JID innovations : skin science from molecules to population health最新文献_第2页

Sun-protection awareness, habits, and recommendations of USA Swimming coaches 美国游泳教练的防晒意识、习惯和建议。

JID innovations : skin science from molecules to population health Pub Date : 2026-07-01 Epub Date: 2026-04-17 DOI: 10.1016/j.xjidi.2026.100478

Madisyn L. Cox, Kai-Ping Liao, Candice L. Hinkston, Sanjna Tripathy, Lucy J. Navsaria, Kevin T. Nead, Mackenzie R. Wehner

{"title":"Sun-protection awareness, habits, and recommendations of USA Swimming coaches","authors":"Madisyn L. Cox, Kai-Ping Liao, Candice L. Hinkston, Sanjna Tripathy, Lucy J. Navsaria, Kevin T. Nead, Mackenzie R. Wehner","doi":"10.1016/j.xjidi.2026.100478","DOIUrl":"10.1016/j.xjidi.2026.100478","url":null,"abstract":"<div><div>Swimming is the 5<sup>th</sup> most popular sport in the United States, and many of its athletes train outside. This study aimed to examine the sun-protection habits and recommendations of USA Swimming coaches and perceived sunscreen use among their athletes. We performed a cross-sectional survey of USA Swimming coaches. We evaluated associations between coach sun-protection habits, coach discussing sunscreen use with athletes, and the outcome of perceived sunscreen use among athletes using multivariate ordinal logistic regression. A total of 2729 coaches responded to the survey and were included. Most were women (59.8%), were White (93.1%), were aged 35–64 years (58.0%), and reported having coached outside (89.7%), and 12.0% reported a history of skin cancer. The majority (76.8%) of coaches discuss sunscreen use with their athletes. In multivariable analysis, increased perceived sunscreen use among athletes was associated with increased coach sun-protection habits with a dose–response relationship and was associated with binary discussion of sunscreen use with athletes (OR = 2.37, 95% confidence interval = 1.93–2.89) and, in a separate model, with frequency of discussing sunscreen with athletes with a dose–response relationship (statistically significant OR = 1.62 for yearly to OR = 5.17 for daily). These findings suggest a potential role for swimming coaches in improving sun protection of athletes.</div></div>","PeriodicalId":73548,"journal":{"name":"JID innovations : skin science from molecules to population health","volume":"6 4","pages":"Article 100478"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13316678/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148364298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Patient journey and disparities in the diagnosis and treatment of patients with hidradenitis suppurativa 化脓性汗腺炎的患者历程及诊治差异

JID innovations : skin science from molecules to population health Pub Date : 2026-05-01 Epub Date: 2026-02-24 DOI: 10.1016/j.xjidi.2026.100462

Raj Chovatiya , Julie Gayle , Robert Low , Tae Oh , Isabel Gomez , Ning Rosenthal

{"title":"Patient journey and disparities in the diagnosis and treatment of patients with hidradenitis suppurativa","authors":"Raj Chovatiya , Julie Gayle , Robert Low , Tae Oh , Isabel Gomez , Ning Rosenthal","doi":"10.1016/j.xjidi.2026.100462","DOIUrl":"10.1016/j.xjidi.2026.100462","url":null,"abstract":"<div><div>We compared the patient journey of adult and pediatric patients with hidradenitis suppurativa (HS) and suspected HS and of patients with HS stratified by race, ethnicity, and social determinants of health. Data were from the United States Premier Healthcare Database (including hospital discharge and billing data from inpatient and outpatient encounters) and its linked medical and pharmacy claims database. After diagnosis, adult patients (n = 3065) with HS initiated biologics more quickly and were less likely to have all-cause hospitalizations or all-cause emergency department visits than adult patients with suspected HS (n = 27,280). Adult patients with HS also reported more disease-related outpatient visits (mean ± SD: 3.7 ± 4.9 vs 2.9 ± 4.7) and lower overall costs ($22,128 ± $61,671 vs $36,359 ± $82,762) after diagnosis. Significant differences were found in the patient journey across ethnic groups (adult patients) and social vulnerability index categories (adult and pediatric patients). Differences in the patient journey were evident, particularly between adult patients with HS and adult patients with suspected HS. Although a confirmed diagnosis of HS is beneficial, disparities were prevalent. Increased awareness of these differences may minimize diagnostic delays, facilitate disease management, and reduce costs.</div></div>","PeriodicalId":73548,"journal":{"name":"JID innovations : skin science from molecules to population health","volume":"6 3","pages":"Article 100462"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147797659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cover 封面

JID innovations : skin science from molecules to population health Pub Date : 2026-05-01 Epub Date: 2026-05-19 DOI: 10.1016/S2667-0267(26)00037-8

引用次数: 0

High-salt diet aggravates skin inflammation of psoriasis-like mouse model with CCL20‒CCR6 axis further activation 高盐饮食加重银屑病样小鼠模型皮肤炎症，CCL20-CCR6轴进一步激活

JID innovations : skin science from molecules to population health Pub Date : 2026-03-01 Epub Date: 2026-01-19 DOI: 10.1016/j.xjidi.2026.100451

Mengyan Hu , Han Cao , Li Zhang , Yuhan Xia , Jiayi Zhang , Feng Xue , Xia Li , Jie Zheng

引用次数: 0

Dermoscopy-guided high-frequency ultrasound: Principles and applications in dermatology 皮肤镜引导下的高频超声：原理及其在皮肤病学中的应用

JID innovations : skin science from molecules to population health Pub Date : 2026-03-01 Epub Date: 2025-12-29 DOI: 10.1016/j.xjidi.2025.100446

Mehdi Boostani , Ximena Wortsman , Giovanni Pellacani , Krisztián Füzesi , Mariano Suppa , Veronique Del Marmol , Florencia Vera Morandini , Javiera Perez-Anker , Priscila Giavedoni , Carmen Cantisani , Lucas Boussingault , Miklós Gyöngy , Gyorgy Paragh , Kamran Avanaki , Norbert Kiss

{"title":"Dermoscopy-guided high-frequency ultrasound: Principles and applications in dermatology","authors":"Mehdi Boostani , Ximena Wortsman , Giovanni Pellacani , Krisztián Füzesi , Mariano Suppa , Veronique Del Marmol , Florencia Vera Morandini , Javiera Perez-Anker , Priscila Giavedoni , Carmen Cantisani , Lucas Boussingault , Miklós Gyöngy , Gyorgy Paragh , Kamran Avanaki , Norbert Kiss","doi":"10.1016/j.xjidi.2025.100446","DOIUrl":"10.1016/j.xjidi.2025.100446","url":null,"abstract":"<div><div>Conventional skin imaging modalities are often bulky, expensive, and impractical for routine dermatology practice. There is a need for a portable, multimodal imaging tool that integrates high-resolution surface and subsurface visualization at the point of care. The aim of this study was to describe the design, technical capabilities, and clinical application of dermoscopy-guided high-frequency ultrasound and to evaluate its performance across a range of dermatologic conditions. Dermoscopy-guided high-frequency ultrasound was applied to a total of 130 lesions from 122 patients at the Department of Dermatology, Semmelweis University (Budapest, Hungary); Université Libre de Bruxelles (Brussels, Belgium); and Hospital Clínic, Universidad de Barcelona (Barcelona, Spain). The examined cases included malignant skin cancers and inflammatory disorders. Dermoscopy-guided high-frequency ultrasound enabled simultaneous visualization and correlation of surface dermoscopic patterns with underlying structural alterations in real time. The device identified disease-specific imaging features for both malignant and inflammatory lesions. Artificial intelligence-based segmentation improved image interpretability. Dermoscopy-guided high-frequency ultrasound bridges a critical gap between surface and subsurface dermatologic imaging, offering a practical, portable, and cost-effective solution that could enhance noninvasive diagnosis and management in dermatologic care.</div></div>","PeriodicalId":73548,"journal":{"name":"JID innovations : skin science from molecules to population health","volume":"6 2","pages":"Article 100446"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146078089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing T-Cell Profile Shifts through IL-23 Inhibition by Guselkumab on Psoriasis guelkumab通过IL-23抑制银屑病评估t细胞谱转移

JID innovations : skin science from molecules to population health Pub Date : 2026-03-01 Epub Date: 2025-11-07 DOI: 10.1016/j.xjidi.2025.100433

Yoshifumi Kanayama , Oki Watanabe , Mai Sakurai , Yuki Enomoto , Aya Yamamoto , Shunya Mashiko , Yukako Sugiura , Masahiko Miyashiro , Junya Masuda , Akimichi Morita

{"title":"Assessing T-Cell Profile Shifts through IL-23 Inhibition by Guselkumab on Psoriasis","authors":"Yoshifumi Kanayama , Oki Watanabe , Mai Sakurai , Yuki Enomoto , Aya Yamamoto , Shunya Mashiko , Yukako Sugiura , Masahiko Miyashiro , Junya Masuda , Akimichi Morita","doi":"10.1016/j.xjidi.2025.100433","DOIUrl":"10.1016/j.xjidi.2025.100433","url":null,"abstract":"<div><div>Anti–IL-23 antibody therapies improve the underlying immunopathology of psoriasis. Immune profile dynamics after anti–IL-23 treatment and their association with the treatment response are unclear. Focusing on guselkumab, an anti–IL-23p19 antibody, we comprehensively analyzed immune cells, serum inflammatory molecules, and CD4<sup>+</sup> T-cell transcriptomics to identify drug effects in psoriasis. Peripheral and lesional skin blood samples were collected from 24 biologic-naïve patients at baseline and after treatment with guselkumab. We conducted FACS analysis of regulatory T cells, resident memory T cells, and dendritic cells; measured serum cytokine and chemokine levels; and analyzed RNA-sequencing data for gene expression changes in peripheral CD4<sup>+</sup> T cells. Guselkumab administration increased regulatory T cells and decreased resident memory T cells. Gene expression differences at baseline defined 2 groups on the basis of the treatment response: transcriptomic profile–based high responders and transcriptomic profile–based moderate responders. Expression of certain chemokines, such as CXCL1 and CXCL5, was higher in the moderate responders, suggesting their association with a lower treatment response. RNA-sequencing analysis revealed gene expression changes related to T helper 17 cells and regulatory T cell activity. We observed alterations in regulatory T cells and resident memory T cells in response to guselkumab treatment that may contribute to the long-term suppression of the IL-23–driven inflammatory pathology in psoriasis. Furthermore, baseline peripheral blood transcriptomic immune findings may predict therapeutic outcomes. The G-Grope trial was registered as jRCTs041200070 with the Japan Registry of Clinical Trials on December 8, 2020.</div></div>","PeriodicalId":73548,"journal":{"name":"JID innovations : skin science from molecules to population health","volume":"6 2","pages":"Article 100433"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145697920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Atopic Dermatitis–like mouse model using early inoculation of patient-derived S. aureus together with MC903 早期接种患者源性金黄色葡萄球菌和MC903建立特应性皮炎样小鼠模型

JID innovations : skin science from molecules to population health Pub Date : 2026-03-01 Epub Date: 2025-11-21 DOI: 10.1016/j.xjidi.2025.100436

Aaroh Joshi , Altan Cornu , Josefa Luxner , Gernot Zarfel , Camille Braun , Jean-Francois Nicolas , Richard L. Gallo , Marc Vocanson , Peter Wolf , Vijaykumar Patra

{"title":"Atopic Dermatitis–like mouse model using early inoculation of patient-derived S. aureus together with MC903","authors":"Aaroh Joshi , Altan Cornu , Josefa Luxner , Gernot Zarfel , Camille Braun , Jean-Francois Nicolas , Richard L. Gallo , Marc Vocanson , Peter Wolf , Vijaykumar Patra","doi":"10.1016/j.xjidi.2025.100436","DOIUrl":"10.1016/j.xjidi.2025.100436","url":null,"abstract":"<div><div><em>Staphylococcus aureus</em> (<em>S. aureus</em>) worsens atopic dermatitis (AD), but how individual strains differ in pathogenicity remains unclear. Mouse models that mimic AD and allow direct manipulation of <em>S. aureus</em> in early stages of disease are limited. Moreover, these models rarely incorporate clinical <em>S. aureus</em> strains isolated from patients with AD. In this study, we investigated the inflammatory potential of clinical <em>S. aureus</em> and <em>S. epidermidis</em> isolates from patients with AD in a mouse model. Clinical <em>S. aureus</em> strains showed significant variability in their ability to elicit inflammation. The inflammation was associated with differences in virulence factor expression and, to a lesser extent, with genomic variation. In contrast, <em>S. epidermidis</em> strains (taken from the same lesional skin sites of patients) induced only mild but consistent inflammation, with less variability at the strain level. Next, we examined the impact of a pathogenic clinical <em>S. aureus</em> strains in the presence of an MC903-induced type 2 immune environment. Under these conditions, <em>S. aureus</em> enhanced colonization; increased inflammation; and promoted type 1, type 2, and type 17/22 immune responses. These responses were less evident with either treatment alone. Our findings suggest that clinical <em>S. aureus</em> strains from patients with AD differ in their capacity to modulate skin inflammation, particularly within a type 2–skewed environment. These results highlight the potential value of incorporating clinically relevant <em>S. aureus</em> isolates into early-stage in vivo models to better understand AD immunopathology and to inform microbiome-targeted therapeutic strategies.</div></div>","PeriodicalId":73548,"journal":{"name":"JID innovations : skin science from molecules to population health","volume":"6 2","pages":"Article 100436"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145747576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Population- and haplotype-dependent variation around TYR rs1126809: An in silico study for melanoma risk research 围绕TYR rs1126809的人群和单倍型依赖性变异：黑色素瘤风险研究的计算机研究

JID innovations : skin science from molecules to population health Pub Date : 2026-03-01 Epub Date: 2025-12-23 DOI: 10.1016/j.xjidi.2025.100445

Árpád Ármin Balogh , Márta Széll , Nikoletta Nagy

{"title":"Population- and haplotype-dependent variation around TYR rs1126809: An in silico study for melanoma risk research","authors":"Árpád Ármin Balogh , Márta Széll , Nikoletta Nagy","doi":"10.1016/j.xjidi.2025.100445","DOIUrl":"10.1016/j.xjidi.2025.100445","url":null,"abstract":"<div><div>The common missense variant rs1126809 in the <em>TYR</em> gene, encoding a key enzyme in melanin synthesis, is linked to both albinism and melanoma susceptibility. Although its role in hypopigmentation as part of a risk haplotype is established, its function in melanoma is less understood. To investigate population- and haplotype-dependent associations surrounding <em>TYR</em> rs1126809 that may suggest directions for future studies on melanoma risk and melanocyte biology, we analyzed melanoma GWAS summary statistics using FUMA to identify lead SNPs in linkage disequilibrium with rs1126809 and assessed their regulatory potential using chromatin state data from melanocytes, keratinocytes, and fibroblasts. Haplotype structures were examined in European, American, and South Asian populations using LDlink. rs1126809 emerged as lead SNP in the <em>TYR</em> locus. Thirty SNPs were in high linkage disequilibrium, 6 of which reside in melanocyte-specific regulatory regions. These variants form population-specific haplotypes that may modulate TYR expression. In Europeans and Americans, 2 distinct haplotypes carrying the risk allele showed different linked SNP profiles, suggesting haplotype-dependent effects. The findings suggest that variations surrounding <em>TYR</em> rs1126809 may exhibit population- and haplotype-dependent patterns relevant to melanoma risk, pointing to previously unreported directions for future research and refinement of polygenic risk modeling.</div></div>","PeriodicalId":73548,"journal":{"name":"JID innovations : skin science from molecules to population health","volume":"6 2","pages":"Article 100445"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146078088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deep intronic MSH2 variant confirms Muir-Torre subtype of Lynch syndrome 深内含子MSH2变异证实了Lynch综合征的Muir-Torre亚型

JID innovations : skin science from molecules to population health Pub Date : 2026-03-01 Epub Date: 2025-12-05 DOI: 10.1016/j.xjidi.2025.100438

Fiona Chan-Pak-Choon , Andrew Y. Shuen , Evan Weber , Lili Fu , Barbara Rivera , William D. Foulkes

{"title":"Deep intronic MSH2 variant confirms Muir-Torre subtype of Lynch syndrome","authors":"Fiona Chan-Pak-Choon , Andrew Y. Shuen , Evan Weber , Lili Fu , Barbara Rivera , William D. Foulkes","doi":"10.1016/j.xjidi.2025.100438","DOIUrl":"10.1016/j.xjidi.2025.100438","url":null,"abstract":"<div><div>Whole-genome sequencing can uncover clinically significant noncoding variants missed by standard germline testing, as demonstrated in this report in a patient with Muir–Torre syndrome, a subtype of Lynch syndrome. In this case, despite a convincing clinical phenotype and immunohistochemical loss of MSH2/MSH6 in 1 of the patient’s tumors, conventional gene panel testing failed to detect a germline pathogenic variant. Whole-genome sequencing identified a deep intronic <em>MSH2</em> variant, and tumor sequencing revealed somatic <em>MSH2</em> mutations (second hits) across multiple tumors, confirming mismatch repair deficiency and establishing a Muir-Torre syndrome diagnosis. This report underscores the limitations of routine genetic testing and highlights the clinical utility of whole-genome sequencing in identifying pathogenic variants in noncoding regions. It also emphasizes the role of dermatologists in recognizing cutaneous markers of hereditary cancer syndromes and the importance of interdisciplinary evaluation in guiding both patient care and familial risk assessment.</div></div>","PeriodicalId":73548,"journal":{"name":"JID innovations : skin science from molecules to population health","volume":"6 2","pages":"Article 100438"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145939040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to ‘Superior Antiproliferative and Enhanced Synergistic Effects of a Rock Inhibitor in Multiple Models for Keloid Disease’ JID Innovations, Volume 5, Issue 6, November 2025, 100402 《岩石抑制剂在瘢痕疙瘩疾病多种模型中的卓越抗增殖和增强协同效应》JID Innovations，第5卷，第6期，2025年11月，100402

JID innovations : skin science from molecules to population health Pub Date : 2026-03-01 Epub Date: 2026-01-16 DOI: 10.1016/j.xjidi.2026.100452

Zeinab Ghasemishahrestani , Traci A. Wilgus , Nonhlanhla P. Khumalo , Ardeshir Bayat

引用次数: 0