ISRN cardiology最新文献

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Alcohol-attributable fraction of ischemic heart disease mortality in Russia. 俄罗斯缺血性心脏病死亡率的酒精归因比例
ISRN cardiology Pub Date : 2013-07-15 eCollection Date: 2013-01-01 DOI: 10.1155/2013/287869
Y E Razvodovsky
{"title":"Alcohol-attributable fraction of ischemic heart disease mortality in Russia.","authors":"Y E Razvodovsky","doi":"10.1155/2013/287869","DOIUrl":"https://doi.org/10.1155/2013/287869","url":null,"abstract":"<p><p>Objective. The aim of the present study was to estimate the premature ischemic heart disease (IHD) mortality attributable to alcohol abuse in Russia on the basis of aggregate-level data of mortality and alcohol consumption. Method. Age-standardized sex-specific male and female IHD mortality data for the period 1980-2005 and data on overall alcohol consumption were analyzed by means of autoregressive integrated moving average (ARIMA) time series analysis. Results. The results of the analysis suggest that 41.1% of all male deaths and 30.7% of female deaths from IHD in Russia could be attributed to alcohol. The estimated alcohol-attributable fraction for men ranged from 24.0% (75+ age group) to 62.0% (15-29 age group) and for women from 20.0% (75+ age group) to 64.0% (30-44 age group). Conclusions. The outcomes of this study provide indirect support for the hypothesis that the high rate of IHD mortality in Russia may be related to alcohol, as indicated by a close aggregate-level association between number of deaths from IHD and overall alcohol consumption per capita. </p>","PeriodicalId":73519,"journal":{"name":"ISRN cardiology","volume":"2013 ","pages":"287869"},"PeriodicalIF":0.0,"publicationDate":"2013-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/287869","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31667655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 19
Assessment of Risk Factor for Cardiovascular Disease Using Heart Rate Variability in Postmenopausal Women: A Comparative Study between Urban and Rural Indian Women. 使用心率变异性评估绝经后妇女心血管疾病的危险因素:印度城市和农村妇女的比较研究
ISRN cardiology Pub Date : 2013-07-11 Print Date: 2013-01-01 DOI: 10.1155/2013/858921
Nikhil Narayanaswamy, Shailaja Moodithaya, Harsha Halahalli, Amrit M Mirajkar
{"title":"Assessment of Risk Factor for Cardiovascular Disease Using Heart Rate Variability in Postmenopausal Women: A Comparative Study between Urban and Rural Indian Women.","authors":"Nikhil Narayanaswamy,&nbsp;Shailaja Moodithaya,&nbsp;Harsha Halahalli,&nbsp;Amrit M Mirajkar","doi":"10.1155/2013/858921","DOIUrl":"https://doi.org/10.1155/2013/858921","url":null,"abstract":"<p><p>Cardiovascular diseases are important causes of morbidity and mortality in postmenopausal women. A major determinant of cardiovascular health is the status of autonomic nervous system and assessment of Heart Rate Variability (HRV). Heart Rate Variability is a noninvasive and sensitive technique to evaluate cardiovascular autonomic control. Reduced HRV is an independent risk factor for the development of heart disease. This study evaluated the risk factors for cardiovascular diseases using HRV, between urban and rural Indian postmenopausal women ranging in age from 40 to 75 years. Findings of the analysis of HRV have showed that the total power which reflects overall modulation of cardiac autonomic activity (759 ± 100  versus 444 ± 65), the absolute power of high frequency which is surrogate of cardiovagal activity (247 ± 41  versus 163 ± 45), and low frequency that reflects cardiac sympathetic activity (205 ± 26  versus 127 ± 18) were significantly higher in urban women than that of their rural counterparts. Further, among the anthropometric measures, waist circumference was significantly correlated with indices of HRV. The study concludes that rural Indian women are associated with an additional risk beyond that of ageing and postmenopausal status when compared to the urban women. The higher central obesity could be the contributing factor for developing higher risk for cardiovascular disease among the rural women. </p>","PeriodicalId":73519,"journal":{"name":"ISRN cardiology","volume":"2013 ","pages":"858921"},"PeriodicalIF":0.0,"publicationDate":"2013-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/858921","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31649959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Association of oral health and cardiovascular disease risk factors "results from a community based study on 5900 adult subjects". 口腔健康与心血管疾病危险因素的关联"基于5900名成人受试者的社区研究结果"。
ISRN cardiology Pub Date : 2013-07-09 eCollection Date: 2013-01-01 DOI: 10.1155/2013/782126
Hamid Najafipour, Tayebeh Malek Mohammadi, Foad Rahim, Ali Akbar Haghdoost, Mitra Shadkam, Mahdi Afshari
{"title":"Association of oral health and cardiovascular disease risk factors \"results from a community based study on 5900 adult subjects\".","authors":"Hamid Najafipour,&nbsp;Tayebeh Malek Mohammadi,&nbsp;Foad Rahim,&nbsp;Ali Akbar Haghdoost,&nbsp;Mitra Shadkam,&nbsp;Mahdi Afshari","doi":"10.1155/2013/782126","DOIUrl":"https://doi.org/10.1155/2013/782126","url":null,"abstract":"<p><p>Objectives. This study aimed to determine the association between some oral health status as a risk factor for cardiac diseases and other cardiovascular disease (CVD) risk factors in a sample of Iranian population in 2011. Methods. The study recruited 5900 inhabitants who aged 15-75 years old of Kerman city through a population based cluster sampling. Having collected informed consent, participants were interviewed for CVD risk factors. Some oral health indicators such as DMFT, Gingival Inflammation index, and Community Periodontal Index were assessed. The association between oral health indices and CVD risk factors was tested using multivariate regression models. Results. The mean age of participants was 33.5 years, and 45.1% were male. Moderate gingival inflammation was observed in 67.6% of participants. Presence of sub- or supragingival calculus was more common (90%) in participants. Older age (RR from 2.7 to 3.88), cigarette smoking (RR = 1.49), and high blood glucose (RR = 1.41) showed an increased risk for oral diseases after adjustment for different covariates including established CVD risk factors. Conclusion. The study results showed an increase in periodontal diseases in the presence of some CVD risk factors. Therefore there may be a bilateral but independent association for both conditions and common risk factor approach preventive program is highly recommended. </p>","PeriodicalId":73519,"journal":{"name":"ISRN cardiology","volume":"2013 ","pages":"782126"},"PeriodicalIF":0.0,"publicationDate":"2013-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/782126","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31667656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 15
Left-to-Right Shunt with Congenital Heart Disease: Single Center Experience. 先天性心脏病左向右分流:单中心经验。
ISRN cardiology Pub Date : 2013-06-23 Print Date: 2013-01-01 DOI: 10.1155/2013/301617
Ayhan Cevik, Rana Olgunturk, Serdar Kula, Berna Saylan, Ayhan Pektas, Deniz Oguz, Sedef Tunaoglu
{"title":"Left-to-Right Shunt with Congenital Heart Disease: Single Center Experience.","authors":"Ayhan Cevik,&nbsp;Rana Olgunturk,&nbsp;Serdar Kula,&nbsp;Berna Saylan,&nbsp;Ayhan Pektas,&nbsp;Deniz Oguz,&nbsp;Sedef Tunaoglu","doi":"10.1155/2013/301617","DOIUrl":"https://doi.org/10.1155/2013/301617","url":null,"abstract":"<p><p>Objective. The objective of this study was to determine the frequency of pulmonary arterial hypertension (PAH) in congenital heart disease (CHD) with an isolated, large left-to-right shunt and to indicate the factors in the development of PAH. Methods. The pressure measurements in the cardiac chambers and the calculations based on the Fick's principle were compared among 3 separate groups of patients, respectively, with PAH, with hyperkinetic pulmonary hypertension (HPH), and with neither PAH nor HPH. Results. PAH was diagnosed in 30 (12.3%) patients, HPH in 35 (14.4%), while 177 (73.1%) were free of either. The highest risk for the development of PAH was found in the presence of perimembranous ventricular septal defect. A statistically significant difference was seen among these groups as to their left atrial pressure (p = 0.005) and the mean pulmonary arterial pressure (PAPmean; p < 0.001). While a correlation was present between RpI on one hand and age on the other (p = 0.014), a multiple linear regression could not evidence any correlation among age (p = 0.321), gender (p = 0.929). Conclusion. Our findings do not allow establishing a correlation between the duration of the high pulmonary flow and pulmonary vascular resistance increase or PAH development in isolated left-to-right shunts with congenital heart diseases. </p>","PeriodicalId":73519,"journal":{"name":"ISRN cardiology","volume":"2013 ","pages":"301617"},"PeriodicalIF":0.0,"publicationDate":"2013-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/301617","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31586299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Risk factors for coronary drug-eluting stent thrombosis: influence of procedural, patient, lesion, and stent related factors and dual antiplatelet therapy. 冠状动脉药物洗脱支架血栓形成的危险因素:手术、患者、病变和支架相关因素的影响以及双重抗血小板治疗
ISRN cardiology Pub Date : 2013-06-23 Print Date: 2013-01-01 DOI: 10.1155/2013/748736
Krishnankutty Sudhir, James B Hermiller, Joanne M Ferguson, Charles A Simonton
{"title":"Risk factors for coronary drug-eluting stent thrombosis: influence of procedural, patient, lesion, and stent related factors and dual antiplatelet therapy.","authors":"Krishnankutty Sudhir,&nbsp;James B Hermiller,&nbsp;Joanne M Ferguson,&nbsp;Charles A Simonton","doi":"10.1155/2013/748736","DOIUrl":"https://doi.org/10.1155/2013/748736","url":null,"abstract":"<p><p>The complication of stent thrombosis (ST) emerged at a rate of 0.5% annually for first-generation drug-eluting stents (DES), often presenting as death or myocardial infarction. Procedural factors such as stent underexpansion and malapposition are risk factors for ST in patients. The type of lesion being treated and lesion morphology also influence healing after treatment with DES and can contribute to ST. Second-generation DES such as the XIENCE V everolimus-eluting stent differ from the first-generation stents with respect to antiproliferative agents, coating technologies, and stent frame. Improvements in stent structure have resulted in a more complete endothelialization, thereby decreasing the incidence of ST. Bioresorbable scaffolds show promise for restoring vasomotor function and minimizing rates of very late ST. Post-PCI treatment with aspirin and clopidogrel for a year is currently the standard of care for DES, but high-risk patients may benefit from more potent antiplatelet agents. The optimal duration of DAPT for DES is currently unclear and will be addressed in large-scale randomized clinical trials. </p>","PeriodicalId":73519,"journal":{"name":"ISRN cardiology","volume":"2013 ","pages":"748736"},"PeriodicalIF":0.0,"publicationDate":"2013-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/748736","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31586300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 22
A review of most relevant complications of transcatheter aortic valve implantation. 经导管主动脉瓣植入术的相关并发症综述。
ISRN cardiology Pub Date : 2013-05-12 Print Date: 2013-01-01 DOI: 10.1155/2013/956252
Siyamek Neragi-Miandoab, Robert E Michler
{"title":"A review of most relevant complications of transcatheter aortic valve implantation.","authors":"Siyamek Neragi-Miandoab,&nbsp;Robert E Michler","doi":"10.1155/2013/956252","DOIUrl":"https://doi.org/10.1155/2013/956252","url":null,"abstract":"<p><p>Transcatheter aortic valve implantation (TAVI) has emerged for treating aortic stenosis in patients who are poor candidates for surgical aortic valve replacement. Currently, the balloon-expandable Edwards Sapien valve-which is usually implanted via a transfemoral or transapical approach-and the self-expanding CoreValve ReValving system-which is designed for retrograde application-are the most widely implanted valves worldwide. Although a promising approach for high-risk patients, the indication may be expanded to intermediate- and eventually low-risk patients in the future; however, doing so will require a better understanding of potential complications, risk factors for these complications, and strategies to individualize each patient to a different access route and a specific valve. This paper reviews the most relevant complications that may occur in patients who undergo catheter-based aortic valve implantation. </p>","PeriodicalId":73519,"journal":{"name":"ISRN cardiology","volume":"2013 ","pages":"956252"},"PeriodicalIF":0.0,"publicationDate":"2013-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/956252","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31572051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 47
The Transaxial Orientation Is Superior to Both the Short Axis and Horizontal Long Axis Orientations for Determining Right Ventricular Volume and Ejection Fraction Using Simpson's Method with Cardiac Magnetic Resonance. 心脏磁共振辛普森法测定右心室容积和射血分数时,横轴位优于短轴位和水平长轴位。
ISRN cardiology Pub Date : 2013-04-14 Print Date: 2013-01-01 DOI: 10.1155/2013/268697
Michael K Atalay, Kevin J Chang, David J Grand, Shawn Haji-Momenian, Jason T Machan, Florence H Sheehan
{"title":"The Transaxial Orientation Is Superior to Both the Short Axis and Horizontal Long Axis Orientations for Determining Right Ventricular Volume and Ejection Fraction Using Simpson's Method with Cardiac Magnetic Resonance.","authors":"Michael K Atalay,&nbsp;Kevin J Chang,&nbsp;David J Grand,&nbsp;Shawn Haji-Momenian,&nbsp;Jason T Machan,&nbsp;Florence H Sheehan","doi":"10.1155/2013/268697","DOIUrl":"https://doi.org/10.1155/2013/268697","url":null,"abstract":"<p><p>We sought to determine which of the three orientations is the most reliable and accurate for quantifying right ventricular (RV) volume and ejection fraction (EF) by cardiac magnetic resonance using Simpson's method. We studied 20 patients using short axis (SA), transaxial (TA), and horizontal long axis (HLA) orientations. Three readers independently traced RV endocardial contours at end-diastole and end-systole for each orientation. End-diastolic volumes (EDVs), end-systolic volumes (ESVs), and EF were calculated and compared with the 3D piecewise smooth subdivision surface (PSSS) method. The intraclass correlation coefficients among the 3 readers for EDV, ESV, and EF were 0.92, 0.82, and 0.42, respectively, for SA, 0.95, 0.92, and 0.67 for TA, and 0.85, 0.93, and 0.69 for HLA. For mean data there was no significant difference between TA and PSSS for EDV (-2.6%, 95% CI: -8.2 to 3.3%), ESV (-5.9%, -15.2 to 4.5%), and EF (1.7%, -1.5 to 4.9%). HLA was accurate for ESV (-8.9%, -18.5 to 1.8%) and EF (-0.7%, -3.8 to 2.5%) but significantly underestimated EDV (-9.8, -16.6 to -2.4%). SA was accurate for EDV (0.5%, -6.0 to 7.5%) but overestimated ESV (10.5%, 0.1 to 21.9%) and had poor interrater reliability for EF. Conclusions. The TA orientation provides the most reliable and accurate measures of EDV, ESV, and EF.</p>","PeriodicalId":73519,"journal":{"name":"ISRN cardiology","volume":"2013 ","pages":"268697"},"PeriodicalIF":0.0,"publicationDate":"2013-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/268697","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31445437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Elevated cardiac troponins in setting of systemic inflammatory response syndrome, sepsis, and septic shock. 全身炎症反应综合征、败血症和感染性休克时肌钙蛋白升高。
ISRN cardiology Pub Date : 2013-04-11 Print Date: 2013-01-01 DOI: 10.1155/2013/723435
Nasir Hussain
{"title":"Elevated cardiac troponins in setting of systemic inflammatory response syndrome, sepsis, and septic shock.","authors":"Nasir Hussain","doi":"10.1155/2013/723435","DOIUrl":"10.1155/2013/723435","url":null,"abstract":"<p><p>Elevation of cardiac troponins and creatinine kinase is frequently observed in setting of systemic inflammatory response syndrome (SIRS), sepsis, or septic shock. Underlying pathophysiologic mechanism for such troponin leak, its clinical significance, and what different could be done in such settings remain elusive. In this paper we have briefly overviewed the proposed pathogenic mechanisms for SIRS, sepsis, or septic shock-related troponin elevation (SRTE) and have provided brief overview on its clinical significance. Upon review of the relevant literature we found that majority of patients with the SRTE with no prior history of coronary artery disease (CAD) upon testing are found not to have any CADs. We have also briefly discussed the possible pharmacologic agents and potential targets which are important from pathophysiologic and pharmacologic point of view that may alter the outcomes of SRTE-related myocardial depression in near future.</p>","PeriodicalId":73519,"journal":{"name":"ISRN cardiology","volume":"2013 ","pages":"723435"},"PeriodicalIF":0.0,"publicationDate":"2013-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/723435","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31445438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 28
Dual antiplatelet therapy can be discontinued at three months after implantation of zotarolimus-eluting stent in patients with coronary artery disease. 双重抗血小板治疗可在冠状动脉疾病患者植入佐他莫司洗脱支架后3个月停止。
ISRN cardiology Pub Date : 2013-04-04 Print Date: 2013-01-01 DOI: 10.1155/2013/518968
Tadashi Wada, Makoto Nakahama, Hironobu Toda, Atsuyuki Watanabe, Katsushi Hashimoto, Ritsuko Terasaka, Kazufumi Nakamura, Nobuyuki Yamada, Hiroshi Ito
{"title":"Dual antiplatelet therapy can be discontinued at three months after implantation of zotarolimus-eluting stent in patients with coronary artery disease.","authors":"Tadashi Wada,&nbsp;Makoto Nakahama,&nbsp;Hironobu Toda,&nbsp;Atsuyuki Watanabe,&nbsp;Katsushi Hashimoto,&nbsp;Ritsuko Terasaka,&nbsp;Kazufumi Nakamura,&nbsp;Nobuyuki Yamada,&nbsp;Hiroshi Ito","doi":"10.1155/2013/518968","DOIUrl":"https://doi.org/10.1155/2013/518968","url":null,"abstract":"<p><p>Dual antiplatelet therapy (DAPT) after percutaneous coronary intervention increases the risk of bleeding. We studied the safety and clinical outcomes of switching from DAPT to aspirin monotherapy at 3 months after ZES implantation. We retrospectively evaluated 168 consecutive patients with coronary artery disease who had been implanted with a ZES from June 2009 through March 2010. After excluding 40 patients according to exclusion criteria such as myocardial infarction, 128 patients were divided into a 3-month DAPT group (67 patients, 88 lesions) and a 12-month conventional DAPT group (61 patients, 81 lesions). Coronary angiographic followup and clinical followup were conducted at more than 8 months and at 12 months after ZES implantation, respectively. Minor and major bleeding events, stent thrombosis (ST), and major adverse cardiac events (MACE) (death, myocardial infarction, cerebrovascular accident, target lesion revascularization, and target vessel revascularization) were evaluated. There were no statistically significant differences in the incidences of ST and MACE between the two groups. The incidence of bleeding events was significantly lower in the 3-month group than in the 12-month group (1.5% versus 11.5%, P < 0.05). DAPT can be safely discontinued at 3 months after ZES implantation, which reduces bleeding risk.</p>","PeriodicalId":73519,"journal":{"name":"ISRN cardiology","volume":"2013 ","pages":"518968"},"PeriodicalIF":0.0,"publicationDate":"2013-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/518968","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31503619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Hyperoxic vasoconstriction of human pulmonary arteries: a novel insight into acute ventricular septal defects. 人肺动脉的高氧血管收缩:对急性室间隔缺损的新见解。
ISRN cardiology Pub Date : 2013-03-31 Print Date: 2013-01-01 DOI: 10.1155/2013/685735
Priyadharshanan Ariyaratnam, Mahmoud Loubani, Robert Bennett, Steven Griffin, Mubarak A Chaudhry, Michael E Cowen, Levant Guvendik, Alexander R J Cale, Alyn H Morice
{"title":"Hyperoxic vasoconstriction of human pulmonary arteries: a novel insight into acute ventricular septal defects.","authors":"Priyadharshanan Ariyaratnam,&nbsp;Mahmoud Loubani,&nbsp;Robert Bennett,&nbsp;Steven Griffin,&nbsp;Mubarak A Chaudhry,&nbsp;Michael E Cowen,&nbsp;Levant Guvendik,&nbsp;Alexander R J Cale,&nbsp;Alyn H Morice","doi":"10.1155/2013/685735","DOIUrl":"https://doi.org/10.1155/2013/685735","url":null,"abstract":"<p><p>Objectives. Acute rises in pulmonary artery pressures following postinfarction ventricular septal defects present a challenge. We hypothesised that the abnormally high oxygen content exposure to the pulmonary arteries may be a factor. We investigated the contractile responses of human pulmonary arteries to changes in oxygen tension. Methods. Isometric tension was measured in large and medium sized pulmonary artery rings obtained from lung resections for patients with bronchial carcinoma (n = 30). Fresh rings were mounted in organ baths bubbled under basal conditions with hyperoxic or normoxic gas mixes and the gas tensions varied during the experiment. We studied whether voltage-gated calcium channels and nitric oxide signalling had any role in responses to oxygen changes. Results. Hypoxia caused a net mean relaxation of 18.1% ± 15.5 (P < 0.005) from hyperoxia. Subsequent hyperoxia caused a contraction of 19.2% ± 13.5 (P < 0.005). Arteries maintained in normoxia responded to hyperoxia with a mean constriction of 14.8% ± 3.9 (P < 0.005). Nifedipine inhibited the vasoconstrictive response (P < 0.05) whilst L-NAME had no effect on any hypoxic vasodilatory response. Conclusions. We demonstrate that hyperoxia leads to vasoconstriction in human pulmonary arteries. The mechanism appears to be dependent on voltage-gated calcium channels. Hyperoxic vasoconstriction may contribute to acute rises in pulmonary artery pressures.</p>","PeriodicalId":73519,"journal":{"name":"ISRN cardiology","volume":"2013 ","pages":"685735"},"PeriodicalIF":0.0,"publicationDate":"2013-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/685735","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31376567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
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