Japanese journal of gastroenterology and hepatology最新文献

{"title":"Microrna-145 Inhibits EMT and Fibrosarcoma Cell Proliferation, Migration and Invasion by Targeting HMGA2","authors":"Cheng M, H. W, Cai W, F. M., Chen Y, Wang C, Yan W, L. G.","doi":"10.47829/jjgh.2021.8103","DOIUrl":"https://doi.org/10.47829/jjgh.2021.8103","url":null,"abstract":"1.1 Aim: Fibrosarcoma is a rare malignant tumor of subcutaneous tissue characterized by slow infiltrative growth and a high rate of local recurrence. The participation of microRNAs (miRNAs/miRs) in the pathogenesis of human diseases and the vital role of miR-145 in different types of cancer. However, the role of miR-145 in fibrosarcoma remains unclear. The present study aimed to investigate the effect of miR-145 in the progression of fibrosarcoma and its potential application as a new therapeutic target. 1.2. Methods: The present study screened out a differential gene named high mobility group protein A2 (HMGA2) via bioinformatics analysis. In the present study, the gene expression profiles of fibrosarcoma cells and normal cells were downloaded from GEO Datasets GSE10021 and GSE1774. The human fibrosarcoma cell line HT1080 were transfected with miR-145 mimics, mimic negative control (NC), pCMV6 vector, overexpression plasmid vector of HMGA2, (si)RNA-HMGA2 or siRNA-NC. Reverse transcription-quantitative PCR and western blot analysis were performed to examine the mRNA (miR-145) and protein (HMGA2, N-cadherin, Vimentin and E-cadherin) expression levels in HT1080 cells. Cell Counting Kit-8, wound healing and Transwell assays were used to examine the TH1080 cell viability, proliferation and migratory capacities, respectively. Bioinformatics prediction and luciferase reporter assay were performed to investigate the relationship between miR145 and its potential target gene (HMGA2). 1.3. Results: The results demonstrated that overexpression of HMGA2 promoted cell proliferation, migration and invasion of HT1080 fibrosarcoma cells, whereas HMGA2 knockdown had no effect on the proliferation of HT1080 fibrosarcoma cells. However, overexpression of miR-145 reversed the facilitating effects of HMGA2 in tumor progression via epithelial-to-mesenchymal transition (EMT) modulation. Mechanistically, miR-145 exerted its inhibitory role in fibrosarcoma by directly binding to the 3’-untranslated region of HMGA2. 1.4. Conclusion: miR-145 plays an inhibitory role in fibrosarcoma progression by directly suppressing HGMA2 expression and EMT progression. Thus, miR-145 may act as a potential therapeutic target for malignant fibrosarcoma therapy","PeriodicalId":73535,"journal":{"name":"Japanese journal of gastroenterology and hepatology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70927854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Imaging Findings and Differential Diagnosis of Hepatic Sinusoidal Occlusion Syndrome and Budd-Chiari Syndrome","authors":"Jia Cy, Zhao Dw, Feng Jl, Wang Xx","doi":"10.47829/jjgh.2021.61603","DOIUrl":"https://doi.org/10.47829/jjgh.2021.61603","url":null,"abstract":"","PeriodicalId":73535,"journal":{"name":"Japanese journal of gastroenterology and hepatology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70926201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aggressive Xanthogranulomatous Cholecystitis Mimicking Gallbladder Cancer","authors":"Ghunaim M, Alshammakh Ss, A. M.","doi":"10.47829/jjgh.2021.7602","DOIUrl":"https://doi.org/10.47829/jjgh.2021.7602","url":null,"abstract":"Xanthogranulomatous cholecystitis; Cholecystitis / diagnosis; Gall bladder neoplasm; Surgery Ghunaim M1, Alshammakh SS2* and AlHarthi M3 1Assisstant professor of general surgery, endocrine, baritric and metabolic surgery, department of general surgery, Faculty of medicine, King Abdulaziz University, Saudi Arabia 2General surgery resident, department of general surgery, King Abdulaziz University Hospital, Saudi Arabia 3Assisstant professor, Hepatobiliary surgeon and colorectal surgeon, department of general surgery, Faculty of medicine, King Abdulaziz University, Saudi Arabia","PeriodicalId":73535,"journal":{"name":"Japanese journal of gastroenterology and hepatology","volume":"95 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70926918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased Expression of GNL3L is Associated with Aggressive Phenotypes in Colorectal Cancer","authors":"Z Tiao-Tiao, L. Chen, P Bin-Hui, X. Zhi-Hua, X. Sheng, Z Jia-Min, W Chao-Yi, W Fang-Yan, Changlong Xu, H Ying-Peng, Z. Xiaolong","doi":"10.47829/jjgh.2021.62103","DOIUrl":"https://doi.org/10.47829/jjgh.2021.62103","url":null,"abstract":"Increased Expression of GNL3L is Associated with Aggressive Phenotypes in Colorectal Cancer Tiao-Tiao Z1, Chen L1, Bin-Hui P1, Zhi-Hua X1, Sheng X1, Jia-Min Z2, Chao-Yi W2, Fang-Yan W2, ChangLong XU1*, Ying-Peng H3 and XiaoLong Z4* 1Department for the Treatment and Study of Digestive Diseases, The 2nd Affiliated Hospital & Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, China 2School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, China 3Department of General Surgery, The 2nd Affiliated Hospital & Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, China 4Department of Critical Care Medicine, The 2nd Affiliated Hospital & Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, China","PeriodicalId":73535,"journal":{"name":"Japanese journal of gastroenterology and hepatology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70926665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Uncommon Complication of Peptic Ulcer Disease","authors":"M. Jagielski, M. Jackowski","doi":"10.47829/JJGH.2021.6301","DOIUrl":"https://doi.org/10.47829/JJGH.2021.6301","url":null,"abstract":"Mateusz Jagielski, Department of General, Gastroenterological and Oncological Surgery, Collegium Medicum Nicolaus Copernicus University, 53-59 Sw. Jozefa St, 87-100 Torun, Poland, Tel: +48 56 679-31-99, E-mail: matjagiel@gmail.com Received: 23 Feb 2021 Accepted: 08 Mar 2021 Published: 11 Mar 2021 Copyright: ©2021 Jagielski M, This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and build upon your work non-commercially.","PeriodicalId":73535,"journal":{"name":"Japanese journal of gastroenterology and hepatology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70926857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"18F-FDG PET/CT for Therapy Monitoring in Subcutaneous Panniculitis-Like T Cell Lymphoma","authors":"Jiang H, Li A, Ji Z, Lin J","doi":"10.47829/JJGH.2021.51302","DOIUrl":"https://doi.org/10.47829/JJGH.2021.51302","url":null,"abstract":"1. Abstract 1.1. Purpose: The aim of this study was to describe the role of 18 F-FDG PET/CT imaging in the staging and monitoring therapy response for subcutaneous panniculitis-like T cell lymphoma (SPTCL) and to analyze the maximum standardized uptake value (SUVmax) of FDG uptake with regard to clinical factors. 1.2. Methods: Seven patients with pathologically proven SPTCL who had undergone PET/CT imaging at initial diagnosis and/or remission were included. All seven patients were treated with different protocols of chemotherapy or haematopoietic stem cell transplantation. Characteristic findings of PET/CT imaging in patients","PeriodicalId":73535,"journal":{"name":"Japanese journal of gastroenterology and hepatology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70925945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hyponatremia in Decompensated Chronic Liver Disease, A Marker of Poor Prognosis Hyponatremia; A Red Flag in Chronic Liver Disease","authors":"Naim Mh, A. W, Pirzada S, Tariq Mhr, Adam Am, Naim H","doi":"10.47829/jjgh.2021.7302","DOIUrl":"https://doi.org/10.47829/jjgh.2021.7302","url":null,"abstract":"","PeriodicalId":73535,"journal":{"name":"Japanese journal of gastroenterology and hepatology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70927034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endovascular Management of Pseudoaneurysms and Aneurysms Following Gastrointestinal Surgery","authors":"Kageyama Y, Y. R, T. H, Katono Y, W. S, Aizu K, K. S, S. F, T. Y, I. T","doi":"10.47829/jjgh.2021.7702","DOIUrl":"https://doi.org/10.47829/jjgh.2021.7702","url":null,"abstract":"1. Abstract 1.1. Purpose: This study aimed to evaluate the characteristics of pseudoaneurysms and aneurysms following gastrointestinal surgery treated with endovascular management (i.e., transcatheter arterial embolization or stent-graft placement). 1.2. Methods: This retrospective study included 17 patients with pseudoaneurysms and 1 patient with an aneurysm following gastrointestinal surgery in a tertiary care hospital between 2011 and 2021. There were 15 men and 3 women aged 37–85 years, with an average age of 67 years. All patients underwent endovascular management. We retrospectively analyzed their angiographic features and clinical outcomes. 1.3. Results: Arterial embolization was performed in 11 patients, and stent-graft placement was performed in 7 patients. Additional arterial embolization was necessary for another bleeding lesion in 2 patients, while 1 patient died of multiple organ failure. Stent-graft occlusion occurred after a few days in 3 out of 7 patients without any antithrombotic drugs. Extravascular migration of the occluded stentgrafts was observed in 3 out of 7 patients, wherein these stent-grafts migrated to the intestine and eventually disappeared in 2 patients. There were no clinical symptoms related to the occlusion or migration of the stent-grafts. 1.4. Conclusion: Both arterial embolization and stent-graft placement are effective in the management of postoperative pseudoaneurysms and aneurysms. Stent-graft placement is suitable for cases with poor collateral flow because it preserves arterial patency. The use of antithrombotic treatment and the risk of stent-grafts migration should be taken into consideration. 2. Introduction Traditionally, surgical treatment is considered the first-line approach for pseudoaneurysms and aneurysms. Recently, less invasive techniques have been developed, such as Transcatheter Arterial Embolization (TAE) and stent-graft placement. This study aimed to review our experience on the treatment of pseudoaneurysms and an aneurysm following gastrointestinal surgery and to evaluate the effectiveness of endovascular management. 3. Materials and Methods 3.1. Study Design and Patients We retrospectively reviewed 17 patients with pseudoaneurysms and 1 patient with aneurysm following gastrointestinal surgery between January 2011 and May 2021 at our hospital. There were 15 men and 3 women with an average age of 67 years (range 37–85 years). The following clinical information were also analyzed: primary disease, surgical procedure, postoperative complications and bacterial culture results prior to bleeding, interval from operation to bleeding, symptoms, interval from detection of bleeding via computed tomog-","PeriodicalId":73535,"journal":{"name":"Japanese journal of gastroenterology and hepatology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70927140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complex Innovative Design for Liver Disease Clinical Trials","authors":"Chow Sc, M. W, S. A, K. Y, J. J.","doi":"10.47829/jjgh.2021.7402","DOIUrl":"https://doi.org/10.47829/jjgh.2021.7402","url":null,"abstract":"","PeriodicalId":73535,"journal":{"name":"Japanese journal of gastroenterology and hepatology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70927351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of COVID-19 in Liver Transplant Recipients: A Single Center Experience","authors":"Aktas H, Ozer A, Keceoglu S, C. Mg, E. R.","doi":"10.47829/jjgh.2021.7201","DOIUrl":"https://doi.org/10.47829/jjgh.2021.7201","url":null,"abstract":"","PeriodicalId":73535,"journal":{"name":"Japanese journal of gastroenterology and hepatology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70926494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}