A. Medline, Eric Midenberg, Dattatraya Patil, Sean T. Evans, N. Vettikattu, F. Kamal, K. Ogan, S. Psutka, M. Bilen, V. Master
{"title":"Muscle mass change using linear measurement analysis after nephrectomy for pT3 and pT4 renal cell carcinoma is associated with mortality","authors":"A. Medline, Eric Midenberg, Dattatraya Patil, Sean T. Evans, N. Vettikattu, F. Kamal, K. Ogan, S. Psutka, M. Bilen, V. Master","doi":"10.1002/rco2.66","DOIUrl":"https://doi.org/10.1002/rco2.66","url":null,"abstract":"Preoperative skeletal muscle deficiency is an established risk factor for poor survival outcomes in patients with renal cell carcinoma (RCC). However, given the dynamic nature of skeletal muscle associated with malignancy, there is a need to evaluate the prognostic benefit of muscle area change from the preoperative to postoperative period. We hypothesize that an improvement in muscle area following nephrectomy, measured by linear segmentation of L3 psoas and paraspinal musculature, is associated with improvement in overall survival (OS) and cancer specific survival (CSS) for patients with pT3 and pT4 RCC.","PeriodicalId":73544,"journal":{"name":"JCSM rapid communications","volume":"5 1","pages":"205 - 211"},"PeriodicalIF":0.0,"publicationDate":"2022-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48762448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Thomas G. Francis, O. Jaka, G. Ellison‐Hughes, N. Lazarus, S. Harridge
{"title":"Human primary skeletal muscle‐derived myoblasts and fibroblasts reveal different senescent phenotypes","authors":"Thomas G. Francis, O. Jaka, G. Ellison‐Hughes, N. Lazarus, S. Harridge","doi":"10.1002/rco2.67","DOIUrl":"https://doi.org/10.1002/rco2.67","url":null,"abstract":"The age‐related loss of muscle mass and quality, sarcopenia, has many contributing factors, one of which may be cellular senescence, but this is not well defined in human skeletal muscle.","PeriodicalId":73544,"journal":{"name":"JCSM rapid communications","volume":"5 1","pages":"226 - 238"},"PeriodicalIF":0.0,"publicationDate":"2022-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44143484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Kuchnia, J. Lortie, Katie J Osterbauer, T. Hess, N. Stabo, Nanae Tsuchiya, N. Wheeler, N. Binkley, C. François, M. Schiebler, J. Hermsen, R. Dhingra
{"title":"Computed tomography measured tissue density of pectoral muscle and liver predicts outcomes in heart transplant recipients","authors":"A. Kuchnia, J. Lortie, Katie J Osterbauer, T. Hess, N. Stabo, Nanae Tsuchiya, N. Wheeler, N. Binkley, C. François, M. Schiebler, J. Hermsen, R. Dhingra","doi":"10.1002/rco2.62","DOIUrl":"https://doi.org/10.1002/rco2.62","url":null,"abstract":"Computed tomography (CT)‐derived measures of tissue quality can add to frailty assessment and improve selection of candidates for heart transplant. We investigated the prognostic value of CT measures of tissue density for predicting hospital length of stay (LOS) and mortality post‐transplant.","PeriodicalId":73544,"journal":{"name":"JCSM rapid communications","volume":"5 1","pages":"171 - 181"},"PeriodicalIF":0.0,"publicationDate":"2022-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42461952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Davine Yang, Sameena Iqbal, K. Rafatzand, C. Scheede-Bergdahl
{"title":"Psoas muscle measurement as a marker of sarcopenia predicts risk of Grade 4 or 5 baseline chronic kidney disease and its progression","authors":"Davine Yang, Sameena Iqbal, K. Rafatzand, C. Scheede-Bergdahl","doi":"10.1002/rco2.63","DOIUrl":"https://doi.org/10.1002/rco2.63","url":null,"abstract":"Psoas muscle area (PMA) has recently been found to be an appropriate surrogate for whole‐body skeletal muscle mass and a measure of sarcopenia. Sarcopenia, which includes a decreased muscle mass and correlated with physical disability, morbidity, and mortality, is prevalent in and has deleterious consequences for patients with chronic kidney disease (CKD). The current study investigates the association of PMA, as a marker of sarcopenia, with baseline kidney function and CKD progression.","PeriodicalId":73544,"journal":{"name":"JCSM rapid communications","volume":"5 1","pages":"182 - 193"},"PeriodicalIF":0.0,"publicationDate":"2022-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49600761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Amano, V. Baracos, T. Morita, T. Miura, N. Mori, Ryohei Tatara, Takaomi Kessoku, A. Tokoro, Keita Tagami, Hiroyuki Otani, M. Mori, T. Taniyama, N. Nakajima, Erika Nakanishi, J. Kako, Daisuke Kiuchi, H. Ishiki, H. Matsuoka, E. Satomi, M. Miyashita
{"title":"The impact of cachexia on dietary intakes, symptoms, and quality of life in advanced cancer","authors":"K. Amano, V. Baracos, T. Morita, T. Miura, N. Mori, Ryohei Tatara, Takaomi Kessoku, A. Tokoro, Keita Tagami, Hiroyuki Otani, M. Mori, T. Taniyama, N. Nakajima, Erika Nakanishi, J. Kako, Daisuke Kiuchi, H. Ishiki, H. Matsuoka, E. Satomi, M. Miyashita","doi":"10.1002/rco2.61","DOIUrl":"https://doi.org/10.1002/rco2.61","url":null,"abstract":"The relationships between cachexia stages and the Functional Assessment of Anorexia/Cachexia Therapy Anorexia Cachexia Subscale (FAACT ACS) 12‐item, 5‐item anorexia symptoms, and 4‐item anorexia concerns have not been investigated in Asian patients with advanced cancer.","PeriodicalId":73544,"journal":{"name":"JCSM rapid communications","volume":"5 1","pages":"162 - 170"},"PeriodicalIF":0.0,"publicationDate":"2022-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48780092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L. Oberholzer, Knut Sindre Mølmen, D. Hammarström, G. S. Falch, Anne‐Kristine Meinild Lundby, B. Rønnestad, S. Ellefsen, Carsten Lundby
{"title":"Resistance exercise training increases skeletal muscle mitochondrial respiration in chronic obstructive pulmonary disease","authors":"L. Oberholzer, Knut Sindre Mølmen, D. Hammarström, G. S. Falch, Anne‐Kristine Meinild Lundby, B. Rønnestad, S. Ellefsen, Carsten Lundby","doi":"10.1002/rco2.58","DOIUrl":"https://doi.org/10.1002/rco2.58","url":null,"abstract":"Chronic obstructive pulmonary disease (COPD) is associated with skeletal muscle mitochondrial dysfunction. Resistance exercise training (RT) is a training modality with a relatively small pulmonary demand that has been suggested to increase skeletal muscle oxidative enzyme activity in COPD. Whether a shift into a more oxidative profile following RT also translates into increased mitochondrial respiratory capacity in COPD is yet to be established.","PeriodicalId":73544,"journal":{"name":"JCSM rapid communications","volume":"5 1","pages":"194 - 204"},"PeriodicalIF":0.0,"publicationDate":"2022-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44331897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Microbiota–muscle/immune interactions in rhesus macaque under simulated microgravity revealed by integrated multi‐omics analysis","authors":"Peng Zhang, Libin Shao, Jie Zhang, Lu Wang, Xiangsheng Pang, Wuchen Tao, Guangyi Fan, Ling Peng, Guanghan Kan, Wenjiong Li, Xinming Liang, Xin Liu, Xiaoping Chen","doi":"10.1002/rco2.60","DOIUrl":"https://doi.org/10.1002/rco2.60","url":null,"abstract":"Long‐term exposure to microgravity during spaceflight has adverse effects on human health including muscle atrophy, impaired immune function, and alterations in gut microbiome profile. Gut microorganisms influence a wide range of host biological processes, but their interactions with skeletal muscle and the immune system under microgravity have yet to be elucidated.","PeriodicalId":73544,"journal":{"name":"JCSM rapid communications","volume":"5 1","pages":"212 - 225"},"PeriodicalIF":0.0,"publicationDate":"2022-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46595937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Huibin Tang, Michael Kim, Myung Lee, Kellie Baumann, F. Olguin, Hao He, Yoyo Wang, B. Jiang, Shuhuan Fang, Jinguo Zhu, Kun Wang, Hui Xia, Yang Gao, Harrison B. Konsker, Emmanuel Fatodu, Marco Quarta, Justin Blonigan, T. Rando, J. Shrager
{"title":"Overexpression of thioredoxin‐2 attenuates age‐related muscle loss by suppressing mitochondrial oxidative stress and apoptosis","authors":"Huibin Tang, Michael Kim, Myung Lee, Kellie Baumann, F. Olguin, Hao He, Yoyo Wang, B. Jiang, Shuhuan Fang, Jinguo Zhu, Kun Wang, Hui Xia, Yang Gao, Harrison B. Konsker, Emmanuel Fatodu, Marco Quarta, Justin Blonigan, T. Rando, J. Shrager","doi":"10.1002/rco2.57","DOIUrl":"https://doi.org/10.1002/rco2.57","url":null,"abstract":"Skeletal muscle mass is regulated by intracellular anabolic and catabolic activities. Increased catabolic activity can shift the balance towards net protein breakdown and muscle atrophy. Mitochondrial oxidative stress activates catabolism and is linked to muscle loss. Reducing mitochondrial oxidative stress is thus a plausible approach to prevent muscle atrophy. We tested this concept in age‐dependent muscle atrophy by genetically overexpressing the mitochondrial antioxidant thioredoxin‐2 (TXN2).","PeriodicalId":73544,"journal":{"name":"JCSM rapid communications","volume":"5 1","pages":"130 - 145"},"PeriodicalIF":0.0,"publicationDate":"2022-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43062471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effects of low‐dose metformin on pre‐frailty among middle‐aged and elderly pre‐diabetic people","authors":"Chun‐Feng Huang, M. Shiao, Tso-Yen Mao","doi":"10.1002/rco2.55","DOIUrl":"https://doi.org/10.1002/rco2.55","url":null,"abstract":"Pre‐frailty has been identified as a clinically silent mechanism pre‐disposing people to frailty. The goal of this study is to investigate the impact of low‐dose metformin on pre‐diabetic pre‐frail patients (>50 years) on skeletal muscle mass, speed of gait, handgrip power, and health‐related quality of life (HR‐QoL).","PeriodicalId":73544,"journal":{"name":"JCSM rapid communications","volume":"5 1","pages":"33 - 39"},"PeriodicalIF":0.0,"publicationDate":"2022-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46375631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D. Blum, C. Hertler, R. Oberholzer, S. Wolf-Linder, M. Joerger, C. Driessen, F. Strasser
{"title":"Lenalidomide in cancer cachexia: a randomized trial of an anticancer drug applied for anti‐cachexia","authors":"D. Blum, C. Hertler, R. Oberholzer, S. Wolf-Linder, M. Joerger, C. Driessen, F. Strasser","doi":"10.1002/rco2.54","DOIUrl":"https://doi.org/10.1002/rco2.54","url":null,"abstract":"Cancer cachexia (CC) impacts quality of life, physical function, anticancer treatment response, and survival. Inflammation is a prominent pathomechanism of CC. This small‐scale study sets out to investigate the immunomodulatory drug lenalidomide in inflammatory CC in a randomized, double‐blind, placebo‐controlled trial.","PeriodicalId":73544,"journal":{"name":"JCSM rapid communications","volume":"5 1","pages":"68 - 76"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45699965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}