan Zhao , Caroline Stone , Rui Feng , Victoria P. Werth , Kevin Jon Williams

{"title":"Divergence in Estimated Risks and Actual Rates of Atherosclerotic Cardiovascular Events and their Management in a Longitudinal Cohort of Patients with Dermatomyositis with Skin Involvement","authors":"Megan Zhao , Caroline Stone , Rui Feng , Victoria P. Werth , Kevin Jon Williams","doi":"10.1016/j.xjidi.2025.100399","DOIUrl":"10.1016/j.xjidi.2025.100399","url":null,"abstract":"<div><div>Patients with dermatomyositis (DM), an autoimmune disorder affecting the skin, muscle, and lung, have been reported to be at a heightened risk of clinical events, chiefly heart attacks and strokes, from atherosclerotic cardiovascular disease. In this study, we examined current cardiovascular management in a single-center study of all 388 patients who have DM with skin involvement, either with symptomatic muscle disease (“classic DM”) or with clinically amyopathic DM. By the new guidelines, the most recent low-density lipoprotein cholesterol levels were above goal for 290 of 388 (74.7%). Surprisingly, statin use was similar between this cohort and a longitudinal lupus cohort. Almost two thirds of the cohort had hypertension (249 of 388, 64.2%), which was undertreated or untreated in 199 of 249 (79.9%). One third of the cohort were former or current smokers. Prediabetes and diabetes were generally well-managed. Three published methods for estimating atherosclerotic cardiovascular disease event risk in primary prevention showed meaningful discordance for 196 of 305 (64.3%). The documented rate of atherosclerotic cardiovascular disease events in the first 10 years after enrollment was 12.8% for classic DM and 8.4% for clinically amyopathic DM, indicating at-risk populations. We conclude that patients with DM are undermanaged for conventional therapeutic targets to reduce atherosclerotic cardiovascular disease event risk, particularly hypercholesteremia and hypertension.</div></div>","PeriodicalId":73548,"journal":{"name":"JID innovations : skin science from molecules to population health","volume":"5 6","pages":"Article 100399"},"PeriodicalIF":0.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144904143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of Primary Malignancy Risk after Initiation of Biologic Therapy in Patients with Psoriasis 银屑病患者开始生物治疗后原发性恶性肿瘤风险的评估

JID innovations : skin science from molecules to population health Pub Date : 2025-07-04 DOI: 10.1016/j.xjidi.2025.100397

Chunghwan Ro , Ana Ormaza Vera , Waleed Adawi , Alexander Yap , Clinton W. Enos

{"title":"Assessment of Primary Malignancy Risk after Initiation of Biologic Therapy in Patients with Psoriasis","authors":"Chunghwan Ro , Ana Ormaza Vera , Waleed Adawi , Alexander Yap , Clinton W. Enos","doi":"10.1016/j.xjidi.2025.100397","DOIUrl":"10.1016/j.xjidi.2025.100397","url":null,"abstract":"<div><div>Limited evidence exists regarding the long-term oncologic safety of biologic therapies, particularly IL-17 inhibitors and IL-23 inhibitors, in the management of psoriasis. This propensity score–matched retrospective cohort study assessed the risk of developing a primary malignancy within 10 years after exposure to a Food and Drug Administration–approved biologic among patients with psoriasis compared with that among biologic-naïve controls. After propensity score matching, 32,230 biologic-exposed patients were further grouped into cohorts of TNF inhibitors (n = 16,011), IL-23 inhibitors (n = 5604), IL-12/23 inhibitors (n =3856), and IL-17 inhibitors (n = 5467). During a 10-year period, TNF inhibitor–treated patients had a reduced risk of developing any primary malignancy compared with biologic-naïve patients with psoriasis (hazard ratio [HR] = 0.80; 95% confidence interval [CI] = 0.73–0.87). Similarly, a lower incidence of any malignancy was observed among patients on IL-23 inhibitors (HR = 0.83; 95% CI = 0.68–1.02), IL-12/23 inhibitors (HR = 0.85; 95% CI = 0.71–1.03), or IL-17 inhibitors (HR = 0.87; 95% CI = 0.73–1.04); however, the differences did not reach statistical significance. TNF inhibitor users were less likely to develop nonmelanoma skin cancer (HR = 0.82; 95% CI = 0.71–0.96) than controls, and the risk of nonmelanoma skin cancer did not significantly differ among users of IL-23 inhibitors (HR = 1.09; 95% CI = 0.77–1.55), IL-12/23 inhibitors (HR = 1.22; 95% CI = 0.90–1.64), or IL-17 inhibitors (HR = 1.03; 95% CI = 0.77–1.38). Exposure to any biologic class did not associate with the risk of developing melanoma or lymphoid/hematopoietic malignancies. Overall, these results provide evidence for the long-term oncologic safety of biologic therapies in the management of psoriasis.</div></div>","PeriodicalId":73548,"journal":{"name":"JID innovations : skin science from molecules to population health","volume":"5 6","pages":"Article 100397"},"PeriodicalIF":0.0,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144739006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Cover 封面

JID innovations : skin science from molecules to population health Pub Date : 2025-07-01 DOI: 10.1016/S2667-0267(25)00051-7

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Identification of Keratin 5-Expressing Fibroblasts for Regenerating Keratinocytes in the Necrotic Skin Graft 表达角蛋白5的成纤维细胞在坏死皮肤移植中再生角化细胞的鉴定

JID innovations : skin science from molecules to population health Pub Date : 2025-07-01 DOI: 10.1016/j.xjidi.2025.100394

Yoshikazu Hirose , Asaka Miura , Yuki Kobayashi , Takashi Shimbo , Yuya Ouchi , Tomomi Kitayama , Tomoya Mori , Akio Tanaka , Manabu Fujimoto , Kotaro Saga , Katsuto Tamai

{"title":"Identification of Keratin 5-Expressing Fibroblasts for Regenerating Keratinocytes in the Necrotic Skin Graft","authors":"Yoshikazu Hirose , Asaka Miura , Yuki Kobayashi , Takashi Shimbo , Yuya Ouchi , Tomomi Kitayama , Tomoya Mori , Akio Tanaka , Manabu Fujimoto , Kotaro Saga , Katsuto Tamai","doi":"10.1016/j.xjidi.2025.100394","DOIUrl":"10.1016/j.xjidi.2025.100394","url":null,"abstract":"<div><div>Skin transplantation is commonly used to compensate for normal cutaneous tissues in full-thickness wounds or surgically excised skin. Despite complete termination of initial blood flow, transplanted skin usually maintains its dermal and epidermal structures without scar formation. However, the precise role of engrafted cells in maintaining epidermal and dermal homeostasis remains unclear. In this study, we investigated the chronological changes in neonatal full-thickness skin grafts on mice at the histological and single-cell transcriptomic levels. We found devastating necrotic changes in the dermal and epidermal tissues on postoperative day 3, followed by significant regeneration of follicular and interfollicular tissues after postoperative day 6. We identified a unique mesenchymal subpopulation that expressed keratinocyte-specific genes (keratin 5 gene <em>K</em><em>rt</em><em>5</em>, <em>Epcam</em>, and <em>Irf6</em>) involved in mesenchymal–epithelial transition. Mesenchymal cells transitioning to epithelial cells showed keratinocyte differentiation activity both in vitro and in vivo. These results highlight the contribution of unique mesenchymal cell populations to epithelial regeneration after severe necrosis of a skin graft.</div></div>","PeriodicalId":73548,"journal":{"name":"JID innovations : skin science from molecules to population health","volume":"5 5","pages":"Article 100394"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144723446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Accounting for Biological Sex and Gender Identity in the Pathogenesis, Artistic Depictions, and Quality of Life in Neurofibromatosis Type 1 1型神经纤维瘤病发病机制、艺术表现和生活质量中的生理性别和性别认同

JID innovations : skin science from molecules to population health Pub Date : 2025-06-25 DOI: 10.1016/j.xjidi.2025.100393

Nidhi Kuchimanchi , Renee M. McKay , Lu Q. Le

{"title":"Accounting for Biological Sex and Gender Identity in the Pathogenesis, Artistic Depictions, and Quality of Life in Neurofibromatosis Type 1","authors":"Nidhi Kuchimanchi , Renee M. McKay , Lu Q. Le","doi":"10.1016/j.xjidi.2025.100393","DOIUrl":"10.1016/j.xjidi.2025.100393","url":null,"abstract":"<div><div>Neurofibromatosis type 1 (NF1) is an autosomal dominant neurocutaneous syndrome caused by pathogenic alterations in the tumor suppressor protein neurofibromin. NF1 is characterized clinically by café-au-lait macules, skinfold freckling, iris hamartomas, benign and malignant nerve sheath tumors, optic pathway tumors, skeletal abnormalities, breast malignancies, and neurocognitive challenges. Although progress has been made in understanding biological sex- and gender identity–based differences in a variety of dermatologic conditions, the role of these factors on NF1 and vice versa is not well-defined. In this narrative review, we examine the reciprocal influences of biological sex and gender identity on various NF1 clinical features, discuss the psychosocial and sociocultural factors that may contribute to these observed effects, and highlight historical artistic depictions of NF1. We also identify gaps in our current knowledge in this area that warrant additional research. A comprehensive understanding of NF1 clinical presentations through the lens of biological sex and gender identity can lead to a patient-centered approach of treatment, thereby improving long-term outcomes for affected patients.</div></div>","PeriodicalId":73548,"journal":{"name":"JID innovations : skin science from molecules to population health","volume":"5 5","pages":"Article 100393"},"PeriodicalIF":0.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144680208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Myeloid and Mast Cell Progenitors Are Elevated in Atopic Dermatitis 髓系和肥大细胞祖细胞在特应性皮炎中升高

JID innovations : skin science from molecules to population health Pub Date : 2025-06-20 DOI: 10.1016/j.xjidi.2025.100390

Katie Ridge , Barry Moran , Mark A. Little , Cliona O’Farrelly , Jean Dunne , Julianne Clowry , Clodagh Loftus , Conor M. Finlay , Alan D. Irvine , Niall Conlon

{"title":"Myeloid and Mast Cell Progenitors Are Elevated in Atopic Dermatitis","authors":"Katie Ridge , Barry Moran , Mark A. Little , Cliona O’Farrelly , Jean Dunne , Julianne Clowry , Clodagh Loftus , Conor M. Finlay , Alan D. Irvine , Niall Conlon","doi":"10.1016/j.xjidi.2025.100390","DOIUrl":"10.1016/j.xjidi.2025.100390","url":null,"abstract":"<div><div>Chronic spontaneous urticaria and atopic dermatitis (AD) are chronic skin disorders characterized by itch. Although mast cells play an integral role in the pathogenesis of chronic spontaneous urticaria, their role in AD is unclear, having a contributory role in a disease largely driven by T helper 2 polarization. Despite this, the role of mast cells in AD is important, given their release of proinflammatory mediators. Recently, myeloid and mast cell progenitors were identified as potential biomarkers for treatment response in chronic spontaneous urticaria. These Lin<sup>−</sup>CD117<sup>+</sup>CD34<sup>+</sup>FceRI<sup>+</sup> cells appear to have increased egress from the bone marrow in atopy. We measured Lin<sup>−</sup>CD117<sup>+</sup>CD34<sup>+</sup>FceRI<sup>+</sup> cells in the peripheral blood of 10 individuals with AD and 10 healthy controls. Flow cytometry revealed a significant increase in myeloid progenitors in participants with AD (<em>P</em> = .0067). Total serum IgE levels did not correlate with myeloid progenitors. To our knowledge, examination of this cell type in AD is previously unreported. Our findings suggest increased progenitor egress from the bone marrow in these patients and a possible role for myeloid progenitors in disease pathogenesis.</div></div>","PeriodicalId":73548,"journal":{"name":"JID innovations : skin science from molecules to population health","volume":"5 5","pages":"Article 100390"},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144623413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex Bias in Autoimmunity: New Findings and New Opportunities 自身免疫中的性别偏见：新发现和新机遇

JID innovations : skin science from molecules to population health Pub Date : 2025-06-20 DOI: 10.1016/j.xjidi.2025.100391

Vincent van Drongelen , Joanna Rew , Allison C. Billi

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Effect of Topical Corticosteroid Treatment on microRNA Expression in Infants with Atopic Dermatitis 局部皮质类固醇治疗对婴儿特应性皮炎microRNA表达的影响

JID innovations : skin science from molecules to population health Pub Date : 2025-06-10 DOI: 10.1016/j.xjidi.2025.100388

Janna Nousbeck , Maeve A. McAleer , Elaine M. Kenny , Alan D. Irvine

{"title":"Effect of Topical Corticosteroid Treatment on microRNA Expression in Infants with Atopic Dermatitis","authors":"Janna Nousbeck , Maeve A. McAleer , Elaine M. Kenny , Alan D. Irvine","doi":"10.1016/j.xjidi.2025.100388","DOIUrl":"10.1016/j.xjidi.2025.100388","url":null,"abstract":"<div><div>MicroRNAs (miRNAs) have been implicated in a variety of disorders. Although studies have examined miRNA in pediatric atopic dermatitis (AD), the impact of topical corticosteroid (TCS) therapy on miRNA expression in pediatric AD has not been investigated. We sought to investigate the effects of 6 weeks of TCS therapy on miRNA expression in infants with AD. Small RNA sequencing and real-time RT-qPCR were performed to identify differentially expressed miRNAs in PBMCs of infants with AD after TCS treatment; HTG EdgeSeq was used to identify differentially expressed miRNAs in plasma. Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis was conducted using a list of experimentally verified miRNA targets sourced from the DIANA-TarBase and miRTarBase databases. Five miRNAs were differentially expressed in circulating PBMCs after TCS treatment (miR-143-3p, miR-27a-5p, miR-126-3p, miR-451a, and miR-223-3p); 12 miRNAs were differentially expressed in plasma. These miRNAs have regulatory functions crucial for regulating cell growth and survival, vascular adhesion, angiogenesis, skin barrier integrity, stress and nervous system processes, immune responses, inflammation, and T helper 17 cell differentiation. TCS treatment led to a distinct miRNA expression profile in peripheral blood, providing insights into how this treatment impacts disease mechanisms in childhood AD.</div></div>","PeriodicalId":73548,"journal":{"name":"JID innovations : skin science from molecules to population health","volume":"5 5","pages":"Article 100388"},"PeriodicalIF":0.0,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144535414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0