Japanese journal of gastroenterology and hepatology最新文献

{"title":"Updates on The Management of Hepatocellular Adenomas","authors":"Shafaee Z, Bansal R, Aron J","doi":"10.47829/JJGH.2021.6902","DOIUrl":"https://doi.org/10.47829/JJGH.2021.6902","url":null,"abstract":"Zahra Shafaee, Department of Surgery, NYC Health + Hospitals/ Elmhurst, NY 11373, USA, Tel: 3125439642, E-mail: Shafaeez1@nychhc.org Received: 23 Mar 2021 Accepted: 12 Apr 2021 Published: 20 Apr 2021 Copyright: ©2021 Shafaee Z, This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and build upon your work non-commercially.","PeriodicalId":73535,"journal":{"name":"Japanese journal of gastroenterology and hepatology","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70926579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastric Plexiform Fibromyxoma in Children - A New Case Report and Review of Pediatric Literature","authors":"Moglia C, Parolini F, Villanacci V, Gaetano Gd, M. D., Domenico Dc, Pignata G, A. D.","doi":"10.47829/jjgh.2021.7301","DOIUrl":"https://doi.org/10.47829/jjgh.2021.7301","url":null,"abstract":"Introduction: Plexiform Fibromyxoma (PF), also known as Plexi form Angiomyxoid Myofibroblastic Tumour (PAMT) is a rare mesen chymal myxoid tumour originating in different areas of the digestive system. Symptoms and signs are usually elusive: the most common are abdominal discomfort, dyspepsia, nausea and gastrointestinal bleeding with anemia and hematemesis. Imaging tests are useful to identify plexiform fibromyxoma, but only pathology provides the definitive diagnosis and differentiate it from other mesenchymal tu -mours. PF seems to display a benign behaviour and the only com plete surgical removal of the mass represents the gold standard of treatment; no recurrence or metastasis has been described so far. A little more than 100 cases have been described in adulthood with only 14 cases reported up to now in pediatrics. Case report and review: We report the case of a gastric plexiform fibromyxoma occurred in an 8-year old girl went to our observation with a story of dyspepsia, vomiting, weight loss and anemia. A 4 X 2.5 cm mass was found in the gastric antrum. The tumour was re moved by laparoscopic antrectomy and the pathological exam was consistent with PF. A detailed review of PF pediatric literature is also provided.","PeriodicalId":73535,"journal":{"name":"Japanese journal of gastroenterology and hepatology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70926967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-Expandable Metal Stents for the Management of Gastric Outlet Obstruction: Experience from A Tertiary-Care Facility in Pakistan","authors":"S. Niaz, Syed Zea-Ul-Islam Farrukh, S. A. Haqqi, A. Siddiqui, Abdul Samad Dheddi, Aisha Rumman","doi":"10.47829/jjgh.2021.7903","DOIUrl":"https://doi.org/10.47829/jjgh.2021.7903","url":null,"abstract":"1. Abstract 1.1. Aim Gastric outlet obstruction is commonly considered as advanced malignancies of the stomach, duodenum, pancreas, hepatobiliary, and ampullary regions. Surgical bypass and chemotherapy are the common treatment modalities for gastric obstruction. This study was done to determine the outcomes of self-expandable metal stents in patients with gastric outlet obstruction. 1.2. Methods Forty-seven symptomatic patients with gastric outlet obstruction who underwent self-expandable metal stents in Patel hospital, Karachi-Pakistan from January 2013 till January 2020 were selected for the study. Data on the relief of obstructive symptoms such as; nausea and vomiting and improvement in food intake was the primary clinical success outcome, measured by the gastric outlet obstruction score. Data were statistically analyzed using SPSS version 21.0 (SPSS Inc., Chicago, IL, USA). 1.3. Results Number of 47 patients received uncovered self-expandable stent (Boston Scientific WallFlex) placements during the study period with n=22 (46.8%) single stents, while n=25 (53.2%) dual stents (enteral and biliary), with a mean ±SD age of 60.6 (±14.1) years. Fifteen (31.9%) participants showed good improvement, n=23 (48.9%) patients showed mild improvements, n=04 (8.5%) reported moderate improvement, while only n=05 (10.6%) patients showed no improvements at all after placement of the intervention. The median survival time after the intervention was 8.5 weeks (95% CI: 5.469 – 11.674) in the study population. 1.4. Conclusion The endoscopic stenting for malignant gastric outlet obstruction appears to be an effective alternative to surgical palliative bypass. 2. Introduction Gastric outlet obstruction (GOO) is a result of mechanical gastroduodenal obstruction. Moreover, the incursion of upper abdominal carcinomatosis or metastases from advanced extra-abdominal cancer may also incite GOO. GOO is primarily divided into three major categories, which are benign mechanical, malignant mechanical, and motility disorders [1]. The malignant gastric outlet obstruction (MGOO) typically distresses the areas of the distal stomach or proximal duodenum, resulting in poor prognosis due to gastric and pancreatic malignancies [2]. However, malignant infiltration by neoplasms from adjacent organs and compression by malignant regional lymphadenopathy may also contribute to an exacerbation of existing obstruction [3]. Obstruction is an advanced occurrence in GOO manifesting with nausea, vomiting, poor appetite, and an overall reduction in the quality of life of these patients adding to quality-adjusted life years (QALYs) alongside a significant burden on the healthcare resources [4, 6]. In some patients, symptoms including abdominal pain, esoph-","PeriodicalId":73535,"journal":{"name":"Japanese journal of gastroenterology and hepatology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70927409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical Management of a Caustic Ingestion in a Gastric Bypass Patient: A Case Report","authors":"Boxstael Ve, Terwagne N, Deswysen Y","doi":"10.47829/jjgh.2021.61002","DOIUrl":"https://doi.org/10.47829/jjgh.2021.61002","url":null,"abstract":"","PeriodicalId":73535,"journal":{"name":"Japanese journal of gastroenterology and hepatology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70926013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential Diagnosis of Clinical, Imaging and Pathological Features Between Focal Nodular Hyperplasia and Hepatocellular Carcinoma","authors":"Wen-Hui B, Li- Cheng, Wu Y, Mao-Ming W, Liang-Kun X, W. W, Kai-Huan Y","doi":"10.47829/jjgh.2021.7104","DOIUrl":"https://doi.org/10.47829/jjgh.2021.7104","url":null,"abstract":"Differential Diagnosis of Clinical, Imaging and Pathological Features Between Focal Nodular Hyperplasia and Hepatocellular Carcinoma Wen-Hui B1, Li-Cheng2, Wu Y3, Mao-Ming W1, Liang-Kun X1, Wei-Xing W1* and Kai-Huan Y1* 1Department of Hepatobiliary Surgery, Eastern Campus, Renmin Hospital of Wuhan University, Wuhan, China 2Department of Critical Care Medicine, Eastern Campus, Renmin Hospital of Wuhan University, Wuhan, China 3Department of Pathology, Affiliated Tianyou Hospital of Wuhan University of Science and Technology, Wuhan, China","PeriodicalId":73535,"journal":{"name":"Japanese journal of gastroenterology and hepatology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70926737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bowel Preparation Instructions for Outpatient Colonoscopy Delivered by a Specialist Endoscopy Nurse was Superior to That Delivered by an Endoscopist","authors":"Chee K Hui, Kit Hui","doi":"10.47829/jjgh.2021.7701","DOIUrl":"https://doi.org/10.47829/jjgh.2021.7701","url":null,"abstract":"1.3. Results: Four-thousand-eight-hundred-and-seventy-seven subjects (85.0%) were in the Nurse group while 860 subjects (15.0%) were in the Endoscopist group. A total Boston Bowel Preparation Score ≥6 was achieved in 4721 of the 4877 (96.8%) subjects in the Nurse group when compared with 807 of the 860 (93.8%) subjects in the Endoscopist group (p<0.001). A total of 1624 of the 5737 (28.3%) subjects had adenomas on colonoscopy. There was no significant difference in the adenoma detection rate in the Nurse group when compared with the Endoscopist group [1388/4877 (28.5%) vs. 236/860 (27.4%), p=0.285]. There was also no significant difference in the total number of adenomas detected in the Nurse group when compared with the Endoscopist group [mean± standard deviation 0.48±1.08 vs. 0.44±1.18, p=0.412].","PeriodicalId":73535,"journal":{"name":"Japanese journal of gastroenterology and hepatology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70927050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatocellular Carcinoma Combined with Underlying Alveolar Echinococcosis. Clinical Case Report","authors":"Semenkov Av, Poddubskaya Ev, Yurichenko Yy, Sorokina Mi, Buzdin Aa, Kogan Y, Nekrasova Tp, Lerner Yv, Ippolitov Li, Shchekoturov Io","doi":"10.47829/jjgh.2021.7401","DOIUrl":"https://doi.org/10.47829/jjgh.2021.7401","url":null,"abstract":"Hepatocellular Carcinoma Combined with Underlying Alveolar Echinococcosis. Clinical Case Report Semenkov AV1*, Poddubskaya EV2, Yurichenko YY3, Sorokin MI4,5, Buzdin AA4,5, Kogan Y6, Nekrasova TP6, Lerner YV6, Ippolitov LI3 and Shchekoturov IO7 1Department of oncology, radiotherapy and plastic surgery of the University Clinical Hospital No1, I.M. Sechenov First Moscow State Medical University, Moscow, Russia 2The Scientific-research department of the Center of personalized oncology, I.M. Sechenov First Moscow State Medical University, Moscow, Russia 3Department of oncological surgery No1 of the University clinical hospital No1, I.M. Sechenov First Moscow State Medical University, Moscow, Russia 4Laboratory of Clinical and Genomic Bioinformatics, I.M. Sechenov First Moscow State Medical University, Moscow, Russia 5Moscow Institute of Physics and Technology, Dolgoprudny, Moscow Region, Russia 6Department of anatomic pathology named after Academician A.I. Strukhov, I.M. Sechenov First Moscow State Medical University, Moscow, Russia 7Radiology department of I.M. Sechenov First Moscow State Medical University, Moscow, Russia","PeriodicalId":73535,"journal":{"name":"Japanese journal of gastroenterology and hepatology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70927146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anesthetic Management for Patients With Pheochromocytoma : Series of Three Cases","authors":"Imbelloni Le, Lemos Neto SV, Rivoli Alc, Rosário Ar, Salo Lv, Borges Tg","doi":"10.47829/jjgh.2021.8201","DOIUrl":"https://doi.org/10.47829/jjgh.2021.8201","url":null,"abstract":"1.1. Background. This study describes a case series that addresses the complex anesthetic management of adrenalectomy for patients with pheochromocytoma. It is a rare tumor, originating in the chromaffin cells of the adrenal medulla and a catecholamine-secreting agent, whose most common triad of symptoms is headache, sweating and tachycardia. 1.2. Cases: The first case corresponds to a 47-year-old woman with a history of three acute myocardial infarctions with a lesion located unilaterally in the left adrenal gland. After adrenal removal and due to persistence of hypertension, it was necessary to perform a left nephrectomy. The second case describes the conduction of a multimodal and opioid-free anesthesia of a 26-year-old female patient with dilated cardiomyopathy who underwent video laparoscopic right adrenalectomy The first report involves the case of a 14-year-old male patient with von Hippel-Lindau Syndrome, who underwent bilateral open adrenalectomy. All three cases were successfully preoperatively prepared and operated on and were discharged home between the 5th and 6th day compensated and without physiological changes. No genetic study of the three patients was performed. Continuous epidural anesthesia was performed in two patients, without hypotension and need for vasopressor. 1.3. Conclusion: In this pathology, it is essential to emphasize the extreme importance of the multidisciplinary approaches carried out in the three cases. We can affirm affirm that the favorable outcomes were only possible thanks to a great joint effort and judicious for monitoring the Endocrinology and Pediatrics services and for the coordinated relationship between the anesthetic and surgical teams, which were essential for obtaining hospital discharge in the first six days after surgery","PeriodicalId":73535,"journal":{"name":"Japanese journal of gastroenterology and hepatology","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70927760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microrna-145 Inhibits EMT and Fibrosarcoma Cell Proliferation, Migration and Invasion by Targeting HMGA2","authors":"Cheng M, H. W, Cai W, F. M., Chen Y, Wang C, Yan W, L. G.","doi":"10.47829/jjgh.2021.8103","DOIUrl":"https://doi.org/10.47829/jjgh.2021.8103","url":null,"abstract":"1.1 Aim: Fibrosarcoma is a rare malignant tumor of subcutaneous tissue characterized by slow infiltrative growth and a high rate of local recurrence. The participation of microRNAs (miRNAs/miRs) in the pathogenesis of human diseases and the vital role of miR-145 in different types of cancer. However, the role of miR-145 in fibrosarcoma remains unclear. The present study aimed to investigate the effect of miR-145 in the progression of fibrosarcoma and its potential application as a new therapeutic target. 1.2. Methods: The present study screened out a differential gene named high mobility group protein A2 (HMGA2) via bioinformatics analysis. In the present study, the gene expression profiles of fibrosarcoma cells and normal cells were downloaded from GEO Datasets GSE10021 and GSE1774. The human fibrosarcoma cell line HT1080 were transfected with miR-145 mimics, mimic negative control (NC), pCMV6 vector, overexpression plasmid vector of HMGA2, (si)RNA-HMGA2 or siRNA-NC. Reverse transcription-quantitative PCR and western blot analysis were performed to examine the mRNA (miR-145) and protein (HMGA2, N-cadherin, Vimentin and E-cadherin) expression levels in HT1080 cells. Cell Counting Kit-8, wound healing and Transwell assays were used to examine the TH1080 cell viability, proliferation and migratory capacities, respectively. Bioinformatics prediction and luciferase reporter assay were performed to investigate the relationship between miR145 and its potential target gene (HMGA2). 1.3. Results: The results demonstrated that overexpression of HMGA2 promoted cell proliferation, migration and invasion of HT1080 fibrosarcoma cells, whereas HMGA2 knockdown had no effect on the proliferation of HT1080 fibrosarcoma cells. However, overexpression of miR-145 reversed the facilitating effects of HMGA2 in tumor progression via epithelial-to-mesenchymal transition (EMT) modulation. Mechanistically, miR-145 exerted its inhibitory role in fibrosarcoma by directly binding to the 3’-untranslated region of HMGA2. 1.4. Conclusion: miR-145 plays an inhibitory role in fibrosarcoma progression by directly suppressing HGMA2 expression and EMT progression. Thus, miR-145 may act as a potential therapeutic target for malignant fibrosarcoma therapy","PeriodicalId":73535,"journal":{"name":"Japanese journal of gastroenterology and hepatology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70927854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Imaging Findings and Differential Diagnosis of Hepatic Sinusoidal Occlusion Syndrome and Budd-Chiari Syndrome","authors":"Jia Cy, Zhao Dw, Feng Jl, Wang Xx","doi":"10.47829/jjgh.2021.61603","DOIUrl":"https://doi.org/10.47829/jjgh.2021.61603","url":null,"abstract":"","PeriodicalId":73535,"journal":{"name":"Japanese journal of gastroenterology and hepatology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70926201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}