JCIS open最新文献_第9页

Characteristic length and curvature of the AOT/brine/squalane “sponge” L3 phases AOT/盐水/角鲨烷“海绵”L3相的特征长度和曲率

JCIS open Pub Date : 2023-04-01 DOI: 10.1016/j.jciso.2023.100077

Giuseppe Tartaro, Luigi Gentile, Gerardo Palazzo

{"title":"Characteristic length and curvature of the AOT/brine/squalane “sponge” L3 phases","authors":"Giuseppe Tartaro, Luigi Gentile, Gerardo Palazzo","doi":"10.1016/j.jciso.2023.100077","DOIUrl":"10.1016/j.jciso.2023.100077","url":null,"abstract":"<div><p>The effect of salinity (NaCl concentration) was determined at 25 °C for systems composed of sodium bis(2-ethylhexyl) sulfosuccinate (AOT) and equal volumes of squalane and brine. At all the NaCl concentrations the samples are triphasic with an upper phase made of pure squalane while brine is present in two other phases. At NaCl concentration (in brine) below 1.6 %w/v there is the coexistence of lamellar and sponge (L<sub>3</sub>) phases. Loading with NaCl above 1.6 %w/v one observes the coexistence of L<sub>3</sub> and pure brine. The amount of AOT dissolved in the AOT bilayer has been quantified by thermogravimetric analysis. At salinity above 2 %w/v of NaCl in brine, the AOT sponge phase shrinks expelling brine and the squalane whose presence in the bilayer becomes negligible. The L<sub>3</sub> phases have been further characterized by SAXS and diffusion-NMR. The measured self-diffusion coefficients of water and AOT are essentially coincident with those measured at the same salinity in the absence of squalane. The SAXS curves of sponge phases have been fitted to a single equation accounting for the contributions of the bilayer structure and of the large-scale interactions allowing the determination of the average interpore separation D∗ and the bilayer correlation length ξ. The correlation length has been interpreted as reflecting static randomness of connected bilayer instead of the dynamic thermal undulations. Considering the correlation length as the displacement along the bilayer surface subtending a critical angular change (θ∗) below which the surface appears as flat, permits to define the curvature (H) as |H| <span><math><mrow><mo>=</mo><mfrac><msup><mi>θ</mi><mo>∗</mo></msup><mi>ξ</mi></mfrac></mrow></math></span>. The correlation length scales linearly with the square of the bilayer volume fraction as proposed by a previous theoretical model assuming the sponge phases are thermodynamically constrained to a curvature that equals the spontaneous curvature.</p></div>","PeriodicalId":73541,"journal":{"name":"JCIS open","volume":"9 ","pages":"Article 100077"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44976440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Low doses of pharmaceutical formulations loaded with UFMG-V4N2 immunogen induce the production of IgG anti-cocaine antibodies and provide evidence of cerebral protection in the preclinical model 低剂量加载UFMG-V4N2免疫原的药物制剂可诱导抗可卡因抗体IgG的产生，并在临床前模型中提供脑保护证据

JCIS open Pub Date : 2023-04-01 DOI: 10.1016/j.jciso.2023.100078

Bruna Rodrigues Dias Assis , Paulo Sérgio de Almeida Augusto , Raissa Lima Gonçalves Pereira , Sordaini Maria Caligiorni , Brian Sabato , Larissa Pires do Espírito Santo , Karine Dias dos Reis , Leonardo da Silva Neto , Simone Odília Antunes Fernandes , Valbert Nascimento Cardoso , Maila Castro Lourenço das Neves , Ângelo de Fátima , Frederico Duarte Garcia , Gisele Assis Castro Goulart

{"title":"Low doses of pharmaceutical formulations loaded with UFMG-V4N2 immunogen induce the production of IgG anti-cocaine antibodies and provide evidence of cerebral protection in the preclinical model","authors":"Bruna Rodrigues Dias Assis , Paulo Sérgio de Almeida Augusto , Raissa Lima Gonçalves Pereira , Sordaini Maria Caligiorni , Brian Sabato , Larissa Pires do Espírito Santo , Karine Dias dos Reis , Leonardo da Silva Neto , Simone Odília Antunes Fernandes , Valbert Nascimento Cardoso , Maila Castro Lourenço das Neves , Ângelo de Fátima , Frederico Duarte Garcia , Gisele Assis Castro Goulart","doi":"10.1016/j.jciso.2023.100078","DOIUrl":"10.1016/j.jciso.2023.100078","url":null,"abstract":"<div><p>Anti-cocaine vaccines are a promising therapeutic strategy for treating cocaine use disorders. Here we hypothesize that nanoemulsions (NE) or suspensions (SS) loaded with the calix [4]arene-based immunogen UFMG-V4N2 can induce the production of anti-cocaine antibodies and decrease the passage of radiolabeled cocaine analog [<sup>99m</sup>Tc]Trodat-1 through of the brain barrier. UFMG-V4N2 was characterized (solubility, morphology, DSC, XRD) and loaded into NEs and SSs using excipients approved for human use. Immunogenic efficacy was assessed by quantifying the titers and determining the specificity of anti-cocaine IgG antibodies, and by assessing the inhibition of [<sup>99m</sup>Tc]Trodat-1 trafficking across the mice brain-barrier. UFMG-V4N2 is an amorphous, thermally stable molecule with very low hydrophilicity. The immunogenicity of NE or SS was similar, but aluminum phosphate and the lower dose of UFMG-V4N2 induced higher anti-cocaine IgG antibody titers, minimizing [<sup>99m</sup>Tc]Trodat-1 uptake in the brain. Therefore, the UFMG-V4N2 may represent an alternative for the treatment of cocaine use disorder.</p></div>","PeriodicalId":73541,"journal":{"name":"JCIS open","volume":"9 ","pages":"Article 100078"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47332051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Low viscosity liquid bridges: Stretching of liquid bridges immersed in a higher viscosity liquid 低粘度液桥:浸在高粘度液体中的液桥拉伸

JCIS open Pub Date : 2023-04-01 DOI: 10.1016/j.jciso.2023.100079

Ramon Lopez , Jovina Vaswani , Dylan T. Butler , Joseph McCarthy , Sachin S. Velankar

{"title":"Low viscosity liquid bridges: Stretching of liquid bridges immersed in a higher viscosity liquid","authors":"Ramon Lopez , Jovina Vaswani , Dylan T. Butler , Joseph McCarthy , Sachin S. Velankar","doi":"10.1016/j.jciso.2023.100079","DOIUrl":"10.1016/j.jciso.2023.100079","url":null,"abstract":"<div><p>We examine the dynamics of a liquid bridge between a sphere and a flat plate being separated from each other. Unlike previous research, this paper focuses on the case where the viscosity of the bridge is lower than that of the external fluid within which the particle, the plate, and the liquid bridge are immersed. For the general case of a viscosity mismatch between the bridge fluid and the external fluid, we develop a lubrication theory-based model for the viscous force during separation. The model predicts that a low viscosity bridge reduces the force as compared to both - separation without a liquid bridge, or separation with a bridge of matched viscosity. The magnitude of force reduction is expected to be more severe at small sphere-plate separations and at large bridge volumes. Experiments confirm all these predictions qualitatively, but unexpectedly the magnitude of the reduction is even larger than predicted. Experiments also find that the bridge length at rupture for specified velocity exceeds that for quasistatic rupture by an amount that increases with the squareroot of the velocity. Although we only examine bridges between a plate and a spherical particle, all results are expected to apply for bridges between a pair of particles as well.</p></div>","PeriodicalId":73541,"journal":{"name":"JCIS open","volume":"9 ","pages":"Article 100079"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45965116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A GM-CSF and DOX co-delivery nanoplatform modulates macrophage polarization to promote tumor suppression GM-CSF和DOX共递送纳米平台调节巨噬细胞极化以促进肿瘤抑制

JCIS open Pub Date : 2023-04-01 DOI: 10.1016/j.jciso.2023.100081

Miao Wang , Jiayu Zhang , Jiaruo Tang , Xiaomeng Cai , Rui Dou , Chen Guo , Yi Hu , Jun Chen

{"title":"A GM-CSF and DOX co-delivery nanoplatform modulates macrophage polarization to promote tumor suppression","authors":"Miao Wang , Jiayu Zhang , Jiaruo Tang , Xiaomeng Cai , Rui Dou , Chen Guo , Yi Hu , Jun Chen","doi":"10.1016/j.jciso.2023.100081","DOIUrl":"10.1016/j.jciso.2023.100081","url":null,"abstract":"<div><p>The immunosuppressive tumor microenvironment often compromises chemotherapeutic efficacy. Tumor-associated macrophages (TAM) are a critical component of the tumor immune microenvironment, a large portion of which is in M2-polarization with immunosuppressive effects. Priming the TAM to M1 polarization is a promising strategy for reversing the immunosuppressive microenvironment for promoting tumor therapy. In this study, a co-delivery nanoplatform that integrates GM-CSF as an immune adjuvant with chemotherapy of DOX has been developed to enhance the efficacy of cancer therapy. The photothermal effect from embedded single-walled carbon nanotubes (SWCNTs) controlled the release of GM-CSF and DOX. The results of MB49 cells verified that the GM-CSF pre-treating macrophages enhanced the anti-proliferative efficacy of DOX. This improvement could be related to GM-CSF inducing macrophages to release TNF-α and other cytokines that prevent the growth of cancer cells. This work provides a facile method to prepare a protein/drug/hyperthermia co-delivery system, promising in cancer combined therapy through reversing the immunosuppressive tumor microenvironment.</p></div>","PeriodicalId":73541,"journal":{"name":"JCIS open","volume":"9 ","pages":"Article 100081"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41717163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Synthesis of MnO from pectin-driven sol-gel route for catalytic oxidation of toluene 果胶驱动溶胶-凝胶法合成甲苯催化氧化MnO

JCIS open Pub Date : 2023-04-01 DOI: 10.1016/j.jciso.2023.100076

Jinggang Zhao, Peifen Wang, Jing Wang, Xiaoxun Ma, Lei Shi, Guangwen Xu, A. Abudula, Guoqing Guan

引用次数: 1

Magnetic and photoactive colloidal shuttles for active cargo transportation 用于主动货物运输的磁性和光活性胶体穿梭机

JCIS open Pub Date : 2023-04-01 DOI: 10.1016/j.jciso.2022.100071

Xinyuan Zhang, Zequ Chen, Yurou Li, Xiyue Li, Ruiyao Li, Jiayu Zhang, Muhammad Imran, Yongxiang Gao

{"title":"Magnetic and photoactive colloidal shuttles for active cargo transportation","authors":"Xinyuan Zhang, Zequ Chen, Yurou Li, Xiyue Li, Ruiyao Li, Jiayu Zhang, Muhammad Imran, Yongxiang Gao","doi":"10.1016/j.jciso.2022.100071","DOIUrl":"10.1016/j.jciso.2022.100071","url":null,"abstract":"<div><p>Colloidal shuttles are micro/nanoscale motors that display controllable cargo loading/release and programmable navigation, which are emerging delivery vehicles at the small scale. Here we present a hydrogen peroxide-fueled catalytic colloidal shuttle composed of a hematite cube half coated with platinum, i.e. a Pt/hematite Janus cube, which can be remotely controlled with ease by light and magnetic field. Interestingly, the dynamic behaviors of the Pt/hematite motor under light illumination in lower fuel concentration are similar to those Pt-based motors in higher fuel concentration without UV light, including the self-propulsion direction and the interaction with passive particles. In lower fuel concentration, we demonstrate the ability of the Pt/hematite motor for light-switchable cargo loading and release, and programmable and directional transportation of cargoes using the intrinsic magnetic property of hematite. Our work offers an efficient colloidal shuttle that operates at favorable fuel concentration and light intensity in comparison to earlier reported cargo-towing colloidal motors, which should find applications as microscale delivery vehicles, particularly for cargo transportation on microchips.</p></div>","PeriodicalId":73541,"journal":{"name":"JCIS open","volume":"9 ","pages":"Article 100071"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45276661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Zinc porphyrin covalent organic nanodisks synthesized from covalent organic frameworks and their photocatalytic antibacterial activity 由共价有机框架合成的锌卟啉共价有机纳米片及其光催化抗菌活性

JCIS open Pub Date : 2023-03-01 DOI: 10.1016/j.jciso.2023.100083

Xinxi Li, Zheming Su, M. Fujitsuka, Y. Osakada

引用次数: 0

Recent advances on graphene polymeric bionanoarchitectures for biomedicals 生物医学用石墨烯聚合物生物纳米结构研究进展

JCIS open Pub Date : 2023-01-01 DOI: 10.1016/j.jciso.2022.100070

Christopher Igwe Idumah

引用次数: 16

Micromechanics and strength of agglomerates produced by spray drying 喷雾干燥制备团聚体的微观力学与强度

JCIS open Pub Date : 2023-01-01 DOI: 10.1016/j.jciso.2022.100068

Lorenzo Vasquez Giuliano , Antonio Buffo , Marco Vanni , Graziano Frungieri

引用次数: 6

Analyzing the surfactant classification confusion through the HLD formulation equation 通过HLD配方方程分析表面活性剂的分类混乱

JCIS open Pub Date : 2022-12-01 DOI: 10.1016/j.jciso.2022.100060

Jean-Louis Salager , Alain Graciaa , Ronald Marquez

{"title":"Analyzing the surfactant classification confusion through the HLD formulation equation","authors":"Jean-Louis Salager , Alain Graciaa , Ronald Marquez","doi":"10.1016/j.jciso.2022.100060","DOIUrl":"10.1016/j.jciso.2022.100060","url":null,"abstract":"<div><p>The qualitative presentation from Winsor on an interfacial balance of interactions between the surfactant and the oil and water phases has been transformed into a multivariable linear equation so-called hydrophilic-lipophilic deviation (HLD). This relation involves at least 6 independent variables (surfactant head and tail specifications, water salinity, oil nature, temperature, and pressure) with a MacLaurin series first order approximation, <em>i.e.</em>, a linear multivariable expression. After 40 years of practical experience, it can be said that the HLD relation matches well the experimental data, with only very few exceptions with complex mixtures. Herein, we clear the confusion concerning the meaning and the mathematical handling of the surfactant parameter in the HLD equation. We start with a presentation of simple surfactant systems with only 4 parameters (water salinity, oil nature, surfactant nature, and temperature) as was done 40 years ago. Later, we present a critical discussion on the surfactant term, concerning binary surfactant systems, and on strategies for applications in ternary surfactant mixtures. We have found that the surfactant parameters can only be compared in a series of surfactants with the same head group, where the surfactant parameter is a linear function of the surfactant tail length.</p></div>","PeriodicalId":73541,"journal":{"name":"JCIS open","volume":"8 ","pages":"Article 100060"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666934X22000186/pdfft?md5=6737f0c31bfd628c11a793971f3ec281&pid=1-s2.0-S2666934X22000186-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42082787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5