JCSM rapid communications最新文献

{"title":"Expert Consensus on Diagnosis and Management of Secondary Sarcopenia in Adults in Colombia: A Modified Delphi Study","authors":"Claudia Contreras,&nbsp;Diana Paola Córdoba-Rodríguez,&nbsp;Robinson Cuadros,&nbsp;José Ricardo Jauregui,&nbsp;Ángel Labán Castro Castro,&nbsp;Diana Trejos-Gallego,&nbsp;Fernando Pereira,&nbsp;Susan Martínez,&nbsp;Linda Ibatá,&nbsp;Julieth Carolina Castillo","doi":"10.1002/rco2.70051","DOIUrl":"https://doi.org/10.1002/rco2.70051","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Secondary sarcopenia driven by chronic disease, acute illness, immobilization, malnutrition or treatment-related factors contributes to functional decline, falls, disability, readmission and mortality. In Colombia, uneven access to body composition assessment, nutrition services and rehabilitation limits timely recognition and management.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We conducted a modified Delphi expert consensus to develop Colombia-focused recommendations for adults with suspected or confirmed secondary sarcopenia. Seven invited experts from geriatrics, intensive care medicine, clinical nutrition, physiotherapy, rehabilitation and surgery accepted participation and completed the consensus process. A structured evidence review from 2015 to 2025 informed 90 candidate statements across screening, diagnosis, nutrition, therapeutic exercise and follow-up. Statements were rated using a 5-point Likert scale. For each statement, a weighted consensus score was calculated as the sum of Likert scores divided by the maximum possible score and multiplied by 100. A weighted score of 70% or higher was prespecified as the approval threshold.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The 90 candidate statements were reduced to 50 final recommendations, representing a net reduction of 40 statements. The recommendations were organized into six thematic tables and address screening triggers, stepwise diagnostic confirmation, early interdisciplinary management, individualized nutrition strategies, structured multicomponent exercise and longitudinal reassessment using consistent baseline measures.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This evidence-informed expert consensus provides practical recommendations for screening, diagnosis, treatment and follow-up of secondary sarcopenia in adults in Colombia. The document is intended as expert consensus guidance rather than a formal clinical practice guideline. Selected elements may be relevant to settings with similar access constraints, but external validation is required.</p>\u0000 </section>\u0000 </div>","PeriodicalId":73544,"journal":{"name":"JCSM rapid communications","volume":"9 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/rco2.70051","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149206036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Possible Association of Elevated Delta-Like Protein 4 Concentration With Low Walking Speed and Low Handgrip Strength in Japanese Older Adults","authors":"Keisuke Endo,&nbsp;Kei Nakata,&nbsp;Tatsuya Sato,&nbsp;Marenao Tanaka,&nbsp;Erika Ishiwata,&nbsp;Yukinori Akiyama,&nbsp;Wataru Kawaharata,&nbsp;Hiroki Aida,&nbsp;Masayuki Koyama,&nbsp;Hirofumi Ohnishi,&nbsp;Masato Furuhashi","doi":"10.1002/rco2.70052","DOIUrl":"https://doi.org/10.1002/rco2.70052","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;A recent study using mice showed that delta-like protein 4 (Dll4), a ligand released from the impaired vascular endothelium, can activate Notch receptor 2 signals in skeletal muscles, leading to muscle atrophy and dysfunction. However, it remains unclear whether circulating Dll4 is associated with ageing-related physical dysfunction in humans and sarcopenia diagnosed by both low muscle mass and low muscle strength.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;We investigated the associations of serum Dll4 level as the main outcome with physical performance, muscle strength and muscle mass in 283 Japanese older adults defined as ≥ 65 years of age (men/women: 125/158, mean age: 75 ± 6 years) who received annual health checkups in the Tanno–Sobetsu Study, a population-based cohort.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Dll4 concentration was negatively correlated with levels of high-density lipoprotein cholesterol (HDL-C) (&lt;i&gt;r&lt;/i&gt; = −0.17, &lt;i&gt;p&lt;/i&gt; = 0.01) and fasting glucose (&lt;i&gt;r&lt;/i&gt; = −0.12, &lt;i&gt;p&lt;/i&gt; = 0.048) and with walking speed (&lt;i&gt;r&lt;/i&gt; = −0.14, &lt;i&gt;p&lt;/i&gt; = 0.02) but not with handgrip strength (&lt;i&gt;r&lt;/i&gt; = −0.04, &lt;i&gt;p&lt;/i&gt; = 0.47) or appendicular skeletal muscle mass index (ASMI) (&lt;i&gt;r&lt;/i&gt; = 0.01, &lt;i&gt;p&lt;/i&gt; = 0.85). When subjects were divided by sex, Dll4 level was inversely correlated with walking speed (&lt;i&gt;r&lt;/i&gt; = −0.17, &lt;i&gt;p&lt;/i&gt; = 0.03) and handgrip strength (&lt;i&gt;r&lt;/i&gt; = −0.17, &lt;i&gt;p&lt;/i&gt; = 0.04) in women but not in men. Multivariable regression analysis after adjustment of age, sex, body mass index and levels of HDL-C and fasting glucose showed that walking speed (β = −0.15, &lt;i&gt;p&lt;/i&gt; = 0.04) or handgrip strength (β = −0.24, &lt;i&gt;p&lt;/i&gt; = 0.03) was independently associated with Dll4 level. Conversely, Dll4 level was independently associated with walking speed (β = −0.12, &lt;i&gt;p&lt;/i&gt; = 0.03) or handgrip strength (β = −0.09, &lt;i&gt;p&lt;/i&gt; = 0.03) but not ASMI (β = 0.06, &lt;i&gt;p&lt;/i&gt; = 0.22) after adjustment of age, sex and body mass index as consistent confounders in exploratory analyses. There was no significant interaction between sex and Dll4 level for walking speed and handgrip strength. Furthermore, the addition of Dll4 level into the consistent confounders significantly improved discriminatory capacity for predicting low walking speed, but not low handgrip strength and low ASMI, in the integrated discrimination improvement and continuous net reclassification improvement.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusions&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;A high serum level of Dll4 is independently associated with low walking speed and low musc","PeriodicalId":73544,"journal":{"name":"JCSM rapid communications","volume":"9 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/rco2.70052","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149145992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myopenia in HFpEF: Impaired Muscle Quality Beyond the Heart","authors":"Alessandro Pocai","doi":"10.1002/rco2.70048","DOIUrl":"https://doi.org/10.1002/rco2.70048","url":null,"abstract":"<p>Heart failure with preserved ejection fraction (HFpEF) is increasingly understood as a systemic disorder of impaired energetics and metabolic inflammation rather than an isolated disease of cardiac structure or haemodynamics. Although cardiac abnormalities define the diagnosis, they do not explain the severity of exercise intolerance, fatigue and loss of physical function that dominate the clinical phenotype. Converging physiological, metabolic and clinical evidence identifies extracardiac mechanisms, particularly skeletal muscle dysfunction, as key determinants of disability in HFpEF. Recent studies have reported an association between expansion of epicardial adipose tissue (EAT) and skeletal muscle fatigability in HFpEF, independent of generalized obesity or body mass index. Strikingly, muscle endurance is disproportionately impaired relative to muscle mass or maximal strength, revealing a qualitative defect in muscle performance rather than classical sarcopenia. This dissociation, illustrated by preserved force generation alongside accelerated fatigue, implicates impaired mitochondrial oxidative capacity and reduced fatigue resistance as central contributors to functional limitation. In this review, we synthesize emerging evidence on skeletal muscle bioenergetics, mitochondrial dysfunction and adipose–muscle crosstalk to propose a myopenic phenotype as a unifying framework for HFpEF-related disability. Myopenia, defined as clinically meaningful muscle dysfunction driven primarily by impaired muscle quality rather than overt muscle wasting, captures a pattern of wasting biology without obligatory loss of muscle mass. Within this framework, EAT is conceptualized as a metabolically active visceral fat depot that may amplify systemic inflammation and disrupt skeletal muscle oxidative metabolism through an integrated adipo-muscular axis. By shifting emphasis from cardiac mechanics and muscle quantity towards muscle endurance, metabolic efficiency and inter-organ energetic signalling, this framework aligns HFpEF with systems-level paradigms underlying cachexia, metabolic ageing and chronic organ failure. Framing HFpEF as a clinically relevant myopenic state supports muscle-centric outcome measures and integrated therapeutic strategies aimed at correcting multisystem energetic failure and preventing loss of physical function.</p>","PeriodicalId":73544,"journal":{"name":"JCSM rapid communications","volume":"9 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/rco2.70048","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149048166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resistance Exercise Training for Skeletal Muscle Health in Adults Living With Multiple Long-Term Conditions: A Scoping Review","authors":"Christopher Hurst,&nbsp;Jonas Johansson,&nbsp;Miles D. Witham,&nbsp;Sian M. Robinson,&nbsp;Rachel Cooper,&nbsp;Avan A. Sayer","doi":"10.1002/rco2.70045","DOIUrl":"https://doi.org/10.1002/rco2.70045","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Low muscle strength is prevalent in individuals living with multiple long-term conditions (MLTC). Resistance exercise (RE) training is the most effective treatment for improving strength and physical performance across the life course, but little is known about RE in people living with MLTC. This scoping review aimed to identify published evidence on RE as a treatment for improving muscle mass, strength and physical performance in adults living with MLTC.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Six electronic databases were searched to identify studies published up to May 2025 that included adults aged ≥ 18 years who were living with two or more long-term conditions and undertaking a RE intervention.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Sixty-eight papers representing 66 unique studies met the inclusion criteria. A range of methods for characterising MLTC were reported; almost half of the papers (30/68) that included people living with ≥ 2 LTC focused on comorbidity (i.e., participants selected based on the presence of an index condition plus one or more coexisting conditions). There were only seven papers that specifically described their population as living with MLTC. Importantly, only 11 of the included studies involved interventions that were RE only with most including RE performed as part of a multicomponent exercise programme (RE-MCT). None of the RE interventions reported increases in muscle mass, although improvements in muscle strength were observed in four of seven papers and physical performance in five of eight papers. In studies involving RE-MCT, one paper reported a postintervention increase in muscle mass, whereas muscle strength improved in 44% (12/27) of papers where it was measured. Improvements in physical performance were reported across most RE-MCT studies (85%). Exercise session attendance was generally good with few reported adverse events across both RE and RE-MCT interventions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>RE training may be effective for improving strength and physical performance in adults living with MLTC. However, only a small number of studies have evaluated the effects of RE alone in this population, with RE typically incorporated within a broader multicomponent exercise programme. Consequently, more research is needed to understand the effects of interventions, which involve RE alone, but also in comparison with RE-MCT programmes, in individuals living with MLTC across the adult life course.</p>\u0000 </section>\u0000 </div>","PeriodicalId":73544,"journal":{"name":"JCSM rapid communications","volume":"9 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/rco2.70045","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148848632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fibre Type and Stimulus Determine Progression of Skeletal Muscle Atrophy","authors":"Gregory L. Maas,&nbsp;Marcus P. Mullen,&nbsp;Brooke D. Shepard,&nbsp;Jack F. Gugel,&nbsp;Dakota R. Hunt,&nbsp;Virginia Ferguson,&nbsp;Sarah Calve,&nbsp;Thomas G. Martin,&nbsp;Leslie A. Leinwand","doi":"10.1002/rco2.70047","DOIUrl":"https://doi.org/10.1002/rco2.70047","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Skeletal muscle atrophy is prevalent worldwide and is a major detractor from length and quality of life. It is often diagnosed and treated as a single disorder, but the causal stimuli and progression of atrophy vary widely. Malnutrition and disuse are two common causes of muscle atrophy, and despite their prevalence and extensive characterization, there have been no direct comparisons of how these two types of atrophy progress and whether they differentially affect skeletal muscle fibre types. The purpose of this study is to directly compare atrophy from starvation and disuse and provide a transcriptomic resource for future research.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Twelve-week-old female C57BL/6 mice were starved for 3 days to induce malnutrition atrophy or were hindlimb suspended (HS) for 3, 7, 14 or 28 days to induce disuse atrophy. At each timepoint, three muscles (tibialis anterior [TA], extensor digitorum longus [EDL] and soleus) were collected, weighed, sectioned and stained, and RNA was extracted for transcriptomic analysis. Atrophy progression and gene expression changes were compared across muscle fibre types and atrophy stimuli.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;We found differences in atrophy progression between muscle fibre types based on fibre twitch speed and atrophy stimulus. Starved mice lost 25% total body weight, 18% fast-twitch TA mass and 6% TA fibre cross sectional area (CSA), 21% EDL mass and 10% CSA, and 12% soleus mass and 3% CSA. In contrast, 7-day HS mice lost 18% slow-twitch soleus, 8% TA mass and 2% EDL mass. The soleus mass loss progressed to ~40% by 14 and 28 days of HS with 20% CSA loss. Gene expression varied across both atrophy stimuli. In starvation, 3618 and 2556 genes were significantly differentially expressed in the EDL and soleus, respectively. With HS, expression of 312 was altered in the EDL and 1072 in the soleus. Gene set enrichment analysis identified increased abundance of aerobic respiration genes in the EDL versus soleus with starvation and increased amino acid metabolism gene expression in the unloaded soleus versus EDL.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusions&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Atrophy progression varies based on stimuli and muscle fibre type. This study provides a large, matched data set where the effects of different atrophic stimuli can be easily and directly compared in multiple fibre types. This work demonstrates that atrophy is not a single disorder at the molecular scale and suggests that therapeutic development may need to be tailored t","PeriodicalId":73544,"journal":{"name":"JCSM rapid communications","volume":"9 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/rco2.70047","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148848633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gluteus Maximus Shape Reveals Sex-Specific Associations Between Morphology and Metabolic Dysfunction","authors":"Marjola Thanaj,&nbsp;Brandon Whitcher,&nbsp;Hamzah Raza,&nbsp;Camilo Bradford-Bell,&nbsp;Marili Niglas,&nbsp;Jimmy D. Bell,&nbsp;Dimitri Amiras,&nbsp;E. Louise Thomas","doi":"10.1002/rco2.70046","DOIUrl":"https://doi.org/10.1002/rco2.70046","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The gluteus maximus (GM) is a major hip extensor essential for mobility and metabolic health. Previous studies rely on global measures, such as muscle volume or fat fraction, which can overlook spatially localised differences in shape across the GM. Here, we integrate conventional volumetric and fat fraction metrics with 3D mesh-based shape phenotypes to provide a spatially resolved characterisation of GM morphology in relation to anthropometric, lifestyle and cardiometabolic factors, with a focus on type 2 diabetes (T2D) and sex-specific effects.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;We analysed T1 Dixon MRI from UK Biobank participants to quantify GM muscle volume, fat fraction and regional surface morphology using 3D meshes. Statistical parametric mapping was used to assess regional associations with anthropometric, lifestyle and clinical variables. Statistical shape analysis was used to derive principal components (PCs) summarising major modes of GM shape variation, which were evaluated for associations with disease outcomes. Bidirectional causal mediation analyses were performed using GM volumetric and PCs of shape variation. Longitudinal changes in GM composition were assessed in participants with repeat imaging.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;GM muscle volume and fat fraction were strongly associated with age, adiposity and physical activity. Shape analysis identified spatially localised remodelling patterns that were not captured by global measures, revealing region-specific surface shrinkage linked to age, BMI, alcohol intake, grip strength, physical activity, frailty, osteoporosis and cardiometabolic disease. T2D exhibited distinct sex-specific patterns: Men showed predominantly inward deformation across the anterior and central GM, whereas women demonstrated outward deformation in corresponding anterior regions and throughout the posterior muscle, with several posterior regions significant only in women. Mediation analyses suggested that T2D-related changes in GM morphology partly mediated increases in fat fraction, indicating that diabetes influences regional muscle shape beyond overall muscle size. PCs representing variation in the central-superior posterior and anterior GM differentiated T2D cases from controls and were associated with incident T2D risk (men: left GM PC6 HR per SD 0.81 [0.70–0.95], false discovery rate [FDR]-adjusted &lt;i&gt;p&lt;/i&gt; = 0.038; right GM PC6 HR 0.76 [0.65–0.88], &lt;i&gt;p&lt;/i&gt; = 0.002; women: right GM PC5 HR 1.32 [1.08–1.61], &lt;i&gt;p&lt;/i&gt; = 0.032).&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusions&lt;","PeriodicalId":73544,"journal":{"name":"JCSM rapid communications","volume":"9 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/rco2.70046","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148696261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Creatine Supplementation in Patients With Cancer: A Systematic Review and Meta-Analysis","authors":"Luciana de Moura Leite,&nbsp;Heloísa Carneiro Brito,&nbsp;Rafael Lara Nohmi,&nbsp;Fabrícia Cardoso Marques,&nbsp;Pedro Paulo Dal Bello,&nbsp;Daniel V. Araújo","doi":"10.1002/rco2.70044","DOIUrl":"https://doi.org/10.1002/rco2.70044","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Creatine supplementation (CrSUPP) has demonstrated benefits in improving body composition, muscle strength and physical function in healthy older adults. However, preclinical studies have raised concerns about the potential for CrSUPP to negatively impact cancer outcomes. This systematic review and meta-analysis aimed to evaluate the efficacy and safety of CrSUPP in patients with cancer.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;PubMed, Embase and Cochrane databases were systematically searched for randomized controlled trials (RCTs) comparing CrSUPP to placebo (PBO) in cancer patients. Outcomes included changes in body composition (lean mass [LM] and fat mass [FM]), muscle strength, physical function, quality of life (QoL), safety and survival. Standardized mean differences (SMD) or mean differences (MD) with 95% confidence intervals (CI) were calculated. Heterogeneity was assessed using the &lt;i&gt;I&lt;/i&gt;&lt;sup&gt;2&lt;/sup&gt; statistic (significance: &lt;i&gt;p&lt;/i&gt; &lt; 0.1, &lt;i&gt;I&lt;/i&gt;&lt;sup&gt;2&lt;/sup&gt; &gt; 25%). Random-effects models were applied. The protocol was registered in PROSPERO (CRD42025634948).&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Five RCTs including 373 patients (190 CrSUPP, 183 PBO) were analysed. Three studies included patients with non-metastatic disease, whereas two included predominantly advanced cancer cases. Most patients were receiving active oncologic treatment. CrSUPP regimens varied, with three trials using a loading dose (20 g/day for 5–7 days), followed by maintenance (2–5 g/day), and two trials using either a loading or maintenance dosing strategy. Intervention duration ranged from 1 to 12 weeks, combined with resistance training in two studies. There were no significant differences between CrSUPP and PBO for LM (MD 0.55 kg [95% CI, −3.96, 5.07], &lt;i&gt;p&lt;/i&gt; = 0.81, &lt;i&gt;I&lt;/i&gt;&lt;sup&gt;2&lt;/sup&gt; = 0%) or muscle strength (SMD −0.05 [95% CI, −0.29, 0.18], &lt;i&gt;p&lt;/i&gt; = 0.65, &lt;i&gt;I&lt;/i&gt;&lt;sup&gt;2&lt;/sup&gt; = 0%). FM was significantly reduced in the CrSUPP group (MD −2.81 kg [95% CI, −4.21, −1.41], &lt;i&gt;p&lt;/i&gt; &lt; 0.001, &lt;i&gt;I&lt;/i&gt;&lt;sup&gt;2&lt;/sup&gt; = 0.9%). Physical function showed no significant changes (SMD −0.20 [95% CI, −0.68, 0.28], &lt;i&gt;p&lt;/i&gt; = 0.41, &lt;i&gt;I&lt;/i&gt;&lt;sup&gt;2&lt;/sup&gt; = 0%). QoL was assessed in three studies, with data available from two, showing no CrSUPP effect. Safety data from three studies revealed no differences in adverse events between groups; renal function was assessed in one trial and showed non-clinically relevant creatinine elevations. Overall survival was reported in one trial, showing no impact of CrSUPP.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclus","PeriodicalId":73544,"journal":{"name":"JCSM rapid communications","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/rco2.70044","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148282372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":73544,"journal":{"name":"JCSM rapid communications","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148066497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":73544,"journal":{"name":"JCSM rapid communications","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148063582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":73544,"journal":{"name":"JCSM rapid communications","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148093880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}