International journal of cardiology. Congenital heart disease最新文献

{"title":"Assessing subaortic right ventricle function after atrial switch repair through myocardial work analysis","authors":"Ana Moya ,&nbsp;Sofie Verstreken ,&nbsp;Dimitri Buytaert ,&nbsp;Monika Beles ,&nbsp;Elayne Kelen de Oliveira ,&nbsp;Marc Vanderheyden ,&nbsp;Alexander Van De Bruaene ,&nbsp;Werner Budts","doi":"10.1016/j.ijcchd.2024.100537","DOIUrl":"10.1016/j.ijcchd.2024.100537","url":null,"abstract":"<div><h3>Background</h3><div>The Mustard and Senning operations for dextro-transposition of the great arteries (D-TGA) establish a biventricular physiology with a subaortic right ventricle (sRV). While prolonged QRS has been associated with worse prognosis in these patients, current echocardiographic tools fall short in adequately assessing the (mal)performance and function decline of the sRV during follow-up. The present study is the first to characterize Myocardial Work (MW) indices of the sRV in D-TGA patients after Mustard/Senning repair.</div></div><div><h3>Methods and results</h3><div>All adult D-TGA patients at follow-up in the University Hospital of Leuven between 2018 and 2022 were screened for inclusion. We retrospectively collected the most recent electrocardiogram parameters, 2D echocardiographic images and serum biomarkers’ values. Offline calculations of MW indices were performed. We established correlations between all variables and categorized patients into QRS&lt;120 ms and QRS≥120 ms for further analysis. A total of 51 D-TGA patients were included (13 Mustard, 33 male, 39 ± 6 years). QRS duration increased with age and was correlated with sRV dimensions and serum levels of troponins (R = 0.42, p &lt; 0.01) and NT-proBNP (R = 0.31, p = 0.03). However, no significant correlation was found between QRS duration and intraventricular desynchrony or conventional functional echocardiographic parameters. QRS prolongation was associated with a deterioration in septal, but not lateral, MW parameters. Patients with QRS≥120 ms had significantly larger ventricles and higher levels of troponins and NT-proBNP.</div></div><div><h3>Conclusion</h3><div>QRS prolongation after Mustard/Senning repair is linked to ventricular dilatation and worse performance, particularly affecting the septal wall. Global and regional MW analysis may be useful to assess the subclinical deterioration of sRV function.</div></div>","PeriodicalId":73429,"journal":{"name":"International journal of cardiology. Congenital heart disease","volume":"18 ","pages":"Article 100537"},"PeriodicalIF":0.8,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142320251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Imaging in chronic thromboembolic pulmonary disease: Current practice and advances","authors":"Hakim Ghani ,&nbsp;Jonathan R. Weir-McCall ,&nbsp;Alessandro Ruggiero ,&nbsp;Joanna Pepke-Zaba","doi":"10.1016/j.ijcchd.2024.100536","DOIUrl":"10.1016/j.ijcchd.2024.100536","url":null,"abstract":"<div><p>Chronic thromboembolic pulmonary disease (CTEPD) with or without pulmonary hypertension (PH) occurs when thromboemboli in pulmonary arteries fail to resolve completely. Pulmonary artery obstructions due to chronic thrombi and secondary microvasculopathy can increase pulmonary arterial pressure and resistance leading to chronic thromboembolic PH (CTEPH). Mechanical interventions and/or PH medications can improve cardiopulmonary haemodynamic, alleviate symptoms, and decrease mortality risk. Imaging is pivotal throughout the CTEPD management journey, spanning diagnosis, treatment planning, and assessing treatment outcome. With just computed tomography (CT) pulmonary angiogram and right heart catheterisation, an experienced multidisciplinary team can determine surgical candidacy in most cases. Dual energy CT, lung subtraction iodine mapping CT, and dynamic contrast-enhanced magnetic resonance imaging (MRI) offer comparable sensitivities with ventilation-perfusion scintigraphy in diagnosing CTEPD. Pulmonary angiogram with digital subtraction angiography although considered the gold standard for assessing thrombi extent and vasculature morphology is now mostly used to assess targets for balloon pulmonary angioplasty. Advancements in CT modalities and innovative MRI metrics offer better insight into CTEPD management but are limited by the availability of technology and expertise. Learning from current artificial intelligence application in medical imaging, there is promise in tapping the wealth of data provided by CTEPD imaging through automating cardiopulmonary and vascular morphology analysis.</p></div>","PeriodicalId":73429,"journal":{"name":"International journal of cardiology. Congenital heart disease","volume":"17 ","pages":"Article 100536"},"PeriodicalIF":0.8,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666668524000454/pdfft?md5=00d52e64d87991bb3e2bcda91db0bbb9&pid=1-s2.0-S2666668524000454-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141991426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep disordered breathing and adult congenital heart disease","authors":"M. Vakali,&nbsp;M. Memon,&nbsp;M. Gatzoulis,&nbsp;M. Polkey","doi":"10.1016/j.ijcchd.2024.100532","DOIUrl":"10.1016/j.ijcchd.2024.100532","url":null,"abstract":"","PeriodicalId":73429,"journal":{"name":"International journal of cardiology. Congenital heart disease","volume":"18 ","pages":"Article 100532"},"PeriodicalIF":0.8,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666668524000417/pdfft?md5=47a102e5eaf897094c5c4fb720b240df&pid=1-s2.0-S2666668524000417-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142274041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The latest definition and classification of pulmonary hypertension","authors":"Seshika Ratwatte ,&nbsp;David S. Celermajer","doi":"10.1016/j.ijcchd.2024.100534","DOIUrl":"10.1016/j.ijcchd.2024.100534","url":null,"abstract":"<div><p>Pulmonary hypertension (PH) is a serious potential complication of some congenital heart diseases (CHDs). PH encompasses a range of diseases which may be idiopathic or inherited, or secondary to cardiac, respiratory, systemic or thromboembolic conditions, amongst others. Our increasing understanding of the normal ranges of pulmonary haemodynamics, as well as evidence supporting the benefits of early treatment, has resulted in a number of recent revisions to the haemodynamic definition of PH. In this Review Article, we report on the recent updates to haemodynamic definitions and classification of PH, as reflected in the 2022 Pulmonary Hypertension Guidelines and particularly focus on the CHD related sub-type of PH, where the aetiology is often multi-factorial.</p></div>","PeriodicalId":73429,"journal":{"name":"International journal of cardiology. Congenital heart disease","volume":"17 ","pages":"Article 100534"},"PeriodicalIF":0.8,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666668524000430/pdfft?md5=2f474a94fabfc36da592cb9b263a8b26&pid=1-s2.0-S2666668524000430-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141962033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subpulmonary ventricular function and inflammation are related to clinical heart failure in patients with a systemic right ventricle","authors":"Valérie Spalart ,&nbsp;Aleksandra Cieplucha ,&nbsp;Werner Budts ,&nbsp;Pieter De Meester ,&nbsp;Els Troost ,&nbsp;Thilo Witsch ,&nbsp;Walter Droogne ,&nbsp;Lucas NL Van Aelst ,&nbsp;Magalie Ladouceur ,&nbsp;Kimberly Martinod ,&nbsp;Alexander Van De Bruaene","doi":"10.1016/j.ijcchd.2024.100535","DOIUrl":"10.1016/j.ijcchd.2024.100535","url":null,"abstract":"<div><h3>Background</h3><p>Timely diagnosis of heart failure (HF) in patients with a systemic right ventricle (sRV) is difficult but important since clinical deterioration is fast once HF develops. We aimed to compare echocardiography and biomarker profile between sRV patients with and without HF and patients with a systemic left ventricle diagnosed with HF (sLV-HF).</p></div><div><h3>Methods and results</h3><p>Eighty-seven sRV patients and 30 sLV-HF patients underwent echocardiographic evaluation and blood sampling. Compared to sRV patients without HF, sRV-HF patients had more remodeling of the subpulmonary LV (spLV) (internal diameter 3.9 cm [3.3–5.7] vs 3.4 cm [2.9–3.9], P = 0.03, posterior wall 0.93 cm [0.76–1.20] vs 0.71 cm [0.59–0.91], P = 0.006) and lower spLV systolic function: ejection fraction (59 % ± 14 vs 70 % ± 10, P = 0.011), mitral annular plane systolic excursion (1.7 cm ± 0.5 vs 2.1 cm ± 0.4, P = 0.003), fractional area change (47 % [38–58] vs 59 % [51–70], P = 0.002) and lateral strain rate (−1.2/s ± 0.46 vs −1.5/s ± 0.39, P = 0.016). Inflammatory biomarkers were higher in sRV-HF patients compared to those without HF: red cell distribution width (13.3 fL [12.8–14.1] vs 12.6 fL [12.3–13.1], P &lt; 0.001), neutrophil lymphocyte ratio (NLR, 3.7 [2.2–4.9] vs 2.4 [1.9–3.0], P = 0.015), C-reactive protein (CRP, 2.5 mg/dL [1.0–4.2] vs 1.2 mg/dL [0.0–2.0], P = 0.005) and compared to sLV-HF patients (NLR (3.7 [2.2–4.9] vs 2.5 [1.7–3.3], P = 0.044) and CRP (2.5 mg/dL [1.0–4.2] vs 0.85 mg/dL [0.6–2.0], P = 0.006).</p></div><div><h3>Conclusion</h3><p>Biventricular echocardiographic evaluation with a focus on the subpulmonary LV together with assessing inflammatory status in sRV patients could help in an earlier detection of HF.</p></div>","PeriodicalId":73429,"journal":{"name":"International journal of cardiology. Congenital heart disease","volume":"17 ","pages":"Article 100535"},"PeriodicalIF":0.8,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666668524000442/pdfft?md5=98391a18df1fea3bb58f2b154788fef1&pid=1-s2.0-S2666668524000442-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141991425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes, mortality risk factors, and functional status post-Norwood: A single-center study","authors":"Alaa Aljiffry ,&nbsp;Ashley Harriott ,&nbsp;Shayli Patel ,&nbsp;Amy Scheel ,&nbsp;Alan Amedi ,&nbsp;Sean Evans ,&nbsp;Yijin Xiang ,&nbsp;Amanda Harding ,&nbsp;Subhadra Shashidharan ,&nbsp;Asaad G. Beshish","doi":"10.1016/j.ijcchd.2024.100533","DOIUrl":"10.1016/j.ijcchd.2024.100533","url":null,"abstract":"<div><h3>Background</h3><p>The Norwood operation (NO) for infants with univentricular physiology has high interstage mortality. This study evaluated outcomes and risk factors for mortality following NO.</p></div><div><h3>Methods</h3><p>Retrospective single-center study of patients undergoing NO from 2010 to 2020. Analysis used appropriate statistics.</p></div><div><h3>Results</h3><p>Of 269 patients undergoing NO, 213 (79.2 %) survived to discharge. Non-survivors had longer bypass times, delayed sternal closure, required nitric oxide, higher vasoactive scores, required post-operative catheterization, Extracorporeal Life Support (ECLS), and longer ventilation (p &lt; 0.05). Logistic regression showed moderate-severe atrioventricular valve regurgitation on intraoperative TEE (OR 2.6), requiring nitric oxide (OR 2.63), delayed sternal closure (OR 2.94), post-operative catheterization (OR 10.48), and ECLS (OR 14.54) increased mortality odds (p &lt; 0.05). Multivariable analysis confirmed catheterization (aOR 10.48) and ECLS (aOR 14.54) as significant predictors. Of survivors, 26 (12.3 %) developed new morbidity, 9 (4.2 %) had unfavorable outcomes. Functional status improved from 6.0 to 8.04, mainly in feeding and respiratory domains (p &lt; 0.0001).</p></div><div><h3>Conclusions</h3><p>Norwood survival was 79.2 %. Requiring post-operative catheterization and ECLS significantly increased mortality risk. Multicenter evaluation of these modifiable risk factors is needed to improve outcomes in this high-risk population.</p></div>","PeriodicalId":73429,"journal":{"name":"International journal of cardiology. Congenital heart disease","volume":"17 ","pages":"Article 100533"},"PeriodicalIF":0.8,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666668524000429/pdfft?md5=e08ecc7ded54dee64f3ee71a698dc086&pid=1-s2.0-S2666668524000429-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141852509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare presentation of pulmonary hypertension","authors":"Nazek Abuhalaweh ,&nbsp;Stephen John Wort ,&nbsp;John Dunbar ,&nbsp;Alex Kempny ,&nbsp;Michael Brown","doi":"10.1016/j.ijcchd.2024.100531","DOIUrl":"10.1016/j.ijcchd.2024.100531","url":null,"abstract":"","PeriodicalId":73429,"journal":{"name":"International journal of cardiology. Congenital heart disease","volume":"17 ","pages":"Article 100531"},"PeriodicalIF":0.8,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666668524000405/pdfft?md5=b334fb2d0d62ee8f246900eb7b6d82f6&pid=1-s2.0-S2666668524000405-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141846827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Congenital heart defects and consanguinity: An analysis of the Sidra cardiac registry data in Qatar","authors":"Mange Manyama ,&nbsp;Dana Al Sayegh ,&nbsp;Khalifa Al-Sulaiti ,&nbsp;Muna Almasri ,&nbsp;Omna Sharma ,&nbsp;Aya El Jerbi ,&nbsp;Zakariya Al-Riyami ,&nbsp;Padma Kumari Sarada ,&nbsp;Samir Gupta ,&nbsp;Hesham Al-Saloos ,&nbsp;Kholoud N. Al-Shafai","doi":"10.1016/j.ijcchd.2024.100529","DOIUrl":"10.1016/j.ijcchd.2024.100529","url":null,"abstract":"","PeriodicalId":73429,"journal":{"name":"International journal of cardiology. Congenital heart disease","volume":"17 ","pages":"Article 100529"},"PeriodicalIF":0.8,"publicationDate":"2024-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666668524000387/pdfft?md5=01a3dbe06445fd5b7d931a8f94fef8a3&pid=1-s2.0-S2666668524000387-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141848881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosis and management of peripartum cardiomyopathy and recurrence risk","authors":"Giulia Iannaccone ,&nbsp;Francesca Graziani ,&nbsp;Polona Kacar ,&nbsp;Pietro Paolo Tamborrino ,&nbsp;Rosa Lillo ,&nbsp;Claudia Montanaro ,&nbsp;Francesco Burzotta ,&nbsp;Michael A. Gatzoulis","doi":"10.1016/j.ijcchd.2024.100530","DOIUrl":"10.1016/j.ijcchd.2024.100530","url":null,"abstract":"<div><p>Peripartum cardiomyopathy (PPCM) is a rare, but serious condition, with a non-negligible risk of adverse events. Several risk factors for PPCM have been individuated over the years, including Afro-American ethnicity, preeclampsia, advanced maternal age, genetic predisposition, multiparity, twin pregnancy, obesity, smoking and diabetes. However, PPCM pathophysiology is still poorly understood, thus making it challenging to develop disease specific therapies. At present, Bromocriptine is the only targeted drug, but further evidence is needed to establish indication and timing of administration. Therefore, these patients are mainly treated following general heart failure guidelines. Even though in most patients left ventricular ejection fraction recovers during follow-up, cases of persistent left ventricular dysfunction are not uncommon. Moreover, all patients detain a certain risk of recurrence after subsequent pregnancies, which is difficult to estimate due to the dearth of long-term prospective data.</p><p>In this manuscript, we aim to provide an updated review of current evidence about PPCM pathophysiology, diagnosis, treatment and recurrence risk. In addition, we discuss the gaps in knowledge that should be addressed by future research.</p></div>","PeriodicalId":73429,"journal":{"name":"International journal of cardiology. Congenital heart disease","volume":"17 ","pages":"Article 100530"},"PeriodicalIF":0.8,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666668524000399/pdfft?md5=00741532785c03321c9fc76821035632&pid=1-s2.0-S2666668524000399-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141845476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Indexing right ventricular volumes in obese patients with tetralogy of fallot","authors":"Alexander C. Egbe ,&nbsp;William R. Miranda ,&nbsp;Snigdha Karnakoti ,&nbsp;Sriharsha Kandlakunta ,&nbsp;Muhammad Eltony ,&nbsp;Christopher J. Francois ,&nbsp;Heidi M. Connolly","doi":"10.1016/j.ijcchd.2024.100528","DOIUrl":"10.1016/j.ijcchd.2024.100528","url":null,"abstract":"","PeriodicalId":73429,"journal":{"name":"International journal of cardiology. Congenital heart disease","volume":"17 ","pages":"Article 100528"},"PeriodicalIF":0.8,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666668524000375/pdfft?md5=e595bae2c7bce5c6d04edb56fe14f14a&pid=1-s2.0-S2666668524000375-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141707132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}